Reaction of group 12 metal dihalides in ethanolic media with 2‐acetylpyridine 4N‐phenylthiosemicarbazone ( H4PL ) and 2‐acetylpyridine‐N‐oxide 4N‐phenylthiosemicarbazone ( H4PLO ) afforded the compounds [M(H4PL)X2] (X = Cl, Br, M = Zn, Cd, Hg; X = I, M = Zn, Cd) ( 1–8 ), [Hg(4PL)I]2 ( 9 ) and [M(H4PLO)X2] (X = Cl, Br, I, M = Zn, Cd, Hg) ( 10–18 ). H4PL , H4PLO and their complexes were characterized by elemental analysis and by IR and 1H and 13C NMR spectroscopy (and the cadmium complexes by 113Cd NMR spectroscopy), and H4PL , H4PLO , ( 5 · DMSO) and ( 9 ) were additionally studied by X‐ray diffraction. H4PL is N,N,S‐tridentate in all its complexes, including 9 , in which it is deprotonated, and H4PLO is in all cases O,N,S‐tridentate. In all the complexes, the metal atoms are pentacoordinate and the coordination polyhedra are redistorted tetragonal pyramids. In assays of antifungal activity against Aspergillus niger and Paecilomyces variotii, the only compound to show any activity was [Hg(H4PLO)I2] ( 18 ). 相似文献
New organotin(IV) complexes have been synthesized by treating potassium o‐isopropyl carbonodithioate with R2SnCl2/R3SnCl in 1 : 2/1 : 1 M/L ratio. All complexes have been characterized by IR and NMR (1H, 13C) spectroscopy. IR results shows that ligand acts as bidentate which is also confirmed by semi‐empirical study. NMR data reveals four coordinated geometry in solution. Computed positive heat of formation shows that complex 5 is thermodynamically unstable. UV/visible spectroscopy was used to assess the mode of interaction and binding of the complexes with DNA which shows that complex 5 exhibits higher binding constant as compared to complex 3 . In protein kinase inhibition assay, compound 3 was found most active, while other biological activities shows that triorganotin(IV) complexes are biologically more active as compared to diorganotin(IV) complexes. 相似文献
The six organotin complexes dibutyltin(IV) bis(heteroaromatic carboxylate) were synthesized by the reaction of (n‐Bu)2SnO with heteroaromatic carboxylic acid in 1:2 molar ratio. These complexes have been characterized by elemental analysis, IR, 1H, 13C and 119Sn NMR. The crystal structure of dibutyltin(IV) bis(2‐thiazolylcarboxylate) was determined by X‐ray single crystal diffraction. This compound is a weakly bridged dimer through weak interaction Sn···O between molecules. The tin atoms took six‐coordinate skew‐trapezoidal bipyramidal geometry. The crystal of complex 3 belongs to monoclinic symmetry with space group P21/c, a=1.863(2) nm, b=2.220(3) nm, c=1.0395(10) nm, β=90.275(16)°, Z=8, V=4.292(8) nm3, Dc=1.514 Mg/m3, μ=1.406 mm‐1, F(000)=1968, S=0.999, R=0.0549, wR=0.1011. 相似文献
Abstract Diorganotin(IV) complexes R2Sn(OC6H4Me-4)2 (R = Ph, Me, and n-Bu) have been synthesized in good yields by the reaction of Ph2SnCl2, n-Bu2SnCl2, and Me2SnCl2 with NaOC6H4Me-4, while complex n-Bu2SnCl(OC6H4Me-4) has been obtained from the reaction of n-Bu2SnCl2 with 4-methylphenol in the presence of triethylamine in carbon tetrachloride. The complexes have been characterized by elemental analyses, molar conductance measurements, molecular weight determination, IR, 1H, 13C, and 119Sn NMR spectroscopy as well as by mass spectrometry. The reactions of the complexes with 2- and 3-cyanoanilines yielded 1:2 coordination compounds authenticated by physicochemical as well as by IR, 1H, and 13C NMR spectroscopic data. The bases behaved as monodentate ligands wherein 2-cyanoaniline is bonded through nitrile nitrogen atom, while 3-cyanoaniline is coordinated through amino nitrogen atom. The diorganotin(IV) complexes have also been screened for their antibacterial activity against Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, Shigella flexneri, Proteus mirabilis, and Pseudomonas aeruginosa. The minimum inhibitory concentration values of these complexes show enhanced activity. [Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental resource: Scheme S1, S2, and Table S1] GRAPHICAL ABSTRACT相似文献
The preparation and structures of 2, 2′‐dihydroxyazobenzenato‐dibutyl‐tin [Bu2SnL] and 2, 2′‐dihydroxyazobenzenato‐dimethyl‐tin [Me2SnL] are described. The complexes were characterized by IR, NMR (1H, 13C, 119Sn) and UV/VIS spectra. The crystal structures were determined by X‐ray diffraction on single crystals. [Bu2SnL]: monoclinic, space group P21/c, cell constants at 208 K: a = 860.73(5), b = 973, 51(18), c = 2340.0(3) pm, β = 93.615(11)°; R1 = 0.0546. [Me2SnL]: orthorhombic, space group Pbcn, cell constants at 208 K: a = 1914.6(4), b = 1041.3(3), c = 1323.27(14) pm; R1 = 0.0529. 相似文献
Abstract The organotin(IV) complexes, SnPh2La (1), SnMe2La (2), SnBu2La (3), SnPh2Lb (4), SnMe2Lb (5), SnPh2Lc (6), SnMe2Lc (7), and SnBu2Lc (8) were obtained by reaction of SnR2Cl2 (R = Ph, Me, and Bu) with 1-(5-bromo-2-hydroxybenzylidene)-4-phenylthiosemicarbazide (H2La), 1-((2-hydroxynaphthalen-1-yl)methylene)-4-phenylthiosemicarbazide (H2Lb), and 1-(2-hydroxy-3-methoxybenzylidene)-4-phenylthiosemicarbazide (H2Lc). The synthesized complexes have been investigated by elemental analysis, IR, 1H NMR, and 119Sn NMR spectroscopy. The data show that the thiosemicarbazone acts as a tridentate dianionic ligand and coordinates via the thiol group, imine nitrogen, and phenolic oxygen. The coordination number of tin is 5. The in vitro antibacterial activities of the ligands and their complexes have been evaluated against Gram-positive (Bacillus subtilis and Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria and compared with the standard antibacterial drugs. [Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the following free supplemental files: Additional figures and tables] 相似文献
Surrounded by six : A series of novel neutral hexacoordinate silicon(IV ) complexes with SiO2N4 skeletons, containing two bidentate monoanionic O,N ligands and two monoanionic NCX (X = O, S) ligands, was synthesized. The formation of the title compounds involved some unexpected transformations of the bidentate O,N ligands.
Reactions of aquapentachloroplatinic acid, (H3O)[PtCl5(H2O)]·2(18C6)·6H2O ( 1 ) (18C6 = 18‐crown‐6), and H2[PtCl6]·6H2O ( 2 ) with heterocyclic N, N donors (2, 2′‐bipyridine, bpy; 4, 4′‐di‐tert‐butyl‐2, 2′‐bipyridine, tBu2bpy; 1, 10‐phenanthroline, phen; 4, 7‐diphenyl‐1, 10‐phenanthroline, Ph2phen; 2, 2′‐bipyrimidine, bpym) afforded with ligand substitution platinum(IV) complexes [PtCl4(N∩N)] (N∩N = bpy, 3a ; tBu2bpy, 3b ; Ph2phen, 5 ; bpym, 7 ) and/or with protonation of N, N donor yielding (R2phenH)2[PtCl6] (R = H, 4a ; Ph, 4b ) and (bpymH)+ ( 8 ). With UV irradiation Ph2phen and bpym reacted with reduction yielding platinum(II) complexes [PtCl2(N∩N)] (N∩N = Ph2phen, 6 ; bpym, 9 ). Identities of all complexes were established by microanalysis as well as by NMR (1H, 13C, 195Pt) and IR spectroscopic investigations. Molecular structures of [PtCl4(bpym)]·MeOH ( 7 ) and [PtCl2(Ph2phen)] ( 6 ) were determined by X‐ray diffraction analyses. Differences in reactivity of bpy/bpym and phen ligands are discussed in terms of calculated structures of complexes [PtCl5(N∩N)]— with monodentately bound N, N ligands (N∩N = bpy, 10a ; phen, 10b ; bpym, 10c ). 相似文献
Oxovanadium(IV) complexes of Schiff bases, derived from 2-amino-4-phenyl thiazole/substituted 2-amino-4-phenyl thiazoles and thiophene-2-aldehyde have been synthesized and characterized on the basis of elemental analysis, molar conductance measurements, magnetic susceptibility data, and UV-visible, and IR spectral studies. All the complexes are monomeric possessing a 1:2 (metal:ligand) stoichiometry. On the basis of these data, a square pyramidal geometry has been assigned for the complexes. A few complexes have been subjected to thermal decomposition studies. The ligands and their metal complexes have been screened for their antibacterial activities. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. 相似文献
Two rare metal coordination complexes of yttrium(III) including 1,10‐phenanthroline, Y(phen)2(NO3)3 and (phenH)2[Y2(pydc)3(NO3)2·6H2O] (phen=1,10‐phenanthroline, pydc=2,6‐pyridinedicarboxylate), and a proton transfer compound (phenH+)2(pydc2?) were synthesized and characterized by elemental analysis, molar conductance, infrared spectra (IR), nuclear magnetic resonance (NMR) and thermal analysis. The proposed structures of yttrium complexes were exhibited. The in vitro biological activities of the newly synthesized complexes have also been investigated against Bacillus coli, Staphylococcus aureus and Candida albicans. The results showed that yttrium(III) complexes including 1,10‐phenanthroline exhibited better antibacterial/antifungal activity than their ligands and corresponding compounds. 相似文献
The preparation of oxovanadium(IV, V) coordination compounds with 2‐acetylpyridine‐2‐furanoylhydrazone (Hapf) is described. [VO(apf)(acac)] was prepared from oxovanadium(IV) diacetylacetonate [VO(acac)2] by reaction with Hapf in methanol or dichloromethane. The complex is paramagnetic and its EPR spectrum is consistent with an octahedral coordination for the vanadium(IV) atom. Voltammetry studies of [VO(apf)(acac)] indicate an irreversible oxidation, in agreement with the chemical behavior of the compound in solution. The vanadium(IV) complex undergoes slow oxidation in alcoholic solution, losing the acetylacetonate ligand to form [VO2(apf)] and [V2O2(μ‐O)2(apf)2]. The crystal structures of these last compounds were determined by X‐ray diffraction methods. [V2O2(μ‐O)2(apf)2] crystallizes monoclinic [P21/c, Z = 2, a = 817.400(10), b = 1650.90(3), c = 984.70(2) pm, β = 112.7190(10)°]. The crystal structure consists of dimeric units, in which two μ‐oxo ligands subtend asymmetric bridges between the vanadium atoms in a very distorted octahedral coordination. In the crystal of [VO2(apf)], orthorhombic [Pnma, Z = 4, a = 1630.000(10), b = 675.10(4), c = 1136.40(2) pm], the vanadium(V) atom is pentacoordinated. 相似文献
This research describes the utility of 4‐(4‐bromophenyl)‐4‐oxobut‐2‐enoic acid as a key starting material for preparation of a novel series of aroylacrylic acids, pyridazinones, and furanones derivatives. These heterocyclic compounds were synthesized by reaction of 4‐(4‐bromophenyl)‐4‐oxobut‐2‐enoic acid with benzimidazole, ethyl glycinate hydrochloride, anthranilic acid and o‐phenylenediamine under Aza–Michael addition conditions. Every Aza–Michael adduct was allowed to react with haydrazine hydrate and acetic anhydride to form pyridazinones and furanones derivatives, respectively. In further step, some pyridazinones were allowed to react with ethyl acetoacetate, acetyl acetone, acetyl chloride, and aromatic aldehydes to form novel heterocylces. Finally, studying antibacterial activities of these compounds was performed. 相似文献
Electrochemical oxidation of cadmium in an acetonitrile solution of N‐2‐pyridyl‐sulfonamides (HL) afforded cadmium coordination compounds of composition [CdL2]. Heteroleptic complexes of composition [CdL2L′] (L′ = 2, 2′‐bipyridine or 1, 10‐phenanthroline) were obtained when the coligand L′ was added to the electrolytic phase. The crystal structures of several compounds have been determined by X‐ray diffraction. In all cases the cadmium atom is hexacoordinated, but the coordinative behaviour of the N‐2‐pyridyl‐sulfonamide ligand depends on the location of the substituents in the pyridyl ring. When the substituent is in position 3, the ligands act as N, O‐donors. In all other cases, the ligands act as N, N′‐bidentate systems. 相似文献
The cationic complexes with hexacoordinate silicon(IV), tris[1‐oxopyridine‐2‐olato(1–)]silicon(IV) trifluoromethanesulfonate ( 4 ), 4 · 1/2 C5H5NO2, tris[1‐oxopyridine‐2‐olato(1–)]silicon(IV) ethyl sulfate–ethanol ( 5 · EtOH), and tris[1‐oxopyridine‐2‐olato(1–)]silicon(IV) isopropyl sulfate ( 6 ), were synthesized. The identities of 4 , 4 · 1/2 C5H5NO2, 5 · EtOH, and 6 were established by elemental analyses (C, H, N, S), mass‐spectrometric studies (FAB MS) as well as solid‐state (29Si) and solution (1H, 13C, 19F, 29Si) NMR experiments. In addition, 4 · 1/2 C5H5NO2 was structurally characterized by single‐crystal X‐ray diffraction. 相似文献
Di‐ and triorganotin(IV) carboxylates, RnSn(OCOC(R2)=CHR1)4–n (n = 2 and 3; R = Me, Et, n‐Bu, Ph; R1 = 3‐CH3O‐4‐OHC6H3, R2 = C6H5) were prepared by reacting the corresponding organotin(IV) chloride with the silver salt of the (E)‐3‐(4‐hydroxy‐3‐methoxyphenyl)‐2‐phenylpropenoic acid. The title compounds were investigated and characterized by elemental analysis, infrared (FT‐IR), multinuclear (1H, 13C, 119Sn) NMR, and mass spectrometry, and possible structures were proposed. The complexes and ligand acid ( HL ) have been evaluated in vitro against various bacteria and fungi. The results noticed during the biocidal activity screenings proved their in vitro biological potential. They were also tested for cytotoxicity. 相似文献
In the title complex, [RuCl2(C7H7NO)(C2H6OS)2], the metal ion is at the centre of a distorted octahedral NOCl2S2 coordination sphere. The neutral 2‐acetylpyridine ligand binds to the metal ion through the pyridine N and carbonyl O atoms, forming a five‐membered chelate ring. The monodentate S‐coordinating dimethyl sulfoxide molecules are mutually cis, and the two remaining positions in the coordination sphere are occupied by two mutually trans Cl? ions. 相似文献
A series of novel thiazolidinones, that is, 2‐(2‐hydroxy‐5‐((aryl)‐diazenyl)phenyl)‐3‐(4‐hydroxyphenyl)‐thiazolidin‐4‐one, have been synthesized by reaction of various Schiff bases 2‐(4‐hydroxyphenylimino)methyl)‐4‐(aryl)diazenyl)phenol with ethanolic thioglycolic acid. Schiff bases were obtained by the reactions of 4‐amino phenol with 2‐hydroxy‐5‐((aryl)diazenyl)benzaldehyde. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR, mass spectra, and C, H, N elemental analysis. The thiazolidinone derivatives were evaluated for their antibacterial and antifungal activity. 相似文献