The Synthesis of Polyfluoroalkylbiphenyl

Polyfluoroalkylated biphenyl was obtained from reaction of benzene with R_FI/Na_2S_2O_4 using cetyltrimethylammonium bromide (CTAB) as PTC followed by dehydrogenation with DDQ in 38-43% yield.     

The Synthesis of Glycoglycerolipids

A convenient synthetic route was developed for the synthesis of the novel glycolipids: 1,2-di-O-acyl-3-O-(2‘-acylamide-2‘-denxy-ct-D-glucopyranosyl)-sn-glycerols. 10 new compounds of glycolipids with different acyl groups were obtained.     

Synthesis of Tetracycline Analogues and Test of Their Affinity of Synthetic Hydroxyapatite

Eight of new 5-oxo[1] benzopyrano [2,3-b] pyridines as the analogues of tetracycline, were designed and synthesized, and their affinity to the hydroxyapatite-the inorganic composition of bone were tested.     

The Stereoselective Synthesis of Indoloquinolizines

Carboline was reduced with lithium aluminum hydride to provide carboline-alcohol whichreacted with methyl vinyl ketone to form the corresponding hydroxymethyl-amino-ketone. Underphase transfer condition it can be converted into enantiomerically pure indoloquinolizines. The cycliza-tion mechanism was also illustrated here.     

Synthesis of Tetracycline Analogues and Test of Their Affinity on Synthetic Hydroxyapatite

To develop bone target drugs is an attractive field for increasing the potency and selectivity of these drugs in the treatment of osteoporosis and Pagets disease etc. As known, after systematic administration tetracycline can be distributed in bone and bind to hydroxyapatite with high affinity1. Thus we tried to use tetracycline as a bone targeted carrier. However, tetracycline is less stable, and its complex structure bring much difficulty in the coupling reaction and purification of the p…     

The Total Synthesis of 14—Deoxycrassin and Pseudoplexaurol：A Convergent Synthesis of Cyclization Precursor

The synthesis of epoxy aldehyde 4, a cyclization precursor for the total synthesis of 14-deoxycrassin and pseudoplexaurol,starting from geraniol in a convergent and stereoselective manner, is described.     

The World of Synthetic Polymers. An Industrial Perspective

Synthetic polymers have become the building block in almost every aspects of our daily life. Billions of pounds of polymers are produced each year and the demand is continuously growing both in terms of volume and advanced performance. The general property of a class of polymers is often bounded by the synthetic process that produces the polymer. For example, polyolefins, are non-polar polymers due to the poor tolerance of transition metal catalysts toward polar monomers. Conversely, latices a…     

The Synthesis of Cyclotriphosphazene Liquid Crystals

Generally,thermotropicliquidcrystalsareconstructedoforganiccomPoundsofanisotropicshaPe.Inthesearchfornewmoleculardesignsformesogensoforiginalshapes,onecanroughlyfollowtwodirections.Thefirstideaistovarythenumberofalkylchainsgraftedaroundagivencore.Thesecondideaofshapemodificationconsistsintheformationofclustersofafewidenticalmesogens,generallyatwin.Accordingtothesetwoideas,manynewkindsofliquidcrystalshavebeensysthesized.Hexakis(4-(4'-alkoxy)biphenoxy)cyclotriphosphazeneswerethemostinteresting…     

The Synthesis of a Novel Lignan

Lignans have attracted much interest over the years on account of their widespread ocurrence in nature1, and on account of their broad range of biological activity2. Thus, several lignans are known to exhibit anti-tumor activity3-7, while others function as growth inhibitors and antifungal agents8,9. The importance is the isolation of lignans from animals, including human beings10-12, which has led to the suggestion that such compounds may be an example of a novel class of hormone controlling …     

The Synthesis of Bridged Purine Dinucleoside

Nuc1eosides/tideswithmodificahonareofinterestinconnectionwiththeirpossiblebiologicalactivity,somemodifiedpurinederivativeshavelicensedforantiviraltheraPeuticagentSsuchasAIa-A,cyc1ardin,6-deoxyaCyclovir,acylovir,DHPHandDHBEI1].Duringrecenyears,greatattentionhasbeenfocusedonseveralderivahvesof2,6-diaminoTdrie,andsomederivativeshaveshowedanhviralachvityagainstHIVl231.lnthispaPer,wewishtorePortthesynthesisofthebridgedpurinedinudeosidesinfollowingroute(schemel).Thesynthesis0ftargetc0mPounds…     

The Synthesis of Cyclic Amino Acids

Several cyclic amino acids (1-4) were synthesized from glycine. Isocyanate ester was prepared as the key intermediate and reacted with dibromoalkanes to afford the target compounds.     

The Synthesis of Star Style Metaloporphyrin

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The Synthesis of Third—order Optical Nonlinear Organic Polyheterocyclic Materials

Synthesis of the third-order nonlinear materials:bis (1,4-dihydroxynaphthalene) tetrathiafulvalene and bis (1,4-dialkoxylnaphthalene) tetrathiafulvalene has been achieved in four steps, starting from 2,3-dichloro-1,4-naphthaquinone. The materials exhibit larger third-order nonlinear optical susceptibilities χ.     

The Synthesis of a Series of Phosphoryl Coumarins

Different hydroxy substituted coumarins were successfully phosphorylated with diisopropylphophite （DIPPH） by the Atherton-Todd reaction in 76-89% yields. Moreover, the reaction activities of different hydroxys of the coumarins in the Atherton-Todd reaction were studied.     

The Synthesis of 2-Cyanomethylbenzaldehyde—Useful Substrate for Construction of Fused Ring Compounds

Abstract

The title compound 4 has been prepared by four-step synthesis starting from methylaminoacetonitrile hydrochloride (5) and α-cyanobenzyl benzenesulfonate (6), in good yield.     

Synthetic Potential of Fucosyltransferase III for the Synthesis of Fluorescent‐labeled Milk Oligosaccharides

Various fundamental biologic roles of milk oligosaccharides have been recognized; however, their structure‐affinity relationship is still not fully revealed. Herein, we describe the synthesis of the fluorescent‐labeled milk oligosaccharides 3‐(5‐dimethylaminonaphthalene‐1‐sulfonylamino)propyl β‐D‐galactopyranosyl‐(1→3)‐[α‐L‐fucopyranosyl‐(1→4)]‐2‐acetamido‐2‐deoxy‐β‐D‐glucopyranoside (1) and 3‐(5‐dimethylamino‐naphthalene‐1‐sulfonylamino)propyl β‐D‐galactopyranosyl‐(1→3)‐[α‐L‐fucopyranosyl‐(1→4)]‐β‐D-glucopyranoside (2) as useful tools for synthetic, analytic, and biologic applications. For the fucosylation of lactose and lacto‐N‐biose, the chemical and the enzymatic syntheses using fucosyltransferase III were compared.     

A Stereoselective Synthesis of (±) Exobrevicomin; Synthetic Applications of Gamma-Alkoxy Allylboronates

A synthesis of the naturally occurring bicyclic acetal, “exobrevicomin” is described. The requisite threo stereochemistry of keto diol precursors is obtained selectively by condensation of a gamma-alkoxy allylboronate with an appropriate aldehyde.     

The Rapid Synthesis of Schiff—Base withou Solvent under Microwave Irradiation

A microwave-assisted preparation of a series of Schiff-base via efficient condensation of salicylaldehyde and aryl amines without solvent is described in high yield as well as environmental friendship reaction in organic synthesis.