共查询到20条相似文献,搜索用时 46 毫秒
1.
Karnaukhova R. V. Nakhmanovich A. S. Larina L. I. Lopyrev V. A. 《Russian Journal of General Chemistry》2002,72(9):1433-1434
The reactions of 2-(2-cyanoethyl)-1,1-dimethylhydrazine with prop-2-ynyl bromide, 1,3-dibromopropyne, and allyl bromide involve alkylation by a tertiary nitrogen atom to form 2-(2-cyanoethyl)-1,1-dimethyl-1-(prop-2-ynyl)-, 1-(3-bromoprop-1-ynyl)-2-(2-cyanoethyl)-1,1-dimethyl-, and 1-allyl-2-(2-cyanoethyl)-1,1-dimethylhydrazinium bromides. 相似文献
2.
1-(2-氰乙基)-2-氧代环戊基甲酸甲酯的选择性水解脱羧 总被引:1,自引:0,他引:1
对1-(2-氰乙基)-2-氧代环戊基甲酸甲酯(4)的选择性水解脱羧反应进行了系统研究. 发现上述化合物在碱的催化作用下主要生成开环副产物2-(2-氰乙基)己二酸二甲酯及2-(2-氰乙基)己二酸; 由于氰基在酸性介质中也可发生水解, 因此对1-(2-氰乙基)-2-氧代环戊基甲酸甲酯在酸性情况下水解脱羧的反应条件进行了探索, 发现在4 mol8226;L-1盐酸介质中, 50 ℃下反应24 h, 以84.0%的收率得到目标产物3-(2-氧代环戊基)-丙腈. 相似文献
3.
A series of nitroimidazoles were subjected to hydroxymethylations under a variety of conditions. Hydroxymethylation of 1-(2-hydroxyethyl), 1-(2-acetoxyethyl), and 1-(2-chloroethyl) substituted 5-nitroimidazoles with paraformaldehyde in dimethyl sulfoxide yielded the respective 2-hydroxymethyl analogs (5–7). However, attempts to hydroxymethylate 1-(2-hydroxyethyl), 1-(2-acetoxyethyl), 1-(2-cyanoethyl) substituted 4-nitroimidazoles and 1-(2-hydroxyethyl)-2-nitroimidazole were unsuccessful. Treatment of 1-(2-acetoxyethyl)-5-nitro-2-imidazolecar-baldehyde(10) with hydroxylamine-O-sulfonic acid afforded a mixture of corresponding 2-carbonitrile (12) and 2-(N-hydroxy)carboximidamide (13). Hydrolysis of 10 with ethanolic hydrochloric acid yielded 8-ethoxy-5,6-dihydro-3-nitro-8H-imidazo[2,1-c] [1,4]oxazine (11) which, on subsequent reaction with hydroxylamine-O-sulfonic acid, afforded 1-(2-hydroxyethyl)-5-nitroimidazole-2-(N-hydroxy)carboximidamide (15). Reaction of 4(5)-nitroimidazole with chloropropionitrile produced a mixture of the isomeric 1-(2-cyanoethyl) substituted 4- and 5-nitroimidazoles. Treatment of 2,4(5)-dinitroímidazole with chloropropionitrile afforded a mixture of 4(5)-chloro-5(4)-nitroimidazole and 1-(2-cyanoethyl)-4-nitro-5-chloroimidazoIe. Reaction of nitroimidazoles with acrylonitrile in the presence of Triton B yielded the corresponding 1-(2-cyanoethyl) substituted derivatives. 相似文献
4.
A. Sh. Sharifkanov K. Kh. Tokmurzin T. G. Sarbaev 《Chemistry of Heterocyclic Compounds》1969,5(1):61-61
Synthesis of 1-(β-cyanoethyl)-4e-ethynyl-2e, 5e-dimethylpiperidin-4a-o1 and the corresponding 4e-vinyl compounds (β-isomers), 1-β-cyanoethyl-4a-ethynyl-2e, 5e-dimethylpiperidin-4c-ol (and the corresponding 4a-vinyl compound) (γ-isomers), and l-(β-cyanoethyl)-2e, 5a-dimethyl-4a-vinylpiperidin-4e-o1 (α-isomer) have been effected. 相似文献
5.
N. M. Mikhailova A. N. Levov S. V. Gozun O. O. Timonina F. Toze A. V. Varlamov 《Chemistry of Heterocyclic Compounds》2006,42(10):1291-1295
Cyanoethylation of 9-phenacyl(β-hydroxy-β-phenylethyl-, or acetamido)-4-azafluorenes under conditions of the Michael reaction
occurs regioselectively at position 9. 1-Amino-4-azafluorene under these conditions forms 1-[N,N-di-(β-cyanoethyl)amino)]-(9-β-cyanoethyl)-4-azafluorene.
The cyclization of 9-(β-cyanoethyl)-9-phenacyl-4-azafluorene has been carried out into 1′-cyano-2′-phenylspiro[4-aza-fluorene-9,4′-cyclopentene
and 1′-imino-2′-hydroxybenzylidenespiro[4-azafluorene-9.3′-cyclopentane]-substituted in the five-membered fragment.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1496–1501, October, 2006. 相似文献
6.
3-(3-Aryl-4-formyl-1-pyrazolyl)propionic acids were synthesized by the reaction of 3-aryl-1-(2-cyanoethyl)-4-formylpyrazoles with concentrated hydrochloric acid. They were converted into the corresponding amides by the carbodiimide method.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1483–1486, October, 2004.For Communication 2, see [1]. 相似文献
7.
Yujiro Nomura Takashi Bando Yoshito Takeuchi Shuji Tomoda 《Tetrahedron letters》1979,20(36):3453-3456
The reaction of 2,3,4,5-tetrahydropyridine with electron-deficient olefins such as methyl acrylate, acrylonitrile, and N-phenylmaleimide, provided 1-(2-methoxycarbonylethyl)-5-[1- (2-methoxycarbonylethyl)-2-piperidyl]-1,2,3,4-tetrahydropyridine, 1-(2-cyanoethyl)-5-[1-(2-cyanoethyl)-2-piperidyl]-1,2,3,4-tetrahydropyridine, and 2-(2-methoxypiperidino)-N-phenylsuccinimide, respectively, in high yields. 相似文献
8.
A. R. Kaliev V. Yu. Serykh I. B. Rosentsveig 《Russian Journal of Organic Chemistry》2017,53(8):1191-1194
Reaction of N-(2,2,2-trichloroethylidene)- or N-(1-phenyl-2,2-dichloroethylidene)arenesulfonamides with acetone cyanohydrin in acetone in the presence of potassium carbonate led to the formation of N- (2,2,2-trichloro-1-cyanoethyl)- or N-(2-phenyl-2,2-dichloro-1-cyanoethyl)arenesulfonamides. 相似文献
9.
Treatment of 1-arylmethyl-2-(2-cyanoethyl)aziridines with a nitrile hydratase afforded the corresponding 2-(2-carbamoylethyl)aziridines, which underwent rearrangement into 5-hydroxypiperidin-2-ones upon heating under microwave irradiation. In addition, treatment of 2-(2-cyanoethyl)aziridines with a nitrilase selectively afforded 5-hydroxypiperidin-2-ones in good yields. On the other hand, chemical hydrolysis of 2-(2-cyanoethyl)aziridines using KOH in EtOH/H(2)O furnished the corresponding potassium 3-(aziridin-2-yl)propanoates, which, upon acidification with acetic acid, smoothly rearranged into 4-(aminomethyl)butyrolactones. 相似文献
10.
The azidation of 2,2-bis(2-cyanoethyl)-20-hydroxydammar-24-en-3-one afforded new tetrazole derivatives of natural dipterocarpol, 2-(2-cyanoethyl)-2-[2-(1H-tetrazol-5-yl)ethyl]-20-hydroxydammar-24-en- 3-ones, 2,2-bis[2-(1H-tetrazol-5-yl)ethyl]-20-hydroxydammar-24-en-3-one, and 2,2-bis[2-(1H-tetrazol-5-yl)- ethyl]-3-oxo-25,26,27-trinordammaran-(20S),24-olide. The structure of the final and intermediate products was determined by NMR spectroscopy and X-ray analysis. 相似文献
11.
The synthesis and chemical transformations of 3-(2-cyanoethyl)-6-aryl- or 6-(trans-4-alkylcyclohexyl)cyclohex-2-enones into nematic and smectic liquid crystalline compounds are discussed. These 3,6-disubstituted cyclohex-2-enones were prepared by the condensation of appropriate Mannich salts or trans-4-alkylcyclohexyl 2-bromoethyl ketones with ethyl 2-(2-cyanoethyl)acetoacetate. 相似文献
12.
Aroylketenes, generated by the thermolysis of 5-aryl-2,3-dihydro-2,3-furandiones, react with S-methyl-N-cyano-N′-phenylisothiourea,
N-cyano-N′,N′-dimethylformamidine, and N,N-bis(β-cyanoethyl)-cyanamide with the formation of 6-aryl-2-[(methylthio)(phenylamino)methylene]amino-,
6-aryl-2-dimethylaminomethyleneamino-, and 6-aryl-2-[N,N-bis(β-cyanoethyl)amino]-4H-1,3-oxazin-4-ones respectively. Modeling
has been carried out of the interaction of benzoylketene with the indicated cyano compounds by the SSP MO LCAO semiempirical
method using the MNDO-PM3 approach. A mechanism is proposed for the formation of substituted 4H-1,3-oxazin-4-ones.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1490–1501, October, 2005. 相似文献
13.
手性催化剂催化下的不对称合成反应是近年来不对称合成研究中受到重视的领域,如在手性催化剂如,在手性冠醚,手性镧配合物、手性硒、手性铑及手性脯氨酸铷盐等催化下,醛、酮与二烃基锌形成手性醇和不对称羟醛缩合反应等,催化下通过Michael加成反应合成手性化合物的方法近年来也有报道, 相似文献
14.
The synthesis of dihydrocytosines 4 from 3-aminopropionitriles 1 has been broadened and the dihydrocytosines themselves have now been successfully converted to cytosines 9 . Unsubstituted 3-(H, alkyl or aryl) aminopropionitriles ( 1 , X = H) convert with cyanate to 1-(H, alkyl or aryl)-1-(2-cyanoethyl)ureas ( 2 , X = H), which in turn easily cyclize with anhydrous strong acid or base to 1-(H, alkyl or aryl)-5,6-dihydrocytosines ( 4 , X = H). The 1-arylaminopropionitriles ( 1 , X = H) which are poorly reactive with cyanic acid combine readily with benzoylureas to form 3-benzoyl-1-(2-cyanoethyl)-1-arylureas ( 3 , X = H). These benzoylureas likewise cyclize with strong acid or base but with simultaneous elimination of the benzoyl moiety to yield the 1-aryldihydrocytosines 4 (X = H). Amines have successfully been added to 2-chloroacrylonitrile to yield 2-chloro-3-(amino and substituted amino)propionitriles ( 1 , X = Cl). These 2-chloropropionitriles also could be converted with cyanate or benzoylisocyanate to ureas and benzoylureas, respectively (1-(H or alkyl)-1-(2-chloro-2-cyanoethyl)ureas ( 2 , X = Cl) or 1-(H or alkyl)-1-(2-chloro-2-cyanoethyl)-3-benzoylureas ( 3 , X = Cl). The chlorine substituted ureas were unstable especially to base and to heat but with anhydrous acid were cyclized in high yield to 1-(H or alkyl)-5-chloro-5,6-dihydro-cytosines ( 4 , X = Cl). Direct chlorination of unsubstituted dihydrocytosines 4 (X = H) did not afford these same 5-chlorodihydrocytosines 4 (X = Cl) under any conditions investigated. 1-Ethyl-5,6-dihydrocytosine ( 4b ) as the cation (hydrobromide) is converted directly in good yield to 1-ethylcytosine hydrobromide ( 7 ) by bromine in nitrobenzene at 140-160° in a concomitant bromination dehydrobromination reaction. 1-(Alkyl or aryl)-5,6-dihydrocytosines ( 4 , X = H) are halogenated at low temperature in the presence of base to form (N3 or N4)halogenodihydrocytosines ( 8 , R = H). The N-chlorodihydrocytosines 8 are stable. The N-bromo and N-iodo compounds isomerize spontaneously to 5-halogeno-5,6-dihydrocytosines ( 4 , X = Br, I; R = H). The 5-halogeno-5,6-dihydrocytosines 4 (X = Cl, Br, I) whether from cyclization or direct halogenation are readily dehydrohalogenated to the corresponding cytosines 9. 相似文献
15.
We have studied the photolysis and the fragmentation in the mass spectrometer of bis(2-cyanoethyl)mercury, bis(2-cyanoethyl) selenide, bis(2-cyanoethyl) sulphide, dibutylbis(2-cyanoethyl)stannane, and bis[2-(methoxycarbonyl)ethyl] selenide. The mercury compound gave a high yield of adiponitrile on photolysis and in the mass spectrometer it gave the fragmentation pattern of adiponitrile, including the molecular ion, as part of the total fragmentation pattern. A low yield of bialkyl was also formed on photolysis of the bis[2-(methoxycarbonyl)ethyl] selenide but no peaks corresponding to biakyl were observed in the mass spectrum. None of the other compounds yielded alkyl dimer.
A preliminary discussion of the results in terms of orbital symmetry is presented. 相似文献
16.
A. N. Antimonova N. V. Uzenkova N. I. Petrenko M. M. Shakirov E. E. Shul’ts G. A. Tolstikov 《Russian Journal of Organic Chemistry》2011,47(4):589-601
Cyanoethylation of lupane triterpenoids was performed. Amide oximes of 3β-O-(2-cyanoethyl)-betulinic acid methyl ester and 3β-O-acetyl-28-O-(2-cyanoethyl)betulin and the corresponding O-[2-(1,2,4-oxadiazol-3-yl)ethyl] lupane derivatives were obtained. 相似文献
17.
以价廉易得的己二酸二甲酯为原料, 在甲醇钠的催化下, 通过Dieckmann缩合反应得到2-氧代环戊烷羧酸甲酯, 收率82.2%; 2-氧代环戊烷羧酸甲酯再与丙烯腈在40%(质量比)苄基三甲基氢氧化铵甲醇溶液存在下, 经Michael加成制得1-(2-氰乙基)-2-氧代环戊烷羧酸甲酯, 收率82.5%; 进一步酸性脱羧得到3-(2-氧代环戊基)丙腈, 收率84.0%; 将脱羧产物通入装有Ni-Cu/γ-Al2O3催化剂的固定床反应器中, 催化环合最终得到6,7-二氢-5H-1-氮茚, 反应总收率33.8%. 相似文献
18.
Alexey A. Voronin Sofya P. Balabanova Ivan V. Fedyanin Aleksandr M. Churakov Alla N. Pivkina Yurii A. Strelenko Michael S. Klenov Vladimir A. Tartakovsky 《Molecules (Basel, Switzerland)》2022,27(19)
A strategy for the synthesis of 5-((2-cyanoethyl)-X-amino)-[1,2,3]triazolo[4,5-c][1,2,5]oxadiazol-5-ium-4-ides (X = H; CH2CH2CN; NO2 (4a); CN (4b); CO2Et (4c)) starting from 3-amino-4-azido-1,2,5-oxadiazole was developed. The key step in this strategy is the intramolecular thermolytic cyclization of the azido group and the bis(2-cyanoethyl)triazene group. Removal of the 2-cyanoethyl protecting group from amides 4a–c gave potassium salt of the corresponding nitramide and sodium salts of cyano- and ethoxycarbonylamide. The structure and thermal stability of the synthesized compounds were studied experimentally using multinuclear NMR spectroscopy, X-ray crystallography, thermogravimetry, and differential scanning calorimetry. 相似文献
19.
I. V. Ukrainets O. V. Gorokhova K. V. Andreeva 《Russian Journal of Organic Chemistry》2014,50(1):63-65
Treatment of 1-(2-cyanoethyl)-4-hydroxy-N-(hydroxyalkyl)-2-oxo-1,2-dihydroquinoline-3-carboxamides with a solution of hydrogen chloride in aqueous acetic acid ensures selective transformation of the cyano group into amide or carboxy with simultaneous acetylation of the hydroxyalkyl fragments. 相似文献
20.
Moriwaki H Harino H Hashimoto H Arakawa R Ohe T Yoshikura T 《Journal of chromatography. A》2003,995(1-2):239-243
We describe a novel method for the determination of two kinds of aromatic amine mutagens, 2-[2-(acetylamino)-4-[bis(2-methoxyethyl)-amino]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-1) and 2-[2-(acetylamino)-4-[bis(2-cyanoethyl)-ethylamino]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-2), in river water based on liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS-MS). A solid-phase extraction procedure was used for the extraction of PBTA-1 and PBTA-2 from river water. The procedure was rapid and the relative standard deviations were below 4%. The detection limits of PBTA-1 and PBTA-2 in river water using the proposed method were found to be 1 and 2 ng/l, respectively. The compounds were detected by this method in river water taken from two sites in the Yodo River system at the ng/l level. 相似文献