Obtusinin — A new coumarin fromHaplophyllum obtusifolium

The epigeal part ofHaplophyllum obtusifolium collected in Ustyurt has yielded -sitosterol, isofraxetin, and a new coumarin — obtusinin — with the composition C₁₅H₁₈O₆, mp 135–137°C (methanol), [] _D ²⁰ +140.9° (c 0.44; chloroform). The structure of obtusinin has been established on the basis of the results of a study of UV, IR, PMR, and mass spectra and also of some chemical transformations (hydrolysis, acetylation).Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Combined Institute of Natural Sciences of the Karakalpak Branch, Academy of Sciences of the Uzbek SSR, Nukus. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 328–330, May–June, 1980.     

Spatial structure of the germacrane lactones hanphyllin, salonitenolide, and sachosin

An x-ray structural study has been made of the sesquiterpene lactones hanphyllin, salonitenolide, and sachosin: diffractometer; CuK radiation; 997, 950, and 1245 reflections, respectively; direct method; R factors 0.049, 0.099, and 0.081. All three molecules have the chair-chair conformation with configurations of the₁D¹⁴ and¹⁵D₅ types.Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 775–780, November–December, 1989.     

Separation of the alkaloids deoxypeganine,peganol, and deoxyvasicinone by the HPLC method

Institute of Chemistry of Plant Substances Academy of Sciences of the Uzbek SSR, Tashkent. Scientific Center for Chromatography, Academy of Sciences of the Uzbek SSR. Institute of the Chemistry and Physics of Polymers, Academy of Sciences of the Uzbek SSR, Tashkent. Iranslated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 297–298, March–April, 1991.     

Structure of fegolide

A chloroform extract of the seeds ofFerula penninervis Rgl et Schmahl has yielded a new sesquiterpene lactone of the guaiane type — fegolide: C₂₀H₂₈O₅, mp 165–166°C []_D –150°C (c 0.17; chloroform).Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 335–337, May–June, 1985.     

Alkaloids ofFumaria vaillantii

FromFumaria vaillantii, collected in the Tashkent province, 18 alkaloids have been isolated of which N-methyladlumine with mp 198–199°C, []_D-45° (c 0.5; methanol) has proved to be new. Its structure has been established on the basis of spectral characteristics and a direct comparison withl-adlumine methiodide.Institute of the Chemistry of Plant Substances of the Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 602–604, September–October, 1981.     

Structure of zangezurine

A new base with []_D +208° (c 0.7; methanol) has been isolated from the combined nonphenolic alkaloids ofPapaver zangezuricum A. D. Mikheev, and has been called zangezurine (I). The acetylation of (I) with acetic anhydride in pyridine yielded O-acetylzangezurine (II). The structure of zangezurine has been established on the basis of the UV, IR, mass, PMR, and¹³C NMR spectra of (I) and (II).Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Pyatigorsk Pharmaceutical Institute. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 858–862, November–December, 1987.     

Structure of lederine

The new spirobenzylisoquinoline base lederine with mp 208–209°C (methanol), []_D +13° (c 0.84; chloroform) has been isolated fromCorydalis ledebouriana Kar et Kir andDicentra peregrina (Rudolphi) Fedde. Its structure has been established on the basis of spectral characteristics and chemical reactions.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Pyatigorsk Pharmaceutical Institute. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 540–542, July–August, 1980.     

Structure of fertenin

Summary The roots ofFerula tenuisecta have yielded a new ester C₂₂H₃₀O₅, mp 209–211°C, [] _D ²² +125° (c 0.8; ethanol), which has been called fertenin. On the basis of chemical transformations and spectral characteristics, a structure has been proposed for it as the 8-p-hydroxy-benzoate of fertenol — 9-epoxygermacr-5-ene-4,8-diol.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 161–164, March–April, 1979.     

Structure and stereochemistry of pallinin

The roots ofFerula pallida Korov. have yielded pallinin, C₂₅H₃₈O₅, mp 79–80°C, []D²⁰ –148.5° (c 0.1; CHCl₃) — an ester of the new carotane alcohol pallinol and angelic acid. A structure and absolute configuration have been proposed for it on the basis of chemical transformations and spectral characteristics.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 53–56, January–February, 1986.     

Structure and stereochemistry of lapidin

The roots ofFerula lapidosa Eug.Korov. have yielded lapidin, C₂₀H₃₀O₄, mp 80–81°C (hexane), []D²⁰ +166° (c 1.5; chloroform) — an ester of a new carotane alcohol lapidol and angelic acid. A structure and absolute configuration has been suggested for it on the basis of chemical transformations and spectral characteristics.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedenii, No. 3, pp. 318–323, May–June, 1981.     

Diterpenoids ofPulicaria salviifolia. II. Structure of salvicin

A new diterpenoid acid of the clerodane series, C₂₀H₃₂O₄, [] _D ²⁰ –75.4° (c 0.26; methanol), which has been called salvicin, and the known flavonoid rutin have been isolated from a chloroform extract of the epigeal part ofPulicaria salviifolia. The structure of salvicin has been established on the basis of spectral characteristics and chemical transformations.Deceased.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 299–301, May–June, 1986.     

Crystal and molecular structure of the sesquiterpene lactone mucrin

An x-ray structural investigation has been made of the sesquiterpene lactone mucrin, diffractometer: Cu K radiation, 942 reflections, direct method, R factor 0.083. The spatial structure of the molecule has been determined: the lactone ring is trans-linked with the germacrane ring, the epoxide group in the 1,10 position has the 1,10-orientation, and the hydroxy group in position 6 has the -orientation.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Institute of Bioorganic Chemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 59–63, January–February, 1988.     

NMR investigation of alkaloids

On the basis of a study of the spin-spin coupling constants J_CH and the¹³C chemical shifts of haplophyllidine an assignment has been made of the signals of the carbon atoms of the 5,6,7,8-tetrahydrofuranoquinoline alkaloids haplophyllidine, perforine, anhydroperforine, their derivative (IV), and the furanoquinoline base -fagarine.Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 25–30, January–February, 1989.     

4',4”- and 4',5”-di-sec-butyl-2,3:11,12-dibenzo-18-crown-6 — An ionophore for magnesium in natural and model systems

The ionophoric properties of the di-sec-butyl derivatives of dibenzo-18-crown-6 have been studied in natural and model membranes. It has been shown that the di-sec-butyl substituents in the benzene rings of dibenzo-18-crown-6 impart to the cyclopolyether the properties of an ionophore for magnesium. The Mg²⁺/Ca²⁺ selectivity of the cyclopolyether investigated was 4.8 according to results obtained on artifical membranes and mitochondria.Institute of Biochemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Institute of Bioorganic Chemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 234–239, March–April, 1981.     

Neutral lipids of the seeds of Eremostachys moluccelloides

Summary From the sum of the neutral lipids of the seeds ofE. moluccelloides we have isolated the natural di-and monoglycerides, have determined their structure, and have established that these classes of lipids contain a higher amount of saturated acids in the position than the triglycerides of the seeds.It has also been established that in the hydrolysis of natural diglycerides with the nonspecific lipase of the fungusO. lactis synthetic triglycerides are formed that differ from natural triglycerides by an increased amount of saturated acids.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Microbiology Division of the Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 44–48, January–February, 1978.     

Components of the roots ofFerula tschatcalensis

With the aid of column chromatography, the following compounds have been isolated from the roots ofFerula tschatcalensis M. Pimen. and identified: juniferin, ferocinin, xeroferol, and fexerin, and also the new sesquiterpene ester chatferin, C₂₀H₃₂O₄, [] _D ²⁰ +6.2° (1.53; ethanol), n _D ²⁰ 1.5136. On the basis of spectral characteristics and a transition to known substances, it has been established that chatferin has the structure of 2-tigloyl-7,8-epoxyjuniferol.Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 721–724, November–December, 1983.     

X-ray structural investigation of sesquiterpene esters from plants of the genus Ferula. V. Structure and stereochemistry of ferticin

An x-ray structural investigation has been made of the sesquiterpene ester ferticin: diffractometer, CuK radiation, 1037 reflections, direct method, R factor 0.105. The spatial structure of the molecule has been determined.Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 68–73, January–February, 1989.     

Composition of the neutral lipids of Chlorella vulgaris

Summary The qualitative and quantitative compositions of the neutral lipids and the fatty-acid composition of the individual classes of neutral lipids isolated from fresh, freeze-dried, and air-dry cells of the algaChlorella vulgaris have been investigated.The presence of natural fatty acid methyl esters in the lipid extract of the fresh and air-dry chlorella cells has been established.It has been shown that the fatty acid methyl ester fraction is enriched with palmitic acid as compared with the triglyceride and free fatty acid fractions.The main unsaturated acids of the chlorella lipids contain the first double bond in the ⁹ position.Division of Microbiology of the Academy of Sciences of the Uzbek SSR, Tashkent. Institute of the Chemistry of Plant Substances, Academy of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 49–53, January–February, 1978.