Synthesis and properties of 2-isopropyl-3-aryl-4-quinazolones

A number of N-isobutyrylanthranilic acid arylamides (I) were obtained. Under the influence of phosphorus trichloride, I are cyclized to 2-isopropyl-3-aryl-4-quinazolones. The UV and IR spectra and biological activity of the quinazolone compounds were studied.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1000–1002, July, 1972.     

Reaction of 3α-Hydroxy-4β-Chlorocarane with POCl3

Conclusions The action of POCl₃ on 3-hydroxy-4-chlorocarane gives products of cleavage, substitution, and allyl rearrangement with retention of the carane skeleton of the starting molecule.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 4, pp. 919–922, April, 1985.     

Synthesis of 2-methyl-3-(3,5-diallyl-4-hydroxyphenyl)-4-quinazolones as possible anticonvulsants

A series of 2-methyl-3-(3,5-diallyl-4-hydroxyphenyl)-4-quinazolones were prepared as possible anticonvulsants. All compounds were evaluated for their anticonvulsant activity against pentylene-tetrazol-induced seizures and their ability to potentiate sodium pentobarbital sleeping time in albino mice.     

Simple method for the synthesis of 2-trichloromethyl-4-quinazolones

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 698–699, May, 1991.     

Synthesis of substituted 2-ethyl-3-(4-hydrazinocarbonylphenyl)-4-quinazo-lones and 2-ethyl-3-(4-hydrazinocarbonylmethylphenyl)-4-quinazolones

Some substituted 2-ethyl-3-(4-hydrazinocarbonylphenyl)-4-quinazolones and 2-ethyl-3-(4-hydrazinocarbonylmethylphenyl)-4-quinazolones were synthesized and characterized by their sharp melting points, elemental analyses and spectral data.     

Phosphorylation of 4-Oxo-2-thioxo-1,3-thiazolidine with POCl3 in the Solid Phase

Lithium salt of 4-oxo-2-thioxo-1,3-thiazolidine was phosphorylated with POCl₃.     

Kristallstruktur des Molybdändioxiddichlorid-Phosphoroxidtrichlorid-Addukts MoO2Cl2 · POCl3

Crystal Structure of the Molybdenum Dioxide Dichloride — Phosphorus Oxide Trichloride Adduct MoO₂Cl₂ · POCl₃ The crystal structure of MoO₂Cl₂ · POCl₃ was determined by X-ray methods (R = 0.046; 2497 independent reflexions). MoO₂Cl₂ · POCl₃ crystallizes monoclinic in the space group P2₁/c with Z = 8. It forms nearly linear chains in which the Mo atoms are linked together via weakly bent and asymmetric oxo bridges (Mo? O = 172 and 218 pm). The Mo atoms are surrounded in a distorted octahedral coordination by one O and two Cl atoms (Mo? Cl = 230–232 pm) as terminal ligands and by the POCl₃ molecule and the bridging O atoms as well. The POCl₃ molecule (Mo? O = 233 pm) is located in trans position to the terminal oxo ligand (Mo? O = 166 pm).     

Evaluation of some derivatives of 4-quinazolones as antioxidants and antirads in rubber

Derivatives of 4-quinazolones were compounded with rubber. The relation between their efficiencies as antioxidants and antirads was studied. It was found that their efficiencies as antioxidants and antirads fall in the same order but differ in degree.     

Synthesis of substituted 2-methyl-3-(3,4-dimethoxy/dihydroxyphenylethyl)4-quinazolones as possible antiparkinson drugs

Several substituted 2-methyl-3-(3,4-dimethoxy/dihydroxyphenylethyl)-4-quinazolones were synthesized as possible antiparkinsonism agents. The structure of these compounds were confirmed by their elemental and spectral analysis.     

TG study of the chlorination of WO3 by COCl2 and CCl4

The chlorination kinetics of tungsten trioxide was studied by thermogravimetry, using COCl₂ and gaseous CCl₄ as chlorinating agents. Thermochemical calculations were made on the main chlorination reactions and also on some assumed side reactions. On the basis of the kinetic results CCl₄ proved to be more reactive than COCl₂. For both gases apparent activation energies of about 100 kJ.mol^–1 and reaction orders of 0.5 were obtained in the temperature ranges where the reaction was controlled by chemical processes.During the chlorination by COCl₂ the conversionvs. time data could be described by the contracting sphere model. When chlorinating by CCl₄ a continuous decrease of the linear reaction rate was observed. Thus, for describing the isothermal TG curves a kinetic model, based on the retarding effect of non-removable surface side products, was assumed. With this model a fairly good correspondence of the measured and calculated kinetic curves was obtained.

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Zusammenfassung Mittels Thermogravimetrie wurde die Kinetik der Chlorierung von Wolframtrioxid mit COCl₂ bzw. gasförmigem CCl₄ untersucht. Für die Hauptchlorierungsreaktionen und einige angenommene Nebenreaktionen wurden thermochemische Berechnungen getÄtigt. Ausgehend von den kinetischen Ergebnissen erwies sich CCl₄ als reaktionsfreudiger als COCl₂. In dem Temperaturbereich, in dem die Reaktion durch chemische Prozesse kontrolliert wird, erhielt man eine scheinbare Aktivierungsenergie von etwa 100 kJmol^–1 und eine Reaktionsordnung von 0.5.Bei der Chlorierung mit COCl₂ können die Konversion/Zeit Daten mit dem Contractingsphere Modell beschrieben werden. Bei der Chlorierung mit CCl₄ kann eine stÄndige Abnahme der linearen Reaktionsgeschwindigkeit beobachtet werden. Somit wurde für die Beschreibung der isothermen TG-Kurven ein kinetisches Modell angenommen, welches auf dem Rückhalteeffekt von unabspaltbaren Nebenprodukten an der OberflÄche beruht. Mit diesem Modell konnte eine gute übereinstimmung zwischen experimentellen und rechnerischen kinetischen Kurven erzielt werden.

     

Reaction of [P3N3Cl4(NH2)2] with [HN(POCl2)2]; The crystal structure of the phosphazenium salt [P3N3HCl4(NH2)2]+[N(POCl2)2]−

The reaction of diaminotetrachloro-cyclotriphosphazene with tetrachloride of μ-imino-diphosphoric acid leads to the formation of the salt-like compound [P₃N₃HCl₄(NH₂)₂]⁺[N(POCl₂)₂]⁻ which identity was unambiguously established by means of X-ray structure analysis. The structure is composed of [P₃N₃HCl₄(NH₂)₂]⁺ cations and [N(POCl₂)₂]⁻ anions joined by a system of H-bonds. As in other phosphazenium salts, the protonation of the ring N atom leads to significant changes in the endocyclic P N bond lengths.     

Die Reaktion von Molybdänpentachlorid mit Trichlornitromethan; die Kristallstruktur von [MoOCl3 · POCl3]2

Reaction of Molybdenum Pentachloride with Trichloronitromethane. Crystal Structure of [MoOCl₃ · POCl₃]₂ An improved method for the preparation of MoO₂Cl₂ by the reaction of MoCl₅ with CCl₃NO₂ is reported. In the presence of the solvens POCl₃, molybdenum pentachloride reacts with trichloronitromethane forming the oxonitrosyl complex Mo(NO)OCl₃ · POCl₃. In CH₂Cl₂ solution this complex is decomposed forming [MoOCl₃ · POCl₃]₂. The crystal structure was solved by X-ray methods. [MoOCl₃ · POCl₃]₂ crystallizes monoclinic in the space group P2₁/c with two dimers in the unit cell (R = 0.07, 2327 independent reflexions). The complex dimerizes by symmetric chloro bridges; the oxoligand is in terminal position. The MoO bond length of 163 pm corresponds with a Mo?O triple bond. The POCl₃ molecule is coordinated in position trans to the oxoligand. The IR spectra are reported and assigned.