共查询到20条相似文献,搜索用时 828 毫秒
1.
This review covers the main strategies for the synthesis of N‐pivot lariat ethers as well as their specific syntheses. 相似文献
2.
Five series of new heterocyclic compounds of 1,2,4‐triazole Mannich bases, 1,3,4‐oxadiazole Mannich bases, 1,3,4‐oxadiazolines, 1,2,4‐triazolo[3,4‐b]1,3,4‐thiadiazines and 1,2,4‐triazolo[3,4‐b]1,3,4‐thiadiazoles, in which 1,2,3‐triazolyl and isoxazolyl have been united, were synthesized from the intermediate of 5‐methyl‐3‐(2‐phenyl‐2H‐1,2,3‐triazol‐4‐yl)isoxazole‐4‐carbohydrazide, Their structures were established by spectroscopy. 相似文献
3.
Karine Scarpellini‐Charras Gérard Boyer Nathalie Filloux Jean‐Pierre Galy 《Journal of heterocyclic chemistry》2008,45(1):67-70
The preparation of symmetric 2,2′‐dimethoxy‐10,10′‐biacridinyl‐9,9′‐dione atropisomers were obtained by the oxidative coupling of 9(10H)‐acridinone with 1,3‐dibromo‐5,5‐dimethyl‐imidazolidine‐2,4‐dione 相似文献
4.
H. M. T. Bandara Herath N. P. Dhammika Nanayakkara 《Journal of heterocyclic chemistry》2008,45(1):129-136
Concise and efficient methods for the synthesis of enantiomers of fire ant venom alkaloids solenopsin and isosolenopsin A, B, and C are described. These syntheses are based on diastereoselective electrophilic substitution of enatiomerically‐pure α‐lithiated 2‐alkylpiperidine. 相似文献
5.
A series of new carbazolo[2,1‐a]carbazoles was synthesized from 4‐oxo‐1,2,3,4‐tetrahydrobenzo[a]‐carbazole derivatives. 相似文献
6.
Anton V. Dolzhenko Anna V. Dolzhenko Wai‐Keung Chui 《Journal of heterocyclic chemistry》2008,45(1):173-176
The 2‐amino‐4‐(het)aryl‐4,6‐dihydro‐1(3)(11)H‐[1,3,5]triazino[2,1‐b]quinazolin‐6‐ones were prepared readily by cyclocondensation of anthranilic acid derived 4‐oxo‐3,4‐dihydroquinazolinyl‐2‐guanidine with a variety of aldehydes. The structures of the compounds were confirmed by nmr spectroscopy, including 2D NOESY experiments. 相似文献
7.
Treatment of 2‐cyano‐3‐phenyl‐2‐pentenedinitrile with some heterocyclic diazonium salts afforded the corresponding heterocyclic hydrazones. Some of the latter hydrazones were converted into fused polyaza‐heterocycles upon boiling in pyridine. Reaction of 2‐cyano‐3‐phenyl‐2‐pentenedinitrile with phenylisothiocyanate gave a tricyano‐thiole derivative which on treatment with hydrazonoyl chlorides and 1‐(benzothiazol‐2‐yl)‐2‐bromoethanone furnished 1,3,4‐thiadiazole and thiazole derivatives, respectively. 相似文献
8.
Zhongjiao Ren Weiguo Cao Weiqi Tong Jie Chen Changqing Wang 《Journal of heterocyclic chemistry》2008,45(1):85-90
An efficient and highly stereoselective approach for the preparation of highly functionalized cyclopropyl heterocycles via the cyclopropanation of olefines with arsonium salts in the presence of KF2H2O has been developed. 相似文献
9.
Reaction between α‐halo‐nicotinic esters and a nucleophilic source such as the N‐methylpyrrolidin‐2‐one (NMP) gave unexpected results. The presence of the halide on the pyridine gave a very interesting migration reaction. Extension to 6‐methylnicotinic ester derivatives lead to an unexpected carbanion condensation. 相似文献
10.
Jairo Quiroga Débora Cobo Braulio Insuasty Rodrigo Abonía Silvia Cruz Manuel Nogueras Justo Cobo 《Journal of heterocyclic chemistry》2008,45(1):155-159
New fused indeno[1,2‐b]pyridine derivatives have been prepared in a multicomponent reaction from benzaldehydes, indanedione and the appropriate aminoheteroaryl compound. The simple methodology permitted the syntheses of a series of indeno[1,2‐b]pyrazolo[4,3‐e]pyridines 4 from 5‐aminopyrazol 1 and modulated by the corresponding benzaldehyde 2 . 相似文献
11.
Nilo Zanatta Claudia C. Madruga Patricia C. Marisco Luciana S. Da Rosa Liana Da S. Fernandes Darlene C. Flores Alex F. C. Flores Robert A. Burrow Helio G. Bonacorso Marcos A P. Martins 《Journal of heterocyclic chemistry》2008,45(1):221-227
This work describes the synthesis of a novel series of 2‐methylsulfanyl‐tetrahydropyrimidines, from the cyclocondensation reaction of β‐alkoxyvinyl trihalomethyl ketones with 2‐methyl‐2‐thiopseudourea sulfate, in good yields. A detailed 1H‐ and 13C‐NMR study was performed on the 2‐methylsulfanyl‐tetrahydropyrimidines obtained and 3D structures were proposed based on AM1 calculations supported by 1H NMR coupling constants and NOESY experiments. 相似文献
12.
Malek Taher Maghsoodlou Sayyed Mostafa Habibi Khorassani Lotfali Saghatforoush Farhad Maghfuri Ghasem Marandi Roya Kabiri 《Journal of heterocyclic chemistry》2008,45(1):289-293
High hindrance Hexa tert‐butoxy carbonyl dipyrrolophenanthroline and helical dihydropyrrolophen‐anthroline compounds were prepared from reactions between di tert‐butyl acetylenedicarboxylate and 1,10‐phenanthroline in polar solvents media. 相似文献
13.
Zhenjiang Li Weisi Li Yingjie Sun He Huang Pingkai Ouyang 《Journal of heterocyclic chemistry》2008,45(1):285-288
Amidosulfonic acid NH2–SO3H catalyzed direct condensations of o‐phenylenediamines with α‐diketones at room temperature in organic solvents to afford quinoxalines in excellent yields. The amidosulfonic acid as a solid acid catalyst in this preparation was efficient and recoverable. 相似文献
14.
Saifidin Safarov Rahmonov Rahmon Muhamacho Amadovich Kukaniev Dieter Schollmeyer Elena Karpuk Herbert Meier 《Journal of heterocyclic chemistry》2008,45(1):299-302
The reaction of primary or secondary amines with 2,5‐dibromo‐6‐phenylimidazo[2,1‐b][1,3,4]‐thiadiazole ( 5 ) leads to a chemoselective replacement of the 2‐Br substituent. The process represents a convenient route to the corresponding 2‐ylamines 7a‐d . Hydrazine reacts in an analogous fashion ( 5 → 7e ). The structure determinations are based on an X‐ray crystal structure analysis and on one‐ and two‐dimensional NMR measurements. 相似文献
15.
Olga V. Serdyuk Anna V. Gulevskaya Alexander F. Pozharskii Vadim E. Avakyan 《Journal of heterocyclic chemistry》2008,45(1):195-199
Molecular structure, aromaticity and some spectral properties of benzobis(pyrrolopyrimidopiridazines) 2 that are the first π‐electronic analogues of the still unknown dibenzo[a,o]picene are discussed. 相似文献
16.
Several 1,2‐diazaspiro[4,4]nona‐2,8‐diene‐6‐one derivatives were synthesised via cycloaddition of nitrilimides to 3‐aryliden‐2(3H)‐furanone derivatives. The formed products react with hydrazine hydrate to give the corresponding pyrazolecarbohydrazide derivatives which undergo intramolecure cyclization upon treatment with HCl/AcOH mixture to affored 1,2,7,8‐tetrazaspiro[4.5]deca‐2,9‐diene‐6‐one derivatives. Molecular mechanics energy minimization techniques and related structural parameters for compound 8‐(4‐methylphenyl)‐1,3,4‐triphenyl‐7‐oxa‐1,2‐diazaspiro[4.4]nona‐2,8‐diene‐6‐one 5a are reported. 相似文献
17.
Daniel P. Walker Brad A. Acker E. Jon Jacobsen Donn G. Wishka 《Journal of heterocyclic chemistry》2008,45(1):247-257
Three new azabicyclic amines, namely exo‐3‐amino‐1‐azabicyclo[3.2.1]octane, 3‐amino‐1‐azabicyclo‐[3.2.2]nonane and exo‐6‐amino‐8‐azabicyclo[3.2.1]octane, have been designed and prepared as isosteres of 3‐aminoquinuclidine. Aryl amides derived from each series were prepared and tested in an α7 nicotinic acetylcholine receptor assay as part of a drug discovery program to treat the cognitive deficits in schizophrenia. All new amides showed significant α7 nAChR activity and one series displayed potent α7 activity equal to the quinuclidine series. 相似文献
18.
Georg Uray Naresh S. Badgujar Sona Kováčková Wolfgang Stadlbauer 《Journal of heterocyclic chemistry》2008,45(1):165-172
Stepwise demethylation of fluorescent 6,7‐dimethoxy‐3‐trifluoromethylcarbostyrils 5 leads to 6‐hydroxy derivatives 6 and 6,7‐dihydroxyderivative 7 . Phenolate formation shifts excitation and emission maxima from 370 and 430 nm to 430 and 480 nm for the anion of 6 and as far as 500 and 580 nm for the dianion of 7 . Dependence of fluorescence quantum yield on media and polar structure, varying from 0.02 to 0.51, is discussed. O‐Alkylation of 6 with alkyl bromoacetate yields esters of type 8 in good yield. Reactive succinimidoyl (OSu) esters of type 11 were prepared after saponification to acids 9 . With amino acids or their esters, peptides and aminoglucose, linking to labeled derivatives 13 or 15 could be achieved under mild conditions in slightly basic aqueous media. 相似文献
19.
Myeong Jong Cha Young Seok Song Eun‐Gu Han Kee‐Jung Lee 《Journal of heterocyclic chemistry》2008,45(1):235-240
A new route to 2H‐thiochromenes using the tandem SN2′ and SNAr reaction of several Baylis‐Hillman acetates having an ortho‐substituent, such as a halogen or nitro group, with sodium sulfide in aqueous dimethyl sulfoxide has been described. 相似文献
20.
Milan S. Dekić Biljana R. Dekić Vidoslav S. Dekić Stojadin V. Deki 《Journal of heterocyclic chemistry》2008,45(1):295-297
Condensation of 4‐chloro‐2‐oxo‐2H‐chromene‐3‐carbonitrile ( 1 ) with heteroarylamines 2a‐d in acetonitrile containing a catalytic amount of triethylamine followed by spontaneous intramolecular cyclization gave the novel coumarin derivatives 3a‐d , respectively. These compounds underwent acid hydrolysis giving the corresponding oxoderivatives 4a‐d . The structural assignments of the synthesized compounds were based on elemental, IR, 1H and 13C NMR analyses. 相似文献