共查询到20条相似文献,搜索用时 15 毫秒
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Naumov MI Sutirin SA Shavyrin AS Ganina OG Beletskaya IP Bourgarel-Rey V Combes S Finet JP Fedorov AY 《The Journal of organic chemistry》2007,72(9):3293-3301
2-(methoxymethoxymethyl)aryllead triacetates, obtained in situ from the corresponding arylboronic acids, reacted with 4-hydroxycoumarins, leading to 3-(2-methoxymethoxymethyl)aryl-4-hydroxycoumarin derivatives in good to high yields. These compounds underwent a cascade sequence of reactions, deprotection-halogenation-annulation, to afford polyoxygenated tetracyclic 6H,11H-[2]benzopyrano-[4,3-c] [1]benzopyran-11-ones in good yields. Some compounds showed a moderate cytotoxicity against human epithelial mammary HBL100 cells. 相似文献
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[reaction: see text] Novel and highly efficient syntheses of oxazolo[4,5-c]quinoline-4(5H)-ones (1) and thiazolo[4,5-c]quinoline-4(5H)-ones (2) from ethyl 2-chlorooxazole-4-carboxylate (4) and ethyl 2-bromo-5-chlorothiazole-4-carboxylate (13), respectively, are described. 相似文献
4.
Jean-Pierre Vors 《Journal of heterocyclic chemistry》1991,28(4):1043-1046
The synthesis of new pyrido[4,3-c]pyridazin-5(6H)-one from ethyl 3-methyl-4-pyridazinecarboxylate using an enamination/ring closure sequence is described. The starting material is easily available from a hetero Diels-Alder reaction between a 1,2-diaza-1,3-diene and ethyl vinyl ether and oxidation of the resulting 1,4,5,6-tetrahydropyridazine. 相似文献
5.
P. Giori A. C. Veronese T. Poli C. B. Vicentini M. Manfrini M. Guarneri 《Journal of heterocyclic chemistry》1986,23(2):585-588
The reaction of pyrazolo[4,3-c][1,2,5]oxadiazin-3(5H)-ones 1 with carbanions prepared in situ from compounds containing an activated methylene group afforded pyrazolo[3,4-b]pyrazines 4–13 in good yields. The possible reaction mechanism is proposed and discussed. 相似文献
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Bernard Chantegrel Christian Deshayes Bernard Pujol Zhong Jia Wei 《Journal of heterocyclic chemistry》1990,27(4):927-934
The title compounds were prepared from ethyl 5-acyl- or 5-(1-hydroxyethenyl)isoxazole-4-carboxylates which in turn were prepared from ethyl 3-methylamino-2-butenoate or 3(2H)-furanones. 相似文献
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Zincated pyridazin-3(2H)-ones generated via bromine-magnesium exchange followed by transmetalation using ZnCl(2) or via lactam-directed ortho C4-H zincation with TMPZnCl·LiCl have been synthesized. These in situ created organometallics can be used in Negishi reactions with iodo(hetero)arenes delivering a new approach toward (hetero)arylpyridazin-3(2H)-ones. 相似文献
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Al-Ayed AS 《Molecules (Basel, Switzerland)》2011,16(12):10292-10302
A series of new coumarin derivatives 4 containing a 4-arylbut-3-en-2-one moiety were synthesized by condensation of 3-acetylcoumarin 1 with aryl aldehydes 2 in chloroform in the presence of piperidine. The interactions of 3-formyl-4-chlorocoumarin (3) with nitrogen-containg nucleophiles leading to the corresponding substituted chromen-[4,3-c]pyrazol-4-ones 5 are described. The structures of the obtained compounds were established on the basis of 1D NMR, 2D NMR and IR and further the compounds were evaluated for possible antioxidant activities. The coumarinic chalcone 4a has been found to be the most active (IC?? = 2.07 μM) in this study. 相似文献
10.
Nosova E. V. Kopotilova A. E. Ivan’kina M. A. Moshkina T. N. Kopchuk D. S. 《Russian Chemical Bulletin》2022,71(7):1483-1487
Russian Chemical Bulletin - A series of [1,2,4]triazolo[4,3-c]quinazolines, bearing 3-positioned p-bromophenyl or 5-bromothiophen-2-yl fragment, was synthesized by oxidative cyclization of the... 相似文献
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Fedoseev S. V. Belikov M. Yu. Ershov O. V. Tafeenko V. A. 《Russian Journal of Organic Chemistry》2020,56(9):1540-1544
Russian Journal of Organic Chemistry - Heating of 2-halopyridine-3,4-dicarboxylic acids in propionic anhydride led to the formation of 4-halofuro[3,4-c]pyridine-1,3-diones as a result of... 相似文献
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I. V. Ukrainets S. G. Taran L. V. Sidorenko O. V. Gorokhova A. V. Turov 《Chemistry of Heterocyclic Compounds》1997,33(11):1328-1333
We consider different variants for synthesis of 2-R-oxazolo[4,5-c]quinolin-4(5H)-ones based on 3-amino-1H-2-oxo-4-hydroxyquinolines
and their 3-N-acyl derivatives. We show, that in the latter case, formation of the oxazole ring is possible via two routes,
depending on the nature of the substituent on the acyl residue.
For Communication 35, see [1].
Ukrainian Pharmaceutical Academy, Kharkov 310002. Translated from Khimiya Geterotsiklicheskikh Soedinenii. No. 11. pp. 1536–1541,
November, 1997. 相似文献
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Russian Journal of Organic Chemistry - The reaction of 4-halo-3-hydroxyfuro[3,4-c]pyridin-1(3H)-ones with acyclic and alicyclic secondary amines in ethyl acetate afforded the corresponding... 相似文献
14.
Christian Deshayes Michel Chabannet Suzanne Gelin 《Journal of heterocyclic chemistry》1986,23(5):1595-1598
The title compounds were prepared by acid-catalyzed cyclization of aryloxymethyl- or (2-arylethyl)-4-carboxymethylisoxazoles which in turn were synthesized from aryloxymethyl- or (2-arylethyl)isoxazole-4-carboxylic acids by Arndt-Eistert homologation. 相似文献
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The reaction of 2H-thiopyran-3,5(4H,6H)-dione with N,N-dimethylformamide dimethyl acetal gave in good yield 4-dimethylaminomethylene-2H-thiopyran-3,5(4H,6H)dione (II), which afforded 1-substituted 5,7-dihydrothiopyrano[3,4-c]pyrazol-4(1H)-ones with aliphatic and aromatic hydrazines, 5H-thiopyrano[4,3-d]isoxazol-4(7H)-one (IV) with hydroxylamine hydrochloride and 2-substituted 6H-thiopyrano[3,4-d]pyrimidin-5(8H)-ones with amidines and guanidines, generally in satisfactory yields. 4-(t-Butylhydrazonoformyl)-2H-thiopyran-3,5(4H,6H)-dione was isolated as an intermediate in the reaction of II with t-butylhydrazine, whereas formamidine gave with II 4-iminoformyl-2H-thiopyran-3,5(4H,6H)-dione as the sole product. The isoxazole IV isomerized easily with sodium methoxide to 3,4,5,6-tetrahydro-5,5-dihydroxy-3-oxo-2H-thiopyrano-4-carbonitrile. 相似文献
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1,3-Dipolar cycloadditions of diazoalkanes to pyridazin-3(2H)-ones 1–7 and pyridazin-3(2H)-thiones 8 and 9 are regioselective producing 3H -pyrazolo[3,4-d]pyridazin-4(5H)-ones 15–19, 27–29 and 34–38 as the major products. In some instances, the isomeric 3H-pyrazolo[3,4-d]pyridazin-7(6H)-ones, such as 20 and 23 were isolated as the minor products. From 3 and 6 the primary 3a,7a-dihydro cycloadducts 25 and 26 , and rearranged 1,2-dihydro intermediate 31 were isolated. From 10 and 1-diazoindane the isomeric exo- and endospiro products 39 and 40 were formed. 相似文献
17.
R. Richard L. Hamer Richard C. Effland Joseph T. Klein Francis P. Huger Jeffrey C. Wilker 《Journal of heterocyclic chemistry》1988,25(2):517-521
The synthesis of a series of 5-phenylpyrrolo[1,2-b][1,2,5]triazepin-2(3H)-ones 1 as potential anxiolytic agents is described. Benzoylation of 1-phthalimidopyrrole, followed by hydrolysis, gave the 1-amino-2-benzoylpyrroles 3 . These were further functionalized to give the penultimate 1-aminoacetamido-2-benzoylpyrroles 8 and 9 , which were cyclized to the target pyrrolotriazepines 1. 相似文献
18.
The crystal structure of the title compound 2-ethoxycarbonylmethyl-8-chloro-3a,4-dihydro-3a-methyl-chromeno[4,3-c]pyrazol-3(2H)-one(C15H15ClN2O4,Mr = 322.74) has been prepared and determined by single-crystal X-ray diffraction.The crystal is of orthorhombic,space group Pccn with a = 16.7246(10),b = 19.6626(12),c = 9.3013(6) ,V = 3058.7(3) 3,Z = 8,Dc = 1.402 g/cm3,μ = 0.269 mm-1,F(000) = 1344,the final R = 0.0506 and wR = 0.1464 for 2568 reflections with I 2σ(I).In addition,disordered C(14) and C(15) atoms exist in the crystal structure. 相似文献
19.
Summary The reaction of 3,4-methylenedioxycinnamic acid (1) with thionyl chloride resulted in the formation of 7-chlorothieno[2,3-f]-1,3-benzodioxole-6-carbonyl chloride (2) and cinnamoyl chloride (3). Subsequent reaction of the former withp-substituted anilines led to the formation of 7-chloro-N-(p-substituted phenyl)-thieno[2,3-f]-1,3-benzodioxole-6-carboxamides (4a–c) which on photocyclization afforded 2-substituted [1,3]dioxolo[5,6][1]benzothieno[2,3-c]quinolin-6(5H)-ones (5a–c) in fairly good yields and high purity. The structures have been confirmed by IR,1H NMR, and analytical methods.Accepted for presentation at the Hong Kong International Symposium on Heterocyclic Chemistry (August 13–16, 1995) 相似文献
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《Tetrahedron letters》1986,27(27):3127-3128
The unknown title phenols have been prepared by condensation of ethyl orthoformate with 5-benzyloxy-4-hydrazino-pyrimidine and subsequent hydrogenolysis of the protecting group. 相似文献