共查询到20条相似文献,搜索用时 15 毫秒
1.
Frederico B. Souza Stanley N.S. Vasconcelos Joel S. Reis Daniel C. Pimenta Hélio Stefani 《Tetrahedron letters》2017,58(11):1057-1060
A small library of novel molecules was generated using a rapid and efficient methodology for the synthesis of N-sulfinyl imine triazole compounds. The process involves a coupling step from the Sonogashira cross-coupling reaction and then, in a one-step reaction, deprotection of the trimethylsilyl group and triazole heterocyclic ring formation using a microwave reactor. 相似文献
2.
《Journal of Saudi Chemical Society》2022,26(2):101416
Chloramine-T (CAT), the sodium salt of N-chloro-p-toluenesulfonamide, is a low-cost mild oxidizing agent with a wide range of uses. Most importantly, it can be used in acidic, neutral, and basic conditions. As a result, it’s been widely used in chemistry, particularly in organic synthesis and analytical chemistry. Chloramine-T acts as a source of halonium cation and nitrogen anion and thus acts as base and nucleophile. It reacts with a wide range of functional groups and carries different molecular transformations. This paper thoroughly summarises and highlights the synthetic and analytical effectiveness of CAT. This study focuses on current developments as well as some older techniques in which CAT has been employed as an oxidizing agent. This review article stretches a comprehensive profile of the CAT reagent in organic synthesis and analytical chemistry, which will be very useful for further research exploration in this field. 相似文献
3.
Sakineh Asghari Nastaran Malekian Roya Esmaeilpour Mohammad Ahmadipour Mojtaba Mohseni 《中国化学快报》2014,25(11):1441-1444
Isoquinoline reacts with dialkyl acetylenedicarboxylates in the presence of kojic acid or8-hydroxyquinoline to generate 1,2-dihydroisoquinoline derivatives. The simplicity, mild reaction conditions and high yields of products make it an interesting process compared to other approaches. The compounds have been analyzed for antibacterial activity against Gram negative and Gram positive bacteria. The results indicated that 1,2-dihydroisoquinolines derived from kojic acid are effective against all of the studied bacteria especially against Bacillus subtilis, while the products obtained from8-hydroxyquinoline are active only against Gram positive bacteria. 相似文献
4.
Jonathan Guild Michael J. Morris Craig C. Robertson Alexander W.H. Speed 《Tetrahedron letters》2019,60(39):151079
The reaction of phenyl acetylide anion with aryl isocyanates followed by quenching with water is shown to produce pyrrolopyrrole (iso-DPP) derivatives in addition to the isomeric cyclopentadienone imines previously reported. If the reaction is quenched with dilute HCl, 5-ylidenepyrrol-2(5H)-ones, formed by a Meyer-Schuster rearrangement, can be isolated instead. A possible mechanism for this reaction is suggested. 相似文献
5.
An efficient synthesis of 2-alkoxy-4-aryl-6-ferrocenyl-3-cyanopyridines via the condensation of ferrocenyl substituted chalcones with malononitrile in a freshly prepared sodium alkoxide solution under ultrasound irradiation was investigated. Especially noteworthy, the reaction of 1-ferrocenyl-3-(pyridin-2-yl)prop-2-ene-1-one with malononitrile afforded 2-alkoxy-4-pyridyl-6-ferrocenylpyridine, with the loss of CN group on the 3-position of pyridine ring was first observed. 相似文献
6.
Priya Chacko 《合成通讯》2018,48(11):1363-1376
A novel synthesis of N-fused imino-1,2,4-thiadiazolo derivatives is described. This approach involves the inexpensive, nontoxic, recoverable, and easy to handle montmorillonite K10 that catalyzes the coupling of 3-aminoisoquinolines and phenylisothiocyanates to afford the N-fused imino-1,2,4-thiadiazolo isoquinoline motifs in exemplary yields. The main attractions of this synthetic strategy were simple procedure and excellent yields. 相似文献
7.
An efficient iodine-mediated electrophilic tandem cyclization of substituted 2-alkynylbenzaldehydes with anthranilic acids under basic medium leading to iodo-1,2-dihydroisoquinoline-fused benzoxazinones is presented. Success of the protocol for the reaction of substituted 2-alkynylbenzaldehydes with 2-aminobenzamides to furnish isoquinoline-fused quinazolinones is also described. 相似文献
8.
Zhang LiuWenteng Chen Marc A. GiulianottiRichard A. Houghten 《Tetrahedron letters》2011,52(32):4112-4113
We have developed an efficient solid-phase synthetic approach for the synthesis of 2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine derivatives. The methodology is of value for high throughput synthesis of these potentially bioactive molecules. 相似文献
9.
Norbornene reacts with elemental sulfur to give a mixture of trithiolane and pentathiepane. Sulfuration of norbornene derivatives was achieved with elemental sulfur, by using a catalytic amount of a nickel complex, to afford selectively the corresponding trithiolanes. The most effective catalytic system was Ni(NH3)6Cl2 in dimethylformamide. The trithiolanes were reduced with super-hydride into 1,2-dithiolate salts, and quenched in situ to form vicinal-dithioethers. 相似文献
10.
Satoru Kobayashi 《Tetrahedron》2008,64(41):9705-9716
Cross-conjugated azatrienes bearing an electron-withdrawing sulfonyl or benzoyl group on the nitrogen atom underwent, on heating or in the presence of a Lewis acid (TMSOTf), an initial inverse electron-demand hetero Diels-Alder reaction with electron-rich dienophiles (vinyl ether, vinyl thioether, and allenyl ether) to produce 1:1 cycloadducts with high endo selectivity. The initial cycloadducts thus obtained underwent a second Diels-Alder reaction stereoselectively on the newly formed diene unit with electron-deficient dienophiles to give the crossed bis-cycloadducts, octahydroquinolines, with high diastereo-π-facial selectivity. The N-sulfonylazatrienes tethering an ortho-cinnamyloxyphenyl dienophile at the triene terminal underwent an initial intramolecular hetero Diels-Alder reaction of the inverse electron-demand type. The subsequent second Diels-Alder reaction of the formed mono-cycloadducts completed the diene-transmissive hetero Diels-Alder protocol to give benzopyrano[3,4-c]quinolines in a highly stereoselective manner. 相似文献
11.
The formal GaCl3-assisted [3+2] cycloaddition of two (Me3Si)2N–N(SiMe3)–PCl2 molecules resulting in the formation of a triazadiphosphole has been studied by means of B3LYP/6-31G(d,p) computations. These calculations revealed a stepwise reaction mechanism starting from the disguised 1,3-dipole and dipolarophile
(Me3Si)2N–N(SiMe3)–PCl2. Comparison of the potential energy surface for the formation of a triazadiphosphole in the presence and without a Lewis
acid indicate, that addition of a Lewis acid such as GaCl3 decreases the activation barriers to Me3Si–Cl elimination, in accord with experiment.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
12.
S?awomir Szumacher 《Journal of organometallic chemistry》2005,690(5):1125-1132
The dicyclopentadienylaluminum thiolates [Cp2Al(μ-SR)]2, where R = Et (1), iPr (2), were obtained by reacting Cl2AlSR with CpNa at the molar ratio 1:2, respectively. Use of CpLi instead of CpNa at the same molar ratio of reagents leads to the formation of cyclopentadienyl(chloro)aluminum thiolates [Cp(Cl)Al(μ-SR)]2, exclusively, where R = Et (3), iPr (4), iBu (5), and nBu (6). The compounds were characterized by 1H, 13C, and 27Al NMR spectroscopy. The structures of the compounds 1 and 4 were determined by X-ray crystallography. 相似文献
13.
V. Sai Sudhir 《Tetrahedron》2010,66(6):1327-2694
This work reports the synthesis of a wide range of ferrocenyl-amino acids and other derivatives in excellent yield. Diverse amino acid containing azides were synthesized and ligated to ferrocene employing click reaction to access ferrocenyl amino acids. Chiral alcohols, esters, diols, amines containing azido group were tagged to ferrocene via click reaction to generate ferrocene derived chiral derivatives. A novel strategy for direct incorporation of ferrocene into a peptide and a new route to 1, 1′disubstituted ferrocene amino acid derivative are reported. 相似文献
14.
《Tetrahedron letters》2019,60(49):151289
An elemental sulfur mediated reaction of benzyl chlorides with benzylamines is developed, which allows the practical synthesis of valuable 1,3,5-triazines. This protocol that is metal free, ligand free, and uses inexpensive elemental sulfur as oxidant or raw material displays mild reaction conditions, a broad substrate scope and moderate to good yields. Moreover, the modified sulfur-mediated reaction system can also be used to synthesize 1,2,4-thiadiazoles, by simply switching the stoichiometry of sulfur powder from 0.75 equivalents to 5 equivalents. 相似文献
15.
Shifa Zhu Lijuan ChenChao Wang Renxiao LiangXiujun Wang Yanwei RenHuanfeng Jiang 《Tetrahedron》2011,67(30):5507-5515
A practical system for synthesizing the multiple-substituted 2,5-dihydrofuran through intermolecular dipolar cycloaddition reactions of acceptor/acceptor diazo reagents, aldehydes, and acetylenedicarboxylate was developed. The reactions proceeded effectively under ambient temperature with low reactant ratios. The control reactions revealed that there are two competitive paths: one forms 1,3-dioxolane and the other forms 2,5-dihydrofuran. These two paths could be controlled by modifying the steric hindrance of the diazo reagents. 相似文献
16.
17.
A new solvothermal method for the synthesis of thiol-protected silver nanoparticles starting from silver thiolates is reported. The method has been tried with thiols of different chain length, such as octane and octadecane thiols, and the particle size was found to be nearly the same for both molecules. The synthesis was dependent on heating conditions and the best results were obtained when the temperature was between 180 and 200 degrees C. Addition of complexation agents such as acetyl acetone or triethylamine to the solvent did not change the product distribution significantly. 相似文献
18.
《Journal of Coordination Chemistry》2012,65(8):1478-1490
A series of diphenylarsenic(III) and triphenylarsenic(V) derivatives of heterocyclic dithiocarbamates of the type: and [where X = >?CH2 (Pipdtc), >CH–CH3 (4-MePipdtc), >O (Morphdtc), >N-CH3 (N-MePzdtc), and?>?NH (Pzdtc)] [n?=?1 or 2] have been synthesized by reactions of diphenylarsenic(III) chloride and triphenylarsenic(V) dibromide with the sodium salt of heterocyclic dithiocarbamates in 1?:?1 and 1?:?2?M ratios, respectively, in refluxing benzene. All these newly synthesized compounds have been characterized by their elemental analyses, molecular weight measurements, and ESI mass studies. Structures of the compounds have been proposed on the basis of IR, 1H, and 13C NMR spectral data which suggest anisobidentate mode of bonding. 相似文献
19.
Cycloaddition reactions between 5-ethoxyoxazole derivatives [2,4-dimethyl 5-ethoxyoxazole and 4-methyl 5-ethoxyoxazole] and various trifluoromethyl alkenes [ethyl 4,4,4-trifluorocrotonate CF3CHCHCO2Et, 3,3,3-trifluoro 1-(phenylsulfonyl)-1-propene CF3CHCHSO2Ph and 2-(trifluoromethyl) propenoic acid CF3(HO2C)CCH2] gave several trifluoromethyl-substituted pyridine systems in moderate yield (20-56%). Their structures were determined by multinuclear NMR techniques including 1H-13C HETCOR spectroscopy. 相似文献
20.
《Tetrahedron letters》2014,55(51):6979-6982
We report the synthesis of seven new sanguinamide B (SanB) analogues. Substitution of amino acids along the backbone of SanB and testing in HCT-116 colon cancer cell lines identified new biologically active SanB derivatives. These compounds establish a structure–activity relationship and show that a Cbz-lysine moiety is important for biological activity. We also identified the most effective stereochemistry at each position around the molecule. The biological activity of the macrocycle is extremely sensitive to stereochemistry and amino acid placement. 相似文献