Comparative Study on the Inclusion Complexation of Rutin with Cyclodextrin Supramolecules

Naturalandchemicallymodifiedcyclodextrinshaveabilitytorecogformanyinorgan-..icororganlcguestmoleculesfOrminghost-guestinclusioncomplexest13.Inrecentyears,increasingattentionhasbeenpaidtoalterphisical,chemicalandbiologicalpropertiesofmolecules'-Theunderstanding'ofthebehaviorofthedrugincyclodextrionmicroenwton-mentisaprerequisitetodevelopmentofanovelandeffectivecarrierspptemforthedrug.6-CDcanforminclusioncomplexeswithrutin[2J.WereporthereastudyoninclusioncomplexationofcyClodextrinsbyfluorAnetr…     

Comparison of Four Deoxygenation Techniques for Cyclodextrin Induced Room Temperature Phosphorescence

INTRoDUCTIoNInl984,C1ineLoveetal[1'2JproposedCirRTPinwhichgenerallyoxygenwasre-movedbynitrogencurrent[1-sjinordertodecreasequenchingofoxygentophosphores-cence'Butdeoxygenationbynitrogenpurgingistediousandthoe-consuming'Inl986.~Garciaetal['Jreportedchemica1deoxygenationinmicellarstabiliZ6dRTPwithsodiumsulfiteasoxygenscavenger'Afterthat,chemicaldeoxygenationarewidelyusedinCD-RTP[vaJandmicellarstabilizedRTP[1o-12J.However,deoxygenationwithsodiumsulfitehastwoobviousdisadvantages:firs…     

Synthesis of Snake-cage Resins and Study of Their Separation Ability

IntroductionSnake-cageresin,alsoca1ledsnake-cagepolyelectrolyte['],isaspecialkindofamphotericresin.ItwasfirstinvestigatedbyHatchM.J.etal.in1957[z].Thetypicalandusefulsnake-cageresinisRetardation11A-8(l1A-8inthecon-text)manufacturedbyDowChemicalCoI,TD.Itissynthesizedbypolymerizingacrylicacidinsidethenetworkofastrongbasicanionexchangeresinwith8%crosslinking.Thus,theresinconsistsofacrosslinkedpolymermatrix,cage,andalinearpolymer,socalledsnake,whichisphysicallytrappedinsidethecage.Thecagepol…     

Synthesis of Bis(macrocyclic) Polyamines Containing Rigid Bridging Groups

Thesgnthesi8ofbis(macrocyclic)POlyamineligandsandtheirdinuclearcomplexesoftransitionmetalionshaveattractedmuchinterestinrecentyears.Andava-rietyofsyStemshavebeenreported[1-s1.Theprotonatedfreeligandshavebeenusedashostsforanionicsubstrates.Theresultingdinuc1earcomplexeshavebeenstudiedasmodelsfortheactivesitesofphosphateases.Ofspecialinterestisthehydrolysisofactivatedphosphatemonoester[3J.Here,weconfineourreporttothesrothe8isofthreenew8ymmetricalbis(1,4,7-triazacyclononane)ligandsNa-ccontaini…     

Spectrometric Study of α-Phenylcinnamic Acids

TheanalwisofMSdataofl4substitutalatwcbocacidsindicateSaclassofpeificfragmenpeakS(Tatrl)'fllcdevelopn1en1oftLhesefragmentPeaksistnggeredb)].3-shift[1J7-heMSIYapoenta[1onpattenlot'compotmdf;8belou'illustratesthegenera1mechanjs1nScbemc.lTbemajorMShagmentationpatternofa-phenysubstitutedcinnamicacidAstheSCheInshows,afterthel,3-shiftofhydr0xyinCOmpoUndE8-tberesultinginterInwhatewhllosetheRCX=0grOUfollowinthebondeq,chchleadstOtheformationofmlZl25anditscomPleInentaIyPeakYnlzl63,withthebo…     

Synthesis of New Ointment-like Poly(ortho esters)

Poly(orthoesters)isaclassofbiodegradablepolymersandtheirdegrada-tionratecanbereadilycontrolledbytheincorporationofacidicorbasicexcipi-entsintothepo1ymermatrix[1J.Severaltypes0fbiocompatiblepoly(orthoes-ters)havebeenextensivelyinvestigatedasthecarrierfordrugdeliverysys-tem[2J.However,lessw0rkhasbeendone0nointment-1ikepoly(orthoesters).Asadrugcarrier,theointment-likepoly(orthoesters)hastheadvan-tageofincorporatingtherapeuticagentsatr0omtemperatureandwithouttheuseofsolvents,andisidealf0rthedeliv…     

Thin-Layer Chromatographic Separation of Amino Acid Enantiomers using Ligand Exchange

ManyopticaIantiPOdescanexertverydifferenteffects0nIivingorganisms.ThedevelopentofnewtechniquesfortheresoIution0fracemicmixtureshasbeenreceivingmuchattention[1-6],eSPeciallyinbiologicalandpharrmcoIogicaIfields,Inthispeper.anewmethodoffigandexchang6thin-layerchreretogr8phyfortheresoIutionofaminoacidenantiarersispresented..ThesilicageIplatestr0atedwithL-arginlneandcopP6ra0etatecombinedwiththesoIventsystemo+MeOH/AocTHF/H,0=8O/8-2/'5.8/6wereusedfortheseParationoftenpeirsofaminoacidenantim…     

Crystal Structure of N-Phenylisothiocyanatido-Phosphonamidothioate

1INTRODUCTIONLawess0n,Sreagent(LR),2,4-Bis(4-meth0xyphenyl)-1,3,2'4-dithiadiphosphetane-2,4-disulfide,notonlyisaselectivereagentf0rthi0natingcar-bonylcompounds,buta1soreactswithcertainsubstratestogivephosph0rushetero-cyclecompoundswhichcontainthe(4-methoxyphenyl)phosphinothi0ylidene"4-CH,OC,H'P(S)"m0iety.Theseheterocycliccompoundshavesomepotentialbiologi-calactivitiesasherbicides,fungicides,andinsecticides[l'2J.Wehavestudiedthecy-clizationofthebifunctionalsubstrateswithLRtogive5-and6…     

Anticancer Drugs ( Ⅳ )——New Derivatives of Podophyllotoxin

Four new derivatives of podophyllotoxin, N'-podophyllic acid-N-[3-(2, 2, 5, 5-te-tramethyl-pyrrolinenyloxy)] semicarbazide(GP-11, 6), podophyllic acid [3-(2,2,5,5-te-tramethyl-pyrrolinenyloxy)]hydrazone (GP-12, 7), podophyllic acid-[4-(2, 2, 6, 6-tetramethyl-1-hydroxy piperidine)]hydrazone(GP-1-OH, 8) and podophyllic acid[4-(2,2, 6, 6-tetramethyl piperidine)]hydrazone(GP-1-H, 9) were synthesized. The inhibition effect of the four new compounds on L-1210 cells were determined. The antitumor activity and toxicity of GP-1(2), GP-1-OH(8), GP-1-H(9) and VP-16-213(1) were discussed.     

Crystal Structure of Quaternary Mixed Anion Complex of Labthanide [Ce(CH_3COO)_2(NO)_3(phen)]_2

11NTRODUrmNSomequaternarymixedanioncomplesesoflanthanidesweresynthesized.karasavetalsynthesized">Eu(acac)(NO3)(bipy)2.3H2OandJin[2ietal.Synthe-sizedEu(m-MBA)(NO3)(phen)andEu(o-MBA)(NO,)(phen).Onlyacrystalstructureofceriumcontainingphenwasstudied,Ce(CH,COCHCOCH,)3(phen),fromCambridgeStructureDatabase.SowesynthesizedthecomplexoftCe(CH,Coo)z(Noa)(phen)J,andthecrystalstructure.2EXPERmENTAL2.1Cry8talpreparationThecrystalwasseparatedfromtheethanol/waterso-lutionofceriumnitrate…     

Study on the Interaction of Rare Earth with 3, 5, 3''''-Triiodothyronine

HormoneisaveryhoP0tatkindofbiol0glcalmolede,ltplaTharegulationro1einmetabelism.TheinterachoLofrareeothwithborm0nehasearelybeenreporteds0far[1'2J.lntheprerentwork,theinteraedonofrareearthwith3.5,3'-triiodothryor`ire(T.)wasstodiaibyusingNMRandPOtentiometrictitrationat37tandanionicstrenotofO'15mo1e/LNaC1,TheP0tenhometrictitrah0nwasperformedin1:1DMSO-H.O(vol1imeratio)usingthemethoddedndinprevi01ispeper[3].TheNMR8peaofsarnples(PH=4,to)wererecorded'onBrukerARX-4ooNMRSpeCtrometerusingT…     

Measurement of Ion Mobilities of Selected Amines by Ion Mobility Spectrometry

IlltIoduchontIonmobilityspectrometry(IMS)isagasphaseelectTophoreticandlyticaltechniqueinwhichionsatahaosphericpressureareallowedtodrift,separateandcollectbasedontheirdoferentmobilitiesinanelectricfield.ThequalitativeandquantitativeinformationoftheanalytescanbeacquiredfromthereducedmobilitiesandrelativeintensihesoftheirpeaksinIMSspectTa.IMSwasdevelopedtobeanewtecndqueinfieldapplications[1J.Thereducedmobility(Ko)iscalculatedaccordingtothefollowingequation:h=(L/Et)(P/7so)(2=s/nwhereListhed…     

Synthesis and Efficiency of a Spherical Macroporous Epoxy-dicyandiamide Chelate Resin for Preconcentrating and Separating Trace Au, Hg, Pd and Ru from Samples

IntroductionThe preconcentration and separation of elements in samples by means of a chelateresin[l--5J or a chelate fibre[6'7J have been reported. However, the synthesis of the resin or thefibre usually takes a long time and a complex synthetic process. Accordingly, the epoxy--tan-ning chelate resin[8] and the epoxy-urea chelate .esin[9] have been synthesized and used for thepreconcentration of trace elements. However, these chelate resins could not be used for theenrichment of trace element…     

Synthesis and Crystal Structure of a Decanuclear Silver(Ⅰ)-thiolate Compound Ag_(10)S[S_2P(OEt)_2]_8

Introduction Polynuclear Ag(I)-thiolate compounds are of interests due to their unique molecular structures and metal-metal interactions. There were some such compounds reported in literatures, including Ag8(6-S)(dtp)6 [dtp=S2P(OEt)2] with [Ag8] cube,1 {Ag[S2P(OC3H7)2]}6 with a [Ag6] distorted octahedron,2 Ag11S(Et2dtc)9 [Et2dtc=S2CN(C2H5)2] with a [Ag11] cage of a 3-fold axis,3 and Ag14(6-S)(SPh)12(PPh3)8 4CH3OH13H2O with a [Ag14S12] cage composed of a staggered [Ag6] octahedr…     

Synthesis and Structure Characterization of Mn2（CO）6（μ—S2CP^iPr3）

1INTRODUCTIONThechemistryofhomobinuclearcomplexeshasbeenaveryactivefieldofresearchinthepastdecadesbecauseoftheirnovelstructuresandapplicationsinorganicsynthesis[1,2].Atthesametimephosphine-carbondisulfideadducts,S2CPR3,areveryversatileligandswithavarietyofcoo-rdinationmodestotransitionmetalcenters.Itisabletoformallydonatefrom2to8etoametalormetals[3].AlthoughMn2(CO)6(m-S2CPiPr3)hasbeensynthesizedbyMiguelD.etal.[4,5],nocrystallo-graphicdatatillnowareavailableforit.Inthispaperwewilldesc…     

A New Diterpene Acid from the Flowers of Heteropappus altaicus

A new compound, named heteraltaic acid was isolated from the flowers of Heteropappus altaicus (willd) Novopokr. The compound was elucidated as (5R, 6S, 8aS) -5-[2-(3-furyl) ethyl-5, 6, 8a-trimethyl-4a, 5, 6, 7, 8, 8a -hexahydro-l-naphthalenecarboxylic acid] by the combination of 1D and 2D NMR techniques (HSQC, HMBC) and X-ray analysis.     

Total Synthesis of Przewaquinone A

PrzetvaquinolleA,anaturalortloquinoneisoIatedfromSalviaPrzewakiiMtalmvarmandarinorunIShb.['J.hasbeenshowedanhtumorachvityinaVariety'oftumormodels,sucha5Let`dsIungcarcil1oma,Il1e1anolnaBl6,sarcomal8Oandleuke1niaPss8,bothinvitroandvivo.Inthepresentpaper,h1efirsttota19'11tl1esisofprzett2q[linoneAisdescribed.Targetmoleculeunpreparedtliroughareactionsequence(asshoxvnil1scheme.).Con1pound5ttasobtalnedbycyclizahonof4in56.l%}jeld.Dicarbox})licacid5washeatedwithcoPperPOwderinquinolinetoaffordmo…     

Preparation of a New Polyoxometalate-based Nanoparticles

Polyoxometalates (POMs) α-K8H6[Si2W18Ti6O77] (Si2W18Ti6) loaded starch nanoparticles have been prepared and structurally characterized by elemental analyses, IR spectra and ^29Si spectroscopy. The particle size of Si2W18Ti6/starch was estimated by a Transmission electron microscope (TEM) and a 1000HSA MALVIRN Zetasizer instrttment. The result shows that the polyoxometalate retained the parent structure after encapsulated by starch microspheres.     

Synthesis and Structural Characterization of a Novel Sphere Compound of Mo_8V_2O_(28)·7H_2O

Polyoxometalates( POMs) are attractivebuilding blocks for functional materials withpotential application in electrocatalysis and thepreparations of molecular electronic,orelectrooptical devices[1,2 ] . With the recentdiscovery of giant nanoporous and spherePOMs[3— 6] ,it remains a great challenge tosynthesize rationally new nanoscale materialspossessing novel structures and desirableproperties.The present paper covers a novelstructure characterization of Mo8V2 O2 8· 7H2 O( abbreviated Mo…     

The Reaction of Molybdenum with 2,3-Dihydroxynaphthalene

[H2N（CH2）3NH312[MoO2（C10H6O2）2] （1） was synthesized by the 2,3-dihydroxynaphthalene in the mixed solvent of CH3OH, CH3CN reaction of （n-Bu4N）4[Mo8O26] with and 1,3-propanediarnine. （C5HllN2）2- [HeN（CH2）3NH2][MoO2（CloH6O2）2] （2） was obtained by the reaction of Na2MoO4.2H20 with 2,3-dihydroxynaphthalene in the same solvent above. Both of the complexes possess complex anion [Mo（VI）O2（OC10H6O）2]^2- which shows pseudo-octahedrally coordinated fashion, while the counterions are two protonated 1,3-propanediamine in complex 1 and （CsH11N2）^＋ in complex 2. （C5H11N2）＋ is the byproduct of reaction 2, which results from combination of acetonitrile with 1,3-propanediamine. Packing diagrams of the two complexes are also different. There is anti-parallel-aligned-double-meso-bilayer unit in complex 1. However there are four chiral anions arranged in anticlockwise orientation in complex 2.