Synthesis, structure, and action of some gossypol derivatives on the peroxidation of the lipids of biosubstrates

The synthesis has been effected of new gossypol derivatives using piperidino-and morpholinoethylamines. According to their PMR spectra, these substances exist in the keto-amine form. Their action on the peroxidation of lipids (POL) of various biosubstrates has been studied. Gossypol bis(piperinoethylimine) and bis(morpholinoethylimine) in concentrations of 1·10^–7–5·10^–6 mM exert a pronounced antioxidant action on human blood serum and rat brain synaptosomes. In the same concentrations, these substances suppressed the POL in enzymatic and nonenzymatic systems of the oxidation of rat liver microsomes.A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Institute of Hematology and Blood Transfusion, Ministry of Health of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 707–712, September–October, 1989.     

Inhibition of transport (Na+, K+)-ATPase by cardenolides of the strophanthidin group and a study of the structure-activity relationship

Summary A comparative study of the inhibiting action on transport (Na⁺,K⁺)-ATPase of 15 derivatives of strophanthidin and four rhamnosides of other aglycones have been made on the microsomal fraction of the cells of the rat cerebral cortex.It has been shown that the method of determining the activity of cardiotonic substances by determining the lethal dose and the enzyme test give completely comparable results. Both biological methods objectively reflect the characteristic features of the chemical structure of the cardenolides.Institute of Biochemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 188–194, March–April, 1976.     

Sesquiterpene lactones ofTanacetum santolina

Cumambrins A and B, artecalin, rupicolins A and B, and the new sesquiterpene lactone tansanin have been isolated from the epigeal part ofTanacetum santolina C. Winkl. For tansanin the structure and configuration of 3-keto-4β, 6β(H)-germacra-1(10), 11·(13)-dien-6,12-olide has been established. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 633–636, September–October, 1980.     

Comparative study of amino acid compositions of flavoproteins of the cotton plant and of the fungus Verticillium dahliae

Institute of Experimental Plant Biology, Academy of Sciences of the Uzbek SSR, Tashkent. Tashkent Agricultural Institute. Translated from Khimiya Prirodynkh Soedinenii, No. 6, pp. 893–895, November–December, 1988.     

Gas-chromatographic investigation of the products of the thermolysis of hydrolysis lignin

Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. All-Union Scientific-Research Institute of the Chemical Technology of the Medical and Microbiological Industry, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 420–421, May–June, 1990.     

Spatial structure of the germacrane lactones hanphyllin,salonitenolide, and sachosin

An x-ray structural study has been made of the sesquiterpene lactones hanphyllin, salonitenolide, and sachosin: diffractometer; CuK_α radiation; 997, 950, and 1245 reflections, respectively; direct method; R factors 0.049, 0.099, and 0.081. All three molecules have the chair-chair conformation with configurations of the₁D¹⁴ and¹⁵D₅ types. Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 775–780, November–December, 1989.     

Immunomodulating activity of gossypol derivatives

Information is given on the immunosuppressive activity of a number of gossypol derivatives, and it is shown that practically all the compounds studied are immunotropic. The structural-functional relationship and the dose-dependent nature of the action of the substances obtained are shown.A. S. Sadykov Institute of Bioorganic Chemistry, Uzbek SSR Academy of Sciences, Tashkent. Tashkent State Medical Institute, Uzbek SSR Ministry of Health. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 647–650, September–October, 1988.     

Modification by endogenous phospholipids of porcine kidney Na,K-ATPase

Institute of Physiology, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodynkh Soedinenii, No. 6, pp. 872–873, November–December, 1988.     

Components of Artemisia santolinifolia

Institute of Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 697–698, September–October, 1990.     

NMR investigation of alkaloids. XI.13C NMR spectra and structure of codonopsine and codonopsinine

An assignment of the signals in the¹³C NMR spectra of the alkaloids codonopsinine and codonopsine has been made on the basis of selective double heteronuclear resonance experiments. Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 536–538, July–August, 1989.     

Minor phospholipids of the cotton plant of variety 159-F

Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, Vol. 6, pp. 847–848, November–December, 1989.     

Difference-perturbation spectra of iodotyrosines and iodothyronines in polyethyleneglycols

The difference-perturbation absorption spectra of monoiodotyrosine, diiodotyrosine, triiodothyronine, and thyroxine with low- and high-molecular-mass polyethyleneglycols as perturbants have been measured and characterized. The SDP spectra, and their intensity and the position of the main maximum depend on the number of iodine atoms and the state of ionization of the hydroxyl in accordance with their electron-accepting properties. Institute of Physiology, Uzbek SSR Academy of Sciences, Tashkent. Institute of Biochemistry, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, Vol. 6, pp. 840–845, November–December, 1989.     

Triterpene glycosides of Scabiosa soongorica. V. β-Sitosterol β-D-glucopyranoside and songoroside A

Institute of Organic Chemistry, Academy of Sciences of the Kirgiz SSR, Frunze. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodynkh Soedinenii, No. 6, pp. 885–886, November–December, 1988.     

An investigation of the venom of Renard's viperVipera ursini renardi. IV. The hemolytic action of the phospholipases A2

The whole venom of the viper and the pure phospholipases A₂ isolated from it possess no independent hemolytic action but acquire it in the presence of pure cytotoxins from the venom of the Central Asian cobra. The efficiency of the hemolytic action of the mixture of the venom or the phospholipases A₂ with the cytotoxins depends on the concentration and activities of both constituents of the mixture. Institute of Biochemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 684–686, September–October, 1980.     

Polysaccharides of Eremurus. XXIII. Carbohydrates from leaves of some species of Eremurus

Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 588–589, July–August, 1988.     

Phosphono analogue of phosphatidylethanolamines from kenaf seeds

Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, Vol. 6, pp. 848–849, November–December, 1989.     

Phytoecdysteroids of plants of the genus Lychnis

Siberian Botanical Garden, Tomsk. Institute of Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 584–585, July–August, 1991.     

Synthetic analogues of Peganum alkaloids. V. Peganol from deoxpeganine

Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, Vol. 6, pp. 857–858, November–December, 1989.     

Products of tansformation of gossypol in methanol

Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 590–591, July–August, 1988.     

Withasteroids of Physalis. IX. Physangulide — The first natural 22S-withasteroid

A new withasteroid — physangulide — has been isolated from the leaves ofPhysalis angulata L. It has been shown that physangulide is the first natural 22S-withanolide. Its structure has been determined as 3β,4β,20,24,25-pentahydroxy-1-oxo-5β,6β-epoxy-20R,22S,24S,25R-withanolide. Its¹H and¹³C NMR spectra, confirming this interpretation, are given. Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 366–371, May–June, 1990.