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N,N-二甲基氨甲酰基三甲基硅烷与一系列N-甲基-N-甲氧甲基α-羰基酰胺在无水无氧、105℃的条件下反应,合成了不对称α-烃基-α-羟基丙二酰胺类化合物或不对称α-烃基-α-三甲基硅氧基丙二酰胺衍生物,收率71%~86%,其结构用元素分析、1H NMR、13C NMR和IR等方法进行了表征.通过研究反应的影响因素发现,反应底物α-羰基酰胺中与α-羰基直接相连的烃基的空间位阻是该加成反应的重要影响因素,而α-羰基直接相连的芳环上取代基的电子效应则主要影响反应完成的时间.并提出了可能的反应机理. 相似文献
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Highly substituted pyridine derivatives have been accessed through an efficient, one-pot, multicomponent reaction of aldehydes, malononitrile, and ammonium acetate in the presence of triethylamine as a catalyst under solvent-free conditions. This procedure affords the desired products in high purity and has advantages such as short reaction time, excellent yields, and simple workup procedure. This procedure affords the desired products in moderate to high yields and has such advantages as short reaction time and simple workup procedure. 相似文献
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Ji Shan WU Chun Yan CHI Xian Hong WANG* Xiao Jiang ZHAO Ji LI Fo Song WANG State Key Laboratory of Polymer Physics Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 《中国化学快报》2001,(5)
IntroductionFerrocene-containing compounds have been widely used as important probes to investigate the electron transfer/transport properties of the molecular materials1. Recently, this technique was employed in molectronics research, where the ferrocenes were incorporated on the ends of conjugated molecular wires, and the electron transfer/transport abilities of the molecular wires were conveniently studied by electrochemical method2. Ethynylferrocene and iodoethynylferrocene were two import… 相似文献
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A simple and efficient procedure was developed for the synthesis of 11H(2H)-4-oxothiophene[3',4':6,5]pyrido[3,2-a]azulene-10-carboxylates(3) in moderate to good yields via the Gewald reaction of ethyl 1-cyanoacetyl-2-methoxyazulene-3-carboxylate(1) with carbonyl compounds(2) and elemental sulfur utilizing imidazole as catalyst.This reaction provides a new procedure for synthesis of pyridinone-fused azulenes. 相似文献
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A new synthetic procedure for the polysubstituted 2-aminothiophenes was developed via Gewald type ring-opening reaction of 1,1-dicyano-2,3-diarylcyclopropanes with elemental sulfur in N,N-dimethylformamide in the presence of morpholine as base. 相似文献
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An efficient and practiacal procedure for the synthesis of dihydropyrimidinones from aldehydes,1,3-dicarbonyl compounds and urea under solvent-free reaction condition using zinc triflate as a catalyst is described.In comparison with the classical Biginelli reaction,the yields for this new procedure increased from 20%-50% to 75%-98% while the reaction time was significantly shortened from 18h to 20min. 相似文献
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Amol Maruti Jadhav Sandip Gangadhar Balwe Kwon Taek Lim Yeon Tae Jeong 《Tetrahedron》2017,73(19):2806-2813
A green, efficient, and rapid procedure for the synthesis of novel spiro[chromeno[4′,3′:4,5] pyrimido[1,2-b]indazole-7,3′-indoline]-2′,6(9 H)-dione derivatives has been developed by one-pot condensation of 4-hydroxy-2H-chromen-2-one, isatin, and 1H-indazole-3-amine, in the presence of acetic acid in EtOH. This method has the advantages of operational simplicity, and high yield of products via a simple experimental and work-up procedure as compared to the conventional methods. The reaction mechanism and substrate scope of this novel reaction is briefly discussed. 相似文献
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Fabian Brockmeyer Denis Kröger Timo Stalling Pasqual Ullrich Jürgen Martens 《Helvetica chimica acta》2012,95(10):1857-1870
A new three‐step synthetic pathway to generate polycyclic annulated hydantoins via rarely investigated heterocyclic imines is described. This procedure includes a one‐pot reaction forming imines as precursor structures (e.g., Asinger reaction), followed by an Ugi reaction to build up a bisamide structure that allows a ring‐closing reaction to the targeted hydantoins via substitution. This pathway leads to a multiplicity of substances with a potential pharmacological activity. 相似文献
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Ning Gu Miaochang Liu Hepan Wang Song Sun Zhen Zhou Weiming Hu Jin-Tao Yu Jiang Cheng 《Tetrahedron letters》2017,58(34):3398-3400
An iridium-catalyzed annulation between 1,2-diarylethanone and 3-aminopropanol was developed, leading to site specific 2,3-diarylpyridines in moderate yields. 3-Aminopropanol served as both a four-atom component and solvent during this procedure, releasing water as a clean by-product. The reaction may proceed with sequential imine formation, alcohol oxidation and intramolecular cyclization by Knoevenagel reaction. 相似文献
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Dr. Anton Guryev Florian Schuster Lars Herrmann Dr. Friedrich Hahn Christina Wangen Dr. Jan Hodek Dr. Jan Weber Prof. Dr. Manfred Marschall Prof. Dr. Svetlana B. Tsogoeva 《European journal of organic chemistry》2023,26(5):e202200994
We report the development of a metal-free four-step one-pot synthetic strategy to access high-value functionalized phthalazines using o-methyl benzophenones as starting compounds. Combining a light-mediated enolization of o-methyl benzophenones/Diels-Alder reaction domino process with a subsequent deprotection/aromatization domino reaction in one-pot leads to sustainable and efficient organic synthesis. The tangible advantages, i. e., absence of catalysts or additives, utilization of commercially available and/or easily accessible substrates, mild reaction conditions, simplicity, and single work-up procedure, make this combined process highly appealing for the direct construction of various 1-aryl-phthalazines. Importantly, in vitro bioactivity evaluation of these newly prepared heterocyclic compounds demonstrated a strong antiviral efficacy against major human pathogens like HCMV and SARS-CoV-2. 相似文献
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Jia Xu Yong Li Jiang-Ping Meng Jie Lei Zhong-Zhu Chen Dian-Yong Tang Jin Zhu Zhi-Gang Xu 《Tetrahedron letters》2017,58(16):1640-1643
A series of compounds containing the benzoxazepine-isoquinoline scaffold was synthesized in a one-pot procedure via an Ugi reaction followed by tautomerization reaction between the keto and enol forms and intramolecular nucleophilic substitution. The microwave-assisted strategy allowed the facile synthesis of a library of target compounds and is applicable to the construction of diverse libraries of related compounds for high throughput screening in medicinal chemistry. 相似文献