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1.
Benson M. Kariuki Bakr F. Abdel-Wahab Hanan A. Mohamed Mohamed S. Bekheit Gamal A. El-Hiti 《Molecules (Basel, Switzerland)》2022,27(24)
Reactions of 1-(5-methyl)-1H-1,2,3-triazol-4-yl)ethan-1-ones and benzaldehydes in ethanol under basic conditions gave the corresponding chalcones. Reactions of the chalcones combined with thiosemicarbazide in dry ethanol containing sodium hydroxide afforded the corresponding pyrazolin-N-thioamides. Reactions of the synthesized pyrazolin-N-thioamides and several ketones (namely, ethyl 2-chloro-3-oxobutanoate, 2-bromoacetylbenzofuran, and hydrazonoyl chloride) gave the corresponding novel 2-(1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazoles in high yields (77–90%). Additionally, 2-(4,5-dihydro-1H-pyrazol-1-yl)-4-(1H-1,2,3-triazol-4-yl)thiazoles were obtained in high yields (84–87%) from reactions with N-pyrazoline-thioamides and 4-bromoacetyl-1,2,3-triazoles under basic conditions. The structures of six of the newly synthesized heterocycles were confirmed by X-ray crystallography. 相似文献
2.
Danilyuk I. Yu. Vas’kevich R. I. Vovk M. V. 《Russian Journal of Organic Chemistry》2018,54(6):954-956
Russian Journal of Organic Chemistry - Heating of 4-aryl-N-(1H-pyrazol-4-yl)but-3-enamides in polyphosphoric acid selectively afforded 5-aryl-1-(1H-pyrazol-4-yl)pyrrolidin-2-ones. 相似文献
3.
4.
I. B. Dzvinchuk A. V. Turov M. O. Lozinskii 《Chemistry of Heterocyclic Compounds》2009,45(11):1325-1330
2-(3,5-Diaryl-1H-pyrazol-4-yl)-1H-benzimidazoles have been obtained by the cyclocondensation of 2-phenacyl-1H-benzimidazoles
with 4-nitro- and 4-methoxybenzoylhydrazines. The reaction mechanism and the isomerism of the obtained products are discussed.
According to the data of 1H NMR spectroscopy the stabilized isomer is that in which the electron-withdrawing aryl substituent is located in position
3 and the electron-donating substituent in position 5 of the pyrazole ring. 相似文献
5.
A. V. Ivashchenko O. N. Garicheva L. V. Shmelev Yu. S. Ryabokobylko 《Chemistry of Heterocyclic Compounds》1980,16(3):309-312
New 2, 4-diamino-and 2-amino-4-(1H-pyrazol-1-yl) pyrimidine derivatives, which are of interest as mono-and bidentate ligands,
were synthesized. From an examination of the UV, IR, and PMR spectra of the synthesized compounds it was concluded that they
exist in the “amino” form.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 404–407, March, 1980. 相似文献
6.
Vera L.M. Silva Artur M.S. Silva Rosa M. Claramunt Concepción López Dionisia Sanz Lourdes Infantes Ángela Martínez López Felipe Reviriego Ibon Alkorta José Elguero 《Tetrahedron》2019,75(48):130690
Tetrakis(1H-pyrazol-1-yl)methanes are very rare compounds of which only two are known: the unsubstituted 1 obtained classically by Hückel in 1937 from carbon tetrachloride and prepared again several times and the 3,5-dimethyl substituted 2 obtained serendipitously by Pombeiro in 2009. We have now extended this group to include four new derivatives 8, 9, 11 and 12 bearing methyl groups. The X-ray crystal structure of the four compounds has been determined. They have been studied by NMR both in solution (1H, 13C, 15N) and in the solid state (13C and 15N). DFT calculations of the six compounds (geometries, energies and absolute shieldings) have been used to discuss the experimental observations. 相似文献
7.
The cyclocondensation of 1-methyl-2-phenacyl-1H-benzimidazole with aroylhydrazines yields 2-(3,5-diaryl-1H-pyrazol-4-yl)-1-methyl-1H-benzimidazoles.
The 1H NMR spectra indicate that these products display tautomerism. The more stable tautomers have structures containing electron-donor
aryl substituents at C-5 and electron-withdrawing aryl substituents at C-3 of the pyrazole ring. 相似文献
8.
9.
以水合肼和硝酸胍为原料,经过环合、氧化和肼化,得到3-(3,5-二甲基-1H-吡唑-1-基)-6-肼基-1,2,4,5-四嗪(4),以此为原料和不同芳香醛发生腙化反应,得到系列1-芳基亚甲基-2-(6-(3,5-二甲基-1H-吡唑-1-基)-1,2,4,5-四嗪-3-基)肼(5),产物经元素分析、1H NMR、IR和MS表征。所合成的系列化合物抗菌活性测试表明,它们对大肠杆菌、金黄色葡萄球菌、枯草杆菌等3种细菌表现出一定程度的抑制活性。 相似文献
10.
Alex F. C. Flores Juliana L. Malavolta Leandro M. Frigo Morgana Doneda Darlene C. Flores 《合成通讯》2013,43(10):1198-1204
We develop an efficient method to synthesize novel propionyl-spaced bisheterocyclic compounds. It entails cyclocondensation of 3-(5-trifluoromethyl-1H-pyrazol-3-yl)propanoyl hydrazide obtained from levulinic acid, with 1,1,1-trifluoro-4-methoxy-3-alken-2-ones proceeding regiospecifically to 1-[(5-trifluoromethyl-5-hydroxy-3-substituted-4,5-dihydro-1H-pyrazol-1-yl)-3-(5-trifluoromethyl-1H-pyrazol-3-yl)propan-1-one derivatives. 相似文献
11.
3,3-二硝基氮杂环丁烷和1,1''''-亚甲基-双(3,3-二硝基-1-氮杂环丁烷)的合成研究 总被引:1,自引:0,他引:1
3,3-二硝基氮杂环丁烷(DNAZ)的含能盐及衍生物是一类重要的高能量密度材料,因此DNAZ的合成和应用受到了密切关注.采用新的合成方法,以1-叔丁基-3,3-二硝基氮杂环丁烷为起始原料,以76.3%的总收率得到了DNAZ,然后以DNAZ为原料,与多聚甲醛反应,得到了1,1'-亚甲基-双(3,3-二硝基-1-氮杂环丁烷)(DNAZ-CH2-DNAZ).用红外和核磁共振光谱等对各化合物的结构进行了表征. 相似文献
12.
Synthesis of linear and cyclic compounds containing the 3,4-bis(furazan-3-yl)furoxan fragment 总被引:1,自引:0,他引:1
A. I. Stepanov A. A. Astrat’ev D. V. Dashko N. P. Spiridonova S. F. Mel’nikova I. V. Tselinskii 《Russian Chemical Bulletin》2012,61(5):1024-1040
Some chemical transformations of 3,4-bis(4-aminofurazan-3-yl)furoxan (1) and 3,4-bis-(4-nitrofurazan-3-yl)furoxan (2) were considered. Compounds 1 and 2 are valuable synthons for the preparation of linear and cyclic compounds containing the 3,4-bis(furazan-3-yl)furoxan fragment. The reaction of compound 2 with a series of N- and O-nucleophiles afforded novel heterocyclic systems: 7-R-7H-difurazano[3,4-b:3′,4′-f]furoxano[3″,4″-d]azepine and difurazano[3,4-b:3′,4′-f]furoxano[3″,4″-d]oxepin. 相似文献
13.
O. A. D'yachenko Yu. A. Sokolova L. O. Atovmyan V. M. Berestovitskaya E. V. Trukhin G. A. Berkova 《Russian Chemical Bulletin》1985,34(12):2528-2532
Conclusions 3,4-Dinitro-3,4-dimethyl-1,1-diphenyl-1-silacyclopentane in the liquid phase has a half-chair conformation, and in the solid phase, its conformation is described by a form intermediate between the half-chair and the envelope conformation.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2731–2736, December, 1985. 相似文献
14.
Prashant P. Thakare Yogesh Walunj Abhijit Chavan Vivek D. Bobade Dhiman Sarkar Pravin C. Mhaske 《Journal of heterocyclic chemistry》2020,57(11):3918-3929
A new series of 4-(4-(1-benzyl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-pyrazol-3-yl)quinoline ( 6a-t ) have been synthesized by a click reaction of 4-(4-ethynyl-1-phenyl-1H-pyrazol-3-yl)quinoline ( 4a-d ) with a substituted benzyl azide ( 5a-e ). The starting alkyne derivatives 4a-d are obtained from Bestmann-Ohira reaction of 1-phenyl-3-(quinolin-4-yl)-1H-pyrazole-4-carbaldehyde and dimethyl(1-diazo-2-oxopropyl)phosphonate. The newly synthesized compounds are screened against M. tuberculosis H37Ra dormant and active, Escherichia coli, Pseudomonas fluorescence, Staphylococcus aureus and Bacillus subtilis strains at 30 μg/mL concentration. Most of the screened compounds showed good to moderate antibacterial activity against S. aureus, B. subtilis, and Mycobacterium tuberculosis H37Ra strains. The synthesized derivatives of quinolinyl-pyrazole-4-carbaldehyde and quinolinyl-pyrazole-4-ethyne reportd good to moderate activity against both strains of M. tuberculosis H37Ra. Ten derivatives of quinolinyl-pyrazole presented good activity against B. subtilis. These results suggested that further optimization and development of quinolinyl-pyrazolyl-1,2,3-triazole moeity could serve as lead compounds for antimycobacterial activity. 相似文献
15.
A short and efficient synthesis of 1-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl) urea derivatives (1a–c), a novel type of p38 MAPK inhibitors, is described. The Claisen thermal rearrangement of arylpropargyl ethers was employd as a key step to synthesize the chromene core. The solvent effect on the ratio of the resultant two isomers of Claisen thermal rearrangement, namely 2-methylbenzofuran and 2H-chromen, was also investigated. 相似文献
16.
Marcin Kublicki Błażej Ogonowski Dariusz Wieczorkowski Krzysztof Durka Tomasz Kliś 《Tetrahedron letters》2019,60(29):1918-1923
The key photocatalytic properties of a transition-metal-free heteroleptic complex derived from 1,4-phenyldiboronic acid were evaluated. This compound was utilized in the atom transfer radical addition of iodoperfluoroalkanes to a series of alkenyl group bearing organoboron compounds. The products of these reactions retained the BC bond, and Suzuki-Miyaura coupling of one product gave biphenyl derivatives. The X-ray analysis of one of the obtained perfluoroalkylated boronic acids revealed the presence of open star-shaped channels. 相似文献
17.
Synthesis and biological activity of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives 总被引:1,自引:0,他引:1
Jing-Qian Huo Liu-Yong Ma Zhe Zhang Zhi-Jin Fan Jin-Lin Zhang Tetyana V. Beryozkina Vasiliy A. Bakulev 《中国化学快报》2016,27(9):1547-1550
A series of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives were designed and synthesized. Their structures were confirmed by 1H NMR, 13C NMR and HRMS. All title compounds were evaluated for their herbicidal and antifungal activities. Preliminary bioassay results indicated that the title compounds showed good to moderate herbicidal activity at 1000 mg/L. Compound 6q presented the best activity against Digitaria sanguinalis (L) Scop., Amaranthus retroflexus L. and Arabidopsis thaliana with an inhibition degree of five. Compound 6d also showed an inhibition degree of five against D. sanguinalis. In addition, at 50 mg/L, most compounds exhibited good in vitro antifungal activity against Sclerotinia sclerotiorum, with compound 6c showing over 90% antifungal activity against S. sclerotiorum and Pellicularia sasakii. 相似文献
18.
Hiroyuki Obase Haruki Takai Masayuki Teranishi Nobuhiro Nakamizo 《Journal of heterocyclic chemistry》1983,20(3):565-573
Structural modifications of 4-piperidylbenzimidazolinones (I) by replacing the benzimidazolinone group with other heterocycles (2-cyanoamino, 2-ethoxy, and 2-methylbenzimidazole and 2-cyanoamino-3,4-dihydroquinazoline) has been made and a number of new piperidines (II) were synthesized as potential antihypertensive agents. 相似文献
19.
A. V. Fokin Yu. N. Studnev V. P. Stolyarov R. Sh. Valiev 《Russian Chemical Bulletin》1999,48(1):131-135
A preparative method for the synthesis ofC- andN-difluoroaminooxy compounds was elaborated. The method involves the reaction ofN,N-difluoro-O-fluorosulfonyl hydroxylamine with the corresponding alkoxides andN-oximide salts. It was shown thatN-difluoroaminooxy compounds can add to olefins at the double bond.
Deceased
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 130–134, January, 1999. 相似文献
20.
The title compound, 1-(naphthalene-2-yl)-2-(1H-pyrazol-1-yl)ethanone O-butyl oxime, I, was synthesized. The crystal and molecular structures of I were determined by IR, 1H-NMR, mass spectrum, elemental analysis and X-ray single crystal diffraction. Molecular geometry from X-ray experiment of I in the ground state was compared using the Density Functional Theory (DFT) with B3LYP/6-311G(d,p) basis set. In addition, DFT calculation, molecular electrostatic potentials (MEP) and frontier molecular orbitals of I were performed at the B3LYP/6-311G(d,p) level of the theory. 相似文献