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《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(42):13287-13291
The first enantioselective conjugate addition of silyl ketene imines to in situ generated indol‐2‐ones was performed in the presence of a chiral N ,N ′‐dioxide/NiII catalyst. This method provides efficient access to chiral β‐alkyl nitriles bearing congested vicinal all‐carbon quaternary stereocenters in up to 90 % yield with 23:1 d.r. and 98 % ee . The products enable facile transformations to chiral pyrroloindoline frameworks and spirocyclohexane oxindole derivatives. A possible transition state was also proposed to explain the origin of the asymmetric induction. 相似文献
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