共查询到20条相似文献,搜索用时 31 毫秒
1.
Aibin Wu Jide Liu Shaoxiong Qin Ping Mei 《Monatshefte für Chemie / Chemical Monthly》2010,21(3):95-99
Abstract
A series of mono and bis-2-(2-(dimethylamino)-ethyl)-5-nitro-1H-benzo[de]isoquinoline-1,3(2H)-diones with different amino side chains, a novel family of antitumor agents, has been designed and synthesized. Their antitumor activity was evaluated against HeLa, A549, P388, HL-60, MCF-7, HCT-8, and A375 cancer cell lines in vitro. Preliminary results showed that most of the derivatives had antitumor activity comparable with that of mitonafide, with IC 50 values of 10−6–10−5 M. More importantly, the derivatives had distinct antitumor selectivity against different cancer cell lines. This work provided a novel class of mitonafide-based lead compounds with improved antitumor selectivity against cancer cell lines for further optimization. 相似文献2.
Vera L. M. Silva Artur M. S. Silva Diana C. G. A. Pinto José A. S. Cavaleiro José Elguero 《Monatshefte für Chemie / Chemical Monthly》2009,45(2):87-95
Abstract
An efficient synthesis method for the preparation of a series of new (Z)- and (E)-3(5)-(2-hydroxyphenyl)-4-styrylpyrazoles was developed. The reaction of (Z)- and (E)-3-styrylchromones with hydrazine hydrate afforded the corresponding (Z)- and (E)-3(5)-(2-hydroxyphenyl)-4-styrylpyrazoles, except for nitro derivatives, where both (Z)- and (E)-4′-nitro-3-styrylchromones afforded (E)-3(5)-(2-hydroxyphenyl)-4-(4-nitrostyryl)pyrazoles. The reaction mechanism for these transformations is discussed and the stereochemistries of all products were established by NMR experiments. 相似文献3.
D. F. Saifina V. R. Ganieva V. A. Mamedov 《Russian Journal of Organic Chemistry》2009,45(8):1244-1247
A two-stage method was developed for the synthesis of 3-(α-chloroalkyl- and α-chlorophenylalkyl)-quinoxalin-2(1H)-ones proceeding from methyl chloroalkyl- and chlorophenylalkylpyruvates obtained by Darzens reaction from methyl dichloroacetate
and appropriate aldehydes in the presence of t-BuOK. 相似文献
4.
N. B. Patel A. I. Gandhi R. D. Sharma 《Monatshefte für Chemie / Chemical Monthly》2010,46(2):1123-1133
Abstract
6-(Substituted amino)-4-(4-ethoxyphenyl)-1-phenyl-2(1H)-pyridinones were prepared from β-aryl glutaconic acid, which, on fusion with aniline, results in 4-(4-ethoxyphenyl)-1-phenylpyridine-2,6(1H,5H)-dione. This, on further treatment with phosphorus oxychloride gave 6-chloro-4-(4-ethoxyphenyl)-1-phenyl-2(1H)-pyridinone, and further treatment with secondary amines yielded 6-(substituted amino)-4-(4-ethoxyphenyl)-1-phenyl-2(1H)-pyridinones. These were subjected to azo coupling with different aryldiazonium chlorides furnishing two isomers, which were separated by column chromatography. All compounds were characterized by elemental analysis, and use of IR and NMR spectral data, and were evaluated for antimicrobial activity. 相似文献5.
Mahboubeh Rostami Ahmad Reza Khosropour Valiollah Mirkhani Iraj Mohammadpoor-Baltork Majid Moghadam Shahram Tangestaninejad 《Monatshefte für Chemie / Chemical Monthly》2011,7(1):1175-1180
Abstract
A new and practical promoter system for one-pot, efficient, chemoselective synthesis of 4-arylidene-2-phenyl-5(4H)-oxazolones using [(C14H24N4)2W10O32]-[bmim]NO3 under solvent-free conditions is described. The present work opens up a new and ecofriendly synthetic route to Erlenmeyer–Pl?chl adducts from primary benzyl alcohols in a one-pot operation. 相似文献6.
Andrii I. Kysil Viktoria S. Moskvina Marian V. Gorichko Volodimyr P. Khilya 《Monatshefte für Chemie / Chemical Monthly》2012,40(1):165-170
Abstract
Methyl 4-chloro-6-fluoro-3-formyl-2H-chromene-2-carboxylate was synthesized conveniently using Vilsmeier reagent. A series of new 2H-chromenes was prepared in high yields by introducing a corresponding β-halovinylaldehyde into condensation and cyclization reactions with active methylene compounds. 相似文献7.
E. S. Denislamova N. V. Bubnov A. N. Maslivets 《Russian Journal of Organic Chemistry》2011,47(6):933-936
Methyl 1-aryl-3-benzoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates reacted with 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione to give methyl 11-aryl-12-benzoyl-9-hydroxy-4,6-dimethyl-3,5,10-trioxo-4,6,8,11-tetraazatricyclo[7.2.1.02,7]dodec-2(7)-ene-1-carboxylates which underwent thermal recyclization to 1-aryl-3-benzoyl-4-hydroxy-1′,3′-dimethylspiro[pyrrole-2,5′-pyrrolo[2,3-d]pyrimidine]-2′,4′,5,6′(1H,1′H,3′H,7′H)-tetraones. 相似文献
8.
Minoo Dabiri Peyman Salehi Mahboobeh Bahramnejad Mohsen Alizadeh 《Monatshefte für Chemie / Chemical Monthly》2010,46(6):877-881
Abstract
An effective one-pot three-component route to 4(3H)-quinazolinones from commercially available starting materials is reported. Thus, isatoic anhydride reacted with ammonium acetate or primary amines and aldehydes in the presence of iodine to produce the corresponding quinazolinone derivatives in moderate to good yields. 相似文献9.
Au?ra Voskien? Birut? Sapijanskait? Vytautas Mickevi?ius Kristina Kantminien? Maryna Stasevych Olena Komarovska-Porokhnyavets Rostyslav Musyanovych Volodymyr Novikov 《Monatshefte für Chemie / Chemical Monthly》2011,17(1):529-537
Abstract
Mono- and disubstituted [(tetrahydro-2,4-dioxopyrimidin-1(2H)-yl)phenoxy]naphthalene-1,4-diones were synthesized by the reaction of dihydro-1-(3-hydroxy- and 4-hydroxyphenyl)pyrimidine-2,4(1H,3H)-diones and their 5- and 6-methyl derivatives with 2,3-dichloro-1,4-naphthoquinone. Their stability in alkaline and acidic media was investigated. Four of the compounds exhibited good antimicrobial activity against Staphylococcus aureus, Mycobacterium luteum, Candida tenuis, and Aspergillus niger. 相似文献10.
Eva Petrlíková Karel Waisser Rafael Dole?al Pavel Holy Ji?í Gregor Ji?i Kune? Jarmila Kaustová 《Chemical Papers》2011,65(3):352-366
A series of forty-five derivatives of 3-phenyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and forty-five derivatives of 3-phenyl-2H-1,3-benzoxazine-2,4(3H)-dithiones was synthesised. The compounds exhibited in-vitro activity against Mycobacterium tuberculosis, M. kansasii (two strains), and M. avium. The most active derivatives were more active than isonicotinhydrazide (INH). The quantitative relationships between the
structure and antimycobacterial activity were calculated. The activity against M. tuberculosis increased with the lipophilicity of the substituents. 相似文献
11.
Iraj Mohammadpoor-Baltork Ahmad R. Khosropour Majid Moghadam Shahram Tangestaninejad Valiollah Mirkhani Saeid Baghersad Arsalan Mirjafari 《Comptes Rendus Chimie》2011,14(10):944-952
An efficient and novel synthesis of 2,3-disubstituted 2,3-dihydroquinazolin-4(1H)-ones via one-pot, three-component reaction of isatoic anhydride, primary amines and aromatic aldehydes catalyzed by Bi(NO3)3·5H2O under solvent-free conditions is described. Oxidation of these 2,3-dihydroquinazolin-4(1H)-ones to their quinazolin-4(3H)-ones was also successfully performed in the presence of Bi(NO3)3·5H2O. This new method has the advantages of convenient manipulation, short reaction times, excellent yields, very easy work-up, and the use of commercially available, low cost and relatively non-toxic catalyst. The role of Bi(NO3)3·5H2O was also investigated in these transformations. 相似文献
12.
V. P. Rybalkin Ya. Yu. Vorobeva G. S. Borodkin A. D. Dubonosov A. V. Tsukanov V. V. Tkachev S. M. Aldoshin V. A. Bren V. I. Minkin 《Russian Chemical Bulletin》2005,54(12):2783-2789
New photochromic (2Z)-2-(N-acyl-N-arylaminomethylidene)benzo[b]thiophen-3(2H)-ones containing L-amino acid derivatives as migrating groups were synthesized. Light irradiation of their solutions at 436 nm leads to the
photoinduced acylotropic rearrangement N → O accompanied by migration of the chiral fragment. The bulky N-acyl group causes steric strain thus destabilizing the amide form of compounds and facilitating the photorearrangement.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2690–2696, December, 2005. 相似文献
13.
Krishna C. Majumdar Safalla K. Ghosh Paritosh Biswas 《Monatshefte für Chemie / Chemical Monthly》2000,52(10):967-973
A simple and efficient synthesis of the hitherto unreported ring systems pyrano[3,2-f]quinolin-2(7H)-one and furo[3,2-f]quinolin-2-one was accomplished via a thermal [3,3]-sigmatropic rearrangement. 相似文献
14.
K. S. Bozdyreva Z. G. Aliev A. N. Maslivets 《Russian Journal of Organic Chemistry》2008,44(4):607-611
3-[(Z)-3,3-Dimethyl-2-oxobutylidene]-3,4-dihydroquinoxalin-2(1H)-one and its 1-phenyl-substituted analog reacted with oxalyl chloride to give the corresponding 3-pivaloylpyrrolo[1,2-a]quinoxaline-1,2,4(5H)-triones. Reactions of the latter with o-phenylenediamine led to the formation of 3,3′-(3,3-dimethyl-2-oxobutane-1,1-diyl)di[quinoxalin-2(1H)-ones].
Original Russian Text ? K.S. Bozdyreva, Z.G. Aliev, A.N. Maslivets. 2008, published in Zhurnal Organicheskoi Khimii, 2008,
Vol. 44, No. 4, pp. 612–616.
For communication LVI, see [1]. 相似文献
15.
Liqiang Wu Suying Ma Fulin Yan Chunguang Yang 《Monatshefte für Chemie / Chemical Monthly》2010,122(3):565-568
Abstract
An efficient synthesis of 4-aryl-3-methyl-1-phenyl-1H-benzo[g]pyrazolo[3,4-b]quinoline-5,10-diones from the three-component condensation reaction of 3-methyl-1-phenyl-1H-pyrazol-5-amine, aromatic aldehydes, and 2-hydroxy-1,4-naphthoquinone under solvent-free conditions in good to excellent yields and short reaction times using sulfamic acid as heterogeneous acid catalyst has been investigated. 相似文献16.
Hamid Reza Memarian Asadollah Farhadi 《Monatshefte für Chemie / Chemical Monthly》2009,12(5):1217-1220
Abstract
UV light irradiation of Biginelli 3,4-dihydropyrimidin-2(1H)-ones in chloroform in an argon atmosphere leads to dehydrogenation of these compounds to their corresponding pyrimidin-2(1H)-ones in excellent yields. Irradiation in the same solvent under an oxygen atmosphere generates, in addition, various hitherto unidentified products. A light-induced electron transfer from the substrate to the solvent is proposed as the initial event, supported by the detection of dichloromethane and hydrogen chloride in the photolysate. 相似文献17.
Honggen Wang Lanying Liu Yong Wang Changlan Peng Jiancun Zhang Qiang Zhu 《Tetrahedron letters》2009,50(49):6841-6843
An efficient synthesis of 4-alkyl-2(1H)-quinazolinones has been achieved by cyclization of 1-(2-alkynylphenyl)ureas (2 R2 = alkyl) in dichloroethane catalyzed by TfOH. In the case of aryl substitution (2 R2 = aryl), a mixture of quinazolinone tautomers is obtained in dichloroethane with TFA as co-solvent. Chlorination of the resulting mixture affords 4-alkyl-2-chloro-quinazolines as sole products. 相似文献
18.
Abstract
An effective diastereoselective synthesis of (S)-N,N-diethyl-2-formyl-2-(methoxymethoxy)butanamide and (S)-2-formyl-2-(methoxymethoxy)butanoic acid ethyl ester, which are two key chiral building blocks for the synthesis of 20(S)-camptothecins, has been developed by employing an asymmetric bromolactonization using (R)-proline. The (R) compounds were also synthesized to obtain 20(R)-camptothecin. 相似文献19.
Mass spectra of 5-substituted N(3)-acyl-4,6-diaryl-3,4-dihydropyrimidin-2(1H)-ones are studied. The features of the dissociative ionization of their molecular ions, which occurs with ketene elimination
from the acyl group, are revealed. The subsequent fragmentation of fragment ions proceeds according to the rules established
for pyrimidin-2(1H)-one derivatives. 相似文献
20.
Bhawana Gupta Nidhi Kalgotra Savit Andotra Sushil K. Pandey 《Monatshefte für Chemie / Chemical Monthly》2012,39(5):1087-1095