共查询到20条相似文献,搜索用时 31 毫秒
1.
V. G. Andrianov V. G. Semenikhina A. V. Eremeev 《Chemistry of Heterocyclic Compounds》1991,27(7):783-784
The acid halides of 1,2,4-oxadiazol-3-carbohydroxamic acids react with formaldehyde dimethylhydrazone to give the corresponding -oximohydrazones, which with hydrochloric acid rearrange to yield the dimethylhydrazone of 3-amino-4-formylfurazane. In the absence of an acid catalyst, the 5-trifluoromethyl derivative undergoes a rearrangement to give 1-dimethylamino-4-nitroso-3-trifluoroacetamidopyrazole.For Communication 4, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 976–978, July, 1991. 相似文献
2.
Geoffrey T. Crisp 《合成通讯》2013,43(11-12):2117-2123
The palladium-catalysed coupling of 3,5 Di-O-p-toluoyl-5-iodo-2′ -deoxyuridine with functionalized and non-functionalized alkenylstannanes gave moderate to good yields of the corresponding 5-alkenyl-2 -deoxyuridines. 相似文献
3.
U. M. Dzhemilev A. G. Ibragimov A. B. Morozov R. R. Muslukhov G. A. Tolstikov 《Russian Chemical Bulletin》1992,41(6):1089-1093
A new stereoselective method is developed for the synthesis of 1-chloro-, 1-alkoxy-, and 1-N,N-dialkylaminoalumino-cyclopentanes from -olefins, metallic magnesium, and aluminum halides (AlCl3, RO-AlCl2, R2N-AlCl2) in the presence of catalytic amounts of Cp2ZrCl2 (Cp=5-C5H5). The products from hydrolysis and deuterolysis of the Al-substituted 3,4-dialkylaluminocyclopentanes (ACP) have the threo configuration.For Communication 8, see [1].Institute of Organic Chemistry, Urals Branch, Russian Academy of Sciences, 450054 Ufa. Translated fromIzvestiya Akademii Nauk, Seriya Khimicheskaya, No. 6, pp. 1393–1397, June, 1992. 相似文献
4.
R. A. Karakhanov E. S. Bogacheva I. Romero V. I. Kelarev 《Chemistry of Heterocyclic Compounds》1991,27(4):354-357
3,5-Disubstituted 2-isoxazolines containing furan fragments have been synthesized by 1,3-dipolar cycloaddition reactions.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 449–452, April, 1991. 相似文献
5.
É. E. Korshin L. G. Zakharova Ya. A. Levin L. Kh. Ashrafullina E. A. Podval'nyi Yu. Ya. Efremov 《Russian Chemical Bulletin》1992,41(11):2082-2090
Triaryl-substituted -aminoamidines were obtained by the reaction of ,-unsaturated N-arylimidoyl chlorides with arylamines. Acylation of the products gave the products from monosubstitution at the -amino group. Triaryl-substituted -aminoamidines react with phosgene and with oxalyl chloride to form 4-aryliminoperhydropyrimidin-2-ones and 5-aryliminoperhydro-1,4-diazepine-2,3-diones, respectively.For previous communication, see [1].A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan' Scientific Center, Russian Academy of Sciences, 420083 Kazan'. Translated fromIzvestiya Akademii Nauk, Seriya Khimicheskaya, No. 11, pp. 2633–2642, November, 1992. 相似文献
6.
7.
LIU Hsing-Jang CHEW Sew-Yeu YEH Wen-Lung Department of Chemistry The University of Alberta Edmonton Alberta Canada TG G 《有机化学》1993,(3)
Starting from (--)-β-pinene,an efficient synthesis of qinghaosu (8) in natural form hasbeen accomplished. The synthesis involves keto ester 7 as a key intermediate which is conveniently pre-pared using the Diels-Alder chemistry developed in our laboratory. 相似文献
8.
The reactions of 3-chloropropylphosphonates, 3-chloropropylthiophosphonates, or 3-chloropropylphosphinates with 2-aryloxyethylamines or N-phenylpiperazine afford the corresponding 3-(2-aryloxyethylamino)propylphosphonates and -phosphinates or 3-(4-phenylpiperazin-1-yl)propylphosphonates and -phosphinates. The compounds obtained exhibit -adrenolytic and hypotensive activities, the latter being found to depend on the substituents at the P atom. 相似文献
9.
Ahmed E. -S. Abdel-Megied Erik B. Pedersen Carsten M. Nielsen 《Monatshefte für Chemie / Chemical Monthly》1991,122(1-2):59-70
Summary A modified synthesis of protected 2,3-dideoxyribose5 starting fromL-glutamic acid (1) is described. Reaction of5 with silylated 5-hydroxymethyluracil7 a and 5-alkoxymethyluracils7 b–e in the presence of trimethylsilyl triflate afforded an anomeric mixture of 2,3-dideoxyuridine derivatives8 a–e and9 a–e. Deprotection with methanolic ammonia and separation by chromatography gave the corresponding nucleosides10 a–e and11 a–e. Treatment of9 b–e with tri(1H-1,2,4-triazol-1-yl)phosphine oxide and subsequent reaction of12 b–e with ammonia in dioxane afforded the cytosine derivatives13 b–e which on treatment with methanolic ammonia gave the corresponding 2,3-dideoxycytidine derivatives14 b–e and15 b–e. In contrast with the parent compounds, these alkoxymethyl derivatives had no appreciable activity against human immunodeficiency virus (HIV-1).
Synthese von 2,3-Dideoxynucleosiden aus 5-Alkoxymethyluracilen
Zusammenfassung Ausgehend vonL-Glutaminsäure (1) wird eine modifizierte Synthese von geschützter 2,3-Dideoxyribose (5) beschrieben. Reaktion von5 mit silyliertem 5-Alkoxymethyluracilen7 b–e in Gegenwart von Trimethylsilyltriflat ergab anomere Mischungen der 2,3-Dideoxyuridinderivate8 a–e und9 a–e. Abspaltung der Schutzgruppe mit methanolischen Ammoniak und chromatographische Trennung ergab die entsprechenden Nucleoside10 a–e und11 a–e. Behandlung von9 b–e mit Tri(1H-1,2,4-triazol-1-yl)phosphinoxid und nachfolgende Reaktion von12 b–e mit Ammoniak in Dioxan ergab die Cytosinderivate13 b–e, welche nach Behandlung mit methanolischem Ammoniak die entsprechenden 2,3-Dideoxycytidinderivate14 b–e und15 b–e ergaben. Im Gegensatz zur Stammverbindung hatten diese Alkoxymethylderivate keine nennenswerte Wirksamkeit gegen den menschlichen Immunschwächevirus (HIV-1).相似文献
10.
《Tetrahedron letters》1986,27(42):5135-5138
Selective syntheses of α- and gd-damascone, using allylic organoboranes as the key intermediates, are described. 相似文献
11.
ZHANG Lan-ping WANG Ya-lou 《高等学校化学研究》2010,(2):245-248
5-Hydroxy-2-(2-phenylethyl)chromone(1) was synthesized from 2,6-dihydroxyacetophenone(7) obtained via four-steps resorcinol-reacting with phenylpropionic acid,the procedures involved are Baker-Venkataraman rearrangement and cyclization which are easy to conduct,the overall yield is 32%. 相似文献
12.
New bimolecular sulfur-containing -phenylethylamines and N-benzyltetrahydroisoquinolines have been synthesized from formyl derivatives of diaryl sulfides. The possibility of using metals as catalysts for obtaining diaryl sulfides in the reaction of ortho-substituted benzaldehydes with SCl2 has been shown for the first time.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 89 14 75. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 731–735, September–October, 1995. Original article submitted November 11, 1994. 相似文献
13.
D. Shantare M. Yure É. Gudrinietse T. Malinovskaya 《Chemistry of Heterocyclic Compounds》1998,34(3):351-358
In reactions with amines 2-oxo-7-trifluoromethyl-5-phenyl-(1H)-oxazolo[5,4-b]pyridines and alkyl N-(2-oxo-3-pyridyl)carbamates are converted into N-alkyl- and N,N-dialkyl-N-(2-oxo-3-pyridyl)ureas respectively.For Communication 1, see [1].Riga Technical University, Riga LV-1048, Latvia. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 385–391, March, 1998. 相似文献
14.
R. A. Karakhanov V. I. Kelarev A. S. Remizov Yu. N. Polivin D. Oietaio 《Chemistry of Heterocyclic Compounds》1992,28(10):1112-1115
The condensation of N-furfuryl- and N-tetrahydrofurfurylethylenediamines with hydrochloride salts of iminoesters of carboxylic acids gives 1,2-disubstituted 2-imidazolines containing furfuryl or tetrahydrofurfuryl groups at N1.For communication 2, see [1]Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1312–1315, October, 1992. 相似文献
15.
《Tetrahedron letters》1986,27(40):4865-4868
The preparation of highly substituted β-hydroxy carbonyl compounds from isoxazolines is featured in a synthesis of crispatic acid. A β-hydroxy imine, the proposed intermediate in this transformation, is isolated for the first time and a stereoselective hydroboration of a 5-vinyl substituted isoxazoline is also reported. 相似文献
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17.
In the interaction of 2--clzlorobenzylidenehydrazino-4-ethoxycarbonylthiazole with nucleophiles, two competing reactions take place. 1) nucleophilic replacement of the chlorine atom to form the corresponding substitution product; 2) elimination of a hydrogen chloride molecule, concluding in cyclization of the intermediate nitrilimine to form 3 phenyl-5-ethoxycarbonylthiazolo(2, 3-c]-1, 2, 4-triazole. The direction taken by the interaction depends on the nature of the nucleophile and is determined primarily by the ratio of basicity and nucleophilicity of the agent.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, 256–259, February, 1994. Original article submitted December 30, 1993. 相似文献
18.
Enrico Millo Elena Zocchi Andrea Galatini Umberto Benatti Gianluca Damonte 《合成通讯》2013,43(19):3260-3269
Pyrophosphate-linked coenzymes play essential roles in several biochemical systems. Symmetrical diadenosine-5′-pyrophosphate (Ap2A) has been synthesized from adenosine-5′-phosphate in virtually quantitative yield. The simple procedure is carried out in anhydrous pyridine using adenosine phosphoromorpholidate and adenosine monophosphate bis-(tri-n-butylammonium salt) as coupling reagents. 相似文献
19.
《Tetrahedron letters》1987,28(23):2623-2626
2′-5′,3′-5′ Linked triadenylates have been synthesized by direct bisadenylylation of adenosine 2′ and 3′ hydroxyls with an adenosine 5′-phosphorochloridite followed by oxidation. 相似文献
20.
E. F. Dankova V. A. Bakulev V. S. Mokrushin S. A. Talipov B. A. Salakhutdinov K. M. Beketov 《Chemistry of Heterocyclic Compounds》1992,28(7):818-822
The reaction of 5-amino-1,2,3-thiadiazol-4-carbothioamides with methyl iodide basically generates -diazo-S-methylthioimidates and -carbothioimidolates. It is shown that the reactivity of the latter increases when either alkyl or aryl substituents are introduced at the nitrogen atom of the carbothioamide groupTranslated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 979–984, July, 1992. 相似文献