Distilling Reliable Remedies: Hieronymus Brunschwig's Liber de arte distillandi (1500) Between Alchemical Learning and Craft Practice

Abstract

Hieronymus Brunschwig's Liber de arte distillandi, written in German and first published in Strasbourg in 1500, was the first printed manual on the distillation of medicinal waters. Although influential among early modern audiences and well known to modern scholars, its intriguing blend of intellectual and practical traditions has thus far received little attention. This paper identifies these strands in Brunschwig's technical instructions and shows how they intertwine in the production of reliable remedies. Exploring the intellectual dimension of Brunschwig's work, I argue that his concept of distillation is shaped by an alchemical understanding of matter, especially by the writings on ‘quintessence’ of the fourteenth-century alchemist John of Rupescissa. To realise this concept in the workshop, Brunschwig emphasises the central importance of the body and its senses to ensure true craftsmanship. Brunschwig's printed manual was as much a product of skilled artisanal practices as the distilled waters it describes, and I argue that it was shaped by the same concerns about technical precision and reliability.     

Alchemy in Early Modern England

Abstract

The seventeenth-century technologist and colonist William White (ca. 1600–73) has been cited as an alchemical tutor to Gabriel Plattes and George Starkey, and hailed as an early modern "wizard of industrial efficiency." This study — the first that focuses on White individually — pays particular attention to White's extraordinary reputation for furnace design and manufacture. By examining the sources of knowledge and social connections that enabled White to acquire and disseminate his knowledge of metallurgy, the authors develop a genealogy of fornacic design that extends from the continent to the Atlantic world and back again, connecting White to better known figures such as Cornelis Drebbel and Robert Boyle. By foregrounding, through White, the technology of early modern alchemy, the authors also hope to emphasise the importance of practical craft in the development of the chemical arts.     

Alchemical Patronage and the Making of an Adept: Letters of Michael Sendivogius to Emperor Rudolf II and His Chamberlain Hans Popp

Based on four extant letters the famous Polish alchemist Michael Sendivogius wrote to Emperor Rudolf II and his first chamberlain Hans Popp between 1597 and 1602, this paper adds to a growing body of revisionist scholarship on alchemy in Rudolfine Prague. Unlike most of his many rivals – including luminaries such as John Dee and Michael Maier – who hoped for the Emperor's patronage in vain, Sendivogius officially became a courtier at the imperial court in 1594. As such he was in the privileged position of having access to the Emperor and his close advisors. The surviving correspondence shows how the Pole successfully balanced his alchemical promises against Rudolf's expectations for a number of years. The fact that even Sendivogius found it difficult to translate imperial patronage into ready money suggests that Emperor Rudolf II was considerably more circumspect and less gullible than the widespread cliché suggests. Fully contextualised by all available sources on Sendivogius' early career, the four letters emerge as important documents regarding the Polish adept and alchemical patronage in Rudolfine Prague. They also shed new light on the circumstances which led to the writing and publication of Sendivogius' famous treatise De lapide philosophorum (Novum lumen chymicum).     

A Matter of Philosophers and Spheres: Medieval Glosses on Artephius’s Key of Wisdom

The article examines the two Latin versions of Artephius's Clavis sapientiae (Key of Wisdom) that have been preserved in early modern collections of alchemical texts. A comparative analysis of the two versions shows that one of them has undergone a process of textual manipulation. In particular, an interpolation of short philosophical passages concerning the doctrine of prime matter has relevant interpretative implications. These additions appear to be grounded in the early thirteenth-century philosophical debate on cosmology and the first Latinate reception of Aristotle’s metaphysics.     

The Survival of the Frater Medicus? English Friars and Alchemy,ca. 1370–ca. 1425

This essay reinserts friars into the story of alchemy and medicine in late medieval England. Much of the evidence for the activity of friars, mostly Franciscans, is to be found in a Latin text compiled in 1416–1425, the Tabula medicine. Here friars appear as sources for remedies, and a significant number of these remedies are alchemical. The quintessence found in the writings of John of Rupescissa is used for a variety of medical complaints. Some of the alchemical remedies are selected for closer examination here. These include distillations of human blood which are recommended by brother Robert Winstanton for use in surgery, either to knit flesh together or to cut through it. Natural balsam was in very short supply in Western Europe, though it served as a panacea for multiple ailments. The friars offer a number of different recipes to make artificial balsam, ranging from comparatively simple distillations through to the use of multiple fractional distillations to produce the finest of all balsams. The friars found that distilled waters made with herbs were more effective than herbal simples without distillation in the treatment of many different complaints.     

Tinker‐OpenMM: Absolute and relative alchemical free energies using AMOEBA on GPUs

The capabilities of the polarizable force fields for alchemical free energy calculations have been limited by the high computational cost and complexity of the underlying potential energy functions. In this work, we present a GPU‐based general alchemical free energy simulation platform for polarizable potential AMOEBA. Tinker‐OpenMM, the OpenMM implementation of the AMOEBA simulation engine has been modified to enable both absolute and relative alchemical simulations on GPUs, which leads to a ∼200‐fold improvement in simulation speed over a single CPU core. We show that free energy values calculated using this platform agree with the results of Tinker simulations for the hydration of organic compounds and binding of host–guest systems within the statistical errors. In addition to absolute binding, we designed a relative alchemical approach for computing relative binding affinities of ligands to the same host, where a special path was applied to avoid numerical instability due to polarization between the different ligands that bind to the same site. This scheme is general and does not require ligands to have similar scaffolds. We show that relative hydration and binding free energy calculated using this approach match those computed from the absolute free energy approach. © 2017 Wiley Periodicals, Inc.     

Textual Alchemy: The Transformation of Pseudo-Albertus Magnus's Semita Recta into the Mirror of Lights

Abstract

This article explores the strategies of and the reasons behind the reworking of pseudo-Albertus Magnus's Semita recta into the Mirror of Lights. I argue that the redactor sought to provide a more comprehensive defence of the legitimacy of alchemy than found in the Semita recta. In the process of doing so, he reshaped the original text so as to present three units that addressed different parts of the alchemical opus: first, theory and justification of alchemy; second, basic information on substances and procedures; and, third, practice. The redactor employed sophisticated textual tools identical to those seen in scholastic texts. These strategies, I argue, constitute part of the redactor's attempt to bring authority and credibility to his project and to alchemy in general. Certainly, much more attention needs to be paid to these experiments of textual alchemy in order to understand the practice of alchemy in the late medieval period.     

Bad Chemistry: Basilisks and Women in Paracelsus and pseudo-Paracelsus

The basilisk of the pseudo-Paracelsian De natura rerum is the evil twin of the homunculus. Created from menstrual blood by artificial ectogenesis in an alchemical laboratory, the basilisk embodies the poisonous character traditionally ascribed to catamenial women, but magnified and concentrated by its mode of generation to the degree that it can kill by its glance alone. How does this remarkable thought experiment relate to other instances of the basilisk in the genuine and pseudonymous corpus of Paracelsus? The present paper outlines two primary uses which emerge repeatedly: first, in works other than De natura rerum, the basilisk is used by Paracelsus and his imitators as a means of explaining action at a distance, especially in the case of plague. Relying on a medieval association between the basilisk’s deadly gaze and the putative ability of menstruating women to damage mirrors, the genuine Paracelsus links contagious disease to the deleterious action of the female imagination. Second, because the basilisk was traditionally held to be the product of an unnatural birth, being born from an egg laid by a rooster and incubated by a toad, the Paracelsian corpus frequently invokes the monster as a model for unnatural generation in general.     

Glass of the past: The degradation and deterioration of medieval glass artifacts

Medieval artifacts made of glass are at a serious disadvantage concerning the chemical stability compared with ancient or common modern glasses. The total amount of silica and other network formers such as alumina is very low and potassium instead of sodium was introduced into the silicate structure by using local raw material. By means of scanning electron microscopy (SEM), secondary ion mass spectrometry (SIMS) and nuclear reaction analysis (NRA) a weathering mechanism governed by an ion exchange process could be determined for medieval glass paintings exposed to the ambient air for centuries. Additionally, the leached glass surface of medieval hollow glass artifacts found in a well and exposed to moist earth show a brown discoloring due to the oxidation of Mn(II) to Mn(IV) oxide. That process can be converted by a treatment of the glass objects in an aqueous hydrazine solution.     

Cover Picture: Electrophoresis 3'2012

Issue no. 3 is a regular issue consisting of 17 contributions distributed over 5 separate parts. The issue starts with 4 research articles on micro‐ and nanofluidics making up Part I. This is followed by Part II that has 5 research articles involving studies on proteins, peptides and proteomics. Part III has 3 contributions dealing with studies on nucleic acids. Part IV has 3 research articles on enantioseparation methodologies. The last part (Part V) consists of 2 contributions on various aspects of preconcentration in CE of drug of abuse and their metabolites and the sensitive monitoring for ribonucleotide reductase activity. This issue, with as few as 17 contributions, is rich in very important ideas in the field for further investigations. Featured articles include: Modeling of droplet traffic in interconnected microfluidic ladder devices (( 10.1002/elps.201100320 )) Role of streaming potential on pulsating mass flow rate control in combined electroosmotic and pressure‐driven microfluidic devices (( 10.1002/elps.201100414 )) Carotid atherosclerotic plaques: Proteomics study after a low‐abundance protein enrichment step (( 10.1002/elps.201100395 )) Quantitative experimental determination of primer‐dimer formation risk by free‐solution conjugate electrophoresis (( 10.1002/elps.201100452 )) Electromembrane extraction combined with cyclodextrin‐modified capillary electrophoresis for the quantification of trimipramine enantiomers (( 10.1002/elps.201100426 ))