共查询到20条相似文献,搜索用时 15 毫秒
1.
Raczynska ED Decouzon M Gal JF Maria PC Taft RW Anvia F 《The Journal of organic chemistry》2000,65(15):4635-4640
Gas-phase basicities of four polyfunctional N1,N1-dimethyl-N2-azinylformamidines (1-4) are obtained from proton-transfer equilibrium constant determinations, using Fourier transform ion-cyclotron resonance mass spectrometry. Comparison with model amidines and azines (GB revised according to the recent compilation of Hunter and Lias) indicates the aza group as the favored site of protonation. The strong basicity of ortho derivatives is explained in term of intramolecular stabilization (the so-called "internal solvation"). 相似文献
2.
3.
Cole ML Evans DJ Junk PC Smith MK 《Chemistry (Weinheim an der Bergstrasse, Germany)》2003,9(2):415-424
The treatment of N,N'-di(ortho-fluorophenyl)formamidine (HFPhF) in tetrahydrofuran with equimolar amounts of n-butyllithium, sodium bis(trimethylsilyl)amide or potassium bis(trimethylsilyl)amide affords the colourless crystalline formamidinate complexes [Li(FPhF)(thf)] (1), [Na(FPhF)(thf)] (2) and [K(FPhF)] (5). Low-temperature preparation of 2 in diethyl ether yields the Et(2)O adduct [Na(FPhF)(Et(2)O)] (3). At ambient temperature the sodium fluoride inclusion complex [Na(3)(FPhF)(3)(Et(2)O)(NaF)] (4) is also formed. Spectroscopic ((1)H, (13)C and (19)F((1)H) NMR) data for 1-5, microanalytical analyses for compounds 1, 2 and 5 and X-ray structure determinations for 1, 3-5 confirm the formulae of these species. In the solid-state, 1 and 3 possess a dimeric nature in which the formamidinate ligands coordinate through mu(2):eta(2):eta(1) (1) and mu(2):eta(2):eta(2) (3) binding modes. These are enabled by partial ortho-fluoro donation. Compound 4, which is also dimeric, contains two trisodium tris(formamidinate) units that comprise mu(2):eta(2):eta(2)-FPhF ligands, a bridging diethyl ether moiety and an unprecedented mu(3):eta(2):eta(2):eta(2)-formamidinate donor. Together, these trinuclear units encapsulate two sodium fluoride units by eta(2)-N,N-formamidinate chelation of the sodium cations (thereby creating further mu(3):eta(2):eta(2):eta(2)-bound formamidinates) and fluoride-sodium interactions. Compound 5 extends the coordinative versatility of FPhF to mu(2):eta(4):eta(3) coordination by the generation of K(2)(mu(2):eta(4):eta(3)-FPhF)(2) units that exhibit eta(2)-arene interactions. Macromolecularly, the overlaying of these units affords a polymeric solvent-free structure that incites coordination of the FPhF ligands to metal atoms above and below the K(2)(FPhF)(2) plane. Overall, this generates a remarkable mu(4):eta(4):eta(3):eta(2):eta(1)-amidinate binding mode that incorporates both bridging and terminal fluorine donors. Compounds 1-5 are the first non-chromium complexes of N,N'-di(ortho-fluorophenyl)formamidinate. 相似文献
4.
Two Trinuclear copper(Ⅱ) complexes bridged with N,N′-Bis(2-pyridylethyl)-Dithiooxamidate, [Cu3L2](ClO4)2 (1) and [Cu3L2](NO3)2 (2) (H2L=N,N′-Bis(2-pyridylethyl)-Dithiooxamide), have been synthesized, and characterized by elemental analyses, IR, UV-Visible spectra, conductance and EPR spectra. The variable temperature magnetic susceptibility for complex 1 has been measured in the temperature range of 1.5~298 K. Experimental data of magnetic susceptibility are successfully fit to theoretical value based on the spin Hamiltonian operator:(?), S1=S2=S3=1/2, giving the magnetic exchange parameters of 2J=-221.6 cm-1 and 2j=-15.8 cm-1. This result indicates the presence of a strong antiferromagnetic spin exchange interaction between the Cu(Ⅱ) ions. 相似文献
5.
Lino Colombo Marcello Di Giacomo Massimo Serra Simone M. Tambini 《Tetrahedron》2009,65(29-30):5838-5843
We report two different synthetic approaches for the stereoselective synthesis of (2E,4E)-4-(4,4-dimethylpent-2-ynylidene)-N1,N5-dimethyl-N1,N5-bis(naphthalen-1-ylmethyl)pent-2-ene-1,5-diamine 1, an important impurity-reference standard for the chemical characterization of terbinafine. The diamine 1 was obtained in only six steps with a good overall yield starting from commercially available glutaconic acid. 相似文献
6.
Balucani N Casavecchia P Bañares L Aoiz FJ Gonzalez-Lezana T Honvault P Launay JM 《The journal of physical chemistry. A》2006,110(2):817-829
In this paper, we report a combined experimental and theoretical study on the dynamics of the N(2D) + H2 insertion reaction at a collision energy of 15.9 kJ mol(-1). Product angular and velocity distributions have been obtained in crossed beam experiments and simulated by using the results of quantum mechanical (QM) scattering calculations on the accurate ab initio potential energy surface (PES) of Pederson et al. (J. Chem. Phys. 1999, 110, 9091). Since the QM calculations indicate that there is a significant coupling between the product angular and translational energy distributions, such a coupling has been explicitly included in the simulation of the experimental results. The very good agreement between experiment and QM calculations sustains the accuracy of the NH2 ab initio ground state PES. We also take the opportunity to compare the accurate QM differential cross sections with those obtained by two approximate methods, namely, the widely used quasiclassical trajectory calculations and a rigorous statistical method based on the coupled-channel theory. 相似文献
7.
Wu Y Jin L Xue Y Xie DQ Kim CK Guo Y Yan GS 《Journal of computational chemistry》2008,29(8):1222-1232
The hydrolysis reaction of N,N-dimethyl-N'-(2-oxo-1, 2-dihydro-pyrimidinyl)formamidine (DMPFA), a model compound of the antivirus drug amidine-3TC (3TC = 2', 3'-dideoxy-3'-thiacytidine), is investigated by the hybrid density functional theory B3LYP/6-31+G (d,p) method. The hydrolysis reaction of the title compound is predicted to undergo via two pathways, each of which is a stepwise process. Path A is the addition of H2O to the C=N double bond in the amidine group to form a tetrahedral structure in its first step, and then the transfer of the H atom of hydroxyl leads to the corresponding products via four possible channels. Path B simultaneously involves the nucleophilic attack of H2O to the C atom of the C=N bond and the proton transfer to the N atom of amino group leading to the cleavage of the C-N single bond in the amidine group. The results indicate that path A is more favorable than path B in the gas phase. Moreover, to simulate the title reaction in aqueous solution, water-assisted mechanism and the cluster-continuum model, based on the SCRF/CPCM model, are taken into account in our work. The results indicate that it is rational for two water molecules served as a bridge to assist in the first step of path A and that cytosine rather than the cytosine-substituted formamide should be released from the tetrahedral intermediate via s six-membered cycle transition state (channel 2). Our calculations exhibit that the process toward the tetrahedral intermediate is the rate-determining step both in the gas phase and in aqueous solution. 相似文献
8.
9.
A remarkable cluster-cluster interaction is operative in dimers of delocalized Ru3O(OAc)5(py)2 clusters with ortho-metallated 2,2'-bipyrimidine (bpym) in an unprecedented mu4-eta1(C),eta1(C),eta2(N,N),eta2(N,N) bonding mode; interconversion of the dimeric species [{Ru3O(OAc)5(py)2}2(micro4-bpym)]n+ (n = 0, 1 or 2) with different charges is attainable by chemical oxidation or reduction. 相似文献
10.
以取代的二硫代草酰胺根作为桥联配体, 合成了3种新的三核镍配合物[Ni3(Ped)2](ClO4)2(H2O) (1)、[Ni3(Ped)2](NO3)2(H2O) (2)和[Ni3(Ped)2](Ac)2(H2O)2 (3),及2种新的异三核铜镍和铜锰配合物[CuNi2(Ped)2](NO3)2(H2O)2 (4)和[CuMn2(Ped)2](NO3)2(H2O)2 (5) (H2Ped =N,N′-双(2-吡啶乙基)二硫代草酰胺)。通过元素分析、红外光谱、紫外可见光谱、电导、电子顺磁共振谱等对配合物进行了表征,对配合物进行了热分析。测定了配合物(5)的变温磁化率,研究了配合物(5)中Cu(Ⅱ)-Mn(Ⅱ)离子间的磁相互作用,结果表明在Cu(Ⅱ)-Mn(Ⅱ)离子间的磁相互作用具有高自旋基态的非正规自旋态性质。 相似文献
11.
Chan ZK Wu YY Chen JD Yeh CY Wang CC Tsai YF Wang JC 《Dalton transactions (Cambridge, England : 2003)》2005,(5):985-990
The reaction of Kpmf (pmf = anion of N,N[prime or minute]-bis(pyrimidyl-2-yl)formamidine, Hpmf) with CuSCN afforded the complexes K[Cu4(pmF)3(SCN)2], 1, and Cu(4)(pmf)4, 2. Reaction of 1 with [(n-Bu)4N]PF6 in THF gave the complex [(n-Bu)4N][Cu4(pmf)3(SCN)2], 3. Their structures were characterized by X-ray crystallography. Complexes 1 and 3 are the first linear tetranuclear complexes containing only Cu(I) atoms, while complex 2 is cyclic. The four Cu(I) atoms of complexes 1 and 3 are helically bridged by three tetradentate pmf- ligands. The [Cu4(pmf)3(SCN)2]- anions of 1 show weak interactions with adjacent [K(THF)5]+ cations through the sulfur atoms, forming infinite chains which are subjected to a series of intermolecular pi-pi interactions. In complex 2, the pmf- ligands are coordinated to the copper atoms in bidentate fashion through the two central amine nitrogen atoms, leaving the pyrimidine nitrogen atoms uncoordinated. Unexpected fluxional behaviors were observed for complexes 1 and 3 in solution. By the DNMR analysis, the free energy of activation (DeltaGc(not equal)) for the exchange is 12.8 kcal mol(-1) at 278 K (T(c)), and the rate constant of exchange (K(c)) is 470 s(-1) for 1. The DeltaGc(not equal) and Kc are 12.6 kcal mol(-1) at 273 K and 433 s(-1), respectively, for 3. 相似文献
12.
B. A. Arbuzov A. V. Aganov N. N. Zobova V. V. Klochkov 《Russian Chemical Bulletin》1981,30(4):544-548
Summary Hindered rotation around the
bond in the N-acylamidines has been investigated by PMR spectroscopy, and the kinetic parameters of the hindered rotation have been determined.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 4, pp. 758–762, April, 1981. 相似文献
13.
Yu. M. Volovenko T. A. Volovnenko F. S. Babichev T. Shevchenko 《Chemistry of Heterocyclic Compounds》1994,30(4):453-457
The acylation of 3-amino-4-cyano-1(2H)isoquinolines with benzoyl chloride leading to the formation of 1,3 oxazino[4,5-clisoquinoline-6-ones has been studied. Previously undescribed 1-aminopyrimido[4,5-cJisoquinolirt 6-ones have been obtained by the reaction of the appopriate 3-amino-](2H)isoginolones with formamide. Nucleophilic replacement has been carried out with 3-amino-1-chloroisoquinoline by the action of sodium hydroxide, primary alcohols, hydrazine hydrate, and various amines. 1,2,4-Triazino[2,3-b]isoginolone has been synthesized by condensing 2,3-diamino-1 (2H)isoquinolone with mesoxalic acid ethyl ester. 相似文献
14.
According to the density functional theory calculations, the X···H···N (X?N, O) intramolecular bifurcated (three‐centered) hydrogen bond with one hydrogen donor and two hydrogen acceptors causes a significant decrease of the 1hJ(N,H) and 2hJ(N,N) coupling constants across the N? H···N hydrogen bond and an increase of the 1J(N,H) coupling constant across the N? H covalent bond in the 2,5‐disubsituted pyrroles. This occurs due to a weakening of the N? H···N hydrogen bridge resulting in a lengthening of the N···H distance and a decrease of the hydrogen bond angle at the bifurcated hydrogen bond formation. The gauge‐independent atomic orbital calculations of the shielding constants suggest that a weakening of the N? H···N hydrogen bridge in case of the three‐centered hydrogen bond yields a shielding of the bridge proton and deshielding of the acceptor nitrogen atom. The atoms‐in‐molecules analysis shows that an attenuation of the 1hJ(N,H) and 2hJ(N,N) couplings in the compounds with bifurcated hydrogen bond is connected with a decrease of the electron density ρH···N at the hydrogen bond critical point and Laplacian of this electron density ?2ρH···N. The natural bond orbital analysis suggests that the additional N? H···X interaction partly inhibits the charge transfer from the nitrogen lone pair to the σ*N? H antibonding orbital across hydrogen bond weakening of the 1hJ(N,H) and 2hJ(N,N) trans‐hydrogen bond couplings through Fermi‐contact mechanism. An increase of the nitrogen s‐character percentage of the N? H bond in consequence of the bifurcated hydrogen bonding leads to an increase of the 1J(N,H) coupling constant across the N? H covalent bond and deshielding of the hydrogen donor nitrogen atom. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
15.
Zhou M Zeng A Wang Y Kong Q Wang ZX Schleyer PV 《Journal of the American Chemical Society》2003,125(38):11512-11513
This report presents the preparation and characterization of H2OOO+, an important intermediate in water-oxygen chemistry. The H2OOO+ cation was produced by co-deposition of H2O/Ar with radio frequency discharged O2/Ar at 4 K and was identified by four fundamental infrared absorptions. Quantum chemical calculations indicate a doublet ground state with a H2O-O2 hemi-bonded Cs structure. 相似文献
16.
Fernández EJ Laguna A López-de-Luzuriaga JM Monge M Nema M Olmos ME Pérez J Silvestru C 《Chemical communications (Cambridge, England)》2007,(6):571-573
Complex [Au(C6F5)2][Bi(C6H4CH2NMe(2)-2)2] displays the first example of an interaction between Au(I) and Bi(III), the nature of which is shown to be consistent with the presence of a high ionic contribution (79%) and a dispersion type (van der Waals) interaction (21%). 相似文献
17.
Christe KO Boatz JA Gerken M Haiges R Schneider S Schroer T Tham FS Vij A Vij V Wagner RI Wilson WW 《Inorganic chemistry》2002,41(16):4275-4285
SO(2) solutions of azide anions are bright yellow, and their Raman spectra indicate the presence of covalently bound azide. Removal of the solvent at -64 degrees C from CsN(3) or N(CH(3))(4)N(3) solutions produces yellow (SO(2))(2)N(3)(-) salts. Above -64 degrees C, these salts lose 1 mol of SO(2), resulting in white SO(2)N(3)(-) salts that are marginally stable at room temperature and thermally decompose to the corresponding azides and SO(2). These anions were characterized by vibrational and (14)N NMR spectroscopy and theoretical calculations. Slow loss of the solvent by diffusion through the walls of a sealed Teflon tube containing a sample of CsSO(2)N(3) in SO(2) resulted in white and yellowish single crystals that were identified by X-ray diffraction as CsSO(2)N(3).CsSO(3)N(3) with a = 9.542(2) A, b = 6.2189(14) A, c = 10.342(2) A, and beta = 114.958(4) degrees in the monoclinic space group P2(1)/m, Z = 2, and Cs(2)S(2)O(5).Cs(2)S(2)O(7).SO(2), respectively. Pure CsSO(3)N(3) was also prepared and characterized by vibrational spectroscopy. The S-N bond in SO(2)N(3)(-) is much weaker than that in SO(3)N(3)(-), resulting in decreased thermal stability, an increase in the S-N bond distance by 0.23 A, and an increased tendency to undergo rotational disorder. This marked difference is due to SO(3) being a much stronger Lewis acid (pF(-) value of 7.83) than SO(2) (pF(-) value of 3.99), thus forming a stronger S-N bond with the Lewis base N(3)(-). The geometry of the free gaseous SO(2)N(3)(-) anion was calculated at the RHF, MP2, B3LYP, and CCSD(T) levels. The results show that only the correlated methods correctly reproduce the experimentally observed orientation of the SO(2) group. 相似文献
18.
Becerra R Goldberg N Cannady JP Almond MJ Ogden JS Walsh R 《Journal of the American Chemical Society》2004,126(21):6816-6824
Time-resolved kinetic studies of the reaction of silylene, SiH(2), with H(2)O and with D(2)O have been carried out in the gas phase at 297 K and at 345 K, using laser flash photolysis to generate and monitor SiH(2). The reaction was studied independently as a function of H(2)O (or D(2)O) and SF(6) (bath gas) pressures. At a fixed pressure of SF(6) (5 Torr), [SiH(2)] decay constants, k(obs), showed a quadratic dependence on [H(2)O] or [D(2)O]. At a fixed pressure of H(2)O or D(2)O, k(obs) values were strongly dependent on [SF(6)]. The combined rate expression is consistent with a mechanism involving the reversible formation of a vibrationally excited zwitterionic donor-acceptor complex, H(2)Si...OH(2) (or H(2)Si...OD(2)). This complex can then either be stabilized by SF(6) or it reacts with a further molecule of H(2)O (or D(2)O) in the rate-determining step. Isotope effects are in the range 1.0-1.5 and are broadly consistent with this mechanism. The mechanism is further supported by RRKM theory, which shows the association reaction to be close to its third-order region of pressure (SF(6)) dependence. Ab initio quantum calculations, carried out at the G3 level, support the existence of a hydrated zwitterion H(2)Si...(OH(2))(2), which can rearrange to hydrated silanol, with an energy barrier below the reaction energy threshold. This is the first example of a gas-phase-catalyzed silylene reaction. 相似文献
19.
The rate coefficient of the reaction NH(X (3)Sigma(-)) + H((2)S)-->(k(1a) )N((4)S) + H(2)(X (1)Sigma(g) (+)) is determined in a quasistatic laser-flash photolysis, laser-induced fluorescence system at low pressures (2 mbar< or =p< or =10 mbar). The NH(X) radicals are produced via the quenching of NH(a(1)Delta) (obtained by photolyzing HN(3)) with Xe whereas the H atoms are generated in a H(2)He microwave discharge. The NH(X) concentration profile is measured under pseudo-first-order condition, i.e., in the presence of a large excess of H atoms. The room temperature rate coefficient is determined to be k(1a) = (1.9 +/- 0.5) x 10(12) cm(3) mol(-1) s(-1). It is found to be independent of the pressure in the range considered in the present experiment. A global potential energy surface for the (4)A(") state is calculated with the internally contracted multireference configuration interaction method and the augmented correlation consistent polarized valence quadruple zeta atomic basis. The title reaction is investigated by classical trajectory calculations on this surface. The theoretical room temperature rate coefficient is k(1a) = 0.92 x 10(12)cm(3) mol(-1) s(-1). Using the thermodynamical data for the atoms and molecules involved, the rate coefficient for the reverse reaction, k(-1a), is also calculated. At high temperatures it agrees well with the measured k(-1a). 相似文献
20.
Herebian D Bothe E Bill E Weyhermüller T Wieghardt K 《Journal of the American Chemical Society》2001,123(41):10012-10023
The ligand 2-mercapto-3,5-di-tert-butylaniline, H[L(AP)], an o-aminothiophenol, reacts with metal(II) salts of Ni and Pd in CH3CN or C2H5OH in the presence of NEt3 under strictly anaerobic conditions with formation of beige to yellow cis-[M(II)(L(AP))2] (M = Ni (1), Pd (2)) where (L(AP))1- represents the o-aminothiophenolate(1-) form. The crystal structure of cis-[Pd(II)(L(AP))2][HN(C2H5)3][CH3CO2] has been determined by X-ray crystallography. In the presence of air the same reaction produces dark blue solutions from which mixtures of the neutral complexes trans/cis-[M(II)(L(ISQ))2] (M = Ni (1a/1b), Pd (2a/2b), and Pt (3a/3b)) have been isolated as dark blue-black solid materials. By using HPLC the mixture of 3a/3b has been separated into pure samples of 3a and 3b, respectively; (L(ISQ))1- represents the o-iminothionebenzosemiquinonate(1-) pi-radical. The structures of 1a.dmf and 3a.CH2Cl2 have also been determined. All compounds are square-planar and diamagnetic. 1H NMR spectroscopy established the cis <==> trans equilibrium of 1a/1b, 2a/2b, and 3a/3b in CH2Cl2 solution where the isomerization rate is very fast for the Ni, intermediate for the Pd, and very slow for the Pt species. It is shown that the electronic structures of 1a/1b, 2a/2b, 3a, and 3b are best described as diradicals with a singlet ground state. The spectro- and electrochemistries of all complexes display the usual full electron transfer series where the monocation, the neutral species, the mono- and dianions have been spectroscopically characterized. X-band EPR spectra of the monocations [1a/1b]+ and [3a]+ support the assignment of an oxidation-state distribution as predominantly [M(II)(L(ISQ))(L(IBQ))]+ where (L(IBQ))0 represents the o-iminothionequinone level. In contrast, the EPR spectra of the monoanions [1a/1b]- and [3a]- indicate an [M(II)(L(ISQ))(L(AP)-H)]- distribution but with a significant contribution of the [M(I)(L(ISQ))(2)]- resonance hybrid; (L(AP)-H)2- represents the o-imidothiophenolato(2-) oxidation level. Analysis of the geometric features of 120 published structures of complexes containing ligands of the o-aminothiophenolate type show that high precision X-ray crystallography allows to discern the differing protonation and oxidation levels of these ligands. o-Aminothiophenolates are unequivocally shown to be noninnocent ligands; the (L(ISQ))1- radical form is quite prevalent in coordination compounds and the electronic structure of a number of published complexes must be reconsidered. 相似文献