共查询到20条相似文献,搜索用时 15 毫秒
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G. G. Mazgarova K. Yu. Suponitskii R. R. Gataullin 《Russian Journal of Organic Chemistry》2014,50(10):1472-1479
New 6-iodo-1,5,6,7-tetrahydro-3H-4,1-benzoxazonin-3-ones have been synthesized by reaction of N-tosyl- and N-(2-nitrobenzenesulfonyl)-N-[2-(alkenyl)phenyl]aminoacetic acids with molecular iodine. 相似文献
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Pezdirc L Bevk D Groselj U Meden A Stanovnik B Svete J 《Journal of combinatorial chemistry》2007,9(4):717-723
Combinatorial solution-phase cycloadditions of (1Z,4R*,5R*)-4-benzoylamino-5-phenylpyrazolidin-3-on-1-azomethine imines 3 to beta-keto esters 4 afforded a library of 26 bicyclic pyrazolidinones 5 in 6-89% yields and in 14-100% de. All products were isolated in >90% purity according to 1H NMR, and 25 of them were analytically pure. The structures of cycloadducts were confirmed by NMR and X-ray diffraction. Most of the products were isolated as mixtures of the major (1S*,2S*,3R*,5R*,6R*)-epimers 5 and the minor (1R*,2S*,3R*,5R*,6R*)-epimers 6. Epimerization of cycloadducts 5/6 at the anomeric position 1 in solution was confirmed by 1H NMR. 相似文献
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Guliya G. Bizhanova Kyrill Yu. Suponitsky Yulia V. Vakhitova Rail R. Gataullin 《Tetrahedron》2017,73(2):109-115
We synthesized methyl ester of N-(1-methylbut-2-en-1-yl)-N-phenylglycine which underwent acid catalyzed aromatic amino Claisen rearrangement to provide methyl-N-[2-(1-methylbut-2-en-1-yl)phenyl]glycinate. A mixture of syn- and anti-atropisomeric methyl-N-acetyl-N-[4-methyl-2-(1-methylbut-2-en-1-yl)phenyl]glycinates was obtained either by the reaction of this ester with acetyl bromide or by the reaction of the sodium salt of N-acetyl-2-(1-methylbut-2-en-1-yl)-4-methylaniline with methyl bromoacetate. Upon saponification of the synthesized ester mixture the syn-atropisomer of N-acetyl-N-[4-methyl-2-(1-methylbut-2-en-1-yl)phenyl]glycine was isolated by fractional crystallization. Treatment of the obtained acids with acetic anhydride, ethyl chloroformate, dicyclohexylcarbodiimide or isopropenylacetate leads to compounds of 4,5-dihydro-3aH-methano[1,3]oxazolo[3,2-a]quinolin-2-one structure. 相似文献
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Roman Kaiser 《Helvetica chimica acta》1984,67(5):1198-1203
(5 R*,9S*)- and (5R*,9R*)-2,2,9-Trimethyl-1,6-dioxaspiro [4.4]non-3-ene ( 1a and 1b resp.) and their dihydro derivatives 2a and 2b are described as new constituents of geranium oil. The structures and configurations of 1a , 1b , 2a , and 2b , are based on spectra interpretation and syntheses. Also some other monoterpenoid constituents identified in the same boiling range are discussed. 相似文献
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Concellón JM Bardales E Concellón C García-Granda S Díaz MR 《The Journal of organic chemistry》2004,69(20):6923-6926
The use of samarium diiodide as a source of iodides is reported. Thus, 2-hydroxy-3-iodoamides were obtained, with total regioselectivity, by treatment of 2,3-epoxyamides, in which the oxirane ring is 2,3-disubstituted or 2,2,3-trisubstituted, with SmI2. The ring-opening reaction was diastereospecific and (2R*,3R*)- or (2R*,3S*)-2-hydroxy-3-iodoamides were obtained from cis- or trans-epoxyamides, respectively. The relative configuration of 2-hydroxy-3-iodoamides was established by X-ray analysis. A mechanism to explain this transformation has been proposed. The starting compounds 1 are easily prepared by the reaction of enolates derived from 2-chloroamides with aldehydes at -78 degrees C. 相似文献