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固相有机合成的聚合物载体材料研究进展 总被引:2,自引:0,他引:2
本文介绍了目前固相有机合成中常用的几种载体,简述了常见载体的物理化学性质以及常用的几种表征方法,并叙述了载体的环境效应。 相似文献
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0引言氧载体是一类能够可逆吸收分子氧的特殊金属配合物。由于它在贮氧、除氧上有潜在的应用价值及对探索生命科学的重要意义,使得氧载体的研究得以广泛的展开[1~3],目前对氧载体氧合性能的影响因素研究局限于溶剂、温度、配体等因素的研究[4~6],而不同金属盐对氧载体氧合性能影响的探讨很少见于报道。作者在实验中发现,当使用不同阴离子的钴盐进行固相合成氧载体时,所得氧载体吸收分子氧的性能有明显差异。为探讨固相反应中不同钴盐对钴配合物氧合性能的影响,本文以丙二胺为配体,与四种不同钴盐分别发生液鄄固反应和气鄄固反应,再通过氧合… 相似文献
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本文重点介绍了目前实验室和市场上可用于固相组合合成的含羟基的聚合物载体及其主要的化学反应性能。 相似文献
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In recent decades, a large number of reports related to solid-phase synthesis of heterocycles have appeared, owing to the wide variety of their biological activity. This review introduces the key concepts of solid-phase methodology and combinatorial synthesis with particular focus on the important role of solid-phase synthesis in the synthesis of nitrogen-containing five-membered ring heterocycles. 相似文献
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Solid-phase organic synthesis is a rapidly expanding area of synthetic chemistry that is being widely exploited in the search for new medicinally important compounds using combinatorial techniques. In recent decades, a large number of reports related to solid-phase synthesis of heterocycles have appeared because of the wide variety of their biological activity. In this review, we report the important role of solid-phase synthesis in the synthesis of nitrogen containing six-membered ring heterocycles. 相似文献
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Solid-phase organic synthesis is a rapidly expanding area of synthetic chemistry which is being widely exploited in the search for new medicinally important compounds using combinatorial techniques. In recent decades, a large number of reports related to solid-phase synthesis of heterocycles have appeared because of the wide variety in their biological activity. In this review, we report the important role of solid-phase synthesis in the synthesis of oxygen-bearing heterocycles. 相似文献
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Philip A. Helliwell Ruth E. Fake Kevin G. Kerr Barbara Santry Austen Speakman 《合成通讯》2013,43(20):3058-3066
A novel microwave-assisted synthesis of a library of triarylamides has been undertaken on the solid-phase. 相似文献
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Anja Blümler Harald Schwalbe Alexander Heckel 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2022,134(1):e202111613
Herein, we present a multi-cycle chemoenzymatic synthesis of modified RNA with simplified solid-phase handling to overcome size limitations of RNA synthesis. It combines the advantages of classical chemical solid-phase synthesis and enzymatic synthesis using magnetic streptavidin beads and biotinylated RNA. Successful introduction of light-controllable RNA nucleotides into the tRNAMet sequence was confirmed by gel electrophoresis and mass spectrometry. The methods tolerate modifications in the RNA phosphodiester backbone and allow introductions of photocaged and photoswitchable nucleotides as well as photocleavable strand breaks and fluorophores. 相似文献
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Kazuhiko Nakamura Yuki Ohnishi Eiji Horikawa Takeo KonakaharaMasato Kodaka Hiroaki Okuno 《Tetrahedron letters》2003,44(29):5445-5448
A novel linker possessing selenocyanate and masked carboxylic acid was developed for the solid-phase synthesis of dehydropeptides. This linker was used to demonstrate the synthesis of the model compound of RGD-conjugated dehydropeptide. 相似文献
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Yosuke Demizu Kaichi Sano Naoki Terayama Wataru Hakamata Yukiko Sato Hideshi Inoue 《合成通讯》2013,43(12):1724-1730
This study demonstrates solid-phase nucleophilic fluorination. Polymer-bound 1-phenoxy-2-sulfonyloxyethane, as a model compound, is converted to a fluorinated compound in a short time. Furthermore, this method is applied to synthesize a precursor of 2-deoxy-2-fluoro-D-glucose by solid-phase synthesis using a microwave oven. 相似文献
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