The structure of tetronolide,the aglycone of antitumor antibiotic tetrocarcin

X-ray analysis has determined the structure of tetronolide, which has a unique spiro γ-lactone group.     

The structure of tetramycin,a new polyene macrolide antibiotic

The structure of the tetraene antifungal antibiotic tetramycin has been established by detailed studies of mass, ¹H and ¹³C NMR spectra as well as by chemical degradation. A newly developed mass analysis has been introduced for determining the carbon skeleton of the aglycone.     

Synthesis of the antifungal macrolide antibiotic (+)-roxaticin

The total synthesis of the antifungal macrolide antibiotic roxaticin has been accomplished. The synthesis relies principally on aldol and directed reduction steps to construct the extended 1,3-polyol array present in the natural product. Three principal nonpolyene containing fragments were assembled and then coupled using Julia olefination and methyl ketone aldol addition reactions. A series of functionalization reactions incorporated the sensitive polyene and provided the protected roxaticin seco-acid, which was lactonized in good yield. Acidic deprotection completed this convergent synthesis of roxaticin.     

Reversed-phase HPLC analysis of the semisynthetic macrolide antibiotic azithromycin

Summary HPLC is the most convenient method for the assay of the azithromycin (10-dihydro-10-deoxo-11-methyl-11-azaerythromycin A), a semisynthetic macrolide antibiotic and its reaction intermediates. Data concerning the effects of pH, temperature and column type are presented. The analytical procedures enabling the reliable assay of azithromycin and its intermediates, as well as other impurities are defined. Use of a reversed-phase octadecyl column, a pH of 9.3–9.5, and isocratic mode at ambient temperature are the best conditions of analysis.     

Kabachnik-fields phosphorylation of tetaraene macrolide antibiotic pimaricin

Russian Journal of General Chemistry - Polyene macrolide antibiotic pimaricin reacts with dialkyl(diaryl) phosphites and 4-bromobenzaldehyde to form...     

Highlights in oleuropein aglycone structure

Oleuropein hydrolysis products, obtained both by endogenous beta-glucosidase and almond commercial one, were investigated by classic methodologies and by 1HNMR experiments. We found that both presence and relative amount of the different compounds in the reaction mixture are stricly related to the used enzyme.     

Synthesis of the macrolide antibiotic A26771B methyl ester

The total synthesis of the title compound ($\text{1}$) is reported.     

Kinetic spectrophotometric determination of the macrolide antibiotic josamycin in formulations

A simple kinetic spectrophotometric method was developed for the determination of josamycin in its dosage forms. The method is based on oxidation of the drug with alkaline potassium permanganate at room temperature for a fixed time of 20 min and measuring the produced green color at 611 nm. The absorbance-concentration plot is rectilinear over the range of 2-10 microg/mL (2.4 x 10(6)-1.2 x 10(-5)M) with minimum detectability of 1.0 microg/mL (1.2 x 10(-6)M). The determination of josamycin by fixed concentration and the rate-constant methods is also feasible with the calibration equations obtained, but the fixed-time method proved to be more applicable. The procedure was applied successfully to commercial tablets, and statistical analysis showed that the results compared favorably with those obtained by reference methods. The effect of sensitizers and surfactants on the performance of the proposed method was also studied. A proposal of the reaction pathway was presented.     

Highly stereoselective synthesis of methynolide,the aglycone of the 12-membered ring macrolide methymycin,from D-glucose

A highly stereoselective and efficient synthesis of methynolide, the aglycone of 12-membered macrolide methymycin, was achieved from of C1–C8 and C9–C13 segments synthesized from D-glucose by employing some stereoselective reactions and benzyl-type protecting groups.     

First stereoselective total synthesis of antibiotic macrolide Berkeleylactone F

The first stereoselective total synthesis of antibiotic macrolide Berkeleylactone F is described. The synthetic sequence notably features Sharpless kinetic resolution to access chiral epoxide followed by its regioselective ring-opening reaction, Sharpless asymmetric reaction and ring-closing metathesis.     

Asymmetric synthesis of the polyol subunit of the macrolide antibiotic, ossamycin

An asymmetric synthesis of the C1-C16 polyol subunit of the macrolide antibiotic, ossamycin, has been achieved through stepwise carbon-chain elongation reaction from d-glucose.     

Total synthesis of the macrolide antibiotic (±)-A26771B

The total synthesis of the title compound is reported.