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《Tetrahedron letters》1986,27(24):2771-2774
A 5α-hydroxy-guaianolide was synthesized biomimetically from a 5-oxo-E-1(10)-germacrenolide, the stereoselectivity of the cyclization being attributed to preferred conformation. 相似文献
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Evidence for the presence of 3β,6α-dihydroxy-5α-chol-9(11)-en-23-one in the aglycone mixture from the starfish Marthasterias glacialis is provided by the synthesis of 3β,6α-dihydroxy-5α-cholan-23-one (19) and its identification in the hydrogenated aglycone mixture. The side-chain is constructed from the 23,24-dinorcholanol (13) by reaction of the 22-tosylate (16) with the acetylide anion, followed by hydration of the resulting 23-yne (17). 相似文献
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Abstract: The synthesis of 5-iodo-5α-cholestan-6-one (6), its 3β-acetoxy-(7) and 3β-chloro-(8) analogues, 3β-acetoxy-5-iodo-5α-stigmastan-6-one (9) and its 3β-chloro-(10) analogue by the reacion of silver chromate-iodine and pyridine with the corresponding steroidal olefins (1-5) is described. The structures of these products have been established on the basis of their elemental, analytical and spectral data. 相似文献
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Gang ZHOU Xiao Lei GAO Yu Kun GUAN Wei Dong LI Yu Lin LI* National Laboratory of Applied Organic Chemistry Institute of Organic Chemistry Lanzhou University Lanzhou 《中国化学快报》2001,(5)
Sesquiterpenic compounds of the Eudesmane family have attracted considerable attention due to their intriguing biological properties1,2, particularly significant antifeedant activity, cell growth inhibitory and plant growth regulating activities.In 1996, J. Hu and co-workers3 had isolated eudesmane sesquiterpene 5?-hydroxy-isopterocarpolone 1 from the aerial parts of chinese folk medicine Artemisia eriopoda and elucidated its structure by spectropic methods. Herein, we reported the first tota… 相似文献
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The configuration of the hydroxy acid 2, a product from base-catalyzedautoxidation of 3α,5-cyclo-5α-cholestane-6-one,was established on the basis of NMRtechniques and the mechanism of the formation of 2 was discussed. 相似文献
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V. A. Slavinskaya D. É. Sile M. Yu. Katkevich É. Kh. Korchagova É. Lukevits 《Chemistry of Heterocyclic Compounds》1994,30(6):724-728
Methods have been developed for the alkylation of 5-oxazolinone derivatives in DMF in the presence of K2CO3, KOH, or diisopropylethylamine and a phase transfer catalyst as well as for the preparation of-methyl-phenylalanine,-methylalanine,-methylalanine, and the methyl ester of N-benzoyl--methylalanine. Increasing the initial concentration of the starting 5-oxazolinone in the reaction mixture leads to a sharp drop in the yield of reaction products due to side condensation reactions. The reaction of 2-phenyl-4-benzyl-5- oxazolinone with ethyl iodide gave a dimer namely, 3-(benzoylamino)-3,5-dibenzylpyrrolidine-2,4-dione.Latvian Institute of Organic Chemistry, LV-1006 Riga. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 829–833, June, 1994. Original article submitted January 21, 1994. 相似文献
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It has been established that on the interaction of the 5,6-epoxysteroids (1a–c) with trifluoroacetic acid in chloroform the 6-trifluoroacetates of the 5,6-diols (2a–c) are formed in high yield. The alkaline hydrolysis of the trifluoroacetates (2a–c) leads to the corresponding diols (3a–c).Institute of Bioorganic Chemistry, Belarus' National Academy of Sciences, 220141, Belarus', Minsk, ul. Akad. Kuprevicha, 5/2. Translated from Khimiya prirodnykh Soedinenii, No. 2, pp. 201–204, March–April, 1999. 相似文献
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Microbial activation of rings A, B, and C of 5-steroids is reviewed in connection with the prospects for the use of 5-steroids as a new starting material for the manufacturing of steroidal medicinal preparations. The combination of chemical synthesis and microbial methods of steroid transformation allows the successful solution of the problem of selective functionalization of steroid molecules, provided the suitable microorganisms are chosen and the conditions of their cultivation are optimized.Translated fromIzyestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 567–588, April, 1994. 相似文献
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<正>A new 5α-adynerin-type cardenolide,named funingenoside U(1),together with its aglycone,(17R)-3β-hydroxy-4β-acetoxy-8, 14β-epoxy-5α-card-20(22)-enolide,was isolated from the roots of Parepigynumfuningense.Their structures were established on the basis of spectral(MS,1D and 2D NMR) measurements and chemical evidences. 相似文献
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The newderivative 5-chloro-4-methoxysantonin oximewasprepared from5-chloro-4-methoxysantonin by reaction with hydroxylamine hydrochloride in the presence of pyridine. The structure was established by IR, UV, and PMR spectroscopies. 相似文献
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Kádár Z Baji Á Zupkó I Bartók T Wölfling J Frank É 《Organic & biomolecular chemistry》2011,9(23):8051-8057
Stereoselective 1,4-Michael addition of azoimide to 17β-acetoxy-5α-adrost-1-en-3-one was carried out to furnish a 1α-azido-3-ketone, which was reduced to give the 3β- and 3α-hydroxy epimers in a ratio of 5 : 2. The Cu(I)-catalyzed 1,3-dipolar cycloaddition of the major isomer to terminal alkynes afforded 1α-triazolyl derivatives, which were deacetylated to the corresponding 3β,17β-diols or oxidized to the analogous 3-ketones. However, the ability of the minor 1α,3α-azidoalcohol to undergo similar cyclization was found to be affected significantly by the steric bulk of the substituents on the alkyne reaction partner. All triazolyl compounds were tested in vitro on three malignant gynecological cell lines (HeLa, MCF7 and A2780). 相似文献
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In the course of current work on the conformational analysis of cis-hydrindanones1, we required 5α, 13α, 14α and 5α, 13β, 14β-androstan-16-one 5 and 10 the C and D rings of which provide rigid models of the two conformations of cis-hydrindan-2-one. 相似文献
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Illarionov P. A. Torgov V. I. Hancock I. I. Shibaev V. N. 《Russian Chemical Bulletin》2001,50(7):1303-1308
In connection with studies on the biosynthesis of capsular polysaccharides from Staphylococcus aureus, a new synthesis of uridine 5"-(2-acetamido-2,6-dideoxy--d-galactopyranosyl diphosphate) (uridine 5"-diphospho-N-acetyl--d-fucosamine) using 2-azido-3,4-di-O-acetyl-2,6-dideoxy--d-galactopyranosyl nitrate as the key intermediate was carried out. The reaction of this product with cesium dibenzyl phosphate smoothly affords the corresponding -glycosyl dibenzyl phosphate, which undergoes anomerization on treatment with BF3·Et2O and 2-bromopyridine to give -glycosyl dibenzyl phosphate in high yield. This product was then transformed into 2-amino-3,4-di-O-acetyl-2,6-dideoxy--d-galactopyranosyl phosphate, subsequently converted into 2-acetamido-2,6-dideoxy--d-galactopyranosyl phosphate and the target nucleoside diphosphate sugar. 相似文献
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22,25-Dideoxyecdysone (1) and 5-22,25-dideoxyecdysone (1a) were prepared from cholesterol via a new scheme using the key intermediates 3-chloro-5-bromo-6-ketone 3, 3-chloro-7-bromo-6-ketone 4, and 2,7-dien-6-one 7. 相似文献
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M. I. Merlani M. G. Davitishvili N. Sh. Nadaraia M. I. Sikharulidze K. Papadopulos 《Chemistry of Natural Compounds》2004,40(2):144-146
A new method for synthesizing 17-amino-5-androstane was developed based on tigogenin. The configuration at C-17 was proved by PMR. 相似文献
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采用薄层色谱成功地分离了3,3-乙撑二氧-△^5(10),9(11)-雌甾二烯-17α(1-丙炔基)-17β醇的环氧化产物3,3-乙撑二氧-5α,10α-环氧-△^9(11)-雌烯-17α(1-丙烯基)-17β醇(简称Iα)和3,3-乙撑二氧-5β,10β-环氧-△^9(11)-雌烯-17α(1-丙炔基)-17β醇(简称Iβ),并对Iα和Iβ进行了定性和定量分析,其结果在红外谱图、核磁实验中得到验 相似文献
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O. Yu. Slabko N. V. Ageenko G. A. Verbitski V. A. Kaminski 《Chemistry of Heterocyclic Compounds》2002,38(2):226-230
Oxidative coupling of 4,9-diaza-1,2,4,9-tetrahydro-9H-fluorenes with o-aminophenol and o-aminothiophenol in the presence of MnO2 gives o-hydroxyphenyl- and o-mercaptophenylquinonediimines, cyclization of which gives derivatives of phenoxazine and phenothiazine. 相似文献