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1.
Zinc enolates formed from 1-aryl-2,2-dibromoalkanones and zinc react with N′-methyl-N′-phenyl- and N′-benzylidene-N-phenylhydrazides of 2-oxochromene-3-carboxylic acid to form the corresponding hydrazides of 1-alkyl-1-aroyl-2-oxo-1a,7b-dihydrocyclopropa[c]chromene-1a-carboxylic acid as a single geometric isomer. 相似文献
2.
Shchepin V. V. Russkikh N. Yu. Kalyuzhnyi M. M. Shchepin R. V. Vakhrin M. I. 《Russian Journal of Organic Chemistry》2003,39(9):1316-1317
Zinc enolates derived from substituted 1-aryl-2,2-dibromoalkanones react with 3-acetyl-6-bromochromen-2-one to give 1a-acetyl-1-alkyl-1-aroyl-6-bromo-1a,7b-dihydro-1H-cyclopropa[c]chromen-2-ones as a single stereoisomer. 相似文献
3.
V. V. Shchepin P. S. Silaichev M. I. Vakhrin 《Russian Journal of Organic Chemistry》2005,41(11):1598-1600
Zinc enolates prepared from 1-aryl-2,2-dibromoalkanones and zinc react with alkyl and aryl 3-aryl-2-cyanopropenoates affording alkyl and aryl 2-alkyl-3-aryl-2-aroyl-1-cyanocyclopropane-1-carboxylates. 相似文献
4.
Shchepin V. V. Fotin D. V. Fotin V. V. Vakhrin M. I. 《Russian Journal of Organic Chemistry》2004,40(6):892-894
Reformatsky reactions of ethyl -bromopropionate, methyl -bromobutyrate, and methyl -bromo-isobutyrate with N-substituted 6-bromo-2-oxochromene-3-carboxamides in the system diethyl ether–benzene– HMPA give N-benzyl-6-bromo-4-(1-alkoxycarbonylalkyl)-2-oxochroman-3-carboxamides, while in the system diethyl ether–benzene–HMPA–THF, 3-R1-1-R2-1-R3-9-bromo-2,3,4,4a,5,10b-hexahydro-1H-chromeno[3,4-c]-pyridine-2,4,5-triones are obtained. 相似文献
5.
Zhchepin V. V. Kalyuzhnyi M. M. Zhchepin R. V. Vakhrin M. I. 《Russian Journal of Organic Chemistry》2003,39(6):843-845
Zinc enolates formed from 1-aryl-2,2-dibromobutan-1-ones and zinc react with alkyl 6-bromo-2-oxo-2-H-chromen-3-carboxylates affording alkyl 1-aroyl-6-bromo-2-oxo-1-ethyl-1,7b-dihydrocyclopropa[c]-chromen-1a(2H)-carboxylates as a single isomer. 相似文献
6.
V. V. Shchepin M. M. Kalyuzhnyi N. Yu. Russkikh 《Russian Journal of General Chemistry》2005,75(9):1452-1454
Zinc enolates formed from 1-aryl-2,2-dibromoalkanones and zinc react with 2-oxo-2H-chromene-3-carboxylates to give aryl 1-alkyl-1-aroyl-2-oxo-1a,7b-dihydro-1H-cyclopropa[c]chromene-1a-carboxylates as a single geometric isomer. The reaction of the same zinc enolates with 2-oxo-2H-chromene-3-carboxyl chloride to form 2-bromo-1-arylalkenyl 1-alkyl-1-aroyl-2-oxo-1,7b-dihydro-1H-cyclopropa[c]chromene-1a-carboxylates. 相似文献
7.
Shchepin V. V. Kalyuzhnyi M. M. Shchepin R. V. Vakhrin M. I. 《Russian Journal of General Chemistry》2003,73(5):758-759
Zinc enolates derived from substituted 2,2-dibromobutyrophenones react with ethyl 5,5-dimethyl-2-oxo-2,5-dihydrofuran-3-carboxylate to give ethyl 6-aroyl-6-ethyl-4,4-dimethyl-2-oxo-3-oxabicyclo[3.1.0]-hexane-1-carboxylates mostly as a single geometric isomer. 相似文献
8.
V. V. Shchepin N. Yu. Russkikh D. V. Uzun P. S. Silaichev 《Russian Journal of Organic Chemistry》2005,41(1):131-133
Zinc enolates derived from 1-aryl-2,2-dibromoalkanones react with 3-(2-oxo-2H-chromen-3-ylcarbonyl)-2H-chromen-2-one to give 1-alkyl-1-aroyl-1a-(2-oxo-2H-chromen-3-ylcarbonyl)-1a, 7b-dihydrocyclopropa[c]-chromen-2(1H)-ones as a single stereoisomer.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 1, 2005, pp. 131–133.Original Russian Text Copyright © 2005 by Shchepin, Russkikh, Uzun, Silaichev. 相似文献
9.
V. V. Shchepin P. S. Silaichev Yu. G. Stepanyan M. I. Vakhrin 《Russian Journal of General Chemistry》2006,76(6):942-945
Organozinc compounds obtained by treatment of dialkyl 2,2-dibromomalonates with zinc reacted with N-substituted 2-oxochromene-3-carboxamides to give dialkyl 1a-R-carbamoyl-2-oxo-1a,7b-dihydro-2H-cyclopropa[c]chromene-1,1-dicarboxylates or alkyl 2-R-1,3,4-trioxo-2,3-dihydro-1H,9bH-chromeno[3′,4′:1,3]-cyclopropa[1,2-c]pyrrole-9c-carboxylates. Reactions of N-substituted 2-oxochromene-3-carboxamides with zinc enolates derived from methyl 4,4-dibromo-3-oxoalkanoates led to the formation of the corresponding 9c-alkyl-2-R-2,3-dihydrochromeno[3′,4′:1,3]cyclopropa[1,2-c]pyrrole-1,3,4-triones. 相似文献
10.
Shchepin V. V. Russkikh N. Yu. Kalyuzhnyi M. M. Shchepin R. V. Vakhrin M. I. 《Russian Journal of General Chemistry》2004,74(6):937-938
Zinc enolates derived from substituted 1-aryl-2,2-dibromobutanones react with alkyl 3-oxo-3H-benzo[f]chromene-2-carboxylates to form alkyl 1-aroyl-1-ethyl-2-oxo-1,9c-dihydro-3-oxacyclopropa[c]phenanthrene-1a-carboxylate as a single geometric isomer. 相似文献
11.
V. V. Shchepin N. F. Kirillov M. I. Vakhrin O. B. Bayanova S. N. Shurov P. S. Silaichev 《Russian Journal of General Chemistry》2006,76(7):1146-1149
Reformatsky reagent generated from methyl 1-bromocyclohexane-1-carboxylate reacted with N-aryl-2-oxochromene-3-carboxamides and N-aryl-6-bromo-2-oxochromene-3-carboxamides to give, depending on the conditions, the corresponding N-aryl-(6-bromo)-4-(1-methoxycarbonylcyclohexyl)-2-oxochroman-3-carboxamides or 3-aryl-(9-bromo)-1,1-pentamethylene-2,3,4,4a,5,10b-hexahydro-1H-chromeno[3,4-c]pyridine-2,4,5-triones. The products were isolated as a single diastereoisomer. 相似文献
12.
13.
V. V. Shchepin A. E. Korzun M. I. Vakhrin S. N. Shurov P. S. Silaichev M. A. Ezhikova M. I. Kodess 《Russian Journal of General Chemistry》2005,75(12):1935-1938
Zinc enolates formed from 1-aryl-2-bromo-2-phenylethanones and zinc react with dimethyl 2-(1-arylmethylene)malonates to afford dimethyl 2-(1,3-diaryl-3-oxo-2-phenylpropyl)malonates. The latter react with cyclohexylamine, piperidine, or morpholine to give the corresponding monosubstituted amides. The zinc enolate derived from 2-bromoindanone and zinc reacts with dimethyl 2-(4-bromobenzylidene)malonate, yielding dimethyl 2-[(4-bromophenyl)(1-oxoindan-2-yl)methyl]malonate. The final products largely form as a single diastereomer. 相似文献
14.
R. V. Shutov A. N. Kaluzhskikh A. V. Moskvin B. A. Ivin 《Russian Journal of General Chemistry》2006,76(5):814-821
2-Aryl-4-hydroxy-6H-1,3-thiazin-6-ones react with substituted 2-hydroxybenzaldehydes in polar solvents to give N-arylcarbothioyl-2-oxochromene-3-carboxamides in 60–70% yield. 相似文献
15.
16.
V. V. Shchepin M. M. Kalyuzhnyi P. S. Silaichev N. Yu. Russkikh R. V. Shchepin M. A. Ezhikova M. I. Kodess 《Russian Journal of Organic Chemistry》2004,40(9):1353-1358
Zinc enolates derived from substituted 1-aryl-2,2-dibromoalkanones reacted with 2-acyl-3H-benzo-[f]chromen-3-ones to give 1-alkyl-1-aroyl-1a-acyl-1a, 9c-dihydro-1H-3-oxacyclopropa[c]phenanthren-2-ones which were formed as a single stereoisomer. Reactions of the same zinc enolates with 6-bromo-2-oxo-chromene-3-carboxamides (piperidides and morpholides) afforded 1-aroyl-6-bromo-1-alkyl-1a-piperidino-(morpholino)carbonyl-1a,7b-dihydrocyclopropa[c]chromen-2-ones with high stereoselectivity. Likewise, 1-benzoyl-1-methyl-1a-morpholinocarbonyl-1a, 9c-dihydro-1H-3-oxacyclopropa[c]phenanthren-2-one was obtained by reac-tion with 3-oxo-3H-benzo[f]chromene-2-carboxylic acid morpholide.Translated from Zhurnal Organicheskoi Khimii, Vol. 40, No. 9, 2004, pp. 1399–1404.Original Russian Text Copyright © 2004 by V. Shchepin, Kalyuzhnyi, Silaichev, Russkikh, R. Shchepin, Ezhikova, Kodess.This study was performed under financial support by the Russian Foundation for Basic Research (project no. 04-03-96 036). 相似文献
17.
Shchepin V. V. Sazhneva Yu. Kh. Bagara M. V. Russkikh N. Yu. 《Russian Journal of General Chemistry》2003,73(8):1261-1263
Sodium enolates derived from 6-aryl-3,5,5-trimethyl-2,3,5,6-tetrahydropyrane-2,4-diones react with substituted benzenesulfonyl chlorides to give the corresponding O-sulfonation products, 6-aryl-4-(4-R-phenylsulfonyloxy)-3,5,5-trimethyl-5,6-dihydropyrane-2-ones. Reactions of the title compounds with arenediazonium tetrafluoroborates afford 6-aryl-3-arylazo-3,5,5-trimethyl-2,3,5,6-tetrahydropyran-2,4-diones as mixtures of syn and anti isomers. 相似文献
18.
Shchepin V. V. Sazhneva Yu. Kh. Litvinov D. N. 《Russian Journal of General Chemistry》2003,73(4):596-602
Zinc enolates formed from ethyl 4-bromo-2,2,4-trimethyl-3-oxopentanoate react under the conditions of one- of two-stage synthesis with aliphatic, unsaturated, or aromatic aldehydes to form 6-R-2,2,4,4-tetramethyl-2,3,5,6-tetrahydropyran-2,4-diones. Zinc enolates obtained from ethyl 4-bromo-2,2-dimethyl-3-oxopentanoate, -hexanoate, and -2,2,5-trimethyl-3-oxohexanoate under the similar conditions react with aliphatic or aromatic aldehydes to give mainly 5-R1-6-R2-3,3-dimethyl-2,3,5,6-tetrahydropyran-2,4-diones as E or Z isomers or their mixtures. Zinc enolates generated from the ethyl 4-bromo-2,2-diethyl- or 2-benzyl-2-ethyl-3-oxobutanoates react with aromatic aldehydes to give ethyl 5-R-2-R-2-ethyl-3-oxo-4-pentenoates as E isomers. 相似文献
19.
The benzylation and -butylation of the kinetic enolate mixture derived from 2-heptanone has been studied in DME in the absence and in the presence of lithium ion complexing agents (triglyme, benzo-14-crown-4, DMF (neat), DMF, and HMPA). 相似文献
20.
V. V. Shchepin P. S. Silaichev Yu. G. Stepanyan K. P. Lebedev M. I. Vakhrin 《Russian Journal of General Chemistry》2006,76(5):743-746
Zinc enolate derived from 1,1-dibromo-3,3-dimethylbutan-2-one reacts with 3-aryl-2-cyanoprop-2-enamides and aryl 3-aryl-2-cyanoprop-2-enoates to give the corresponding derivatives of 3-aryl-2-(2,2-dimethylpropanoyl)-1-cyanocyclopropane-1-carboxylic acid as a single stereoisomer with cis arrangement of the hydrogen atoms at the cyclopropane ring. The reactions of the same zinc enolate with 3-morpholinocarbonyl-2H-chromen-2-one and 2-morpholinocarbonyl-3H-benzo[f]chromen-3-one lead to formation of 1-(2,2-dimethylpropanoyl)-1a-morpholinocarbonyl-1a,7b-dihydrocyclopropa[c]chromen-2-one and 1-(2,2-dimethylpropanoyl)-1a-morpholinocarbonyl-1a,9c-dihydrobenzo[f]cyclopropa[c]chromen-2-one, respectively as a single stereoisomer. 相似文献