共查询到20条相似文献,搜索用时 187 毫秒
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10-羟基喜树碱首先在N,N-二甲基甲酰胺(DMF)中经N-溴代丁二酰亚胺(NBS)溴代得到9-溴-10-羟基喜树碱, 9-溴-10-羟基喜树碱和氯甲酸乙酯反应得到9-溴-10-羟基喜树碱-10,20-双乙氧基碳酸酯(6). 化合物6和烯丙基三正丁基锡通过Stille偶联反应[9]得到关键中间体7, 最后水解化合物7得到目标化合物. 通过柱层析纯化得到纯度大于99.8%, 单杂小于0.1%的吉咪替康(HPLC). 所有中间体及目标产物经1H NMR, 13C NMR, LRMS, HRMS表征确证. 相似文献
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发展了一种适用范围广、高效且高选择性的官能化二硫缩烯酮的α-溴代反应.在少量水存在下,在四氢呋喃溶液中,以溴化铜为溴代试剂,经由官能化二硫缩烯酮(1)的α-溴代反应制备了结构多样的α-溴代二硫缩烯酮(2). 相似文献
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通过查阅文献和实验探究了苯酚的几种溴代产物在水、苯酚熔液和苯酚水溶液中的溶解性;从有机反应的理论角度探讨了苯酚溴代反应机理及产物的确证,指出苯酚与溴水反应的产物是2,4,6-三溴苯酚。 相似文献
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Allyl tetrahydropyranyl ether (ATHPE) can be used as a versatile protecting reagent. In combination with NBS/I2, O-allyl group can easily be replaced by hydroxyls (including tertiary-OH) or thiols, in the molecules comprising other reactive functional groups such as halogen, nitro, acetonide and alkene under mild reaction conditions (near neutral pH and ambient temperature). 相似文献
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Prabal Bandyopadhyay Sumit K. Agrawal Manisha Sathe Pratibha Sharma M.P. Kaushik 《Tetrahedron》2012,68(20):3822-3827
N-Bromo succinimide (NBS) was found to be an efficient and regioselective reagent in combination with AIBN for an unprecedented, facile and rapid one-step synthesis of 8-substituted xanthine derivatives at room temperature. The inexpensive, nontoxic and readily available NBS efficiently promoted the condensation of several aryl/cycloaryl/heteroaryl aldehydes with 5,6-diamino-1,3-dimethyluracils in presence of catalytic amount of AIBN in a single step via radical chain reaction. The notable advantages of this protocol were short reaction time, milder reaction conditions, simple work-up procedure, no requirement for chromatographic separation, use of non-hazardous reagent/solvent and applicable to a variety of substrates. 相似文献
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Trace amounts of transition elements (Fe, Co, Ni and Cu) in zirconium fluoride and NBS SRM's were determined by substoichiometric radioactivation analysis. The contents of impurities in sublimed sample were less than those of high-purity material and of reagent grade. The detection limits of these elements in zirconium fluoride were 10 ng/g for iron, 0.01 ng/g for cobalt, 1 ng/g for nickel and 0.1 ng/g for copper. The analytical results for iron, cobalt, nickel and copper in NBS SRM's were in good agreement with certified values. 相似文献
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The quantitative determination of ketoprofen using spectrophotometric and voltammetric methods are described. The spectrophotometric procedure depends upon the reaction of ketoprofen with N-bromosuccinimide (NBS). The residual reagent is then determined by formation of violet colour with 2,2-diphenyl-l-picryl hydrazine (DPPH(2)). The consumed NBS would correspond to ketoprofen. Beer's law is valid over the concentration range 5-80 mug/ml of the drug. Direct current (DC) polarography allows to study the reduction behaviour of ketoprofen at the dropping mercury electrode (DME) using different supporting electrolytes at different pH values. Direct current stripping voltammetry (DCSV) was used for the quantitative measurements of the drug. The calibration graph of peak current vs concentration was linear from 0.254 x 10(-2) to 0.254 mug/ml. In model solutions as little as 5.08 x 10(-4) ng/ml ketoprofen can be detected by DCSV. Both methods were applied successfully for the determination of ketoprofen either in pure or dosage forms. 相似文献
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Three simple and sensitive spectrophotometric methods for the determination of sulphinpyrazone (SP) in bulk samples and pharmaceutical formulations are described. They are based on the oxidation of sulphinpyrazone with excess N-bromosuccinimide (NBS) and determination of the unconsumed NBS with metol-isonicotinic acid hydrazide (method A, lambda(max): 620 nm); by the reduction of Folin-Ciocalteu reagent (method B, lambda(max) 770 nm); or by the formation of a chloroform-soluble, coloured ion-association complex between the drug and Methylene Violet (MV) at pH 7.0 (method C, lambda(max) 545 nm). 相似文献
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A radioreagent method for the analysis of traces of mercury using radioactive zinc dithizonate as the reagent has been developed.
As small as 0,2 μg of mercury can be determined using this technique. Possible interferences from most of the metals which
displace zinc from zinc dithizonate can be removed by a simple separation procedure. The method was tested by analyzing the
NBS reference standard SRM 1064 and our value was found to be in agreement with the value certified by NBS.
This paper was presented at the South-East and South-West ACS Regional Meeting, Memphis, Tenn., October 29–31, 1975. 相似文献
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Okada Y Yokozawa M Akiba M Oishi K O-kawa K Akeboshi T Kawamura Y Inokuma S Nakamura Y Nishimura J 《Organic & biomolecular chemistry》2003,1(14):2506-2511
A variety of aromatic compounds with both activating and deactivating substituents were brominated with sodium monobromoisocyanurate (SMBI) 1, diethyl ether, diethyl ether-methanesulfonic acid, trifluoroacetic acid, or sulfuric acid were employed as solvents. Thus nitrobenzene was conveniently brominated in sulfuric acid, benzene was readily monobrominated in diethyl ether-methanesulfonic acid, and phenol was selectively brominated at the ortho position under mild conditions in refluxing diethyl ether. With substituents that are easily protonated, trifluoroacetic acid may be employed as solvent in the reaction with 1, in contrast NBS was ineffective in trifluoroacetic acid. This renders 1 a superior reagent relative to NBS. In addition to aromatics, alkenes, ketones and esters were also brominated with 1. Diethyl malonate was brominated with 1 and then subjected to a Bingel reaction with NaH to afford the desired methanofullerene in reasonable yield. 相似文献
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An efficient synthetic route towards the synthesis of β-keto sulfones has been developed from secondary benzyl alcohols using N-bromosuccinimide (NBS). The present protocol utilizes NBS as oxidant as well as brominating agent, readily accessible benzyl alcohols and sodium arenesulfinates as the sulfonylating reagent under mild conditions. The control experiments revealed that the reaction proceeds via oxidation of alcohol to ketone, α-bromination of ketone and nucleophilic substitution by sodium arenesulfinate. Furthermore, the efficiency of the methodology was tested with a gram scale reaction and also shown the synthetic utility. 相似文献
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Four simple and sensitive spectrophotometric methods for the determination of astemizole (AZ) in pure samples and pharmaceutical formulations are described. They are based on the oxidation of astemizole with excess N-bormosuccinimide (NBS) and determination of the unconsumed NBS with, metol-sulphanilamide (method A, lambda(max): 520 nm) or celestine blue (method B, lambda(max): 540 nm); or by the reduction of Folin-ciocalteu reagent (method C, lambda(max): 720 nm); or by the formation of a chloroform-soluble, coloured ion-association complex between the drug and azocarmine G (AG) at pH 1.5 (method D, lambda(max); 540 nm). The results obtained are reproducible with a coefficient of variation of less than 1.0%. 相似文献