Facile one-pot synthesis of S-alkyl thiocarbamates

We report a novel one-pot two-step synthesis of a variety of S-alkyl thiocarbamates. This method offers a two-directional approach making use of trichloroacetyl chloride, requires no complex starting material, incorporates a variety of substituents, and proceeds in high yields.     

A facile one-pot synthesis of functionalized thiazines in water

An efficient synthesis of thiazines from the three component reactions between dialkyl acetylenedicarboxylates,arylisothio-cyanates and iV-nucleophiles at room temperature in water as the solvent is described.     

A facile and convenient one-pot synthesis of polysubstituted thiophenes from 1,3-dicarbonyl compounds in water

A facile and convenient one-pot synthesis of polysubstituted thiophenes 2 and polysubstituted thieno[2,3-b]thiophenes 3 from 1,3-dicarbonyl compounds 1 has been achieved in high yields catalyzed by tetrabutylammonium bromide (TBAB) in the presence of K₂CO₃ in water. TBAB in the aqueous phase can be recycled after the separation of organic products.     

A facile one-pot synthesis of N-substituted tetrahydroquinolines

An uncatalyzed one-pot synthesis of N-substituted tetrahydroquinolines was achieved in good yields by the reaction of quinoline and alkyl/acyl halides with Hantzsch dihydropyridine ester under mild reaction conditions.     

A facile one-pot synthesis of alkyl aryl sulfides from aryl bromides

A convenient one-pot synthetic method for the formation of alkyl aryl sulfides from various alkyl halides and lithium aryl thiolates that are prepared in situ by direct halogen-lithium exchange is reported. In particular, the method overcomes many of the problems encountered in previous reports; it is very quick, catalyst-free, and does not involve use of unstable aryl thiols.     

A facile,one-pot synthesis of Ephedra-based aziridines

A series of enantiomerically and diastereomerically enriched N-sulfonylaziridines have been prepared by a single-pot process from (1R,2S)- and (1S,2R)-norephedrine and (1S,2S)-pseudonorephedrine. The cyclization process involved N-sulfonylation of the Ephedra alkaloid followed by O-sulfonylation with methanesulfonyl chloride. The bis(sulfonyl)Ephedra derivatives were treated with either hydrazine or sodium hydroxide to afford the N-sulfonylaziridines.     

A facile one-pot synthesis of supercubes of Pt nanocubes

A facile one-pot synthetic strategy is developed to prepare high-quality Pt supercubes. The as-synthesized Pt supercubes are composed of the uniform Pt nanocubes arranged in a primitive cubic structure. The shape and size of the Pt superparticles are readily tuned by varying the structures of pyridyl-containing ligands used in the synthesis. The co-presence of CO and nitrogen-containing ligands is critical to the formation of Pt supercubes. While CO molecules play an important role in the synthesis of Pt nanocube, introducing nitrogen-containing ligands is essential to the successful assembly of those nanocubes into Pt supercubes. Our systematic studies reveal that the electrostatic attraction between positively charged ligands and negatively charged Pt nanocubes is the main driving force for the assembly of Pt nanocubes into supercubes. More importantly, the ligands within the Pt supercubes are readily removed at relatively low temperature to yield surface-clean supercubes which are expected to exhibit unique size-selective catalysis.     

A facile one-pot synthesis of β-keto sulfones from ketones under solvent-free conditions

An easy solvent-free method is described for the conversion of ketones into β-keto sulfones in high yields that involves the in situ generation of α-tosyloxyketones, followed by nucleophilic substitution with sodium arene sulfinate in the presence of tetra-butylammonium bromide at room temperature. The salient features of this one-pot protocol are short reaction times, cleaner reaction profiles, and simple work-up that precludes the use of toxic solvents.     

A facile one-pot synthesis of 8-oxo-7,8-dihydro-(2′-deoxy)adenosine in water

Reaction of 2-mercaptoethanol with 8-bromo-2′-deoxyadenosine and 8-bromo-adenosine in aqueous solution and in the presence of triethylamine gave the 8-oxo-adenine derivatives in very good yields. Some mechanistic details are reported.     

A facile one-pot three-component synthesis of benzylideneamino-3,5-dimethyl-1H-pyrazoles

A facile, one-pot three-component protocol for the synthesis of substituted 4-(benzylideneamino)-5-(3,5-dimethyl-1H-pyrazol-1-yl)-4H-1,2,4-triazole-3-thiols have been reported by the reaction of 4-amino-5-hydrazinyl-4H-1,2,4-triazole-3-thiol with acetyl acetone and various substituted benzaldehydes via multi component reaction. The newly synthesized derivatives were characterized by their elemental analysis and spectral data. The current strategy provides heterocyclic compounds in good yields with broad substrate scope.     

A facile one-pot synthesis of uniform core-shell silver nanoparticle@mesoporous silica nanospheres

The uniform core-shell silver nanoparticle@mesoporous silica nanospheres have been prepared by a simple one-pot synchronous method, which combines several steps into one, including the generation of silver nanocrystals and mesoporous silica, transfer and aggregation of silver nanoparticles in an incompact silica framework.     

A facile one-pot synthesis of 2,5-disubstituted oxazoles using iodobenzene diacetate

A facile one-pot synthesis of oxazoles 1a-h is described that utilizes readily available aromatic α-methyl ketones and a safe hypervalent iodine reagent, iodobenzene diacetate.     

A facile one-pot synthesis of α-fluoro-α,β-unsaturated esters from alkoxycarbonylmethyltriphenylphosphonium bromides

A convenient one-pot synthesis of α-fluoro-α,β-unsaturated esters from ethoxy- and tert-butoxycarbonylmethyltriphenylphosphonium bromide was developed. The fluorinated phosphoranes, generated in situ from alkoxycarbonylmethyltriphenylphosphonium bromides and 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Selectfluor^®), undergo a Wittig reaction with aldehydes to yield α-fluoro-α,β-unsaturated esters with (Z)-selectivity.     

A facile one-pot synthesis and the crystal structure of a molecular clip derived from diphenylglycoluril

A facile procedure for the one-pot synthesis of a clip molecule via condensation of diphenylglycoluril, paraformaldehyde, and 4-dimethoxybenzene in the presence of methanesulfonic acid is described. The advantages of this method are mild conditions, single product formation and good yield. Especially, the procedure of the product purification is more simple and convenient. In addition, the clip molecule is characterized by X-ray crystal structure analysis, which shows different weak interactions forces compared to the structure reported previously. Correspondence: Zhi-Guo Wang, Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Chemistry Department of Central China Normal University, Wuhan 430079, China.     

The Baylis-Hillman reaction: one-pot facile synthesis of 2,4-functionalized 1,4-pentadienes

The Baylis-Hillman coupling between activated alkenes and alkyl 2-(bromomethyl)prop-2-enoates in the presence of DABCO (or DBU) leading to the formation of 2,4-functionalized 1,4-pentadienes, has been described.     

A facile procedure for the one-pot synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles

Unsymmetrically 2,5-disubstituted 1,3,4-oxadiazoles were efficiently synthesized from the cyclization-oxidation reaction of acyl hydrazones. Also, the synthesis of the title compounds was achieved by the condensation of acyl hydrazides and aromatic aldehydes in the presence of ceric ammonium nitrate in dichloromethane.     

A facile and one-pot electrochemical method for the synthesis of a new anthraquinonethioether

The reaction of electrochemically generated anthradiquinone as a Michael acceptor with 2-mercaptobenzothiazole and 2- mercaptobenzoxazole,as nucleophiles in ethanol/water mixtures has been studied by means of cyclic voltammetry.Our voltammetric data indicate that produced anthradiquinone participates in Michael addition reaction with nucleophiles and via an ECEC mechanism converts to the new anthraquinonethioether derivatives.Based on an EC mechanism,the observed homogeneous rate constant of the Michael reaction of anthradiquinone with nucleophiles were estimated by comparing the experimental cyclic voltammograms with the digital simulated results.     

Microwave mediated facile one-pot synthesis of polyarylpyrroles from but-2-ene- and but-2-yne-1,4-diones

Several pyrrole derivates with multiple aryl substituents were prepared conveniently in a one pot-reaction from but-2-ene-1,4-diones and but-2-yne-1,4-diones via hydrogenation of the carbon-carbon double bond/triple bond followed by amination-cyclization. The reaction could be performed with ammonium formate or alkyl/arylammonium formates under Pd/C in polyethylene glycol-200 (PEG-200) under microwave irradiation. Using this procedure, different aryl-substituted pyrroles were prepared. Furthermore, studies on microwave vs thermal conditions indicate faster heating under microwave conditions was responsible for rate enhancement.