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微波辅助组合合成的研究进展 总被引:2,自引:0,他引:2
微波辅助组合合成技术是近年来发展起来的一种新的制备化合物库的组合化学技术, 它不仅可以克服传统固相组合合成技术以及液相组合合成技术无法提高产物收率的不足, 而且利用该技术所制得的化合物库中对应的是高纯度的单一化合物, 采用高通量筛选技术可以快速直接地确定高活性结构, 极大地提高了新药开发的效率. 主要就近年来微波辅助组合合成技术的研究进展情况进行介绍, 内容包括固相组合合成、基于聚合物支载的催化剂的组合合成、液相组合合成、氟相组合合成以及组合平行合成等. 相似文献
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综述了近年来液相组合合成的研究进展,主要包括液相组合合成法(LPCS),氟合成,树状载体组合合成及高分子辅助试剂在液相组合合成中的应用等。 相似文献
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钐试剂在有机合成中的应用 总被引:4,自引:0,他引:4
钐试剂在有机合成中的应用是近年来有机合成方法学研究中的热点之一。综述了十余年来本课题组在钐试剂应用于有机合成方面所开展的有关工作:(1)二碘化钐作为偶联剂和还原剂在有机合成中的应用;(2)金属钐直接应用于有机合成;(3)三碘化钐作为路易斯酸应用于有机合成;(4)有机钐试剂在有机合成中的应用。 相似文献
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Yamagishi H Matsumoto K Iwasaki K Miyazaki T Yokoshima S Tokuyama H Fukuyama T 《Organic letters》2008,10(12):2369-2372
An improved synthesis of the indole unit, a key intermediate for eudistomin C, was established utilizing Makosza's indole synthesis. A concise total synthesis of eudistomin E was achieved on the basis of the improved synthesis. 相似文献
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To date, the synthesis of peptides is concurrent with the production of enormous amounts of toxic waste. DMF, CH2Cl2, and NMP are three of the most toxic organic solvents used in chemical synthesis and are the most common solvents used for peptide synthesis. Additionally, concerns about the hepatotoxicity caused by exposure to DMF and from the toxic and allergenic nature of additives used in peptide synthesis necessitates the need for a green, environmentally friendly, and safer protocol for peptide synthesis. This review summarizes the current literature on green solid‐phase peptide synthesis successes and challenges encountered. The review concludes with suggestions for future research towards a simple and efficient green peptide synthesis protocol. 相似文献
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Solid-phase peptide synthesis in the N-to-C direction, opposite to the classical C-to-N direction of peptide synthesis, provides the synthetically versatile C-terminal carboxyl group for further modification into C-terminally modified peptide mimetics. These are of general interest as potential bioactive agents, particularly as protease inhibitors. Elaboration of peptide mimetics on the solid-phase would facilitate synthesis of peptide mimetic combinatorial libraries. This report describes an effective strategy for solid-phase inverse peptide synthesis based on readily available amino acid tert-butyl esters. The potential of this approach for peptide mimetic synthesis is demonstrated by the solid-phase synthesis of two peptide trifluoromethylketones. 相似文献
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无机纳米材料的合成是纳米科学发展的前提和基础之一。区别于传统的高温湿化学合成法,光化学方法在无机纳米材料的合成中表现出许多优点,并在近年来受到了广泛关注。本文分三个部分综述了近年来光化学方法在无机纳米材料合成中的应用,具体包括贵金属纳米材料的光化学合成与负载,半导体纳米材料的光化学合成以及表面等离子体共振诱导的各向异性金属纳米晶合成。最后,在总结光化学方法在无机纳米材料合成中体现出的优势及目前研究仍存在不足的基础上,我们对其未来可能的发展方向进行了展望。 相似文献
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《Arabian Journal of Chemistry》2020,13(1):799-834
Non-activated olefins represent one of the most explored platform in organic synthesis affording new and useful compounds with several biological applications, among others. The typical reactivity of these compounds is the addition-type reactions. A plethora of transformations and studies were reported in the literature by many research groups. The focus of this review is to organize and describe the most recent synthetic transformations of non-activated alkenes in organic synthesis. Therefore, it is divided into five sections corresponding to each type of the products obtained: synthesis of fluoro-, chloro- and bromo-compounds; synthesis of alkyl/vinyl/aryl/heteroaryl compounds; synthesis of phospho/sulfur/silyl/cyano-compounds; synthesis of amine/amide/oxygenated compounds and synthesis of other functionalized compounds. 相似文献
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Prof. Dr. Shū Kobayashi 《化学:亚洲杂志》2016,11(4):425-436
The concept of flow “fine” synthesis, that is, high yielding and selective organic synthesis by flow methods, is described. Some examples of flow “fine” synthesis of natural products and APIs are discussed. Flow methods have several advantages over batch methods in terms of environmental compatibility, efficiency, and safety. However, synthesis by flow methods is more difficult than synthesis by batch methods. Indeed, it has been considered that synthesis by flow methods can be applicable for the production of simple gasses but that it is difficult to apply to the synthesis of complex molecules such as natural products and APIs. Therefore, organic synthesis of such complex molecules has been conducted by batch methods. On the other hand, syntheses and reactions that attain high yields and high selectivities by flow methods are increasingly reported. Flow methods are leading candidates for the next generation of manufacturing methods that can mitigate environmental concerns toward sustainable society. 相似文献
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A. V. Mashkina 《Chemistry of Heterocyclic Compounds》2002,38(5):503-523
Researches on the synthesis of sulfur-containing heterocyclic compounds at the G. K. Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences, are reviewed. They include the synthesis of thiolane by the recyclization of THF in hydrogen sulfide; the synthesis thiacycloalkanes by the hydrogenation of thiophenes; the synthesis of 4-methylthiazole by the reaction of SO2 with methylisopropylideneamine; the synthesis of thiophenes by the heterocyclization of aliphatic compounds of sulfur and dehydrogenation of thiacycloalkanes; the synthesis of thiolane 1,1-dioxide by the hydrogenation of 2- and 3-thiolene 1,1-dioxides and 3-alkoxythiolane 1,1-dioxides; the synthesis of sulfoxides by the oxidation of thiacycloalkanes with atmospheric oxygen. 相似文献
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[structure: see text] The total synthesis of the polyether antibiotic ionomycin, a calcium ionophore, is described. The synthesis demonstrates the utility of ring-opening methodologies as applied to the synthesis of polypropionate and deoxypolypropionate subunits, which are found in two of the four fragments in the synthesis. 相似文献
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Yoshio Imai 《Macromolecular Symposia》1997,122(1):55-61
This paper reviews our current studies on the high pressure synthesis of polyimides and related condensation polymers. After a brief introduction of the solid-state thermal synthesis of polyimides starting from nylon-salt-type monomers, the paper deals with the high pressure synthesis of polyimides, the preparation of polyimide-silica hybrid materials by the combination of the above synthetic method for polyimides and the sol-gel reaction for silica synthesis, and the high pressure synthesis of polybenzoxazoles and addition-type polyaminoimide. 相似文献
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光化学合成在有机合成化学,特别在一些非常见结构的合成中占有特殊的地位,能大大缩短传统合成化学的步骤而经济实用.本文主要以天然产物及其中间体的合成,举例介绍有机合成光化学及其研究现状. 相似文献
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Hoffmann RW 《Angewandte Chemie (International ed. in English)》2003,42(10):1096-1109
After more than a quarter of a century of development, the methodology of stereoselective synthesis appears to be fully matured. In line with this, the potential that meso compounds offer in stereoselective synthesis is clearly recognized. The use of meso compounds in synthesis is, however, in no way commensurate with this potential, because, ironically, the synthesis of meso compounds in the first place is a problem of stereoselective synthesis. Present-day methodology does not provide many useful solutions to this problem. This Review therefore addresses the strategies available for the synthesis of more elaborate meso compounds whose stereogenic centers have a distance >1,4 between them. meso Compounds with more than four stereogenic centers are also considered. The criteria used in choosing from several strategies in the synthesis of such compounds are discussed. 相似文献
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针对目前教学中存在的理论课程之间、实验课程与理论课程之间关联不够紧密等问题,探索了通过"知识关联"将有机化学基本知识运用到高分子材料合成创新实验中的教学思路。以新试剂合成及应用、荧光聚酯合成、聚酰胺合成、聚酯水解等为例,介绍了如何将有机化学新理论、新方法、新试剂应用于本科高分子化学和高分子材料实验教学,以及如何将有机化学的理论知识和实验手段应用于高分子材料合成教学中。实践表明:通过"知识关联",将有机化学基础理论知识和实验技能应用于高分子合成实验中可以提高学生对所学知识的理解和运用能力,增强学生的实验探索兴趣,有效改进了高分子材料合成实验教学的课堂气氛。 相似文献