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Dr. Sachin Handa Prof. Dr. Martin P. Andersson Dr. Fabrice Gallou Dr. John Reilly Prof. Dr. Bruce H. Lipshutz 《Angewandte Chemie (International ed. in English)》2016,55(16):4914-4918
The new monophosphine ligand HandaPhos has been identified such that when complexed in a 1:1 ratio with Pd(OAc)2, enables Pd‐catalyzed cross‐couplings to be run using ≤1000 ppm of this pre‐catalyst. Applications to Suzuki–Miyaura reactions involving highly funtionalized reaction partners are demonstrated, all run using environmentally benign nanoreactors in water at ambient temperatures. Comparisons with existing state‐of‐the‐art ligands and catalysts are discussed herein. 相似文献
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Cover Picture: HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium‐Catalyzed Cross‐Couplings in Water at Room Temperature (Angew. Chem. Int. Ed. 16/2016) 下载免费PDF全文
Dr. Sachin Handa Prof. Dr. Martin P. Andersson Dr. Fabrice Gallou Dr. John Reilly Prof. Dr. Bruce H. Lipshutz 《Angewandte Chemie (International ed. in English)》2016,55(16):4839-4839
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《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2018,130(30):9596-9599
The homocoupling of aryl halides and the heterocoupling of aryl halides with either aryl bromides or arenes bearing an ortho‐lithiation directing group are presented. The use of a Pd catalyst, in combination with t‐BuLi, allows for the rapid and efficient formation of a wide range of polyaromatic compounds in a one pot procedure bypassing the need for the separate preformation of an organometallic coupling partner. These polyaromatic structures are obtained in high yields, in 10 min at room temperature, with minimal waste generation (E‐factors as low as 1.5) and without the need for strict inert conditions, making this process highly efficient and practical in comparison to classical methods. As illustration, several key intermediates of widely used BINOL‐derived structures are readily prepared. 相似文献
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