Unsaturated acids and macrocylic lactones

Summary The total syntheses of a- and 0-kamlolenic acids were carried out.Communication 7 of the series Stereoregular synthesis of unsaturated compounds.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya No. 11, pp. 2003–2007, November, 1964     

Unsaturated acids and macrocyclic lactones. Communication 13. New method for the synthesis of A 1,5-hexadiene system

Summary With the aid of a stereospecific modification of the Wittig reaction a new way of building up cis-cis 1,5-hexadiene systems was developed.Communication 6 of the Series Stereoregular Synthesis of Unsaturated Compounds. For preceding communication see [13].Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 8 pp. 1453–1456, August, 1964     

Unsaturated lactones

New, biologically active pyrazole derivatives containing an unsaturated -lactone ring were obtained by condensation of 2-(1-etboxycarbonyl-1,3-diketopropyl)-2-buten-4-olides with phenylhydrazine and hydrazine hydrate. A number of transformations of the resulting pyrazole-3-carboxylic acid esters were realized.See [1] for communication XXXIV.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1611–1614, December, 1978.     

Synthesis of new macrocyclic lactones and their extraction study

New macrocyclic lactones were synthesized by reaction of 3-bromo-5-(5-tert-butyl-2-hydroxybenzyl)biphenyl-4-ol with appropriate polyethylene glycol-based dicarboxylic acid dichlorides, and their complexes with Mg(ClO₄)₂·6H₂O, Pb(SCN)₂, NaClO₄·H₂O, and KClO₄ were prepared. The macrocyclic ligands were evaluated as extractants in the transfer of Li⁺, Na⁺, K⁺, Cu²⁺, Ni²⁺, and Hg²⁺ picrates from aqueous to organic phase. Published in Russian in Zhurnal Organicheskoi Khimii, 2008, Vol. 44, No. 9, pp. 1400–1405. The text was submitted by the authors in English.     

Synthesis of macrocyclic lactones with methoxysulfonyl side chain

Two representative macrocyclic lactones with methoxysulfonyl side chain（5a and 5b）were synthesized employing Michael addition with acrolein and ring enlargement as the key steps,starting from potassium,α-oxocycloaikylsulfonates（1）in total yields of 45 and 57%,respectively.     

Synthesis of new macrocyclic lactams,lactones, and thiolactones

A general method has been developed for the preparation of 14-remembered cyclic lactams, lactones, and thiolactones from heteroaromatic amino acids.A. V. Bogatskii Physico-Chemical Institute, Ukraine Academy of Sciences, Odessa 270080. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1128–1131, August, 1996. Original article submitted May 27, 1996.     

Lipase catalyzed synthesis of macrocyclic lactones in organic solvents

A new method for the preparation of macrocyclic lactones from ω-hydroxyacid methyl esters is described. The approach utilizes intramolecular transesterification catalyzed by lipase in organic solvents. This procedure is also applicable to the synthesis of asymmetric lactones.