共查询到20条相似文献,搜索用时 31 毫秒
1.
Zacharias Kohl Martin Regensburger Robert Aigner Mahesh Kandasamy Beate Winner Ludwig Aigner Jürgen Winkler 《BMC neuroscience》2010,11(1):114
Background
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder linked to expanded CAG-triplet nucleotide repeats within the huntingtin gene. Intracellular huntingtin aggregates are present in neurons of distinct brain areas, among them regions of adult neurogenesis including the hippocampus and the subventricular zone/olfactory bulb system. Previously, reduced hippocampal neurogenesis has been detected in transgenic rodent models of HD. Therefore, we hypothesized that mutant huntingtin also affects newly generated neurons derived from the subventricular zone of adult R6/2 HD mice. 相似文献2.
Background
We previously described planar areal differences in adult mouse visual, somatosensory, and neocortex that collectively discriminated C57BL/6J and DBA/2J inbred strain identity. Here we use a novel application of established methods of two-dimensional geometric morphometrics to examine shape differences in the cortical area maps of these inbred strains. 相似文献3.
Abstract
Ag nanoparticles/graphene nanosheet (AgNPs/GN) composites have been rapidly prepared by a one-pot microwave-assisted reduction method, carried out by microwave irradiation of a N,N-dimethylformamide (DMF) solution of graphene oxide (GO) and AgNO3. Several analytical techniques including UV–vis spectroscopy, FT-IR spectroscopy, Raman spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM) have been used to characterize the resulting AgNPs/GN composites. It suggests that such composites exhibit good catalytic activity toward reduction of hydrogen peroxide (H2O2), leading to a H2O2 sensor with a fast amperometric response time of less than 2 s. The linear detection range is estimated to be from 0.1 to 100 mM (r = 0.999), and the detection limit is estimated to be 0.5 μM at a signal-to-noise ratio of 3. 相似文献4.
Background
The ability to regulate neurogenesis in the adult dentate gyrus will require further identification and characterization of the receptors regulating this process. In vitro and in vivo studies have demonstrated that neurotrophins and the p75 neurotrophin receptor (p75NTR) can promote neurogenesis; therefore we tested the hypothesis that p75NTR is expressed by adult dentate gyrus progenitor cells and is required for their proliferation and differentiation. 相似文献5.
Judith Buddensiek Alexander Dressel Michael Kowalski Uwe Runge Henry Schroeder Andreas Hermann Matthias Kirsch Alexander Storch Michael Sabolek 《BMC neuroscience》2010,11(1):48
Background
Neural stem cells (NSCs) are a promising source for cell replacement therapies for neurological diseases. Growing evidence suggests an important role of cerebrospinal fluid (CSF) not only on neuroectodermal cells during brain development but also on the survival, proliferation and fate specification of NSCs in the adult brain. Existing in vitro studies focused on embryonic cell lines and embryonic CSF. We therefore studied the effects of adult human leptomeningeal CSF on the behaviour of adult human NSCs (ahNSCs). 相似文献6.
Le-qun Shan Sai Ma Xiu-chun Qiu Yong Zhou Yong Zhang Lian-he Zheng Peng-cheng Ren Yu-cai Wang Qing-yu Fan Bao-an Ma 《BMC neuroscience》2010,11(1):98
Background
Hydroxysafflor Yellow A (HSYA), which is one of the most important active ingredients of the Chinese herb Carthamus tinctorius L, is widely used in the treatment of cerebrovascular and cardiovascular diseases. However, the potential protective effect of HSYA in spinal cord ischemia/reperfusion (I/R) injury is still unknown. 相似文献7.
He-Ping Tian Bao-Sheng Huang Jie Zhao Xiao-Han Hu Jun Guo Li-Xin Li 《BMC neuroscience》2009,10(1):139
Background
Neurogenesis in the adult mammalian hippocampus may contribute to repairing the brain after injury. However, Molecular mechanisms that regulate neuronal cell proliferation in the dentate gyrus (DG) following ischemic stroke insult are poorly understood. This study was designed to investigate the potential regulatory capacity of non-receptor tyrosine kinase Src on ischemia-stimulated cell proliferation in the adult DG and its underlying mechanism. 相似文献8.
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Background
ALPK1 (α-kinase 1) is a member of an unconventional alpha-kinase family, and its biological function remains largely unknown. Here we report the phenotypic characterization of one mutant line, in which the piggyBac (PB) transposon is inserted into the Alpk1 gene. 相似文献10.
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Background
Conserved proteins preferentially expressed in synaptic terminals of the nervous system are likely to play a significant role in brain function. We have previously identified and molecularly characterized the Sap47 gene which codes for a novel synapse associated protein of 47 kDa in Drosophila. Sequence comparison identifies homologous proteins in numerous species including C. elegans, fish, mouse and human. First hints as to the function of this novel protein family can be obtained by generating mutants for the Sap47 gene in Drosophila. 相似文献12.
Bita Baghernejad Majid M. Heravi Hossein A. Oskooie Nargess Poormohammad Maliheh Khorshidi Yahia Sh. Beheshtiha 《Molecular diversity》2011,15(1):245-248
Abstract
A simple and efficient synthesis of N-cyclohexyl-benzofuran derivatives was achieved via a one-pot three-component reaction of cyclohexylisocyanide, an aromatic aldehydes, and phenols in DMF for 10 h with good yields. 相似文献13.
Sebastien Couillard-Despres Eike Quehl Katrin Altendorfer Claudia Karl Sonja Ploetz Ulrich Bogdahn Juergen Winkler Ludwig Aigner 《BMC neuroscience》2008,9(1):31
Background
During developmental and adult neurogenesis, doublecortin is an early neuronal marker expressed when neural stem cells assume a neuronal cell fate. To understand mechanisms involved in early processes of neuronal fate decision, we investigated cell lines for their capacity to induce expression of doublecortin upon neuronal differentiation and develop in vitro reporter models using doublecortin promoter sequences. 相似文献14.
Alain A Camilleri Raffaella Willmann Gayathri Sadasivam Shuo Lin Markus A Rüegg Matthias Gesemann Christian Fuhrer 《BMC neuroscience》2007,8(1):46
Background
Development of neural networks requires that synapses are formed, eliminated and stabilized. At the neuromuscular junction (NMJ), agrin/MuSK signaling, by triggering downstream pathways, causes clustering and phosphorylation of postsynaptic acetylcholine receptors (AChRs). Postnatally, AChR aggregates are stabilized by molecular pathways that are poorly characterized. Gain or loss of function of Src-family kinases (SFKs) disassembles AChR clusters at adult NMJs in vivo, whereas AChR aggregates disperse rapidly upon withdrawal of agrin from cultured src -/-;fyn -/- myotubes. This suggests that a balance between protein tyrosine phosphatases (PTPs) and protein tyrosine kinases (PTKs) such as those of the Src-family may be essential in stabilizing clusters of AChRs. 相似文献15.
Background
Precise control of developmental and cell-specific expression of the brain-derived neurotrophic factor (BDNF) gene is essential for normal neuronal development and the diverse functions of BDNF in the adult organism. We previously showed that the zebrafish BDNF gene has multiple promoters. The complexity of the promoter structure and the mechanisms that mediate developmental and cell-specific expression are still incompletely understood. 相似文献16.
Background
Notch signaling pathways are conserved across species and traditionally have been implicated in cell fate determination during embryonic development. Notch signaling components are also expressed postdevelopmentally in the brains of adult mice and Drosophila. Recent studies suggest that Notch signaling may play a role in the physiological, rather than developmental, regulation of neurons. Here, we investigate a new non-developmental role for Caenorhabditis elegans lin-12 Notch signaling in neurons regulating the spontaneous reversal rate during locomotion. 相似文献17.
Ljiljana Puskar Evan G. Robertson Don McNaughton 《Journal of Molecular Spectroscopy》2006,240(2):244-250
We report a rovibrational analysis of the ν4 and ν6 fundamentals and the 2ν5 overtone of HNSO from high-resolution Fourier transform infrared spectra. The ν6 band (out-of-plane bend) centred at 757.5 cm−1 is c-type. The ν4 band (HNS bend) centred at 905.9 cm−1 is predominantly a-type with a very weak b-type component (). Numerous global perturbations and localized avoided crossings affecting the v4 = 1 rotational levels were successfully treated by inclusion of Fermi and c-axis Coriolis resonance terms between v4 = 1 and v5 = 2, and a b-axis Coriolis resonance term between v4 = 1 and v6 = 1. The latter term gives rise to an avoided crossing with an extraordinary ΔKa = 5 selection rule. The Fermi resonance between v4 = 1 and v5 = 2 gives rise to strong mixing of their rotational wavefunctions in the vicinity of Ka = 18. The resultant borrowing of intensity made it possible for 2ν5 transitions in the range Ka = 16–19 to be assigned and included in a global rovibrational treatment of all three band systems. 相似文献
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Jonathan P Wisor Bruce F O'Hara Akira Terao Chris P Selby Thomas S Kilduff Aziz Sancar Dale M Edgar Paul Franken 《BMC neuroscience》2002,3(1):20-14
Background
The cryptochrome 1 and 2 genes (cry1 and cry2) are necessary for the generation of circadian rhythms, as mice lacking both of these genes (cry1,2 -/-) lack circadian rhythms. We studied sleep in cry1,2 -/- mice under baseline conditions as well as under conditions of constant darkness and enforced wakefulness to determine whether cryptochromes influence sleep regulatory processes. 相似文献20.
Eric Westman Christian Spenger Johanna ?berg Henry Reyer Jens Pahnke Lars-Olof Wahlund 《BMC neuroscience》2009,10(1):33