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1.
V. V. Golovko A. I. Statsenskaya Yu. A. Baskakov Yu. G. Putsykin 《Chemistry of Heterocyclic Compounds》1986,22(10):1084-1087
Interaction of nitrosyl chloride with 1-arylimidazolin-2-ones in methanol leads to the formation of 4,5-dimethyoxyimidazolidin-2-ones. Under similar conditions 1,5-diarylimidazolin-2-ones give 1,5-diaryl-4-oximino-5-alkoxyimidazolidin-2-ones. When the reaction is carried out in an aprotic solvent 1,5-diaryl-4-nitrosoimidazolin-2-ones are separated, and when treated with alcohol they give the final reaction products. An increase in temperature and duration of the reaction results in the formation of 1,5-diaryl-5-hydroxyhydantoins.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1339–1342, October, 1986. 相似文献
2.
Renata Toplak Jurij Svete Branko Stanovnik Simona Goli Grdadolnik 《Journal of heterocyclic chemistry》1999,36(1):225-235
Methyl 2-(benzyloxycarbonyl)aimno-3-dimemylaminopropenoate ( 2 ) was prepared from methyl N-(benzyloxycarbonyl)glycinate ( 1 ) and t-butoxybis(dimethylamino)methane, and used as a reagent for preparation of substituted 3-(benzyloxycarbonyl)amino-4H-quinolizin-4-ones 5 and 6 , ?2H-pyran-2-ones 17–19 , ?2H-1-benzopyran-2-ones 28–31 , and -naphthopyrans 32–35 , ?2H-pyrano[3,2-c]pyridine-2,5-dione 46 , -pyrano-[4,3-b]pyran-2,5-dione 47 , -pyrano[3,2-c]benzopyran-2,5-dione 48 , -pyrano[2,3-c]pyrazol-6-ones 49 and 50 , -pyrano[2,3-d]pyrirnidin-7-ones 51 and 52 derivatives. In the reaction of 2 with 1,3-diketones trisubsti tuted pyrroles 14–16 were formed. Selective removal of benzyloxycarbonyl group was achieved by cat alytic transfer hydrogenation with Pd/C in the presence of cyclohexene to afford free 3-amino compounds 7 , 8 , 20 , 36–38 and 53–57 in yields better than 80%. 相似文献
3.
Chiral non-racemic bicyclic and tricyclic oxylactams obtained in two steps from N-(2-hydroxy-1(R)-phenylethyl)-succinimide and phthalimide are cyclised diastereoselectively in formic acid to give spiro[cyclohexane-1,2′-pyrrolidin]-5-ones and spiro[cyclohexane-1,1′-isoindolin]-3-ones, respectively. 相似文献
4.
Abstract Thiazolidin-4-ones are known to exhibit diverse biological activities such as antimicrobial, anticancer, antidiarrheal, anticonvulsant, antidiabetic, antihistaminic, and antifungal activities. In the present investigation, a series of 2-haloacetamides was prepared by reacting chloroacetyl chloride with amines in dry benzene under reflux conditions. The formed 2-haloacetamides reacted with potassium thiocyanate in refluxing dry acetone to afford new 2-iminothiazolidin-4-ones. The 5-arylidene-2-imino-3 (napthalen-2yl)-thiazolidin-4-ones were prepared by condensing 2-iminothiazolidin-4-ones with substituted benzaldehydes. All the products were characterized by infrared, mass, and 1H and 13C NMR techniques. 相似文献
5.
Alberto Bargagna Sergio Cafaggi Pietro Schenone 《Journal of heterocyclic chemistry》1980,17(3):507-511
Cycloaddition of dichloroketene to N,N-disubstituted 1-amino-4-methyl-1-penten-3-ones and 1-amino-4,4-dimethyl-1-penten-3-ones occurred in moderate to fair yield only in the case of aromatic N-substitution to give N,N-disubstituted 6-alkyl-4-amino-3,3-dichloro-3,4-dihydro-2H-pyran-2-ones, which were dehydrochlorinated with DBN to afford in good yield N,N-disubstituted 6-alkyl-4-amino-3-chloro-2H-pyran-2-ones. In the case of aliphatic N,N-disubstitution, cyclo-addition led directly to 6-alkyl-4-dialkylamino-3-chloro-2H-pyran-2-ones only for N,N-disubstituted 1-amino-4,4-dimethyl-1-penten-3-ones. The reaction between 1-dimethylamino-4-methyl-1-penten-3-one and dichloroketene gave 3-chloro-4-dimethylamino-3,6-dihydro-6-isopropylidene-2H-pyran-2-one in low yield. 相似文献
6.
The reaction of some 2-aminooxazoles and imidazolidin-2-ones with hydrogen peroxide afforded stable trans-β-hydroxyhydroperoxy- or dihydroperoxyimidazolidin-2-ones according to the reaction conditions. In the case of 3a-hydroxy-7a-hydroperoxyoctahydro-2H-benzimidazolidin-2-one, the trans isomer is forbidden and cis adduct was isolated. A radical pathway to these hydroperoxides is proposed. From 2-amino-4-methyloxazole and hydrogen peroxide 2-amino-2-hydroxy-4-methyloxazolidin-4-yl peroxyacetate was also isolated. 相似文献
7.
V. O. Koz'minykh E. N. Koz'minykh Yu. S. Andreichikov 《Chemistry of Heterocyclic Compounds》1989,25(8):862-865
Reaction of 5-aryl-4-halo-2,3-dihydrofuran-2,3-diones with alkoxycarbonylmethylenetriphenylphosphoranes has given 2-alkoxycarbonylmethylene-5-aryl-4-halo-2, 3-dihydrofuran-3-ones, which readily add halogens at the 2-exocyclic double bond, and on reaction with arylamines recyclize to give 2-hydroxy-2, 3-dihydropyrrol-3-ones.For Communication 1, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1034–1038, August, 1989. 相似文献
8.
A series of 4-(2-keto-substituted)-3,4-dihydro-3-methyl-2H-1,3-benzoxazin-2-ones 1 (Table I) was synthesized by condensation of 3-alkyl-3,4-dihydro-4-hydroxy-2H-1,3-benzoxazin-2-ones 4 with ketones 5 having active alpha hydrogens. In the presence of alcoholic potassium borohydride, compounds 1 underwent reductive transacylation to give 1,3-oxazin-2-one derivatives 3 (Table III, a,b,c). When the other side of the ketone possessed substituents other than hydrogen, there were always also normal reduction products, i.e., secondary alcohols 2 (Table II) in addition to 3. 相似文献
9.
P. A. Sharbatyan A. T. Lebedev A. M. Sipyagin V. G. Kartsev V. S. Petrosyan 《Chemistry of Heterocyclic Compounds》1982,18(3):250-257
A comparison of the mass spectra of 1-diazo-3-sulfonylaminopropan-2-ones and N-sulfonylazetidin-3-ones makes it possible to conclude that under the conditions of electron impact and chemical ionization the molecular ions of diazo ketones lose a molecule of nitrogen and undergo partial cyclization to the corresponding azetidinones without undergoing the Wolff rearrangement.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 334–342, March, 1982. 相似文献
10.
2-Aryl-5,6-dihydro-4H-1,3-oxazin-5-ones were obtained in the reaction of 1-diazo-3-benzamidopropan-2-ones with acidic agents.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1324–1326, October, 1980. 相似文献
11.
The one-pot synthesis of benzo[f]quinolin-3-ones and benzo[a]phenanthridein-5-ones was achieved by the inter- and intramolecular photoannulation of 6-chloropyridin-2-ones and 3-chloroisoquinolin-1-ones with phenylacetylene or tethered phenylacetylene. The reactions were proceeded by photoaddition of 6-chloropyridin-2-ones and 3-chloroisoquinolin-1-ones to phenylacetylene to give the chlorine-substituted stilbenoids, and then 6π electrocyclization of the stilbenoids and oxidation aromatization to afford the polycyclic products. 相似文献
12.
I. A. Maretina 《Russian Journal of Organic Chemistry》2005,41(1):1-27
The review considers the synthetic potential of 4,4-alkoxybutan-2-ones which are promising synthons available from diacetylene-containing industrial gases. The reactivity of 4,4-dialkoxybutan-2-ones toward mono- and difunctional reagents, as well as in cycloaddition processes, is discussed.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 1, 2005, pp. 9–32.Original Russian Text Copyright © 2005 by Maretina. 相似文献
13.
L. M. Yun S. Yangibaev V. Ya. Alekseeva K. A. V'yunov Kh. M. Shakhidoyatov 《Chemistry of Heterocyclic Compounds》1987,23(8):876-878
The acylation of 2-thioxoquinazol-4-ones by various acylating agents was studied. The main products are 2-benzoylthioquinazol-4-ones. Minor amounts of the N(3)-acylation products are formed.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1095–1097, August, 1987. 相似文献
14.
1,5-Disubstituted pyrrolidin-2-ones 18a-g, 19a-h, and 20a-f were synthesized in good to excellent yields via the nucleophilic substitution of 5-(benzotriazol-1-yl)-1-substituted-pyrrolidin-2-ones 9 with allylsilanes, organozinc reagents, and phosphorus compounds. Compounds 9 and 5-(benzotriazol-2-yl)-1-substituted-pyrrolidin-2-one isomers 10 are readily prepared in total 70-84% yields from 2, 5-dimethoxy-2,5-dihydrofuran (7), primary amines 8, and benzotriazole; 9 and 10 react identically with nucleophiles. 相似文献
15.
Anastasia A. Fesenko 《Tetrahedron》2010,66(4):940-462
A novel four-step methodology for the synthesis of 5-acyl-1,2-dihydropyrimidin-2-ones has been developed. The reaction of readily available N-[(1-acetoxy-2,2,2-trichloro)ethyl]ureas with Na-enolates of 1,3-diketones or β-oxoesters followed by heterocyclization-dehydration of the oxoalkylureas formed gave 5-acyl-4-trichloromethyl-1,2,3,4-tetrahydropyrimidin-2-ones. The latter, in the presence of NaH, eliminate CHCl3 to give the target compounds. 相似文献
16.
A. S. Fisyuk Y. P. Bogza N. V. Poendaev D. S. Goncharov 《Chemistry of Heterocyclic Compounds》2010,46(7):844-849
A method has been developed for the synthesis of 3-S-hetaryl-substituted pyridin-2(1H)-ones and 5,6-dihydropyridin-2(1H)-ones
based on the base catalyzed cyclization of N-(3-oxoalkyl)- and N-(3-oxoalkenyl)amides which contain a divalent sulfur atom
in an α-position to a carbamoyl group and bound to the heterocycle. 相似文献
17.
Ibrahim El-Sayed El-Kkoly Morcos Michael Mishrikey Hassan Mostafa Fuid-Alla 《Journal of heterocyclic chemistry》1977,14(5):845-852
The reaction of piperidine or morpholine with 2H-pyran-2-ones was found to give open chain δ-oxoamides, while with 2H-thiopyran-2-ones, thiophene derivatives were formed. For 2H-pyran-2-thiones, either open chain δ-oxothioamides or thiophene derivatives were obtained. From the 1 H nmr data of the pyran derivatives, the effect of the replacement of ring and carbonyl oxygens with sulphur on the chemical shift of the H-3 proton could be studied. 相似文献
18.
Published data on the chemical transformations of pyrrol-2-ones are reviewed and analyzed. The extensive synthetic possibilities of compounds containing a pyrrolone ring in the synthesis of various heterocyclic compounds with complex structures are demonstrated. The reactions are arranged according to the reaction centers of the pyrrol-2-ones: The methylene unit, the C=C double bond, the electron-deficient carbon atom of the carbonyl group.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1463, October, 2004. 相似文献
19.
T. L. Hough 《Journal of heterocyclic chemistry》1989,26(6):1523-1525
The action of trifluoroacetic acid on 4-hydroxyimidazolidin-2-ones 9a,b,c induces the formation of N-carbamoyliminium salts 10a,b,c which rearrange to imidazolin-2-ones 11a,b,c. The reactions proceed in high yield at ambient temperatures. 相似文献
20.
P. S. Lobanov A. L. Grebelkin D. I. Zaitsev V. A. Gindin A. A. Potekhin 《Chemistry of Heterocyclic Compounds》1991,27(10):1116-1119
The 2-aminoacylhydrazines form 1,4,5,6-tetrahydro-1,2,4-triazin-6-ones with orthoesters and iminoesters. Benzylidene and isopropylidene derivatives of the 2-aminoacylhydrazines give the corresponding derivatives of 3-amino-1-imidazolin-4-ones with the same reagents.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1388–1391, October, 1991. 相似文献