共查询到20条相似文献,搜索用时 15 毫秒
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Polet D Alexakis A Tissot-Croset K Corminboeuf C Ditrich K 《Chemistry (Weinheim an der Bergstrasse, Germany)》2006,12(13):3596-3609
A new phosphoramidite ligand was used in the iridium-catalyzed allylic substitution reaction. This permitted high regio- and enantioselectivities on a wide variety of substrates and nucleophiles. Because of the stereospecificity of the reaction obtained by using branched substrates, a kinetic resolution reaction was attempted. The origin of the impressive efficiency of this ligand in terms of kinetics was explored in detail, as was the role of the substituent in the ortho-position of the amine moiety. 相似文献
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Changjiang Li Zhaozhou Li Kunpeng Tan Prof. Dr. Guodu Liu 《European journal of organic chemistry》2023,26(33):e202300398
Rhodium-catalyzed hydroformylation of olefins is an important method for synthesizing aldehydes, and it is worth noting that regioselectivity and enantioselectivity of the product controlled by ligand are the most commonly used strategies. The modular synthesis of phosphite and phosphoramidite ligands have significant advantages of simple synthesis and high catalytic activity, which was why these ligands have been widely used in hydroformylation reactions. Herein, we focus on the synthesis methods and design ideas of such ligands, as well as their application effects in hydroformylation reactions. This review aims to provide a reference for the design and synthesis of ligands in hydroformylation subsequently. 相似文献
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Xiaowei Zhang Bonan Cao Yongjun Yan Dr. Shichao Yu Dr. Baoming Ji Dr. Xumu Zhang Prof. Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(3):871-877
A series of hybrid phosphine–phosphoramidite ligands has been designed and synthesized in moderate yields from chiral BINOL (1,1′‐bi‐2‐naphthol) or NOBIN (2‐amino‐2′‐hydroxy‐1,1′‐binaphthyl). They have achieved highly regio‐ and enantioselectivities in Rh‐catalyzed asymmetric hydroformylations of styrene derivatives (branched/linear ratio up to 56.6, ee up to 99 %), vinyl acetate derivatives (up to 98 % ee), and allyl cyanide (up to 96 % ee). Systematic variation of ligand structure showed that the steric factor on the phsophoramidite moiety determined the performance of the ligand. With the increased hindrance, the branched/linear ratio rose, while the ee value dropped in the hydroformylation of styrene. However, the N‐substituents did not influence the selectivities much. 相似文献
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Dong-Zhao Yang Zhen-Zhen Chen Mei Chi Ying-Ying Dong Shou-Zhi Pu Qi Sun 《Molecules (Basel, Switzerland)》2022,27(3)
5-Hydroxymethyl-2′-deoxycytidine (5hmdC) phosphoramidite and triphosphate are important building blocks in 5hmdC-containing DNA synthesis for epigenetic studies. However, efficient and practical methods for the synthesis of these compounds are still limited. The current research provides an intensively improved synthetic method that enables the preparation of commercially available cyanoethyl-protected 5hmdC phosphoramidite with an overall yield of 39% on 5 g scale. On the basis of facile and efficient accesses to cyanoethyl protected-5hmdU and 5hmdC intermediates, two efficient synthetic routes for 5hmdC triphosphate were also developed. 相似文献
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Maslennikova V. I. Goryukhina S. E. Serkova O. S. Vasyanina L. K. Nifant'ev E. E. 《Russian Journal of General Chemistry》2002,72(5):816-817
Russian Journal of General Chemistry - 相似文献
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Site-Specific Radioiodination of Oligonucleotides with a Phenolic Element in a Programmable Approach
Haitao Zhao Yu Qin Dunfang Liu Xinyao Geng Cheng Wang Ding Ding Xuan Ding Qian Xia Jianjun Liu Ruowen Wang Weihong Tan 《Molecules (Basel, Switzerland)》2022,27(19)
Radioiodination of oligonucleotides provides an extra modality for nucleic acid-based theranostics with potential applications. Herein, we report the design and synthesis of a phosphoramidite embedded with a phenolic moiety and demonstrate that oligonucleotides can be readily functionalized with phenol as a precursor by general DNA synthesis. It was identified that the introduction of the precursor does not block the specificity of an aptamer, and the radioiodination is applicable to both DNA and RNA oligonucleotides in a site-specific approach with a commercial kit. 相似文献
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The oligopeptides of alanine (penta-, deca-, and pentadeca-) were synthesized by solid phase method and new peptide-resin cleaving reagent TFA-BBr3 was used to cleave the peptides from resin-support. Penta-alanine was also synthesized by liquid phase for the comparision and FAB-Mass method was used to determine the molecular weight of penta-alanine. HPLC separation of these new oligopeptides were described. 相似文献
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Chromophoric and Dendritic Phosphoramidites Enable Construction of Functional Dendrimers with Exceptional Brightness and Water Solubility 下载免费PDF全文
Dr. Andrew D. Shaller Wei Wan Baoming Zhao Prof. Alexander D. Q. Li 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(38):12165-12171
The fluorescence brightness of a molecular probe determines whether it can be effectively measured and its water solubility dictates if it can be applied in real‐world biological systems. However, molecules brighter than the most efficient fluorescent dyes or particles brighter than quantum dots are hard to come by, especially when they must also be soluble in water. In this report, chromophoric phosphoramidites are used in a solid‐state synthesis to construct functional dendrimers. When highly twisted chromophores are chosen and the proper spacers and dendrons are introduced, the resultant dendrimers emit exceptionally bright fluorescence. Chromophores, spacers, and dendrons are stitched together by efficient phosphoramidite reagents, which afford high‐yield water‐soluble phosphodiester linkages after deprotection. The resulting water‐soluble dendrimers are exceptionally bright. 相似文献
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Jyoti Singh Nicole Steck Debaditya De Alexandre Hofer Alexander Ripp Ilya Captain Manfred Keller Paul A. Wender Rashna Bhandari Henning J. Jessen 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(12):3968-3973
An iterative polyphosphorylation approach is described, which is based on a phosphoramidite (P‐amidite) derived reagent (c‐PyPA) obtained from the cyclization of pyrophosphate with a reactive diisopropylaminodichlorophosphine. This type of reagent is unprecedented as it represents a reactive P‐amidite without protecting groups. The reagent proved to be stable in solution over several weeks. Its utility is described in the context of iterative monodirectional and bidirectional polyphosphorylations. The ensuing functionalized cyclotriphosphate can be opened with a variety of nucleophiles providing ready access to diverse functionalized polyphosphate chains of defined length with several tags, including both P‐N and P‐O labels. Their interaction with exo‐ and endopolyphosphatases is described. 相似文献
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Zhiyong Wu Kévin Isaac Dr. Pascal Retailleau Dr. Jean‐François Betzer Dr. Arnaud Voituriez Dr. Angela Marinetti 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(10):3278-3281
The key structural feature of the new phosphoramidites is a paracyclophane scaffold in which two aryl rings are tethered by both a 1,8‐biphenylene unit and a O?P?O bridge. Suitable aryl substituents generate planar chirality. The corresponding gold(I) complexes promote the cycloisomerization of prochiral nitrogen‐tethered dienynes. These reactions afford bicyclo[4.1.0]heptene derivatives displaying three contiguous stereogenic centers, with very high diastereoselectivity and up to 95 % ee. 相似文献
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利用TiO2富集、超滤膜滤过实现了选择性富集和分离磷酸化肽和含唾液酸的N-链接糖肽.首先选取截留分子量为1×104的超滤膜分离糖肽和磷酸化肽,然后利用酪蛋白和牛血清白蛋白的酶解物验证所建立的方法,该方法的最低检出限是0.16 pmol.将上述方法应用于肺癌患者的唾液检测,成功检测并鉴定到8个磷酸化肽和5个糖肽.本方法可有效提高磷酸化肽和糖肽检测的选择性和灵敏度,为疾病生物标志物的检测提供了新方法. 相似文献