Structure of vincanidine,an alkaloid from the roots of vinca erecta

Summary The character of the ultraviolet and infrared spectral curves, the large angle of rotation, and the color indicate that the vincanidine molecule contains the 2-methyleneindoline chromophoric system conjugated with an aldehyde group, which is confirmed by the preparation of breakdown products of vincanidine: 3H-indole (II), indoline (III), and indole (IV) derivatives. Such a complex chromophoric system is characteristic for alkaloids of the vincanineakuammicine type.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 11, pp. 1992–1995, November 1965     

A method for the quantitative determination of vincamine in the epigeal part of Vinca erecta

Summary An extraction-photometric method for the determination of vincamine in its raw material — the epigeal part ofVinca erecta — has been developed.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 65–66, January, 1971.     

The polybuffer separation of the alkaloids of Vinca erecta

Chemistry of Natural Compounds - By separating the total alkaloids ofV.erecta according to their basicities in an APS, in addition to bases known previously we have isolated ervincidine,...     

The polybuffer separation of the alkaloids of Vinca erecta

Summary By separating the total alkaloids ofV.erecta according to their basicities in an APS, in addition to bases known previously we have isolated ervincidine, apovincamine, (+)-quebrachamine, dl-eburnamine, (–)-1,2-dehydroaspidospermidine, and kopsanone. This is the first time that these alkaloids have been obtained from this plant. Thin-layer chromatography showed the presence of another 10–12 uncharacterized alkaloids.The region of the passage into the buffer solutions of some alkaloids has also been established.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 713–717, November–December, 1970.     

11-Hydroxypleiocarpamine — A new alkaloid from Vinca erecta

Chemistry of Natural Compounds -     

HPLC determination of majdine in Vinca herbacea

A reliable HPLC method coupled with DAD detection was developed and validated for determination of majdine in Vinca herbacea. The chromatographic separation was carried out on a Symmetry C18 column (250 mm x 4.6 mm, 5 microm, Waters) with an isocratic solvent system of 25 mM potassium phosphate buffer (pH = 3.0)-acetonitrile. UV detection was performed at 225 nm. Good linear behavior over the investigated concentration range was observed with the value of r2 > 0.9978. The method was reproducible with intra- and inter-day variations of less than 4.38%. The proposed method was linear, accurate, precise and specific. The validated method was successfully applied to quantify majdine in various parts of V. herbacea, which was collected during the flowering months of April and May. The results indicated that the developed HPLC method could be used for the quality control of V. herbacea and for the standardization of its extracts in majdine.     

Quantitative determination of the aglycone of the total patrinosides in the roots ofPatrinia intermedia

A method has been developed for the quantitative determination of the aglycone of the total patrinosides present in the roots ofPatrinia intermedia. The method comprises the extraction of the patrinosides from the raw material, their hydrolysis to oleanolic acid, and the potentiometric titration of the aglycone obtained.     

Vinervine — A new alkaloid from the aboveground part of Vinca erecta RGL. ET schmalh

Summary From the aboveground part ofV. erecta gathered in the Shargun' settlement in the Surkhan-Darya region 1% of total alkaloids was isolated, and in the separation of these the bases vincanidine and a new phenolic base vinervine (C₂₀H₂₂O₃N₂) were obtained. Vinervine is an alkaloid of the 2-methyleneindoline group.Translated from Izvestiya Akademii Nauk SSSR, Khimicheskaya, No. 12, pp. 2152–2155, December, 1965