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1.
Abdel‐Sattar S. Hamad Elgazwy Mayssoune Y. Zaki Nahed N. Eid Ahmed I. Hashem 《Heteroatom Chemistry》2003,14(6):570-574
A series of 2‐phenyl‐5‐alkenyl‐1,3,4‐oxadiazoles were synthesized in high yields from the corresponding dicarbonylhydrazides through cyclodehydration. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:570–574, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10197 相似文献
2.
Wael S. I. Abou Elmagd 《Journal of heterocyclic chemistry》2011,48(6):1361-1365
3(2‐pyridinylmethylene)‐5‐aryl‐2(3H)‐furanones and 3(3‐pyridinylmethylene)‐5‐aryl‐2(3H)‐furanones were prepared as a mixture of (E) and (Z) stereoisomers by condensing pyridine‐2‐carboxaldehyde and pyridine‐3‐carboxaldehyde with 3‐aroylpropionic acids. The reaction of the furanones 6 and 7 with anhydrous aluminium chloride in benzene led to the formation of 4,4‐diaryl‐1‐(2‐pyridinyl)but‐1,3‐diene ( 8 ) and 4,4‐diaryl‐1‐(3‐pyridinyl)but‐1,3‐diene ( 9 ) as mixtures of geometrical (E,E‐ and E,Z‐) stereoisomers via an intermolecular alkylation mode. When the reaction was carried out in tetrachloroethane as a solvent, the reaction of 6 gave 5‐arylquinoline‐7‐carboxylic acid via intramolecular alkylation mode. This may be considered as a novel method for the synthesis of quinoline derivatives. J. Heterocyclic Chem., (2011). 相似文献
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A direct and efficient method for the preparation of 5‐benzoyldihydro‐2(3H)‐furanones was realized by cyclization of 4‐benzoylbutyric acids in the presence of phenyliodine(III) triflate. 相似文献
5.
Kamal A. Kandeel Ahmed S. A. Youssef Wael S. I. Abou‐Elmagd Ahmed I. Hashem 《Journal of heterocyclic chemistry》2006,43(4):957-962
Ring closure of 2‐N‐benzylamino‐3‐aroylpropionic acids ( 3 ) with acetic anhydride afforded 3‐N‐benzylamino‐5‐aryl‐2(3H)‐furanones ( 4 ). The reaction of the furanones ( 4 ) with benzylamine in benzene was found to be time dependent. Thus refluxing the reaction mixture for 1 h only afforded the open‐chain amides ( 5a‐c ). When the reaction was conducted for 3 h the 2(3H)‐pyrrolones ( 6 ) were obtained. Hydrazine hydrate affected ring opening of the furanones to give the hydrazides ( 5d‐f ). Also, semicarbazide converted ( 4 ) into the corresponding semicarbazide derivatives ( 5g‐i ). The hydrazides ( 5d‐f ) were reacted with benzoyl chloride to give the corresponding diaroylhydrazines ( 5j‐l ). The open‐chain derivatives ( 5 ) were converted into a variety of heterocycles: isothiazolones ( 7 ), dihydropyridazinones ( 8 ), 1,3,4‐oxadiazoles ( 9 ) and 1,2,4‐triazole derivatives ( 10 ) via cyclization reactions. 相似文献
6.
2(3H)‐Furanones 1 were utilized for the construction of pyrrolinotriazine and oxazolopyrimidine derivatives 4 and 9 . Thus, 1 reacted with glycine in ethanol at 70°C to give the acids 2 , which were cyclized into the pyrrolin‐5‐one derivatives 3 by the action of HCl/AcOH. The later compounds 3 were also obtained by refluxing the furanones 1 with glycine in glacial AcOH for 10 h. The carboxy functionality in 3 was used for the construction of a triazinone ring by treatment with thionyl chloride followed by refluxing the acid chloride with hydrazine in ethanol. The conversion of the furanones 1 into the oxazolopyrimidine derivatives 9 involved the following steps: (i) ring opening of the lactone ring with hydrazine hydrate to give the acid hydrazides 5 , (ii) conversion of the hydrazides 5 into the corresponding acyl azides 6 by action of NaNO2/AcOH, (iv) base‐catalyzed decomposition of the azides in the presence of glycine, (v) ring closure of the urea derivatives 7 into the pyrimidine derivatives 8 , and finally (vi) condensing 8 with benzaldehyde in the presence of NaOAc/AcOH mixture. 相似文献
7.
Adrenoceptors beta‐3‐subtype mediate lipolysis and in the search for potential beta‐3‐adrenergic receptors agonists for the treatment of obesity, we designed new arylethanolamines (structures 4, 5 ) and aryloxypropanolamines (structures 6, 7 ) derived from 2(3H)‐benzoxazolone and 2(3H)‐benzothiazolone. 相似文献
8.
4‐Halo‐2(5H)‐furanones were prepared by the halolactonization of 2,3‐allenoic acids. The subsequent Suzuki coupling reaction of 4‐halo 2(5H)‐furanones with aryl boronic acids was carried out to produce 4‐aryl‐2(5H)‐furanones in excellent yields. 相似文献
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A general synthesis of 6‐azaoxindoles, substituted in the 3‐ and 5‐position, has been developed starting from 4‐methoxycarbomethyl‐3‐nitropyridine, via hydrogenation of the nitro group and cyclisation of the resulting 3‐amino‐4‐methoxycarbomethyl‐pyridine. 相似文献
11.
I. Philipova G. Dobrikov K. Krumova J. Kaneti 《Journal of heterocyclic chemistry》2006,43(4):1057-1063
A series of 2‐substituted‐4(3H)‐quinazolinones 13‐20 has been synthesized in good yields using the reaction of double lithiated 2‐methylquinazolinone‐4 with a variety of aromatic aldehydes. They have been easily transformed in high yields into the corresponding 2‐substituted conjugated derivatives 21‐28 bearing terminal aryl groups by F3CCOOH mediated dehydration. 相似文献
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Milda M. Burbuliene Rita Mazeikaite Povilas Vainilavicius 《Journal of heterocyclic chemistry》2008,45(2):607-610
Reaction of 2‐methylthio‐4(3H)‐quinazolinone with chloroacetone, ω‐bromoacetophenone or ethyl bromoacetate in different solvents (methanol, acetonitrile, dimethylformamide and toluene) using sodium methoxide or potassium carbonate as a base were studied. Regioselective N(3)‐alkylation took place in toluene using potassium carbonate, whereas in dimethylformamide O‐acylmethyl derivatives were obtained. However chloroacetone reacted with 2‐methylthio‐4(3H)‐quinazolinone under various conditions to give a mixture of N(3)/O‐isomers. 相似文献
14.
Vijayakumar N. Sonar Sean Parkin Peter A. Crooks 《Acta Crystallographica. Section C, Structural Chemistry》2005,61(8):o527-o530
In the title compounds, C12H12N2O2, (I), and C17H14N2O2, (II), respectively, the indole rings are planar and the vinyl groups lie out of the indole planes, making dihedral angles of 33.48 (5) and 41.31 (8)°, respectively. In (II), the dihedral angle between the phenyl and indole ring planes is 32.06 (6)°. In both molecules, the double bond connecting the methylnitrovinyl group and the indole nucleus adopts an E configuration. Notwithstanding the differences in space group [C2/c for (I) and P212121 for (II)], the mode of packing of compounds (I) and (II) is determined by similar intermolecular N—H⋯O hydrogen‐bonding interactions, forming chains that run parallel to [101] in (I) and [001] in (II). 相似文献
15.
Four 3‐(3‐benzylidene‐2‐phenylcarbazoyl)‐2(3H)‐benzoxazolone derivatives 3 have been synthesized from benzoxazolone derivatives 1 and benzaldehyde N‐chloroformylphenylhydrazone 2. By acid hydrolysis, these compounds yielded 3‐(2‐phenylcarbazoyl)‐2(3H)benzoxazolone derivatives 4 which were not isolated and were transformed via an intramolecular reaction into 4‐(2‐hydroxyphenyl)‐1‐phenyl‐1,2,4‐triazolidine‐3,5‐dione derivatives 5 in a good yield. Attempts to cyclize these compounds by intramolecular elimination of water into tricyclic compounds 6 with various dehydrating agents were unsuccessful. 相似文献
16.
A number of 3-ethoxycarbonyl-5-hydroxy-2-methyl-5-or-1,5-substituted 4-oxo-2-pyrrolines have been prepared, respectively, by the action of ammonium hydroxide or primary aliphatic amines on 2-arylidene or 2-N-acetyl-N-arylaminomethylene-4-ethoxycarbonyl-5-methyl-3(2H)furanones. The structures of these prepared compounds have been determined by spectroscopic data and chemical means. 相似文献
17.
The synthesis of 5-aryl (or alkyl) aminomethylene-3-(1-amino or 1-alkylaminoethylidene)-2,4-dioxo-(3H,5H)furans and 5-arylaminomethylene-3-(1-hydroxyethylidene)-2,4-dioxo-(3H,5H)furans (new 3-acetyltetronic acid derivatives) are described. The stereochemistry of these compounds from the 1H nmr data is discussed. 相似文献
18.
Hexakis(2‐formylphenoxy)cyclotri‐phosphazene ( 2 ) was obtained from the reaction of hexachlorocylotriphosphazene ( 1 ) with 2‐hydroxy‐benzaldehyde. Hexakis(2‐[(hydroxyimino)methyl]‐phenoxy)cyclotriphosphazene (3) was synthesized from the reaction of 2 with hydroxlaminehydrochloride in pyridine. Hexasubstituted compounds 4, 5, 6, 8, 9 , and 10 were obtained from the reactions of 3 with methyl iodide, ethyl bromide, allyl bromide, propanoyl chloride, benzoyl chloride, and 4‐methoxybenzoyl chloride, respectively. Disubstituted product 7 was obtained from the reaction of 3 with chloroacetyl chloride. Pure and defined products could not be obtained from the reaction of 3 with acetyl chloride, benzyl chloride, and 2‐chlorobenzoyl chloride. The compounds were characterized by elemental analysis and IR, 1H, 13C, and 31P NMR spectroscopy. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:791–797, 2007; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20350 相似文献
19.
Pan
e Naumov Gligor Jovanovski Sheng‐Zhi Hu Il‐Hwan Suh Ibrahim Abdul Razak Suchada Chantrapromma Hoong‐Kun Fun Seik Weng Ng 《Acta Crystallographica. Section C, Structural Chemistry》2001,57(9):1016-1019
The short carbonyl bond in the title compound, [Cu2(C7H4NO3S)4(C3H4N2)4] [Liu, Huang, Li & Lin (1991). Acta Cryst. C 47 , 41–43], is an artifact of disorder in the isothiazol‐3(2H)‐one 1,1‐dioxide part of the 1,2‐benzisothiazol‐3(2H)‐one entity. In the present redetermination, all bond dimensions in the centrosymmetric dinuclear molecule are normal. The five‐coordinate Cu atom shows trigonal–bipyramidal coordination. Hydrogen bonds from the imidazole donor ligand link adjacent molecules into a two‐dimensional layer structure. 相似文献
20.
J. M. Morsy 《中国化学会会志》2008,55(6):1243-1250
3‐Aroyl‐2‐arylpropionic acids 2a‐e were utilized to synthesize 3(2H)‐pyridazinones 3a‐e and 2(3H)‐furanones 6 through reaction with hydrazine hydrate and freshly distilled acetic anhydride, respectively, in the hope of obtaining new 3(2H)‐pyridazinones with no ulcerogenic side effect or with negligible general side effects as those currently used NSAIDS as well as biologically active 2(3H)‐furanones. 相似文献