A New Pregnane and a New Diphenylmethane from the Root Barks of Periploca sepium

A new polyoxygenated pregnane genin and a new diphenylmethane, along with five known pregnane derivatives, were isolated from the root barks of Periploca sepium. The structures of the new compounds were elucidated as (3β,14β)‐3,14‐dihydroxy‐21‐methoxypregn‐5‐en‐20‐one ( 1 ) and 2‐hydroxy‐5‐(2‐hydroxy‐4‐methoxybenzyl)‐4‐methoxybenzaldehyde ( 2 ) on the basis of spectroscopic methods, especially 2D‐NMR and MS analyses. The known compounds were identified by comparing their physical and spectroscopic data with those reported in the literature.     

Further Daphniphyllum Alkaloids from the Leaves of Daphniphyllum macropodum Miq.

Five new polycyclic Daphniphyllum alkaloids, macropodumines F ( 1 ) and G ( 2 ), 17‐oxoyuzurimine ( 3 ), and macropodumines H ( 4 ) and I ( 5 ), were isolated from the leaves of D. macropodum Miq ., collected in Sichuan Province, China. The structures and relative configurations of the new compounds – as well as of four known, related alkaloids – were elucidated on the basis of in‐depth spectroscopic and mass‐spectrometric analyses, by chemical derivatization, and by comparison of spectroscopic data with those of known compounds.     

Isolation and Characterization of Secondary Metabolites from Rhododendron microphyton

Four new iridoids, incarvoids D–F ( 1 – 3 , resp.) and incarvoid B 9‐O‐β‐D ‐glucopyranoside ( 4 ), and one new monoterpenoid, argutoid B ( 5 ), along with 14 known compounds, were isolated from Rhododendron microphyton. Their structures were established by comprehensive 1D‐ and 2D‐NMR spectroscopic analysis.     

Study on the Chemical Constituents of Daphniphyllum angustifolium

Seven new iridoid glucosides, 1 – 7 , two new phenyl glucosides, 8 and 9 , along with eight known compounds were isolated from the bark of Daphniphyllum angustifolium. Their structures were established by ESI‐MS and by 1D‐ and 2D‐NMR spectroscopic methods.     

苔藓植物短肋羽藓Thuidium kanedae sak 中的双二氢黄酮类化合物

A new bidihydroflavonoid, thuidinin 1, together with 5 known compounds including one known biflavonoid 3＇,3＂＇-binaringenin （2） and four other known natural products pentadecane （3）, methyl β-orcinolarboxylate （4）, β-sitosterol （5） and daucostenol （6）, were isolated from leaves of Thuidium kanedae Sak. Their structures were established on the basis of 1D and 2D spectroscopic analysis. The absolute stereochemistry of compounds 1 and 2 was determined by CD spectra.     

Novel Flavonoids in Dragon's Blood of Daemonorops draco

The three novel methylene bis[flavonoids] 1 – 3 , the novel 2‐flavene 4 , the new naturally occurring flavan 5 , and the new retro‐dihydrochalcone 6 were isolated from dragon's blood of Daemonorops draco, together with seven known compounds. The structures were elucidated by extensive 1D‐ and 2D‐NMR spectroscopic analysis.     

ent‐Kaurane Diterpenoids from Isodon japonicus

Two new 6,7‐seco‐ent‐kaurane diterpenoids, isojaponins A ( 1 ) and B ( 2 ), together with 18 known ent‐kaurane diterpenoids were isolated from the aerial parts of Isodon japonicus. The structures of the two new compounds were elucidated by extensive 1D‐ and 2D‐NMR spectroscopic methods in combination with MS experiments.     

Two New Pseudoguaianolides from the Flowers of Parthenium hysterophorus

Chemical investigation on two samples of the flowers of Parthenium hysterophorus afforded two new pseudoguaianolides (one from each sample) together with several known constituents. The structures of the new compounds were established by extensive spectroscopic (1D‐ and 2D‐NMR) studies. The X‐ray crystallographic analysis of one of these compounds was also accomplished.     

Two New Diterpenes from Solidago canadensis

Two new clerodane‐type diterpenes, solidagocanins A and B ( 1 and 2 , resp.), as well as two known compounds, mellein ( 3 ) and physcion ( 4 ), were isolated from the aerial parts of Solidago canadensis. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D‐NMR techniques.     

Five New Steroidal Alkaloid Glycosides from Solanum tuberosum

Five new steroidal alkaloid glycosides, 1 – 5 , along with the known analog 6 , have been isolated from the aerial parts of Solanum tuberosum. The structures of the new compounds were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR and HR‐ESI‐MS techniques, as well as by comparison of the spectral data with those of related compounds. Only compound 6 showed significant cytotoxicity.     

Structure elucidation of new fusarielins from Fusarium sp. and their antimicrobial activity

Three new fusarielins, 3‐epi‐fusarielin H ( 1 ), 3‐O‐methyl‐fusarielin H ( 2 ), and 3‐O‐methyl‐epi‐fusarielin H ( 3 ), were isolated from the fungus Fusarium sp. together with the known analogues, fusarielins F ( 4 ) and G ( 5 ). The structures of these compounds were elucidated by analysis of their ESI‐HRTOFMS, 1D and 2D NMR spectroscopic data. The new compounds exhibited weak antibacterial effect against Staphylococcus aureus.     

Two New Sesquiterpenes from Euonymus alatus

Two new sesquiterpenes, 1 and 2 , as well as the five known compounds 3 – 7 , were isolated from the stems of Euonymus alatus. Compounds 2 – 7 have a β‐dihydroagarofuran skeleton. The structures of these compounds were elucidated mainly by spectroscopic methods (1D‐, 2D‐NMR, ESI‐MS, and HR‐ESI‐MS). We also report the X‐ray crystal structure of evonine ( 3 ) for the first time.     

Four New Compounds from Sinacalia tangutica

Four new compounds, 9α‐hydroxy‐1β‐methoxycaryolanol ( 1 ), stigmast‐5‐ene‐7α,22α‐diol‐3β‐tetradecanoate ( 2 ), 7‐O‐(6′‐acetoxy‐β‐D ‐glucopyranosyl)coumarin ( 3 ), and 8‐O‐(6′‐acetoxy‐β‐D ‐glucopyranosyl)‐7‐hydroxycoumarin ( 4 ), together with ten known compounds, were isolated from the aerial parts of Sinacalia tangutica. The structures of the new compounds were established by means of extensive spectroscopic analyses (1D‐ and 2D‐NMR, EI‐MS, HR‐ESI‐MS, as well as IR and UV) and by comparison of their spectroscopic data with those of structurally related compounds reported in the literature.     

Two New Bis‐alkaloids from the Aerial Part of Piper flaviflorum

Two new bis‐alkaloids, flavifloramides A ( 1 ) and B ( 2 ), as well as two known alkaloids, N‐trans‐feruloyltyramine ( 3 ) and paprazine ( 4 ), were isolated from the aerial part of Piper flaviflorum. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D‐NMR techniques.     

New Isoprenylated Aurones from the Flowers of Rosa damascena

A phytochemical investigation of the flowers of Rosa damascena resulted in the isolation of three new isoprenylated aurones, damaurones C–E ( 1 – 3 , resp.), together with six known compounds, 4 – 9 . The structures of the new compounds were elucidated by spectroscopic methods, including extensive 1D‐ and 2D‐NMR experiments.     

Two New Iridoids from the Stem of Catalpa ovata

Two new iridoids, 6‐O‐[(E)‐feruloyl]jioglutin D ( 1 ) and 6‐O‐(4‐hydroxybenzoyl)jioglutin D ( 2 ), and six known compounds, minecoside ( 3 ), specioside ( 4 ), picroside II ( 5 ), picroside III ( 6 ), 4‐hydroxybenzoic acid ( 7 ), and martynoside ( 8 ), were isolated from the stem of Catalpa ovata. The structures of the new compounds were established on the basis of spectroscopic techniques, including 1D‐ and 2D‐NMR.     

Two New Cytotoxic Alkaloids from Mappianthus iodoides Hand.‐Mazz.

Two new alkaloids, mappine A ( 1 ) and mapposidic acid ( 2 ), together with eleven known compounds, were isolated from the stems of Mappianthus iodoides Hand.‐Mazz. Their structures were elucidated by means of spectroscopic and mass‐spectrometric analyses, particularly 1D‐ and 2D‐NMR spectroscopy. The cytotoxic activities of the two new alkaloids were also evaluated.     

Monoterpenoid Indole Alkaloids from Alstonia mairei

Three new monoterpenoid indole alkaloids, (14α,15α)‐14,15‐epoxyaspidofractinine ( 1 ) and maireines A and B ( 2 and 3 , resp.), together with 19 known alkaloids, were isolated from the leaves and twigs of Alstonia mairei. The structures of the new compounds were elucidated by 1D‐ and 2D‐NMR spectroscopic methods in combination with MS experiments.     

Triterpenoids and other Constituents from Euphorbia Humifusa

A novel lupane‐type triterpenoid, 3,4‐seco‐lupa‐4(23), 20(29)‐dien‐24‐hydroxy‐3‐oic acid (1) and a new cycloartane‐type triterpenoid, 23(E)‐cycloart‐23‐en‐25‐ethoxy‐3β‐ol (7), as well as eighteen known compounds, were isolated from the hot ethanol extract of the whole plant of Euphorbia humifusa Willd. The new structures were characterized by means of spectroscopic methods including 1D, 2D NMR and HRESIMS, and the known ones were established on the basis of comparing their NMR data with those of the corresponding compounds in the literature. In addition, cytotoxicity against selected cancer cell human gastric carcinoma (SGC‐7901) of compounds 1,3,4,6 were measured in vitro.     

A New Hydrolyzable Tannin from Balanophora harlandii with Radical‐Scavenging Activity

One new hydrolyzable tannin, 1‐O‐[(E)‐p‐coumaroyl]‐3‐O‐galloyl‐β‐D ‐glucopyranose ( 1 ), was isolated from the rhizome of Balanophora harlandii, together with 18 known phenolic compounds. Their structures were determined by detailed spectroscopic analysis. Of the known compounds, 3‐O‐caffeoyl‐D ‐glucopyranose ( 6 ) was obtained as a natural product for the first time, and compounds 2 – 6 and 8 – 19 were identified for the first time from this plant. The radical‐scavenging activity of the isolated compounds was tested by a DPPH assay.