共查询到20条相似文献,搜索用时 15 毫秒
1.
Yong An ZHANG Ke Zhong LIU Deng Yuan WANG Yu Zhu WANG Liang Jian QU Chang Jin ZHU 《中国化学快报》2006,17(7):895-898
Sodium ion channels, acetylcholine esterase and neurotransmitter receptors in insect neurons and skeletal muscles are often made as target by practical neurotoxic pesticides. But insects can create resistance after using a pesticide for a long time. So th… 相似文献
2.
Sumei Ren Qing Chen Ning Ding Wei Zhang Yingxia Li Ying Guo 《Journal of carbohydrate chemistry》2013,32(8):647-658
The earliest stage of influenza virus infection is the viral entry to the host cell. In our previous work, we discovered the first three small molecule H5N1 viral entry inhibitors 1–3. Here, based on saponin 3, methyl ursolate 3-O-β-chacotrioside, several analogs were synthesized and evaluated to understand the structure-activity relationships of this type of compound on the H5N1 viral entry inhibitory activity. The preliminary studies demonstrated that unlike saponins 1 and 2, it is possible to reduce the 3-O-chacotriosyl residue of compound 3 to a disaccharide without affecting the viral entry activities significantly. The results obtained will render new clues to the understanding of the antiviral profile for these types of compounds. 相似文献
3.
4.
11 pyrazolyl or pyridinyl substituted tonghaosu analogs were synthesized. Structures of all the new compounds were confirmed by ^1H NMR, IR, MS, HREIMS or elemental analysis. Their antifeedant activity against larvae of large white butterfly (Pieris brassicae L.), larvicidal activity toward mosquito (Culex quinquefasciatus Say) and growth control activity toward larvae of Spodoptera litura Fab were examined. Some of them exhibited antifeeding activities comparable to or stronger than tonghaosu Z-1. Based on the activity data, the preliminary structure-activity relationship was also discussed, which might be instructive for finding out lead compounds with better bioactivities in the future. 相似文献
5.
Six novel Schiff bases have been synthesized by the condensation reaction of 4-amino-5-(4-pyridyl)-2,4-dihydro-1,2,4-triazole-3-thione with various benzaldehydes. The sfructures of the compounds have been confirmed by ^1H NMR, IR and elemental analysis. The preliminary bioassay indicated that the title compounds possessed good fungicidal activities to several vegetable pathogens. 相似文献
6.
A new series of phenoxy-phenyl moieties containing tonghaosu analogs with varied B-ring 9 were synthesized and characterized by spectral studies. Their insect antifeedant activity against Pieris brassicae and insecticidal activity against Culex quinquefasciatus were investigated. Compound 9e exhibited excellent antifeeding activity. 相似文献
7.
Xiang Rui JIANG Lei AO Chang Xin ZHOU Lei Xiang YANG Hai Bo LI Xiu Mei WU Hua BAI Qi Jun ZHANG Yu ZHAO Department of Traditional Chinese Medicine Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou Zhejiang Hisun Naturelite Pharmaceutical R&D Co. Ltd. Hangzhou 《中国化学快报》2005,16(9):1189-1192
As a highly selective and potent acetylcholinesterase(AChE)inhibitor,territrem B wasisolated by Ling et al.from a strain of Aspergillus terreus in19791,2.Zhao et alreported mimic preparation of territrem B analogues from triterpenoids and found thatthe enone moiety and aromatic ring played important roles in their syntheticcompounds3,4.To further detect essential pharmacophors for AChE inhibitors,wesimplified the A/B ring system of territrem B and synthesized a number of pyranonepharmacop… 相似文献
8.
9.
SynthesesandCharacterizationofMetalComplexesOfL-Lysine-N,N,N',N'-tetraaceticAcidandL-Lysine-N,N,N',N'-tetramethylenephOsphoni... 相似文献
10.
Marcus Vinícius Nora de Souza Maria Cristina Silva Lourenço Mônica Amado Peralta Raoni Schroeder Borges Gonçalves Thais Cristina Mendonça Nogueira Camilo Henrique da Silva Lima 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):2990-2997
The series of new N,N′-di(thiopheneacetyl)diamines derivatives, 8–17, were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis(TB), and the activity expressed as the minimum inhibitory concentration (MIC) in μ g/mL. Compound 13 was the only one determined to be active and exhibited a MIC 50 μg/mL, indicating that the alkyl chain-length of the diamines is critical for biological activity. This class of compound has not been evaluated before, and it could be a good starting point to find new lead compounds in the fight against multi-drug resistant TB. 相似文献
11.
12.
Qi CHEN Xing Hai SHEN* Hong Cheng GAO* College of Chemistry Molecular Engineering Peking University Beijing 《中国化学快报》2004,(2)
The hydrophobic cavities of cyclodextrins and the inclusion with various organic molecules in the aqueous solution make them useful in chemical and biological activities1, one of which is the modified cyclodextrins acting as indicators of molecular recognition. Cyclodextrins, which are spectroscopically inert, can be converted into spectroscopically active compounds by modifing one or two of the hydroxy groups with appropriate chromophores, and used as molecular sensor due to the capability of… 相似文献
13.
《Journal of carbohydrate chemistry》2013,32(7-8):743-751
Indolyl N‐glycoside analogs were obtained by a two‐step sequence via indole N‐thioamides. Treatment of thionobutyrolactone with indolylmagnesium bromide provides the corresponding indole N‐thioamide. The use of 10:1 toluene:THF as solvent is important in favoring N‐ over C3‐acylation. Treatment of the ω‐hydroxythioamide with 2 equiv of Meerwein's reagent followed by sodium borohydride gives the corresponding N‐(tetrahydrofuranyl)indole. Addition of carbon nucleophiles gives access to ketose nucleoside analogs, while activation of the ω‐hydroxyl group can give access to tetrahydrothiophene N‐glycosides. 相似文献
14.
ShengLiCAO YuYangJIANG YuPingFENG YanLingNIU YuFenZHAO 《中国化学快报》2003,14(4):343-346
A series of N-phosphoryl branched peptides were synthesized by coupling of various N-phosphoryl amino acids to L-Lysine methyl ester,and their structures were confirmed by ^31PNMR,^1H NMR,MS and elemental analysis.The results of cell biological tests indicated that compound 1d and 1e obviously inhibites the growth of both k562 and A2780 cells. 相似文献
15.
Novel 1,2,4‐triazole isonucleosides (1 and 2) were efficiently synthesized starting from D‐ribose and D‐xylose, respectively. The key steps were condensation of cyclic sulfate 8 with methyl‐1,2,4‐triazole‐3‐carboxylate and nucleophilic displacement of the tosylate 15 with methyl‐1,2,4‐triazole‐3‐carboxylate, respectively. 相似文献
16.
Abstract Previously unreported (?)‐conduramine C‐4 was synthesized in six steps from a bacterial bromobenzene metabolite in 23% overall yield. The chemoenzymatic route involved toluene dioxygenase dihydroxylation, β‐epoxidation, epoxide ring‐opening, Staudinger reduction, radical debromination, and Amberlite‐ catalyzed hydrolysis. (?)‐Conduramine C‐4 and other related compounds synthesised were assayed for galactosidase‐activity inhibition against β‐D‐galactoside galactohidrolase isolated from Aspergillus oryzae. 相似文献
17.
A novel and efficient method for the synthesis of a new variety of methylsulfanylpyrimidines by the reaction of dimethyl N‐cyanodithioiminocarbonate with substituted hydrazides. The synthetic potential of the method is demonstrated. 相似文献
18.
An efficient and simple synthesis of substituted 3‐phenyl‐7‐methoxybenzopyrans as pseudo‐vitamin‐D3 analogs in good yields under mild reaction conditions is described. 相似文献
19.
QiCHEN XingHaiSHEN HongChengGAO 《中国化学快报》2004,15(2):179-180
Substituted 3H-indole modified β-cyclodextrin (β-CD) was prepared by the reaction of 6-deoxy-6-[(2-aminoethyl)amino]-β-CD (CDen) with 2-[(p-amino)phenyl]-3, 3-dimethyl-5-car-boxyl-3H-indole (substituted 3H-indole) in the presence of dicyclohexylcarbodiimide (DCC) and 1-hydroxybenzotriazole (HOBt). The product has been characterized by means of elementalanalysis, MS and ^1H NMR. 相似文献
20.
Inrecentyears,peoplehavepaidmoreattentionto1lliacrownelffersbecause1llesecomPOundshavecomplexabilitiesforsomepositionmetalions."'Althoughiltiacrownetherscanformcomplexeswitilsometrallsitionmetalions,theydemonstratelowselectivityforsomeindividualmetalions.SuchselectivityisgovernedbytoPOlogicalconsidefatioll,cavitysizes,andthenatllfeofhledonoratoms.Thevariationofaledonor-atomhasbeenemployedtOchangetilesanitiesofligandstowardsomeindividualmetalionsinordertoenhancetheselectivityforUlesemetalions… 相似文献