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检测和识别体内某些物质,例如唾液酸化LewisA/X,能够为疾病的诊断、治疗、预后、分子示踪及深入研究相关疾病机理等方面提供重要参考.因此,开发高选择性、高灵敏度的化学传感器具有重要价值.苯基硼酸化合物由于其特殊结构,能够与糖、儿茶酚胺以及氟化物、氰化物等路易斯碱相互作用,使得其能够作为传感器用于相关物质的荧光识别和检测;且此类化合物具有高选择性、高效能、分析速度快等优点.近几年,将硼酸与纳米粒子、量子点等新材料相结合,设计出性能更加优越的硼酸传感器.综述了硼酸类化合物在传感器方面的研究进展. 相似文献
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糖广泛存在于自然界中,与蛋白质和核酸一起并列构成生命体的三大物质单元。由于糖含有多个羟基,含硼酸基的有机物与二醇间有强烈结合作用,故硼酸基团常用于糖类识别和细胞标记。当荧光体与硼酸基团相连接时即可构建识别糖的荧光传感器。本文按发光团结构进行分类,分为:萘基硼酸类受体(包括对二甲氨基萘硼酸衍生物,N-取代的氨基萘硼酸衍生物,1,8-萘二甲酰亚胺为母体的单硼酸衍生物)、杂环硼酸类受体(包括含氮杂环硼酸衍生物、含硫杂环硼酸衍生物以及含氧杂环硼酸衍生物)、蒽环硼酸类受体、芘环硼酸类受体、紫精硼酸类受体及其它类型的硼酸类受体等,详细评述了自2002年以来含硼酸基团的新型荧光受体在单糖识别研究中的最新进展。 相似文献
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利用合成的含有识别基团苯硼酸和荧光读出基团喹啉的新型双亲化合物对硼酸苯甲基-8-十六烷氧基溴化喹啉(BHQB)在水中自组织成囊泡,囊泡的相变温度为52.4℃;当向囊泡体系加糖时,BHQB囊泡中的喹啉生色基在508nm的荧光峰强度急剧减弱,425nm处荧光逐渐增强.荧光强度变化可能归于所形成的硼酸酯改变了双亲化合物中硼原子的杂化轨道形式,进一步引起了整个分子内部的电子云排布所致.BHQB囊泡与糖的相互作用而导致体系荧光强度变化,并且这种变化的幅度与加入糖的种类和量均有关.因此体系有可能应用于检测生物物质如糖的化学传感器. 相似文献
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有机硼化合物中硼原子空的pπ轨道使其作为路易斯酸能够选择性的结合氟离子,其与氟离子的结合破坏了硼中心与芳香取代基的pπ-π共轭,引起有机硼化合物光物理性质的变化。因此,有机硼化合物能够用作高选择性的氟离子化学传感器材料。本文从具有三芳基硼结构及硼酸或硼酸酯结构的这两类有机硼化合物出发,综述了它们在氟离子化学传感器领域的研究进展。 相似文献
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高效毛细管电泳,激光干涉检测快速分离二糖研究 总被引:5,自引:4,他引:5
首次报道一种高效毛细管电泳、激光干涉折射检测快速分离二糖的新方法。详细研究了四硼酸钠溶液中,pH值、四硼酸钠浓度及有机添加剂对二糖-硼酸络离子迁移行为的影响,发现在pH为9.7的0.1mol/L四硼酸钠溶液中,10min内4种二糖得到基线分离。采用自制激光干涉型折射指数检测器,不需对二糖衍生化处理,可直接进行在柱检测。 相似文献
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利用硼酸与茜素红S和糖中的邻二羟基可逆结合的特点,以硼酸为中介运用竞争结合作用机理构建单糖分析法.在pH7.4的KH2PO4-NaOH缓冲溶液中,茜素红S作为指示剂与硼酸结合生成ARS-BA配合物,其结合常数为5.09×102L/mol.糖与指示剂ARS竞争结合硼酸使指示剂游离出来,产生明显的颜色变化,据此建立糖的识别方法.考察了D-葡萄糖、D-山梨醇、D-半乳糖、D-甘露糖、D-果糖、D-阿拉伯糖和L-阿拉伯糖对上述ARS-BA体系光谱的影响.结果显示:该体系对D-山梨醇和D-果糖有较好的光谱响应,其光谱变化灵敏度依D-山梨醇>D-果糖>D-阿拉伯糖~D-半乳糖>D-葡萄糖>D-甘露糖>L-阿拉伯糖之序. 相似文献
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Mulla K Dongare P Zhou N Chen G Thompson DW Zhao Y 《Organic & biomolecular chemistry》2011,9(5):1332-1336
Two phenylboronic acid based saccharide sensors bearing conjugated oligomer fluorophores with linear and cruciform π-frameworks were synthesized in a modular approach utilizing a Cu-catalyzed alkyne azide cycloaddition (click) reaction. The cruciform fluorophore showed excellent saccharide sensing function under physiological conditions in the mM range, whereas the linear fluorophore gave very limited sensing functions. The different fluorescent sensing behaviours highlight the important role of oligomer fluorophore in the development of effective saccharide sensors. 相似文献
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Arimori S Bell ML Oh CS Frimat KA James TD 《Chemical communications (Cambridge, England)》2001,(18):1836-1837
Modular and modular polymer supported fluorescence photoinduced electron transfer (PET) sensors 2 and 3 with two boronic acid receptor units, a pyren-1-yl fluorophore, and hexamethylene linker show selective saccharide binding in aqueous methanolic solution at pH 8.21. 相似文献
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The covalent boron–diol interaction enables elaborate design of boronic acid‐based saccharide sensors. Over the last decade, this research topic has been well developed thanks to the integration of boronic acid chemistry with a range of techniques, including supramolecular chemistry, materials chemistry, surface modification, and nanotechnology. New sensing strategies and platforms have been introduced and remarkable progress has been achieved to fully utilize the unique property of boron–diol interaction and to improve the binding affinity towards different targets, especially under physiological conditions. In this review, the latest progress over the past 30 months (from late 2012 to early 2015) is highlighted and discussed to shed light on this versatile and promising platform for saccharide sensing. 相似文献
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Susumu Arimori 《Tetrahedron letters》2004,45(7):1539-1542
Six modular photoinduced electron transfer (PET) sensors bearing two phenylboronic acid receptors have been evaluated as fluorescent disaccharide sensors. The length of linker separating the two boronic acid moieties was varied and the sensors’ interaction with disaccharides assessed via fluorescence spectroscopy. It was shown that saccharide selectivity was influenced by the choice of linker length. Diboronic acid sensors 3n also displayed significant specificity for the disaccharides linked to the carbon on the 3rd or 6th position (as numbered from the anomeric centre) over those linked at the 4th position. 相似文献
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Equilibrium geometries, energies, and vibrational frequencies of cage-shaped boric acid clusters including the onion-like structure have been calculated at the HF/6-31G and B3LYP/6-31G(d) levels of theory. A family of cage-shaped boric acid clusters becomes evident according to our calculations. Each member of the family is formed by strong O-H...O hydrogen bonds. Higher cage-shaped boric acid clusters are more stable. The calculated stabilization energies for the cage-shaped boric acid clusters appear to steadily increase with the number of boric acid molecules (n) and are nearly linear in n. Similarities between cage-shaped boric acid clusters and fullerenes are also discussed. 相似文献
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The complex formation in concentrated sulfuric acid between boric acid and quinalizarin (1,2,5,8-tetrahydroxyanthraquinone) or alizarin (1,2-dihydroxyanthraquinone) was studied by spectrophotometry. Both systems contained only one species, viz. a complex between one boric acid and one hydroxyanthraquinone molecules. The reactions of boric acid with hydroxyanthraquinones are discussed and compared with the reaction of boric acid with 1,1'-dianthrimide. 相似文献
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Substituent effects on monoboronic acid sensors for saccharides based on N-phenyl-1,8-naphthalenedicarboximides 总被引:4,自引:0,他引:4
In the course of our investigations on new monoboronic acid saccharide sensors with C(0) spacers, a series of probes 1-6 based on 1,8-naphthalenedicarboximide were synthesized. Sensor 1 displays features typical of PET monoboronic acid sensors and shows high selectivity to fructose. Sensor 2 exhibits a novel dual emission and remarkable sensitivity for glucose relative to fructose and galactose through subtle changes in pH. Sensor 3 displays significantly enhanced fluorescence in the presence of galactose at low pH. Although probes 4-6 exhibit unique properties such as high quantum yield (Phi(F) = 0.407) and excellent solubility in water, they did not show significant change in fluorescence intensity in the presence of monosaccharides. The effects of substituent on all six probes lend support to the proposed photoelectrochemical model. 相似文献
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J. Narbutt J. Olza Z. Przybyłowicz S. Siekierski 《Journal of Radioanalytical and Nuclear Chemistry》1979,51(2):185-190
Extractive purification of boric acid from radioactive corrosion and fission products dissolved in aqueous solutions modelling
nuclear reactor coolants has been studied. Aliphatic 1,3-diols containing 8 and 9 carbon atoms per molecule were used as extractants
fro boric acid. The behaviour of some representative corrosion and fission products as well as various factors affecting their
distribution between the organic and aqueous phases have been investigated under the conditions of boric acid extraction.
Conditions for the effective separation of boric acid from most of the radioactive contaminants are presented. 相似文献
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A precise method is described for the determination of boric acid and boron in metal borides by potentiometric titration of the mannitol/boric acid complex with a strong alkali. Titration data are evaluated by a multiparametric curve-fitting procedure on the basis of model functions for this type of titration. The initial boric acid concentration, or parameters like the conditional acidity constant and the association number of the mannitol/boric acid complex can be determined. For a sample of titanium boride, the standard deviation was 0.15% on a boron content of 29.18%. 相似文献