Ilimaquinone,a sesquiterpenoid quinone from a marine sponge

Ilimaquinone (1) is a new sponge metabolite of composition C₂₂H₃₀O₄. Its structure, which was determined by spectral correlations and X-ray crystallography, comprises a rearranged drimane sesquiterpene moiety linked to a 2-hydroxy-5-methoxybenzoquinone at C-3.     

A new sesquiterpenoid quinone with cytotoxicity from Abelmoschus sagittifolius

A new sesquiterpenoid quinone, Acyl hibiscone B (1), together with five known compounds, (R)-lasiodiplodin (2), (R)-de-O-methyllasiodiplodin, (3) dibutyl phthalate (4), (R)-9-phenylnonan-2-ol (5) and hibiscone B (6), was obtained from the stem tuber of Abelmoschus sagittifolius. The structure of compound 1 was elucidated by analysing its ¹H and ¹³C NMR, ¹H–¹H COSY, HSQC, HMBC, NOESY and HR-ESI-MS values. Compound 1 showed significant cytotoxicity against Hela and HepG-2 human cancer cell lines.     

A New Diterpene from Spiraea japonica var.ovalifolia

A new diterpenoid,15-0-accetylspiraminol(1),was isolated from the aerial parts of Spireae japonica L.f.var.ovalifolia.The structure was charaterized mainly based on spectral analysis.     

New Diterpenoid Alkaloids from Spiraea japonica var. Ovalifolia

In the investigation of the chemical constituents of Spireae japonica L. f. var. ovalifolia (Rosaceae), a shrub originated in Songming, Yunnan, five new diterpenoid alkaloids, 19-O-deethylspiramine N (1), deacetylspiramine S (2), spiramidine A (3), spiramidine B (4) and deacetylspiramine F (5), were isolated from aerial parts of the plant and structurally elucidated. Compound 1, a white amorphous powder with [(]+17.99 (c, 0.26, MeOH ), was determined to have the molecular formula of C20H…     

Two new diterpenoids from Rabdosia japonica var.glaucocalyx

Two new diterpenoids, named glaucocalyxin F and glaucocalyxin X, respectively, were isolated from the whole plant of Rabdosia japonica （Burm. f.） Hara var. glaucocalyx （Maxim.） Hara. Their structures was established on the basis of spectral analysis.     

A Novel Atisane Diterpenoid from Spiraea japonica var. acuta

A novel ent‐atisane lactone, spiramilactone E ( 1 ), was isolated from Spiraea japonica var. acuta Yu . Its structure was elucidated by extensive spectroscopic analyses, and unequivocally confirmed by single‐crystal X‐ray diffraction (Fig. 2). Compound 1 contains a γ‐lactone moiety between the 6‐OH function and C(20), and β‐configuration for the 7‐OH group, in contrast to known related diterpenes previously isolated from the S. japonica complex.     

Structure Revision of Caesalpinistas A and B and Isolation of a New Furanoditerpenoid from the Cotyledons of Caesalpinia decapetala var. japonica

A known cassane‐type furanoditerpenoid, caesalpinista B ( 1 ), and a new diterpenoid, deoxycaesaljaponin A ( 2 ), were isolated from the cotyledons of Caesalpinia decapetala var. japonica. The previously reported configurational assignments of 1 and the related diterpenoid caesalpinista A ( 3 ) were revised on the basis of X‐ray crystallography and chemical conversion. The structure of 2 was elucidated by spectroscopic data and chemical conversion into 3 .     

Isolation of hemigossypol quinone from a cotton plant infected with wilt

Summary From the stems of the cotton plant infected with the fungusVerticillium dahliae Kleb. has been isolated a quinone derivative of hemigossypol — hemigossypolone — for which the structure 8-formyl-6,7-dihydroxy-5-isopropyl-3-methyl-1,4-naphthoquinone is proposed, and its fungitoxicity has been determined.Division of Bioorganic Chemistry of the Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 341–344, May–June, 1977.     

Spiramide,a New Diterpene Amide from the Roots of Spiraea japonica var.acuta

Previous chemical investigations on SPiraea j'aponica and its varieties have led to thereport of 7 new atisane-type diterpenoids' and 30 new diterpene alkaloids of atisine- andhetisine-ace'. The chemotaxonomy of S. japonica complex was proposed based onthose chemical data3. A hypothetical pathway of the biosynthesis of atisine-typealkaloids was suggested to be formed from diterpene directly tO the correspoedngalkaloids through double Mannich reactions (unpublished data). In order to search f…     

A new neolignan from the thorns of Gleditsia japonica var. delavayi

A new neolignan, 5-(3″-acetoxypropyl)-2-(4′-hydroxy-3′-methoxyphenyl)-7-methoxy-3-methylbenzofuran (1) along with nine analogues were isolated from the thorns of Gleditsia japonica var. delavayi by solvent extraction and repeated column chromatography. Their structures were elucidated by means of extensive spectroscopic analysis including 1D, 2D-NMR techniques and HR-ESIMS. All the isolates were reported for the first time from this species.     

Two New Diterpene Alkaloids from the Roots of Spiraea japonica var. Acuta

Spiraea japonica L. (Rosaceae) is widely distributed in Yunnan Provence, P. R. China. Previous chemical investigations on S. japonica and its varieties have led to the report of 7 new atisane-type diterpenoids and 38 new diterpene alkaloids of atisine- and hetisine-type1-11. This paper describes the isolation and structure elucidation of two new diterpene alkaloids named spiratines A and B (1-2). Their structures were elucidated on the basis of 1D and 2D NMR experiments (HMQC, HMBC, 1…     

Pterisemipol, a novel sesquiterpenoid from Pteris semipinnata L.

A novel sesquiterpenoid,pterisemipol,was isolated from Pteris semipinnata L.Its skeleton,namely pterisane,was considered to be rearranged from protoilludane and its structure was elucidated on the basis of spectroscopic analysis.     

A 60% Edible Ethanolic Extract of Ulmus davidiana Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis

As abnormal angiogenesis is associated with exacerbation of various diseases, precise control over angiogenesis is imperative. Vascular endothelial growth factor (VEGF), the most well-known angiogenic factor, binds to VEGF receptor (VEGFR), activates various signaling pathways, and mediates angiogenesis. Therefore, blocking the VEGF-induced angiogenic response-related signaling pathways may alleviate various disease symptoms through inhibition of angiogenesis. Ulmus davidiana is a safe natural product that has been traditionally consumed, but its effects on endothelial cells (ECs) and the underlying mechanism of action are unclear. In the present study, we focused on the effect of a 60% edible ethanolic extract of U. davidiana (U60E) on angiogenesis. U60E inhibited the VEGF-mediated proliferation, tube formation, and migration ability of ECs. Mechanistically, U60E inhibited endothelial nitric oxide synthase activation and nitric oxide production by blocking the protein kinase B signaling pathway activated by VEGF and consequently inhibiting proliferation, tube formation, and migration of ECs. These results suggest that U60E could be a potential and safe therapeutic agent capable of suppressing proangiogenic diseases by inhibiting VEGF-induced angiogenesis.     

Isolation of antibacterial diterpenoids from Cryptomeria japonica bark

The aims of the present study were to determine the antibacterial activity of bark extract of Cryptomeria japonica D. Don and to isolate potential antibacterial constituents. The results showed that the ethanolic extract of C. japonica bark possessed a good antibacterial activity. Nine compounds including seven diterpenoids (ferruginol (I), isopimaric acid (II), iguestol (III), isopimarol (IV), phyllocladan-16alpha-ol (V), sandaracopimarinol (VI) and sugiol (VII)) and two steroids (beta-sitosterol (VIII) and beta-sitostenone (IX)) were isolated from active subfractions; beta-sitostenone was isolated for the first time from this plant. Among these compounds, ferruginol possessed the strongest antibacterial activity and had MIC values ranging from 6.3 to 12.5 microg mL(-1) against all bacteria tested. Isopimaric acid was also an antibacterial natural product. Cryptomeria japonica bark extract and its diterpenoids, ferruginol and isopimaric acid, have the ability to inhibit the bacterial growth and can be used as the source for natural bactericides.     

Volvalerelactones A and B, two new sesquiterpenoid lactones with an unprecedented skeleton from Valeriana officinalis var. latifolia

Volvalerelactones A and B (1 and 2), two new sesquiterpenoid lactones with an unprecedented 3/7/6 tricyclic ring system, were isolated from the roots of Valeriana officinalis var. latifolia. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray diffraction crystallography, and the absolute configuration was assigned by computational methods. The possible biosynthetic pathways of 1 and 2 were also proposed.     

Composition and Anti-Inflammatory and Antioxidant Activity of Essential Oil from Aucuba japonica var. variegata

Chemistry of Natural Compounds -     

Isolation and Characterization of Anti-Inflammatory Chromones from Imperata cylindrica var. major

Chemistry of Natural Compounds - One new chromone, 5-hydroxy-8-O-β-D-glucopyranosyl-2-(2-phenylethyl)chromone (1), along with 13 known ones (2–14) were obtained and identified from a 70%...