A new sesquiterpene isolated from Lindera aggregata (SIMS) KOSTERM

A new sesquiterpene, neolindenenonelactone (1), was first isolated from the dried roots of Lindera aggregata (SIMS) KOSTERM., along with four known compounds, linderane (2), isolinderalactone (3), linderalactone (4), and 8-hydroxylindestenolide (5). Their chemical structures were elucidated using spectral analysis of fast atom bombardment mass spectroscopy, one-dimensional nuclear magnetic resonance spectroscopy and two-dimensional-nuclear magnetic resonance spectroscopy including (1)H-NMR, (13)C-NMR, distortionless enhancement by polarization transfer, heteronuclear multiple-bond coherence, and single-crystal X-ray diffraction techniques.     

Chemical Constituents from the Roots of Neolitsea hiiranensis

One triterpenoid, taraxerone ( 1 ); four germacrane-type sesquiterpene lactones, linderane ( 2 ), linderalactone ( 6 ), pseudoneolinderane ( 7 ), (+)-linderadine ( 8 ); one sesquiterpene dilactone, pseudoneoliacine ( 10 ); three elemane-type sesquiterpenes, isolinderalactone ( 3 ), compound 4 and sericealactone ( 9 ); one eudesmane type sesquiterpene, cryptomeridol ( 11 ); one glucoside, β-sitosterol-β-D-glucoside ( 12 ) along with β-sitosterol (5) were isolated from the roots of Neolitsea hiiranensis. The structures of these compounds were identified on the basis of spectral properties.     

Separation and quantitative determination of sesquiterpene lactones in Lindera aggregata (Wu‐yao) by ultra‐performance LC‐MS/MS

An ultra‐performance LC in combination with MS/MS method was established to evaluate the quality of Wu‐yao (the dried root of Lindera aggregata (Sims) Kosterm. (Lauraceae)) through simultaneous quantitation of five sesquiterpene lactones, linderagalactone D ( 1 ), linderagalactone C ( 2 ), hydroylindestenolide ( 3 ), neolinderalactone ( 4 ) and linderane ( 5 ). All compounds were separated on a Waters Acquity ultra‐performance LC HSS T3 column (2.1 mm×100 mm, 1.8 μm particle size) with linear gradient elution of acetonitrile and 0.1% formic acid. An ESI interface in the positive mode was employed prior to MS detection. All the compounds showed good linearity (R²≥0.9992). The recoveries, measured at three concentration levels, varied from 97.3 to 103.4% with RSDs <4.8%. The simple, rapid and reliable method was successfully applied to quantify the five components in 13 samples of Wu‐yao from different areas.     

A new griseofulvin derivative from the mangrove endophytic fungus <Emphasis Type="Italic">Sporothrix</Emphasis> SP.

A new griseofulvin derivative, 7-chloro-2',5,6-trimethoxy-6'-methylspiro(benzofuran-2(3H),1'-(2) cyclohexene)3,4'-dione (1), together with the known 2-acetyl-7-methoxybenzofuran (2), was isolated from the marine-derived mangrove endophytic fungus Sporothrix sp. (No. 4335). The structure of new compound 1 was elucidated by analysis of spectroscopic data.     

Cytotoxic constituents from the leaves of Cinnamomum subavenium

Two new butanolides, subamolide D (1) and subamolide E (2), and a new secobutanolide, secosubamolide A (3), along with 21 known compounds were isolated from the leaves of Cinnamomum subavenium. The structures of 1-3 were determined by spectroscopic analysis. Propidium iodide staining and cytometry analysis were used to evaluate the cell cycle progression of the treated SW480 cells and it was found that 1 and 2 caused DNA damage in a dose- and time-dependent manner.     

Iridoid glucosides from Wendlandia tinctoria roots

A new iridoid glucoside, 8-O-(E)-caffeoylmussaenosidic acid (1), together with ixoside (2), was isolated from the roots of Wendlandia tinctoria. The structure of the new compound was established on the basis of detailed spectroscopic (2D NMR) and chemical analysis.     

Drypetdimer A: a new flavone dimer from Drypetes gerrardii

A new flavone dimer, drypetdimer A (1), was isolated from Drypetes gerrardii J.Hutch The structure of the new compound was elucidated by detailed spectroscopic analysis such as 1H, 13C NMR, COSY, HMQC, HMBC and HREIMS.     

One new cinnamic imide dervative from the fruits of Tribulus terrestris

One new cinnamic imide derivative, named tribulusimide C (1), was isolated from the fruits of Tribulus terrestris, together with three known compounds, N-p-coumaroyltyramine (2), terrestriamide (3), N-trans-caffeoyltyramine (4). The structure of 1 was elucidated based on chemical analysis and spectral methods (IR, 1D and 2D NMR, HR-FAB-MS, EI-MS).     

A new ureido-substituted amino acid from the tubers of Gymnadenia conopsea

A new ureido-substituted amino acid, conopsamide A (1), has been isolated from an ethanolic extract of the tubers of Gymnadenia conopsea. Its structure was elucidated by extensive spectroscopic analysis, and the absolute configuration was assigned by Marfey's method. The new compound was evaluated for in vitro assay for HDAC1 (Histone Deacetylase 1) inhibitory activity.     

Structure elucidation of an unprecedented alkaloid and a new limonoid from Xylocarpus granatum

An unprecedented new limonoid-based alkaloid, granatoine (1), and a new phragmalin, xylocarpin L (2), along with xyloccensin Y were isolated as minor components from the fruits of the Chinese mangrove plant Xylocarpus granatum. Their structures were elucidated by extensive spectroscopic data (1D and 2D NMR) analysis. A possible biogenetic pathway for granatoine was also depicted.     

New quinazolinone alkaloids within rare amino acid residue from coral-associated fungus, Aspergillus versicolor LCJ-5-4

Cottoquinazoline D (3), a new alkaloid with a 1-aminocyclopropane-1-carboxylic acid residue rarely discovered in nature, was isolated and identified together with two new quinazolinone alkaloids, cottoquinazolines B (1) and C (2), from coral-associated fungus Aspergillus versicolor LCJ-5-4. Their structures including absolute configurations were elucidated based on spectroscopic methods, X-ray single crystal diffraction analysis, and chemical methods. A possible biogenetic pathway for them was proposed.     

A New Abietane Diterpenoid from the Barks of Taxus yunnanensis

Along with the major constituents taxoids, some non-taxane diterpenoids have also been isolated1. During the course of our phytochemical investigation on the bark of Taxus yunnanensis. Cheng et L. K. Fu, a new abietane diterpenoid, taxayunnin (1), and the known taxamairin C (2)2, were isolated. The structure elucidation of taxayunnin 1 was established by spectral analysis.Taxayunnin 1, pale yellow needles, mp 215oC, showed a molecular ion peak at m/z 346 [M+] in its EI mass spectrum, which…     

Limonoids from the leaves of Swietenia macrophylla

One new limonoid of the phragmalin type (1) named Swietenine J with nine known compounds methyl-6-β-hydroxy angolensate (2), 1-O-acetylkhayanolide A(3), Khayanolide E (4), Khayalactone (5), Khayanone (6), 1-O-Acetylkhayanolide B (7), 1-O-Deacetylkhayanolide E (8), Khayanolide A (9), Khayanolide B (10) were isolated from Swietenia macrophylla. The structure of 1 was elucidated on the basis of 1D and 2D- NMR spectroscopic analysis.     

A new ent-kauranoid from Isodon lophanthoides var. geradianus

A new ent-kaurane diterpenoid, lophanthodin G (1) and one known abietanoid, 6alpha-hydroxyferruginol (2), were isolated from the leaves of Isodon lophanthoides var. geradianus. The structure of the new compound 1 was established using spectroscopic methods including extensive 1D and 2D NMR analysis.     

A new glycoside from the leaves of Neoalsomitra integrifoliola

A new ionone glycoside （6R,9R）-blumenyl α-L-rhamnopyranosyl-（1 → 6）-β-D-gluco-pyranoside （1）, together with a new natural product 2-methoxyl-4-trans-pmpenyl-phenol α-L-rhamnopyranosyl-（1 → 6）-β-D-glucopyranoside （2）, was isolated from the leaves ofNeoalsomitra integrifoliola. Their structures were elucidated by chemical and spectral analysis. Compound 1 showed weak anti-inflammatory and low-level antioxidant activities.     

A new lignan from the roots of <Emphasis Type="Italic">Stellera chamaejasme</Emphasis>

A new lignan, stellerachama A (1), was isolated from the roots of Stellera chamaejasme. The structure of the new compound was elucidated by analysis of spectrometric data.     

A new resin glycoside from Ipomoea maxima

A new resin glycoside (1) was isolated from the aerial part of Ipomoea maxima, together with three known compounds, pescaprein XX (2), stoloniferin X (3), and stoloniferin IX (4). The structure of 1 was elucidated on the basis of 1D NMR spectroscopy, a fragmentation study by APCIMS, and HRESIMS analysis.     

A new anti-HIV triterpene from Geum japonicum

Geumonoid (1), a new triterpene, was isolated from Geum japonicum. Its structure was elucidated on the basis of 1D, 2D NMR and MS spectroscopic analysis. Compound 1 showed inhibitory activity against HIV-1 protease.     

A new benzylisoquinoline alkaloid from stems of Nelumbo nucifera

A new benzylisoquinoline alkaloid, named nelumstemine （1）, 1-（4＇-hydroxybenzoyl）-6,7-dimethoxy-3,4-dihydroisoquinoline, was isolated from the stems of Nelumbo nucifera Geartn. Its structure was established on the basis of spectral analysis.     

5-Alkylpyrrole-2-carboxaldehyde derivatives from the Chinese sponge Mycale lissochela and their PTP1B inhibitory activities

Two new 5-alkylpyrrole-2-carboxaldehyde derivatives,mycalenitrile-15(1) and mycalenitrile-16(2),along with five known related ones(3-7),were isolated from the South China Sea sponge Mycale lissochela.The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis and by comparison of their NMR data with those reported in the literature.In bioassay,compounds 1 and 7 exhibited significant PTPIB(Protein-tyrosine phosphatase 1B,a recognized target for diabetes and obesity) inhibitory activities with IC_(50) values of 8.6 and 3.1 μmoI/L,respectively.A preliminary SAR analysis of the isolated compounds with their PTP1 B inhibitory effects was described.