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1.
M. D. Alaniya N. Sh. Kavtaradze C. Bassarello A. V. Skhirtladze C. Pizza I. Kutateladze 《Chemistry of Natural Compounds》2006,42(6):681-685
New flavonoid oligosides, the structures of which were established by chemical transformations and UV, IR, PMR, and 13C NMR spectra, were isolated from Astragalus galegiformis leaves.
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Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 555–558, November–December, 2006. 相似文献
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Pisutthanan N Liawruangrath B Liawruangrath S Bremner JB 《Natural product research》2006,20(13):1192-1198
Fractionation of the aerial parts of Chromolaena odorata afforded a new flavonoid, 5,7-dihydroxy-6,4'-dimethoxyflavanone, in addition to 14 known flavonoid compounds, six of which had not been isolated previously from this plant. The structure of the new compound was determined by spectroscopic methods particularly 2D-NMR analysis. 相似文献
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Ten lanostane glycosides (1-10), including two new norlanostane glycosides (2 and 7) and a new lanostane glycoside with a spirolactone ring system (9), were isolated from the fresh bulbs of Chionodoxa luciliae (Liliaceae). The structures of the new compounds were determined on the basis of extensive spectroscopic analysis and the results of hydrolytic cleavage to be (23S)-3beta-[(O-beta-D-apiofuranosyl-(1-->2)-O-[beta-D-glucopyranosyl-(1-->3)]-O-beta-D-glucopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-(1-->6)-beta-D-glucopyranosyl)oxy]-17alpha,23-epoxy-28,29-dihydroxy-27-norlanost-8-en-24-one (2), (23S)-17alpha,23-epoxy-29-hydroxy-3beta-[(O-alpha-L-rhamnopyranosyl-(1-->2)-O-[O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->3)]-O-beta-D-glucopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-(1-->6)-beta-D-glucopyranosyl)oxy]-27-norlanost-8-ene-15,24-dione (7), and (23S,25R)-17alpha,23-epoxy-29-hydroxy-3beta-[(O-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-glucopyranosyl-(1-->3)]-O-beta-D-glucopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-(1-->6)-beta-D-glucopyranosyl)oxy]lanost-8-en-23,26-olide (9), respectively. The cytotoxic activity of the isolated compounds against HSC-2 human oral squamous cell carcinoma cells are also reported. 相似文献
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Ts. Zhapova L. D. Modonova N. N. Pogodaeva A. L. Vereshchagin A. G. Gorshkov S. V. Zinchenko A. A. Semenov 《Chemistry of Natural Compounds》1993,28(5):421-429
Two known flavonoids, the 7-O--L-rhamnopyranosides of kaempferol and of quercetin, and also the new acylated glycoside quercetin 3-O-[O-(6-caffeoyl--D-glucopyranosyl)-(12)--D-glucopyranoside 7-O--L-rhamnopyranoside (czekanoside A) have been isolated from the epigeal part ofAconitum baicalense Turcz, ex Rapaics (A. Czekanovskyi Steinb.). Their structures have been demonstrated by the methods of IR, UV,1H, and13C NMR spectroscopies and FAB mass spectrometry and also with the aid of acid hydrolysis.Deceased.Irkutsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 484–493, September–October, 1992. 相似文献
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Anna Stojakowska Agnieszka Galanty Janusz Malarz Marta Michalik 《Natural product research》2019,33(12):1804-1808
In addition to known constituents of Telekia speciosa, an acetone extract from ray florets of the plant yielded: 5,5?-dibutoxy-2,2?-bifuran (1), 5,5?-diisobutoxy-2,2?-bifuran (2), α-tocopherol (3), β-tocopherol (4), loliolide palmitate (5), a mixture of calenduladiol esters - 16β-hydroxylupeol-3-O-palmitate (7) and 16β-hydroxylupeol-3-O-myristate (8), 1-epiinuviscolide (12), inuviscolide (13), 3-epiisotelekin (16), 4α-hydroxy-9β,10β-epoxy-1β(H)-11(13)-guaien-8α,12-olide (17), 4α-hydroxy-1β(H)-9(10),11(13)-guaiadien-8α,12-olide (18), loliolide (19) and 4β,10β-dihydroxy-1α(H),5α(H)-11(13)-guaien-8α,12-olide (20). Calenduladiol esters and asperilin (14) were the major constituents of the extract. Their cytotoxic effect on human normal prostate epithelial cells (PNT-2), human prostate carcinoma cell lines, human skin fibroblasts (HSF) and human melanoma cell lines was examined in vitro. Triterpene esters showed no cytotoxicity against nearly all cell lines tested, except for Du145 prostate carcinoma cells (IC50 – 62.0 μΜ). Asperilin displayed activity against the cell lines under study, especially against three tested lines of melanomas (A375, IC50 – 17.6 μΜ, WM793, IC50 – 28.2 μΜ and Hs 294T, IC50 – 29.5 μΜ). 相似文献
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Ts. Zhapova L. D. Modonova N. N. Pogodaeva A. L. Vereshchagin A. G. Gorshkov S. V. Zinchenko A. A. Semenov 《Chemistry of Natural Compounds》1992,28(5):421-429
Two known flavonoids, the 7-O-α-L-rhamnopyranosides of kaempferol and of quercetin, and also the new acylated glycoside quercetin 3-O-[O-(6-caffeoyl-β-D-glucopyranosyl)-(1→2)-β-D-glucopyranoside 7-O-α-L-rhamnopyranoside (czekanoside A) have been isolated from the epigeal part ofAconitum baicalense Turcz, ex Rapaics (A. Czekanovskyi Steinb.). Their structures have been demonstrated by the methods of IR, UV,1H, and13C NMR spectroscopies and FAB mass spectrometry and also with the aid of acid hydrolysis. 相似文献
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Pisutthanan N Liawruangrath B Liawruangrath S Baramee A Apisariyakul A Korth J Bremner JB 《Natural product research》2006,20(6):636-640
The chemical composition of the essential oil from the aerial parts of Chromolaena odorata, collected from Phitsanulok, Thailand was analyzed by means of GC-(FID) and GC-MS. Twenty-two constituents were identified. The major components were pregeijerene (17.6%), germacrene D (11.1%), alpha-pinene (8.4%), beta-caryophyllene (7.3%), vestitenone (6.5%), beta-pinene (5.6%), delta-cadinene (4.9%), geijerene (3.1%), bulnesol (2.9%), and trans-ocimene (2.2%). 相似文献
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Two flavonoid glycosides (compounds 1 and 3) of which one is reported for the first time and a methylinositol (compound 2) were isolated from the aerial parts of Ebenus haussknechtii (Leguminosae). The structures were established as quercetin-7-O-[alpha-L-rhamnopyranosyl(1 --> 6)-beta-D-galactopyranoside] (1), morin-3-O-[4-[5-(4-hydroxyphenyl)pentanoyl]-alpha-L-rhamnopyranosyl(1 --> 6)-beta-D-galactopyranosyl]-7-4'-di-O-methyleter (3), and methylinositol (2) on the basis of chemical and spectroscopic means. The antimicrobial activities of the extracts have also been examined. 相似文献
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Cycloartane glycosides from the rhizomes of Cimicifuga racemosa and their cytotoxic activities 总被引:3,自引:0,他引:3
Phytochemical analysis of the rhizomes of Cimicifuga racemosa (Ranunculaceae) resulted in the isolation of twelve cycloartane glycosides (1--12), including four new ones (4--6, 12). The structures of the new compounds were determined by spectroscopic analysis, including two-dimensional (2D) NMR data, and chemical methods. The isolated compounds were evaluated for their cytotoxic activities against human oral squamous cell carcinoma (HSC-2) cells and normal human gingival fibroblasts (HGF). 相似文献
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Steroidal glycosides from the bulbs of Camassia leichtlinii and their cytotoxic activities. 总被引:2,自引:0,他引:2
M Kuroda Y Mimaki F Hasegawa A Yokosuka Y Sashida H Sakagami 《Chemical & pharmaceutical bulletin》2001,49(6):726-731
Phytochemical analysis of the bulbs of Camassia leichtlinii (Liliaceae) resulted in the isolation of six new spirostanol saponins, a new furostanol saponin, a cholestane glucoside, and four known steroidal saponins. The structures of the new saponins were determined by detailed analysis of their spectral data, including two-dimensional NMR spectroscopy, and by the results of hydrolytic cleavage. Cytotoxic activities of the isolated compounds against human oral squamous cell carcinoma (HSC-2) cells and normal human gingival fibroblasts (HGF) are also reported. 相似文献
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Two new steroidal glycosides of the spirostane and furostane classes, derivatives of gitogenin, were found in wastes from
producing acetyldigitoxin preparation from Digitalis ciliata Trautv. (Scrophulariaceae). The structures of the glucosides were established using physical constants, chemical transformations,
and IR, mass, and NMR spectra.
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Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 452–455, September–October, 2006. 相似文献
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Three new phenylethanoid glycosides, incanoside C, incanoside D and incanoside E were isolated together with one known glycoside, beta-D-fructofuranosyl-alpha-D-(6-O-[E]-sinapoyl) glucopyranoside from the whole plant of Caryopteris incana (THUNB.) Miq. On the basis of chemical and spectral analyses, the structures of the new compounds were elucidated to be 1-O-(3,4-dihydroxyphenyl)ethyl-O-beta-D-glucopyranosyl(1-->2)-alpha-L- rhamnopyranosyl(1-->3)-4-O-feruloyl-beta-D-glucopyranoside (incanoside C), 1-O-(3-hydroxy-4-methoxyphenyl)ethyl-O-beta-D-glucopyranosyl(1-->2)-alph a-L- rhamnopyranosyl(1-->3)-4-O-feruloyl-beta-D-glucopyranoside (incanoside D) and 1-O-(3methoxy-4-hydroxyphenyl)ethyl-O-beta-D-glucopyranosyl(1-->2) -alpha-L- rhamnopyranosyl(l-->3)-4-O-feruloyl-beta-D-glucopyranoside (incanoside E). The three new phenylethanoid glycosides exhibited radical scavenging activities against DPPH radical and inhibitory activities against the oxidation of linoleic acid. 相似文献
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Jicheng Shu Linyu Li Meng Zhou Jiangli Yu Caiying Peng Feng Shao 《Natural product research》2018,32(15):1760-1768
Three new flavonoid glycosides, 2(S)-5-hydroxy-6,8-dimethoxyflavonone-7-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranoside (1), 5-hydroxy-3,8-dimethoxyflavone-7-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranoside (2) and 3,7-dihydroxy-8-methoxyflavone-6-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranoside (3), together with five known flavonoids (4–8) were isolated from the roots of Smilax glabra Roxb. Their structures were elucidated on the basis of chemical and spectral evidence, as well as by comparison with literature data. Three new flavonoids were subjected to evaluate anti-inflammatory activity. Compounds 1–3 inhibited the NF κB induction by 32.2, 55.8 and 61.7%, respectively. 相似文献
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Mariana G. Aguilar Fernanda C. G. Evangelista Adriano P. Sabino Sidney A. Vieira Filho Lucienir P. Duarte 《Natural product research》2020,34(6):810-815
AbstractFriedelan-3-one (1) and friedelane-3,16-dione (2) isolated from leaves and branches of Maytenus robusta Reissek were subjected to structural modifications via nucleophilic addition to the carbonyl group and Baeyer-Villiger oxidation in order to synthesize potential cytotoxic compounds. The oximes friedelane-3-hydroxyimino (3) and 3-hydroxyiminofriedelan-16-one (4) together with the lactones friedelane-3,4-lactone (5) and 3,4-lactonefriedelan-16-one (6) were characterized by IR and NMR spectroscopic analyses. Compounds 4 and 6 are reported for the first time. Cytotoxic screening via MTT assay in human leukemia cell lines (THP-1 and K562) demonstrated no significant improvement of compounds 3-6 when compared to the starting materials. Only compounds 3 and 5 demonstrated an improvement against K562 cells. However, the same assay on ovarian and breast cancer cell lines (TOV-21G and MDA-MB-231) showed a reduction in the IC50 for compounds 4-6, indicating that ring A modifications may enhance the biological potential. 相似文献
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Huaran Zhang Xuewei Wu Jinxia Wang Miaomiao Wang Xiaoning Wang Tao Shen 《Natural product research》2020,34(9):1256-1263
AbstractPhytochemical studies on the leaves of Epimedium koreanum Nakai have resulted in the discovery of two new flavonol glycosides, koreanoside F (1) and koreanoside G (2), along with six known flavonoids. Their structures were elucidated on the basis of HRESIMS, UV, IR, 1?D NMR and 2?D NMR data. Absolute configurations of 1 and 2 was further determined by 13C-NMR spectra with gate decoupling (GD). All of the compounds were evaluated for cytotoxic activities by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT) assay. The results indicated that compounds 3, 5, 6, 7 and 8 inhibited the proliferation of A549 and NCI-292 cells with IC50 values of 5.7–23.5?μM. Real-time monitoring in three kinds of lung cancer cells and a kind of human bronchial epithelial cells treated with compound 6 was also assessed. 相似文献
20.
Shan Yu Jun-Jiang Lv Jian-Qiang Zhao Yan Li Dong Wang Chong-Ren Yang 《Natural product research》2016,30(4):419-425
During the process of exploring bioactive lead compounds from Phyllanthus species, two new glycosides including an arylnaphthalene lignan, diphyllin 4-O-α-l-arabinopyranosyl-(1 → 3)-α-l-arabinopyranoside (1), and a phenolic compound, 3,4,5-trimethoxybenzyl alcohol 7-O-α-l-arabinofuranosyl-(1 → 6)-β-d-glucopyranoside (2), were isolated from the methanol extract of the whole plants of Phyllanthus glaucus Wall. ex Müll. Arg. In addition, 31 known compounds, including 19 lignan derivatives (3–21), four phenylpropanoids (22–25), seven simple phenolics (26–32) and one monoterpenoid (33) were obtained. Their structures were determined on the basis of the HR-ESI-MS, 1D and 2D NMR spectroscopic analysis, and pre-column derivative/chiral HPLC analysis in case of 1 for the absolute configurations. All these compounds were obtained from P. glaucus for the first time. Moreover, the known lignan glycoside, phyllanthusmin C (5) showed in vitro cytotoxicities against HL-60, MCF-7 and SW480 cells with IC50 values of 9.2 ± 0.2, 19.2 ± 1.7 and 20.5 ± 0.9, respectively. 相似文献