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1.
Bingru Ren Bing Xia Weilin Li Julan Wu Hanqing Zhang 《Chemistry of Natural Compounds》2009,45(2):182-186
Two new phenolic compounds, 4-O-β-D-(6-O-gentisoylglucopyranosyl) vanillic acid (1), 2-O-β-D-(6-O-gentisoylglucopyranosyl) gentisic acid (2), together with three known compounds, vanillic acid (3), syringic acid (4), and gentisic acid (5), were isolated from the whole part of Stenoloma chusanum (L.) Ching. Structures of the two new compounds 1, 2 were elucidated on the basis of spectroscopic methods, including twodimensional NMR techniques and HR ESI-MS analysis. The
compounds′ activities against Candida albicans, Cryptococcus neoformans, Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis, Epidermophyton floccosum, and Aspergillus niger were determined, and the minimal inhibitory concentrations (MIC) were 25–100 μg/mL.
Published in Khimiya Prirodnykh Soedinenii, No. 2, pp. 161–164, March–April, 2009. 相似文献
2.
A new bicyclo[3.2.1]octanoid neolignan rel-(7S,8R,1′S,2′R,3′S)-Δ8′-2′-hydroxy-5,1′,3′-trimethoxy-3,4methylenedioxy-7,3′,8,1′-neolignan (1) was isolated from ethanol extract from the fruit of Ocotea heterochroma Mez & Sodiro ex Mez as well as the known compounds β-friedelanol (2), meso-dehydroguaiaretic acid (3), and yangambin (4), whose structures were elucidated on the basis of their comprehensive spectroscopic analysis including 2D NMR data. Lethality
bioassay using brine shrimp (Artemia salina Leach) was evaluated with the ethanol extract from the Ocotea heterochroma’s fruit. The toxicity of this extract was greater than the toxicity of those fractions obtained in a first solvent partition
(benzene, ethyl acetate, and butanol subfractions) and that of a mixture of acetylated 2′-epimers from the new neolignan 1.
Published in Khimiya Prirodnykh Soedinenii, No. 2, pp. 158–160, March–April, 2009. 相似文献
3.
Guan-E Yang Wei Li Chao Huang Lin Lin Qingbo Zhang Kazuo Koike 《Chemistry of Natural Compounds》2011,46(6):876-879
A new phenolic glycoside was isolated from the stems of Acanthopanax senticosus together with sixteen known compounds. The structure of the new compound was determined to be 2,6-dimethoxy-4-[(1E)-3,3-dimethoxy-1-propenyl]phenyl β-D-glucopyranoside (1) by means of physical, chemical, and spectroscopic methods. Of the known compounds, salvadoraside (7), (7R,8S)-dihydrodehydrodiconiferyl alcohol 4,9′-di-O-β-D-glucopyranoside (8), 3-(4-O-β-D-glucopyranosylferuloyl)quinic acid (15), rel-5-(1R,5S-dimethyl-3R,4R,8S-trihydroxy-7-oxa-6-oxobicyclo[3,2,1]oct-8-yl)-3-methyl-2Z,4E-pentadienoic acid (16), and lycoperodine-l (17) were first reported from the title plant. The inhibitory activities of the isolated compounds against α-glucosidase from rat intestine were also reported. 相似文献
4.
Zhihui Xiao Fazuo Wang Hao Yin Aijun Sun Chuanrong Li Qingxin Li Si Zhang 《Chemistry of Natural Compounds》2012,48(4):565-567
A new flavanone glycoside, (2S)5,7,4′-trihydroxyflavanone-8-C-β-D-(6″-O-acetyl)glucopyranoside (1), together with six known flavonoids, isohemiphloin (2), vitexin (3), cirsimaritin (4), hispidulin (5), apigenin (6), and eupatorin (7), was isolated from the leaves and stems of Abrus precatorius. Their structures were elucidated on the basis of physical and spectral analysis. Rotamers exist for compounds 1, 2, and 3. Compounds 1–3, 6, and 7 were isolated from this plant for the first time. 相似文献
5.
The extract of Casimiroa edulis was investigated for antihypertensive activity. The ethanol and total alkaloids (in chloroform) extracts were found to have
antihypertensive properties at doses of 500 and 200 mg/kg, respectively. Four quinolinone alkaloids were isolated and identified
as: 2-(2′-hydroxy-4′-methoxyphenyl)-5,8-dimethoxy-3-propyl-1H-quinolin-4-one (1), 5,8-dimethoxy-2-(3′-methoxyphenyl)-3-propyl-1H-quinolin-4-one (2), 5,8-dimethoxy-2-(3′,4′-dimethoxyphenyl)-3-propyl-1H-quinolin-4-one (3), and 5,6-dimethoxy-2-(2′,5′,6′-trimethoxyphenyl)-1H-quinolin-4-one (4). Interestingly, compounds 1, 2, and 3 were found to be new alkaloids. The four isolated alkaloids showed antihypertensive activity at doses of 50, 100, 200, and
300 mg/kg, respectively.
Published in Khimiya Prirodnykh Soedinenii, No. 5, pp. 473–476, September–October, 2007. 相似文献
6.
New substituted anilides of the heterocyclic series 2, 4, 5, 6, 7 together with the earlier described compounds 1 and 3 (Jarak I et al. (2005) J Med Chem 48:2346), were synthesized from the corresponding heterocyclic carbonyl chlorides, methoxycarbonyl-
and cyano-substituted anilines. Compounds 2 and 7 were prepared by methylation with methyl-iodide on the amide and the pyridine nitrogen. The Pinner reaction was used in the
preparations of amidino-substituted compounds. It seems that all the prepared compounds could be biologically interesting,
especially amidino-substituted anilides prepared in the form of water-soluble hydrochlorides or hydroiodides.
Molecular and crystal structures of the three compounds, namely, 4′-methoxycarbonyl-N-phenyl-3-chlorobenzo[b]thiophene-2-carboxamide (1), N-(4′-amidinophenyl)-3-chlorobenzo[b]thiophene-2-carboxamide hydrochloride monohydrate (4) and 1-methyl-N-(4-amidinophenyl)-3-pyridine carboxamide iodide hydroiodide (7) have been determined by X-ray single-crystal diffractometry in the solid state. Compounds 1, 4 and 7 are not planar and the amide group (C=O in relation to NH group) is in trans position in all three compounds. The 3-chlorobenzo[b]thiophene moiety in 1 and 4 is oriented with the chloro substituent in cis position in relation to amide NH group. The conformational characteristics of the compounds result from the introduction
of different substituents or solvent molecules (water molecule in 4), which leads to various intermolecular hydrogen bonds formation (N–H⋯O, N–H⋯Cl, O–H⋯Cl−, N–H⋯I−) in 1, 4 and 7. Hydrogen bond formation could be responsible for the potential biological activity of the compounds. 相似文献
7.
Zhiping Wu Yu Chen Xu Feng Bing Xia Ming Wang Yunfa Dong 《Chemistry of Natural Compounds》2009,45(6):829-833
Two new ceramides were isolated from the bulbs of Zephyranthes candida. Their structures were established as (2S,3S,4R,13E)-1,3,4-trihydroxy-2-[(2′R)-2′-hydroxytetracosanoylamino]-13-octadecene, named zephyranamide A (1) and (2S,3S,4R)-1,3,4-trihydroxy-2-octacosanoylaminohexadecene, named zephyranamide B (2). The structures of the new compounds were elucidated by spectral techniques including 1H NMR, 13C NMR, as well as HSQC, HMBC, DEPT, and COSY. 相似文献
8.
You-Min Ying Zha-Jun Zhan Zhi-Shan Ding Wei-Guang Shan 《Chemistry of Natural Compounds》2011,47(4):541-544
A chemical study of metabolites of the strain Penicillium sp. P-1, an endophyte from the stems of Huperzia serrata, furnished a new chromone derivative, (2S)-2,3-dihydro-7-hydroxy-6,8-dimethyl-2-[(E)-prop-1-enyl]- chroman-4-one (1), an enantiomer of a known compound, and seven known compounds 2–8. The structure and absolute configuration of 1 were established using spectroscopic methods, including extensive 2D NMR and CD analyses. Cytotoxic activity of compounds
1–3 against HeLa and HepG2 cell lines were evaluated, in which compounds 2 and 3 exhibited marked cytotoxic activity against HeLa cells. 相似文献
9.
Seon-Mi Seo Hak-Ju Lee Oh-Kyu Lee Hyun-Jin Jo Ha-Young Kang Don-Ha Choi Ki-Hyon Paik M. Khan 《Chemistry of Natural Compounds》2008,44(4):419-423
A new furofuran lignan (1) along with four knownones (2-5) were isolated from the bark of Magnolia kobus. Their structures were elucidated as (+)-2α-(3’,4’-dimethoxyphenyl)-6α-(3″-hydroxy-4″,5″-dimethoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane
(1), (+)-sesamin (2), (+)-yangambin (3), (+)-kobusin (4), and (+)-eudesmin (5) on the basis of their comprehensive spectroscopic analysis, including 2D NMR, and by comparison of their spectral data with
those of related compounds.
Published in Khimiya Prirodnykh Soedinenii, No. 4, pp. 338–341, July–August, 2008. 相似文献
10.
I. M. Chung H. Y. Park S. C. Chun J. J. Kim A. Ahmad 《Chemistry of Natural Compounds》2007,43(4):417-421
Three new compounds, 4-hydroxymethylene-7-(9,9,13-trimethylcyclohexyl)-heptanyl-3′,7′,7′-trimethylcyclohexa-2′,4′-dien-1′-oate
(1), 1-(n-hexadec-7-enoxy)-6-(n-octadecanoxy)-β-D-glucopyranoside (2), and (Z)-12-hydroxy-9-octadecenoic acid-12-β-D-glucopyranoside (3), along with the known compound hexacosanoic acid (4), were isolated and identified from the rice hulls of Oryza sativa. Their structures were elucidated by 1D and 2D NMR spectroscopic techniques (1H-1H COSY, 1H-13C HETCOR, DEPT) aided by EIMS, FABMS, HRFABMS, and IR spectra.
Published in Khimiya Prirodnykh Soedinenii, No. 4, pp. 344–347, July–August, 2007. 相似文献
11.
A new eudesmane-type sesquiterpenoid, 3β-caffeoxyl-1β,8α-dihydroxyeudesm-4(15)-ene (1), together with two known compounds including ludongnin V (2) and isoneorautenol (3), were isolated from the roots of Pteris multifida. Their structures were determined by spectral and chemical methods, with their antibacterial activities being evaluated by
the microdilution technique, respectively.
Published in Khimiya Prirodnykh Soedinenii, No. 1, pp. 41–43, January–February, 2009. 相似文献
12.
Madalina Tudose Florin D. Badea Gabriela Ionita Maria Maganu Miron T. Caproiu Petre Ionita Titus Constantinescu Alexandru T. Balaban 《Structural chemistry》2010,21(6):1227-1234
Starting from 4-chloro-3,5-dinitrobenzoic acid 1, compounds 2–10 (N-alkoxy-3,5-dinitro-4-aminobenzoic acid esters where alkoxy stands for methoxy, carboxymethoxy, triphenylmethoxy, or corresponding
amides) have been obtained, from which compounds 3–5 and 7–10 are new, and for the known compounds 2 and 6 the synthetic procedure has been improved. The new derivatives have been characterized by appropriate means (IR, UV–Vis,
1H- and 13C-NMR, fluorescence) and their properties were studied. Thus, depending on their structure, the compounds have acid properties,
fluorescence and complexing properties with alkaline cations. 相似文献
13.
A new cerebrogalactoside, Juglans cerebroside A (1), together with five known compounds, quercetin-3-O-β-D-galactopyranoside (2), myricetin-3-O-β-D-galactopyranoside (3), 2″E-quercetin-3-O-β-D-(6″″-O-[3″(4′″-hydroxyphenyl) propylene acyl]) glucopyranoside (4), gallic acid (5), and 2-methyl-1-hexadecanol (6) were isolated from the leaves of Juglans mandshurica Maxim. The structures of these compounds were determined by 1D, 2D
NMR, and MS techniques. 相似文献
14.
Xiao-Jiang Zhou Xue-Song Li Ying Shen Gang Pei Jun-Feng Wang Yong-Xian Cheng 《Chemistry of Natural Compounds》2012,48(3):419-422
Investigations on the EtOH extract of Cucumis sativus roots led to the isolation of 15 compounds (1–15). Their structures were identified using spectroscopic methods. Among these compounds, compound 1, stigmasta-8(14),22-diene-7α-methoxy-3β-ol, is a new steroid, and 2, 4–15 were isolated from this plant for the first time. 相似文献
15.
Summary. The two new compounds Mn(dien)2[MoS4] (1) and Mn(dien)2[Mo2O2S6] (2) (dien = diethylenetriamine) were prepared under solvothermal conditions. Both compounds were obtained as phase-pure products. The
structures consist of new [Mn(dien)2]2+ cations and isolated tetrahedral [MoS4]2− (1) or [Mo2O2S6]2− (2) anions. Between the anions and the cations, hydrogen bonding is observed. Compound 1 crystallizes in the tetragonal space group I (a = 10.219(2), c = 9.259(2) ?, Z = 2), whereas 2 crystallizes in the monoclinic space group P21/c (a = 8.703(2), b = 18.390(4), c = 14.603(3) ?, β = 103.18(3)°, Z = 4). The thermal behaviour of the thiomolybdates was investigated using difference thermoanalysis (DTA) and thermogravimetry
(TG). Both compounds decompose under argon with a single endothermic signal in the DTA curve (peak maximum: 252 (1) and 242°C (2)).
Received November 5, 2001. Accepted December 27, 2001 相似文献
16.
Hua Tang Zeng-lei Wang Hong-jun Zhang Ping Cheng Shu-juan Piao Wan-sheng Chen Hou-wen Lin Hai-feng Tang 《Chemistry of Natural Compounds》2010,46(3):390-392
One new compound, 3β-hydroxy-25-methoxy-(23E)-cholesta-5,23-diene (1), together with five known steroids, cholesteryl myristate (2), cholest-4-en-3-one (3), cholesterol (4), 3β,5α,9α-trihydroxy-(22E,24R)-ergosta7,22-dien-6-one (5), and 3β,5α,6β-trihydroxy-(22E,24R)-ergosta-7,22-diene (6), were isolated and identified from the marine bryozoan Bugula neritina. 相似文献
17.
Shao-peng Wei Jie-yu Luan Zhi-qin Ji Bao-jun Shi Min Xu Ji-wen Zhang 《Chemistry of Natural Compounds》2012,47(6):906-910
Two new antitumor sesquiterpene polyol esters with the β-dihydroagarofuran skeleton, 1 and 2, and three known compounds 3–5 were isolated from the high-polar MeOH extracts of the root bark of Celastrus angulatus. Their chemical structures were elucidated mainly by analyses of MS and NMR spectral data. Preliminary antitumor and insecticidal
activities of these compounds were evaluated. Compounds 1 and 2 exhibited moderate antitumor activity against human breast cancer cell line (Bcap-37); the IC50 were 54.08 and 61.35 μM,
respectively, and all the tested compounds were shown to possess minimal or no inhibitory activities against human colon (HT-29)
and lung (NCI-H460) cancer cell lines. In addition, compounds 1–5 displayed mild insecticidal activities against the 4th instar larvae Mythimna separate, the KD50 were 610.5, 308.8, 917.8, 510.6 and 1120.5, respectively. 相似文献
18.
M. A. Tantray A. S. Shawl B. S. Arora B. Purinima K. Ahmad M. A. Khuroo 《Chemistry of Natural Compounds》2009,45(3):377-380
Three new glutinane-type triterpenes, 19α-glutin-5-en-19-ol (1), 2β,15α,21β-glutin-11-ene-2,15,21-triol (2), and 2β,19α-glutin-7,21-diene-2,19-diol (3), were isolated from the stem bark of Euonymus hamiltonianus. Their structures were determined by 1D and 2D NMR along with MS and IR.
Published in Khimiya Prirodnykh Soedinenii, No. 3, pp. 321–323, May–June, 2009. 相似文献
19.
Ellagic acid derivatives from the stem bark of <Emphasis Type="Italic">Dipentodon sinicus</Emphasis>
Ellagic acid derivatives were isolated from Dipentodon sinicus and their structures were identified as 3,3′,4′-tri-O-methylellagic acid (1), 3,3′-di-O-methylellagic acid (2), 4,4′-di-O-methylellagic acid (3), 3,3′-di-O-methylellagic acid-4′-O-α-L-rhamnopyranoside (4), 3,3′,4′-tri-O-methylellagic acid-4′-O-β-D-glucopyranoside (5), 3,3′-di-O-methylellagic acid-4′-O-β-D-glucopyranoside (6), and ellagic acid (7). All the compounds were isolated for the first time from the title plant.
Published in Khimiya Prirodnykh Soedinenii, No. 2, pp. 106–107, March–April, 2007. 相似文献
20.
Two new lignans were isolated with two other known compounds, eusiderin A and eusiderin I, from Eusideroxylon zwageri (billian). The two new lignans have isomeric structure. The structures of the new lignans were determined to be (2R,3R,4S)-2,3-dimethyl-6,7-dimethoxy-4-ethoxy (3′,4′,5′-trimethoxybenzene)-1,5-dihydroxytetralin and (2R,3S,4S)-2,3-dimethyl-6,7-dimethoxy-4-ethoxy(3′,4′,5′-trimethoxybenzene)-1,5-dihydroxytetralin.
Published in Khimiya Prirodnykh Soedinenii, No. 3, pp. 303–305, May–June, 2009. 相似文献