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1.
2‐Alkylthio‐5‐phenylmethylidene‐4H‐imidazol‐4‐ones 4 were synthesized by S‐alkylation of 2‐thioxo‐3‐alkyl(aryl)‐4‐imidazolidinones 3 , which were obtained via cyclization of isothiocyanates 2 with aliphatic(aromatic) primary amines. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:348–351, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10160 相似文献
2.
V. Padmavathi A. Balaiah T. V. Ramana Reddy B. Jagan Mohan Reddy D. Bhaskar Reddy 《Heteroatom Chemistry》2003,14(6):513-517
Novel spiro heterocycles ( 5–12 ) were obtained by the cyclocondensation of 2,6‐diaryl‐4,4‐dimethoxycarbonyl‐/4‐cyano‐4‐ethoxycarbonyl‐1,4‐dihydropyridines( 3/4 ) with hydrazine hydrate, hydroxylamine hydrochloride, urea, and thiourea. All the compounds were characterized by IR, 1H NMR, and 13C NMR spectral data.© 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:513–517, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10183 相似文献
3.
New amidino‐benzimidazolyl‐substituted bis‐1,2‐(2‐thienyl)ethenes ( 4, 5 , and 6 ) and benzo[1,2‐ b:4,3‐ b′]dithiophenes ( 8, 9 , and 10 ) were prepared by the condensation of amidino‐substituted o‐phenylene diamines with corresponding dialdehydes ( 3 and 7 ). All prepared amidino‐benzimidazolyl‐substituted compounds are of particular interest, because they can serve as intercalators or groove binders on DNA in anticancer therapy. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:218–222, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10126 相似文献
4.
Zheng Hong Zhou Yi Long Tang Kang Ying Li Bing Liu Chu Chi Tang 《Heteroatom Chemistry》2003,14(7):603-606
A series of optically active N‐protected α‐aminoketones were synthesized via the Grignard reaction of the Weinreb amides of the N‐tert‐butoxycarbonyl amino acids. Reduction of the α‐aminoketones by sodium borohydride resulted in the corresponding 1,2‐amino alcohols. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:603–606, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10195 相似文献
5.
N. G. Kandile H. T. Zaky M. I. Mohamed Abdel‐Sattar S. Hamad Elgazwy 《Heteroatom Chemistry》2003,14(4):334-341
4,6‐Disubstituted pyridazin‐3(2H) thiones 3a–f were prepared by thiation of 4,6‐disubstituted pyridazin‐3(2H)‐one 1a–f either with thiourea or phosphorus pentasulphide. The reactivity of 3a‐f towards nucleophilic and electrophilic species under different conditions was studied successively. The structure of the products was confirmed by NMR and mass spectral data. Mechanisms for their formation are also proposed. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:334–341, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10157 相似文献
6.
New 5′‐acetyl‐3′‐1,3,4‐thiadiazoliminothymidines 11, 14 were prepared, via spontaneous rearrangments, by cycloaddition of 5′‐acetyl‐3′‐deoxy‐3′‐isothiocyanatothymidine 9 with 1‐aza‐2‐azoniaallene hexachloantimonates. Similary, 3′‐cyano analogue 19 was reacted with the same cumulenes to furnish 3′‐1,2,4‐triazolo‐thymidines 22, 24 , and 26 . Deblocking of the acylated products afforded the free nucleosides. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:298–303, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10146 相似文献
7.
Liliana Aguilar‐Castro Margarita Tlahuextl Antonio R. Tapia‐Benavides Hugo Tlahuext 《Heteroatom Chemistry》2003,14(3):247-253
N‐(p‐Toluenesulfonyl)glycine o‐phenolamide ( 3a ) and the analogous derivatives of d,l‐alanine ( 3b ), L ‐valine ( 3c ), L ‐leucine ( 3d ), and L ‐phenylalanine ( 3e ) were synthesized in yields >80% by condensation of N‐(p‐toluenesulfonyl)amino acyl chlorides with o‐aminophenol. The structure and conformation of these amides were established by NMR spectroscopy and X‐ray crystallography. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:247–253, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10135 相似文献
8.
The hitherto unreported oxazastibinanes 3 have been synthesized by the sodium borohydride reduction of 3‐phenyl‐1‐arylamino‐3‐oxopropane ( 1 ) and subsequent cyclization of the disodium salt of 3‐phenyl‐1‐arylamino‐3‐hydroxypropane ( 2 ) with R3SbBr2 (R = Ph, p‐tolyl, or mesityl). These compounds have been characterized by elemental analyses, molecular weight determination, and by IR, far IR, 1H, and 13C NMR spectral studies. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:417–420, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10155 相似文献
9.
Aryl‐furyl substituted pyrazolines 2a–c and 4a–c were prepared by the reaction of α,β‐unsaturated carbonyl compounds with hydrazine or phenyl hydrazine. N‐chloroacetyl derivatives 3a–c were obtained by the N‐acetylation of 2a–c . The antibacterial activities of synthesized pyrazolines were examined by employing the disk‐diffusion technique. All synthesized compounds showed antibacterial effects in 1200 μg concentration. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:345–347, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10159 相似文献
10.
The new macrocyclic di‐ and tetralactams 9 , 15 , and 16 were obtained in 16–24% yields by heating the appropriate bis‐amines 7 or 8 with the corresponding bisaldehyde 5 or 14 in refluxing acetic acid under high‐dilution conditions. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:551–559, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10191 相似文献
11.
The hitherto unreported 4‐oxo‐1,3,2‐benzoxazastibinines 2 have been synthesized by the cyclization of disodium salt of salicylanilide ( 1 ) with Ar3SbBr2 (Ar = Ph, p‐tolyl, or mesityl). These compounds have been characterized by elemental analyses, molecular weight determination, and by IR, far IR, 1H, and 13C NMR spectral studies. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:622–624, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10202 相似文献
12.
Alaa A. Hassan Aboul‐Fetouh E. Mourad Kamal M. El‐Shaieb Ashraf H. Abou‐Zied Dietrich Dpp 《Heteroatom Chemistry》2003,14(6):535-541
Microwave and thermal heterocyclization of N,N′‐disubstituted hydrazinecarbothioamide 1a,b and substituted thioureidoethylthioureas 2a–c as well as 1‐phenyl‐3[2‐(3‐phenylthio‐ureido)phenyl]thiourea 6 are reported. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:535–541, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10188 相似文献
13.
Bis‐, tris‐, and tetrakis‐trimethylgermylpropanoyl esters of p‐tert‐butylcalix[4]arenes 5, 7 , and 8 were synthesized and their conformations in solution were determined by 1H and 13C NMR spectroscopy. The characteristic pair of doublets from the Ar CH2 Ar methylene protons was observed, indicating that all the prepared calixarenes were in the cone conformation. These germylated calixarenes failed to exhibit any appreciable cation‐capturing ability, indicating that further modification is required to make these compounds to be effective ditopic hosts. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:365–373, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10164 相似文献
14.
The reaction of O‐menthyl phenylphosphonite 1 with aromatic aldehydes in the presence of Me3SiCl provided the O‐menthyl α‐hydroxyphosphinates 2 . Acidic hydrolysis of 2 gave the corresponding α‐hydroxyphosphinic acids 3 . The (+)‐enantiomer of 3a and 3b , adduct of benzaldehyde and 4‐methylbenzaldehyde respectively, were obtained via multiple recrystallization. The absolute configuration of (+)‐ 3a was determined as S by X‐ray crystallography. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:312–315, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10150 相似文献
15.
Yu‐Xin Li You‐Ming Wang Xiao‐Ping Yang Su‐Hua Wang Zheng‐Ming Li 《Heteroatom Chemistry》2003,14(4):342-344
A useful synthesis of 3‐methylthio‐6‐methyl‐pyrano[4,3‐c]pyrazol‐4(2H)‐ones via 3‐(bis‐methylthio)methylene‐5,6‐dihydro‐6‐alkyl(aryl)‐2H‐pyran‐2,4‐dione with hydrazine as well as methyl and phenyl hydrazines is described and the mechanism of the formation is discussed. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:342–344, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10158 相似文献
16.
In an attempt to find novel plant growth regulators, a series of unsaturated cyclic α‐hydroxyphosphonates were synthesized by the addition reactions of 4‐aryl‐5,5‐dimethyl‐1,3,2‐dioxaphosphinane 2‐oxides with 5‐aryl‐2E,4E‐pentadienaldehydes. The cis and trans isomers of the products were isolated. The structures of all products were confirmed by elemental analyses and by NMR and IR spectroscopy or MS. The results of preliminary bioassay indicate that the title compounds possess potential inhibitory activity on the elongation of wheat coleoptile. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:266–268, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10039 相似文献
17.
Reaction of ω‐carbonyl substituted 1,3,3‐trimethyl‐2‐methyleneindolines with phosphorus(III) halides
Alexej A. Chekotylo Alexandr N. Kostyuk Alexandr M. Pinchuk Andrej A. Tolmachev 《Heteroatom Chemistry》2003,14(1):23-28
The phosphorylation of N‐benzoyl‐2‐(1,3,3‐trimethyl‐2‐methyleneindoline)acetamide ( 2 ) and ω‐(3‐dimethylamino)benzoyl‐1,3,3‐trimethyl‐2‐methyleneindoline ( 6 ) with phosphorus(III) halides resulted in the formation of 2,3‐dihydro‐4H‐1,5,2‐oxazaphosphinin‐4‐one and 1,2‐dihydro‐3H‐phosphindol‐3‐one systems, respectively. The properties of the obtained compounds were studied. Further cyclization of 1,2‐dihydro‐3H‐phosphindol‐3‐one into dihydrophosphindolo[3,2‐c]pyrazole was carried out. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:23–28, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10060 相似文献
18.
Vladimir S. Zyabrev Mikhail A. Rensky Eduard B. Rusanov Boris S. Drach 《Heteroatom Chemistry》2003,14(5):474-480
1,2,4‐Thiadiazol‐5(2H)‐imines 4 react with N‐(2,2,2‐trichloroethylidene)‐substituted amides 5 to form [3 + 2]‐cycloaddition products 6 featured by an extra coordination of the ring sulfur atom to the terminal nitrogen atom of the side 1,3‐diazapropenylidene group, as established by X‐ray diffraction investigation. This coordination evidently plays an important role in the alkylation of compounds 6 into 8 at the oxygen atom under mild conditions. The S N bond “switch‐over” restoring the original 1,2,4‐thiadiazole ring occurs therewith. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:474–480, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10182 相似文献
19.
N‐Substituted N′‐[6‐methyl‐2‐oxido‐1,3,2‐dioxaphosphinino(5,4,‐b)pyridine‐2‐yl]ureas have been accomplished by condensation of equimolar quantities of chlorides of various carbamidophosphoric acids ( 3 ) with 3‐hydroxyl‐6‐methyl‐2‐pyridinemethanol (lutidine diol) ( 4 ) in the presence of triethylamine in dry toluene–tetrahydrofuran (1:1) mixture at 45–50°C. Their structures were established by elemental analyses, IR, 1H NMR, 13C NMR, and 31P NMR spectral data. Their antifungal and antibacterial activity is also evaluated. Most of these compounds exhibited moderate antimicrobial activity in the assays. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:509–512, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10181 相似文献
20.
N‐tert‐Butyl‐N‐benzoylhydrazine was synthesized by a new method. Its condensation and the condensation of its N,N′‐isomer with 3‐(trichlorogermyl)propionyl chloride provided N‐tert‐butyl‐N′‐(3‐trichlorogermyl)propionyl‐N‐benzoylhydrazine or its N,N,N′‐isomer, respectively, in good yields. Subsequent hydrolysis of the trichlorogermyl compounds using saturated sodium carbonate yielded the corresponding germasesquioxide derivatives that have good solubility in organic solvents. The structures of these compounds were confirmed by 1H NMR, IR, MS, and elemental analysis. The hydrolysis of organogermanium trichloride was studied, and the elimination of HGeCl3 was observed when the basicity was too high (pH > 10). © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:293–297, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10174 相似文献