重离子束治癌中深度剂量分布优化

针对兰州重离子研究装置所加速的120MeV/u ¹²C离子束,利用模拟退火优化算法进行了Bragg峰展宽的剂量优化.取相同的展宽区域(30mm),4种不同的步长(2,1,0.5,0.25mm)进行Bragg峰展宽模拟.对所得到的剂量平均值,均方差,入射口剂量,峰坪比等优化结果的参数做了比较.讨论了重离子束治癌临床上最优的Bragg峰展宽模型的选取.     

中能8B和9C与Si反应总截面的测量

能量为75MeV/u的¹²C初级束轰击2mm厚的初级Be靶,并利用RIBLL从弹核碎片中分离出54.2MeV/u质子滴线核束8B和61.1MeV/u的⁹C,再轰击Si靶,用透射法测量了它们与Si的反应总截面σ_R.并应用Glauber模型进行理论计算,分析结果表明⁸B和⁹C都可能具有质子晕结构.     

20—46MeV/u 12C离子和Cu相互作用中靶余核的反冲性质研究

使用离线γ能谱法和厚靶-厚收集箔技术测量了20—46MeV/u ¹²C离子和铜相互作用中余核的前向平均反冲射程.导出了中心碰撞的线性动量转移.当轰击能量为27.5MeV/u时,每个入射核子转移的线性动量达到155MeV/c的最大值.复合系统的最大激发能为每核子2.5MeV.     

HIRFL浅层肿瘤治疗终端治癌碳离子束物理特性的测量

对HIRFL浅层肿瘤治疗终端提供的碳离子束的物理特性进行了首次测量. 结果显示, 能量为80.55MeV/u的¹²C离子束, 其束流强度在0.001—0.1nA范围时, 直径50mm照射野的均匀性为73.48%, 束流强度在一段时间内的稳定性为80.87%. 测得了束流在治疗装置等中心处的深度剂量分布, 其高剂量的Bragg峰位处在13.866mm的水等效深度, 反推出碳离子束在等中心处对应的能量为71.71MeV/u, 与计算值基本吻合. 对自由空气电离室的读数进行了吸收剂量的标定. 测量结果显示, HIRFL浅层肿瘤治疗装置性能与临床治疗的要求相比稍有差距, 为了达到治疗终端进行临床试验的要求, 须对治癌装置性能做进一步的优化.     

40MeV/u 40Ar与Cu相互作用的靶余核

使用离线y能谱法和厚靶──厚收集箔技术测量了40MeV/u ⁴⁰Ar和Cu相互作用中靶余核的生成截面和前向平均反冲射程FW值.根据电荷分布假设得到了靶余核的质量产额分布.从FW值导出了重离子碰撞中的线性动量转移.与¹²C+Cu和²⁰Ne+Cu的类似结果比较指出,在相同的弹核速度下,相应于中心碰撞的相对线性动量转移随弹核质量增加而减小,但是在⁴⁰Ar离子和Cu的中心碰撞中产生的复合系统的激发能比¹²C和²⁰Ne离子碰撞情况下更高,达到每核子5.3MeV.     

45MeV/A 12C和181Ta相互作用中余核的研究

用厚靶-厚收集箔技术测量了45MeV/A ¹²C和¹⁸¹Ta相互作用中余核的生成截面和反冲性质,并将实验得到的质量产额分布与统计碎裂模型进行了比较.根据前向平均反冲射程计算了线性动量转移,在与我们以前工作相比较后指出,在45MeV/A ¹²C离子引起的反应中,中心碰撞的线性动量转移随靶质量而增加,并与引导粒子模型计算结果很好相符.     

135MeV/u 12C和铁相互作用中靶余核的质量分布

用核化学技术测定了135MeV/u ¹²C和铁相互作用中的靶余核的生成截面,通过高斯电荷分布函数得到了靶余核的质量分布.与46MeV/u ¹²C+Cu相比,发现A<30质量区的产额明显增加,且产物有偏向丰中子一侧的趋势.实验测定的质量分布与熔合碎裂模型和级联两体模型的计算结果进行了比较,结果似乎表明在很高入射能情况下多重碎裂衰变是A<30靶余核生成的主要反应机制.     

重离子Bragg峰的研究及其应用

实验测定了由HIRFL引出的25、30MeV/u ⁴⁰Ar,离子经不同厚度降能片后的相对电离(Bragg曲线),并将实验结果同TRIM88程序的计算结果进行了比较,发现⁴⁰Ar离子贯穿深度较浅时,实验结果与程序计算符合很好. 并对中能重离子在水中贯穿深度与相对电离关系的计算,提出了一种对浅层且体积不大肿瘤的重离子治疗方案.     

12N直接碎裂反应研究

描述了在兰州放射性束流线(RIBLL)上用78.6MeV/u的¹⁴N束流轰击Be靶产生出34.9MeV/u的¹²N次级束流. 利用¹²N轰击Si靶作为次级靶, 利用直接碎裂反应测量它的反应总截面. 利用理论模型进行了计算, 理论计算和实验结果符合的很好. 发现¹²N的质子密度分布相对于中子而言, 有一个很大的弥散.     

丰中子核8He在Si靶上的反应总截面的测量

利用HIRFL 50MeV/u ¹³C束流在Be靶上碎裂,RIBLL选择出丰中子放射性次级束流⁸He,实验测量了25—40MeV/u ⁸He在²⁸Si靶上的反应总截面.采用双参数HO密度分布形式,通过微观Glauber模型拟合⁸He实验数据,发现⁸He具有扩展的中子密度分布.实验结果与Warner反应总截面实验和Alkhazov弹性散射实验结果较好地符合.     

Investigation and Application of Heavy lon Bragg Peak

Relative ionizations(Bragg curves)of 30MeV/u and 25MeV/u ⁴⁰Ar ion beams supplied by HIRFL through degraders of Mylar films with different thicknesses were measured respectively.The experimental results were compared with calculations by TRIM88 code.It is found that the experimental results are in good agreement with the calculated ones when the ⁴⁰Ar ions penetrate a smaller distance from target surface.Furthermore,a heavy ion radiotherapy planning for shallow-seated and small tumor is put forward according to the calculated relationship between intermediate energy heavy ion penetration depth in water and relative ionization.     

Neutron production at the heavy ion research facility in Lanzhou

In this work,the neutron radiation field at Heavy Ion Research Facility in Lanzhou (HIRFL) was investigated.Total neutron yields,spectra and angular distributions in the bombardment of various thick targets by 12C and 18O ions with energies up to 75 MeV/u were obtained using the activation method.The neutron dose equivalent rates of 60 MeV/u 18O on various thick targets at different angles were measured with a modified A-B remmeter.Our results are compared with those of other reports.     

Neutron production at the heavy ion research facility in Lanzhou

In this work, the neutron radiation field at Heavy Ion Research Facility in Lanzhou (HIRFL) was investigated. Total neutron yields, spectra and angular     

12C6＋离子辐照人胃癌细胞系BGC823的氧效应研究

氧效应; 碳离子; 人胃癌细胞系BGC823 ;兰州重离子加速器     

Dosimetry of 40 and 70 MeV/n O beams

Using CR-39 plastic track detectors the range values of ¹⁶O ions at two different energies (initially in the beam line, 39.97 MeV/n and 69.98 MeV/n) were measured after escaping the beam pipe and found to be (3050 ± 40) μm and (8210 ± 90) μm, respectively. The longitudinal and projected angular spread of oxygen ions of an initial energy of 69.98 MeV/n in the region of the Bragg peak was derived from the measured geometrical parameters of tracks. Based on a calibration curve (etch rate ratio vs total linear energy transfer in CR-39) and the measured track length distribution at the range end of oxygen ions, the complete depth dose profile of a 67.7 MeV/n ¹⁶O beam in CR-39 (plateau, extended Bragg peak and residual ionization caused by projectile like fragments) was obtained.     

Target Residues from the Interaction of Copper with 40MeV/u 40Ar Ions

Cross Sections and average forward recoil range FW were measured for target residues from the interaction of Cu with 40MeV/u ⁴⁰Ar ions using off-line y-ray spectroscopy.The mass yield distribution was obtained with assumption of charge distribution.The linear momentum transfer was calculated from FW values.A comparison with similar results of ¹²C+Cu and ²⁰Ne+Cu reactions indicates that the fractional linear momentum transfer,corresponding to central collisions,decreases with increasing projectile mass at the same energy per nucleon. However,the excitation energy of the composite system created from the collisions of Cu with ⁴⁰Ar ions reached the value of 5.3MeV /u and was higher than those from the collisions with ¹²C and ²⁰Ne ions.     

Elastic and inelastic scattering of 12C ions at intermediate energies

Elastic and inelastic scattering of ¹²C ions on ¹²C and ²⁰⁸Pb targets have been measured at the incident energies per nucleon E / A = 120 MeV/u and E / A = 200 MeV/u. Optical-model analysis is reported and nuclear surface transparency effects are discussed, together with the nuclear potential-energy dependence. The transparency region extends down to a radial internuclear distance of about 3 fm for the ¹²C-¹²C system and 8 fm for the ¹²C-²⁰⁸Pb system. A decrease of the imaginary potential with increasing incident energy is deduced for the two systems. Anomalous collapse of the real potential in the surface region is observed for ¹²C-²⁰⁸Pb system at 200 MeV/u. DWBA analysis of data on the 2⁺, 4.4 MeV state of ¹²C is reported and trends for the energy dependance of mean-field excitations are deduced.     

能量修正的Glauber模型对中能反应总截面的影响

叙述了对Glauber模型中的透射系数进行半经验的能量修正,并利用该修正模型计算了^12—14C,⁶Li,⁷Be,⁸B+¹²C和⁶Li,⁷Be,⁸B+⁹Be以及²⁰Ne+¹²C,¹²C+²⁷Al等系统的激发函数(能区范围10—1000MeV/u),经与实验值比较,能量修正的Glauber理论计算值能够很好地描述中能条件下的反应总截面实验测量值.     

Induced absorption in yttrium aluminium perovskite crystals irradiated by 12C and 235U ions

The present work is devoted to investigation of optical absorption in pure and neodymium-doped YAlO₃ (YAP) single crystals in the spectral range 0.2–1.1 μm induced by the influence of ¹²C ions irradiation with energy 4.50 MeV/u (MeV per nucleon) and a fluence 2 × 10⁹ cm^?2 or of ²³⁵U ion irradiation with energy 9.35 MeV/u and a fluence 5 × 10¹¹ cm^?2. The induced absorption in the case of ¹²C ions irradiation is caused by recharging of point growth defects and impurities under the radiation influence. After irradiation by ²³⁵U ions with fluence 5 × 10¹¹ cm^?2 the strong absorption rise is probably caused by contribution of the lattice destruction as a result of heavy ion bombardment.