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1.
Yu Xin LIU Xiao Tian LIANG* Institute of Materia Medica Chinese Academy of Medical Sciences &Peking Union Medical College Xian NongTan Street Beijing 《中国化学快报》2001,(1)
In our research on the ring enlargement of certain N-heterocycles, a general procedure for the ring enlargement with the insertion of an extra -CH2- was improved and shown in Scheme I1.Scheme IThe procedure had been carried out with such N-heterocycles as 2-methyl-1,2,3,4-tetrahydroisoquinoline2, tetrahydroberberine and strychnine3 with expected results. Thus, the procedure shown in Scheme I provides a new approach to the synthesis of larger N-heterocycles.Isoindolo[1,2-b][3]benzazepines a… 相似文献
2.
Dong Yamato 《Journal of inclusion phenomena and macrocyclic chemistry》1998,32(2-3):195-207
A new type of host is introduced: homocalix[3]arenes containing three aromatic units. Phane synthesis leading to molecules which may be termed, in the most general sense, homocalix[3]arenes, are outlined in a brief overview. The design, synthesis, conformations and host properties of homocalix[3]arenes are described in detail. 相似文献
3.
Hong Min MA Zhan Zhu LIU Shi Zhi CHEN Xiao Tian LIANGInstitute of Materia Medica Peking Union Medical College & Chinese Academy of MedicalSciences Beijing 《中国化学快报》2004,(7)
A concise and efficient synthesis of the new compounds tetrahydroisoquino [2,1-c] [1,3] benzodiazepine 5 and 7 is reported. 相似文献
4.
[reaction: see text] A new method for the synthesis of substituted pyranone hemiketals from dioxanorbornanes via SmI(2) is described. Also reported is a synthesis of spiro[4.5]ketals from analogous intermediates via acid-promoted deprotection/ketalization. 相似文献
5.
A new two step synthesis of benzo[b]quinolizine ring systems via the rearrangement of 2-[1(3H)-oxodihydrobenzo[c]furan-3-yl] quinuclidin-3-ones is described. 相似文献
6.
A new and efficient synthesis of 2-arylbenzofurans has been achieved via a route involving acylation and subsequent [3,3]-sigmatropic rearrangement of oxime ethers. Its synthetic utility is demonstrated by a short synthesis of stemofuran A and eupomatenoid 6 in which no procedure for protection of the phenolic hydroxyl groups is needed. [reaction--see text] 相似文献
7.
A facile synthesis of benzo[d]benzo[2,3][1,4]diazepino[1,7-b] isothiazole, a new heterocyclic ring system is reported. 相似文献
8.
A new [2 + 2 + 2] approach to construct GPI molecules through the efficient synthesis of glucosamine-inositol and tetramannose intermediates led to a total synthesis of a GPI-anchor of Trypanosoma cruzi, and also afforded a key intermediate for the synthesis of valuable [4-deoxy-Man-III]-GPI analogues. 相似文献
9.
A New Efficient Synthesis of p-Nitrocalix[4]arene 总被引:1,自引:0,他引:1
YongLI JiaSongWANG QiWANG DeShanLI 《中国化学快报》2004,15(4):400-403
A new efficient synthesis of p-nitrocalix[4]arene from calix[4]arene by using nitrogen dioxide is described.The compound is an useful intermediates for the introduction of other functional groups to obtain N containing substituted calix[4]arene.The reaction mechanism is briefly discussed. 相似文献
10.
The first synthesis of the parent compound of the benzo[4,5]thieno[2,3-c]pyrrole ring system and its derivatives, as well as their Diels-Alder reactions with DMAD and N-phenylmaleimide are reported. A new synthesis of the benzo[4,5]thieno[2,3-d]pyridazine ring system is also described. 相似文献
11.
Efeturi Abraham Onoabedje Obioma Chinwe Chinwuko Benjamin Ebere Ezema Mercy Amarachukwu Ezeokonkwo 《Phosphorus, sulfur, and silicon and the related elements》2018,193(7):437-442
A convenient synthesis of new polycyclic mixed phenothiazine-phenoxazine compounds is described. The cross-coupling of 2,4-diaminothiophenol with 2,3-dichloro-1,4-naphthoquin one at room temperature gave reddish brown 10-amino-6-chlorobenzo[a]phenoxazin-5-one which was converted into a benzoxazinophenothiazin-12-amine in 58% yield via reaction with 2-aminothiophenol under anhydrous basic conditions. A three-component one-pot synthesis improved the yield of benzoxazinophenothia-12-amine to 81% a in shorter time compared to two steps reactions. The synthesis of new azomethine derivatives of benzo[a]benzo[5,6] [1,4] oxazino [3,2-c] phenothiazin-12-amine with extended conjugations and excellent yields were also reported. The structural assignments of the prepared compounds were established by combine Ultraviolet-Visible, Fourier Transform Infrared, 1H and 13C Nuclear Magnetic Resonance Spectroscopies, Mass Spectrometry and elemental analytical data. The ease of preparations in high yields and their intense colourations make these compounds applicable as dyestuffs. 相似文献
12.
A new route to the synthesis of 7-functionalised bicyclo[2.2.1]heptane derivatives having a bridgehead alkoxy group is described involving Wolff rearrangement of α-diazo ketone in a bicyclo[2.2.2]octane derivative. 相似文献
13.
Sourav Biswas Christopher S. Qiu Louise N. Dawe Yuming Zhao Graham J. Bodwell 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(27):9264-9268
A new synthetic strategy (contractive annulation) for the synthesis of highly strained cyclophanes has been conceived and its viability has been demonstrated through a nine‐step synthesis of [2](6,1)naphthaleno[1]paracyclophane from [2.2]paracyclophane. 相似文献
14.
Sourav Biswas Christopher S. Qiu Louise N. Dawe Yuming Zhao Graham J. Bodwell 《Angewandte Chemie (International ed. in English)》2019,58(27):9166-9170
A new synthetic strategy (contractive annulation) for the synthesis of highly strained cyclophanes has been conceived and its viability has been demonstrated through a nine‐step synthesis of [2](6,1)naphthaleno[1]paracyclophane from [2.2]paracyclophane. 相似文献
15.
Jinesh M. KuthanapillilSreeja Thulasi Rani RajanK. Syam Krishnan E. SureshK.V. Radhakrishnan 《Tetrahedron》2011,67(6):1272-1280
A new and highly versatile approach towards the synthesis of bicyclo[6.3.0]undecanes and bicyclo[5.3.0]decanes was accomplished. The methodology adopted involved [6+3] and [3+2] cycloaddition reactions of pentafulvenes with 3-oxidopyridinium betaines generated either by the action of a base on the pyridinium salt or thermally from pyridinium betaine dimer. These well-functionalized bicyclo[6.3.0]undecanes and bicyclo[5.3.0]decanes offer a wide range of synthetic options, which can be expected to translate into a variety of rapid and efficient synthesis of natural products. 相似文献
16.
《Tetrahedron letters》1997,38(39):6909-6912
A new synthesis of the 2-dimethylamino-4-hydroxy-6-methoxymethyl-3H-imidazo[4′, 5′:3,4] pyrido[2,3-b]indole, used as key intermediate in the total synthesis of the alkaloids grossularines-1 and -2, based on the step-wise formation of the pyridine and imidazole rings, is described. 相似文献
17.
MM. J. Duflos D. Letouz G. Queguiner P. Pastour 《Journal of heterocyclic chemistry》1973,10(6):1083-1084
This communication describes the synthesis of l-methyl-2,3-diformylpyrrole. This new compound is used to prepare a new heterocycle, l-methylcyclohepta[b]pyrrol-6-one and thus allows a new synthesis of l-methylpyrrolo[2,3-d]pyridazine. 相似文献
18.
Synthesis of Indolo[2,3‐a]pyrrolo[3,4‐c]carbazoles via the Oxidative Cyclization of Bisindolylmaleimides with Pd(TFA)2/Cu(OAc)2 下载免费PDF全文
A new synthetic approach for the synthesis of indolo[2,3‐a]pyrrolo[3,4‐c]carbazoles based on the Cu2+/Pd2+ catalytic system is described. The optimum condition is established via a systematic screening and utilized for the synthesis of four indolocarbazole aglycones with a satisfied yield. 相似文献
19.
The unexpected isomerization of N-ethyl [6,6]-pyrrolidino-Y3N@C80 to the [5,6] regioisomer is reported, as well as the synthesis, characterization, and electrochemical analysis of Er3N@C80 derivatives. A complete electrochemical study of the M3N@C80 species (M = Sc, Y, Er) and their derivatives is presented. We introduce electrochemistry as a new tool in the characterization of the [5,6] and [6,6] regioisomers of trimetallic nitride endohedral metallofullerenes. 相似文献
20.
[Structure: see text] A new strategy for the synthesis of (+/-)-aspidophytine has been developed and is based on a Rh(II)-catalyzed cyclization/dipolar cycloaddition sequence. The resulting [3+2]-cycloadduct undergoes an efficient Lewis acid mediated cascade that rapidly provides the complete skeleton of aspidophytine. The synthesis also features a mild decarbomethoxylation reaction. 相似文献