CRYSTAL STRUCTURE OF THE METHYL 4—（N—（1—OXYPROPYL）—N—PHENYLAMINO]—1—[2—（2—THIENYL）ETHYL]—4—PIPERIDINECARBOXYLATE（R31826）HYDROCHLORIDE

<正> C22H28N2O3S.HCl, Mr = 436.9, triclinic,P1;a=8.557(3),b= 10.299(2),c= 13.894(2)A;α= 99.25(1),β=86.64(2),γ= 107.68(2)°;V= 1151.2(3)A3,Z= 2, DC = 1.27g/cm3,R=0.064. The torsion angle C(14)-C(1)-N(2)-0(19) in the title compound is 137.5 being much larger than that (106°) in R30730. The dihedral angle between mean planes of the thiophene ring and piperidine ring is about 83 .     

4—甲基—7—巯基—2（1H）—喹啉酮的合成

以间氨基苯硫酚为起始原料,与乙酰乙酸乙酯一步环合得目标产物4－甲基－7－巯基－2（1H)-喹啉酮（4）,收率：22％;以间苯二胺为起努原料,经乙酰乙酸乙酯环合,重氮化,二硫化合物的形成及盐酸锌和粉还原获得目标产物4,收率：59％。     

Synthesis and Crystal Structure of Ag2（admtrz）2（CF3CO2）2（admtrz=4—amino—3,5—dimethyl—1,2,4—triazole）

1 INTRODUCTION Transition metal complexes bridged by 1, 2, 4-triazole group can produce interesting structures and specific properties[1]. Many attempts have been made to synthesize a variety of complexes with paramagnetic centers by using such ligands, and their structures and magnetic properties have been characterized[2]. However, the polynuclear Ag(I) complexes bridged by 1, 2, 4-triazole have been poorly studied[3]. Recently, we have prepared a series of silver(I) triazole complex…     

Synthesis and Structure of [Cu2（μ—NO2）（aepy）4]（ClO4）3 （aepy=2—（2—Aminoethyl）pyridine）

1 INTRODUCTION There has been great and considerable interest in the study of copper nitrite complexes because they are relevant to the study of copper-containing enzymes involved in the denitrification process[1]; in particular, copper-nitrite complexes are potentially relevant to the nitrite reductases[2] (the enzyme from Achromobacter Cycloclastes) which convert NO2－ to NO and/or N2O. Many attempts have been made to synthesize a variety of copper-nitrite complexes, in which the n…     

A Facile Solid Phase Synthesis of 2—Alkylthio—4（1H）—quinolones

The resin-bound cyclic malonic acid ester 2 reacted with aryl isothiocyanate and alkyl halides to afford the key intermediate arylthioaminomethylene cyclic malonic ester resin 3.Subsequently,resin 3 proceeded thermal cyclizaiton giving the 2-alkylthio-4(1H)-quinolones in good yields and excellent purties.     

Synthesis and Crystal Structure of N—tert—butyl—N′—（2，4—dichlorobenzoyl）—N—[1—（4—chlorophenyl）—1,4—dihydro—6—methylpyridazine—4—oxo—3—carbonyl]hydrazine

1 INTRODUCTIONPyridazinone derivatives represent one of the most active classes of compounds possessing a wide spectra of biological activity. They are widely used in pharmaceuticals and agrochemicals[1,2]. Rohm- Haas Company had reported that N-tert-butyl- dibenzoylhydrazine exhibits excellent insecti- cides[3, 4] and t-butyl plays an important role in the insecticide activity [5]. In the previous paper, we had reported that 1-aryl-1,4-dihydro-3- acylhydrazino- carbonyl-4-one-6-methylpy…     

1，3—Dipolar Cycloaddition of Substituted Benzonitrile Oxide to 5—（R）—（1—Menthyloxy）—2（5H）—furanone

Several isoxazoline compounds were obtained by the 1,3-dipolar cycloaddition of benzonitrile oxide to 5-(R)-(1-menthyloxy)-2(5H)-furanone. The reaction condition was investigated preliminarily, the structures of these compounds have been established via the analysis of NMR data (involved NOEID or HMBC) and the reaction seems occurred regioselectively.     

A Practical Synthesis of （S）—（＋）—2—（6′—methoxyl—2—naphthyl） propionic Acid

A simplified procedure for enantioselective synthesis of (S)-( )-2-(6′-methoxyl-2-naphthyl)propionic acid ((S)-( )-naproxen), starting from (6-methoxy-α-naphthyl)-1-propanone,with D-mannitol as auxiliary catalyzed by SmCl3 in one-pot is described. The yield is 87.5%(ee value 99%).     

E—1、Z—2（1—咪唑基）—O—（α—甲基对卤苄基）2′，4′—二氯苯乙酮肟硝酸盐的合成与结构表征

首先以2,4－二氯氯代苯乙酮、咪唑、羟胺和对卤苯乙酮为原料,分别合成E－、Z－2－1（1－咪唑基）－2′,4－′二氯苯乙酮肟（IE、IZ）和对卤α－氯乙苯（ⅡA和ⅡB）,ⅠE和ⅠZ分别与ⅡA和ⅡB反应,生成E－、Z－2－1（1－咪唑基）－O－（α－甲基对卤苄基）－2′,4′－二氯苯乙酮肟硝酸盐四个新化合物,产率炒52．0％－60．0％,并经元素分析、IR和^1HNMR进行了表征。