Bifurcation for a free boundary problem modeling the growth of a tumor with a necrotic core

We consider a free boundary problem for a system of partial differential equations, which arises in a model of tumor growth with a necrotic core. For any positive numbers ρ<R, there exists a radially symmetric stationary solution with tumor boundary r=R and necrotic core boundary r=ρ. The system depends on a positive parameter μ, which describes the tumor aggressiveness. There also exists a sequence of values μ₂<μ₃<? for which branches of symmetry-breaking stationary solutions bifurcate from the radially symmetric solution branch.     

Asymptotic stability of a mathematical model of cell population

We consider a simplified system of a growing colony of cells described as a free boundary problem. The system consists of two hyperbolic equations of first order coupled to an ODE to describe the behavior of the boundary. The system for cell populations includes non-local terms of integral type in the coefficients. By introducing a comparison with solutions of an ODE's system, we show that there exists a unique homogeneous steady state which is globally asymptotically stable for a range of parameters under the assumption of radially symmetric initial data.     

Radially Symmetric Solutions of the <Emphasis Type="Italic">p</Emphasis>-Laplace Equation with Gradient Terms

We consider the Dirichlet problem for the p-Laplace equation with nonlinear gradient terms. In particular, these gradient terms cannot satisfy the Bernstein—Nagumo conditions. We obtain some sufficient conditions that guarantee the existence of a global bounded radially symmetric solution without any restrictions on the growth of the gradient term. Also we present some conditions on the function simulating the mass forces, which allow us to obtain a bounded radially symmetric solution under presence of an arbitrary nonlinear source.     

Uniqueness of a positive solution to the Dirichlet problem for a quasilinear equation with <Emphasis Type="Italic">p</Emphasis>-laplacian in a ball

We obtain sufficient conditions for the existence of a unique positive radially symmetric solution to the Dirichlet problem for a quasilinear equation of elliptic type in a multidimensional ball.     

Radially symmetric minimizers for a p-Ginzburg Landau type energy in {\mathbb R^2}

We consider the minimization of a p-Ginzburg-Landau energy functional over the class of radially symmetric functions of degree one. We prove the existence of a unique minimizer in this class, and show that its modulus is monotone increasing and concave. We also study the asymptotic limit of the minimizers as p ?? ??. Finally, we prove that the radially symmetric solution is locally stable for 2?<?p????4.     

Radially symmetric solutions of the Poisson–Boltzmann equation

The electrostatic potential u outside of a charged cylinder contained in an infinitely large container of electrolyte satisfies the Poisson–Boltzmann equation Δu = shu and boundary condition ?u/?n = ? σ on the cylinder and u(∞) = 0. We show that there exists a unique radially symmetric solution of the problem and consider its properties.     

A three-dimensional steady-state tumor system

The growth of tumors can be modeled as a free boundary problem involving partial differential equations. We consider one such model and compute steady-state solutions for this model. These solutions include radially symmetric solutions where the free boundary is a sphere and nonradially symmetric solutions. Linear and nonlinear stability for these solutions are determined numerically.     

Computing steady-state solutions for a free boundary problem modeling tumor growth by Stokes equation

We consider a free boundary problem modeling tumor growth where the model equations include a diffusion equation for the nutrient concentration and the Stokes equation for the proliferation of tumor cells. For any positive radius R$R$, it is known that there exists a unique radially symmetric stationary solution. The proliferation rate μ$\mu$ and the cell-to-cell adhesiveness γ$\gamma$ are two parameters for characterizing “aggressiveness” of the tumor. We compute symmetry-breaking bifurcation branches of solutions by studying a polynomial discretization of the system. By tracking the discretized system, we numerically verified a sequence of μ/γ$\mu /\gamma$ symmetry breaking bifurcation branches. Furthermore, we study the stability of both radially symmetric and radially asymmetric stationary solutions.     

Global fast and slow solutions of a localized problem with free boundary

In this paper,we consider a localized problem with free boundary for the heat equation in higher space dimensions and heterogeneous environment.For simplicity,we assume that the environment and solution are radially symmetric.First,by using the contraction mapping theorem,we prove that the local solution exists and is unique.Then,some sufficient conditions are given under which the solution will blow up in finite time.Our results indicate that the blowup occurs if the initial data are sufficiently large.Finally,the long time behavior of the global solution is discussed.It is shown that the global fast solution does exist if the initial data are sufficiently small,while the global slow solution is possible if the initial data are suitably large.     

Existence and Stability for Spherical Crystals Growing in a Supersaturated Solution

We consider the growth of a spherical crystal in a supersaturatedsolution. In the first part, existence and uniqueness resultsfor radially symmetric growth are obtained, provided that thesupersaturation is not too large; conversely, when the far-fieldsupersaturation exceeds a critical value, it is shown that theradially symmetric solution ceases to exist in finite time.In the second part, we examine the linear stability of a radiallysymmetric similarity solution (in which the radius grows ast?) to shape perturbations. The results are compared with previousquasi-static analyses, and, in particular, the critical radiusat which the crystal becomes unstable is found to be largerfor small supersaturations, but smaller for large supersaturations,than those predicted by the quasi-static analysis     

Analysis of an elliptic-parabolic free boundary problem modelling the growth of non-necrotic tumor cord

We study a free boundary problem modelling the growth of a tumor cord in which tumor cells live around and receive nutrient from a central blood vessel. The evolution of the tumor cord surface is governed by Darcy's law together with a surface tension equation. The concentration of nutrient in the tumor cord satisfies a reaction-diffusion equation. In this paper we first establish a well-posedness result for this free boundary problem in some Sobolev-Besov spaces with low regularity by using the analytic semigroup theory. We next study asymptotic stability of the unique radially symmetric stationary solution. By making delicate spectrum analysis for the linearized problem, we prove that this stationary solution is locally asymptotically stable provided that the constant c representing the ratio between the diffusion time of nutrient and the birth time of new cells is sufficiently small.     

Bifurcation analysis for a free boundary problem modeling tumor growth

In this paper we deal with a free boundary problem modeling the growth of nonnecrotic tumors. The tumor is treated as an incompressible fluid, the tissue elasticity is neglected and no chemical inhibitor species are present. We re-express the mathematical model as an operator equation and by using a bifurcation argument we prove that there exist smooth stationary solutions of the problem which are not radially symmetric.     

A parabolic–hyperbolic system modeling the tumor growth with angiogenesis

In this paper, we study the parabolic–hyperbolic system about the growth of a tumor. The model is a coupled system of PDEs with Robin boundary, which involves nutrient density, extracellular matrix and matrix degrading enzyme. By transforming the free boundary into a fixed boundary and using strict mathematical analysis, we can prove the existence and uniqueness of the radially symmetric stationary solution. By the fixed point theorem, we obtain the existence and uniqueness of the radially symmetric solution globally in time.     

五维空间中半线性波动方程整体解的存在性定理

本文研究五维空间中半线性波动方程u_tt-△u=G（u）整体解的存在性,其中G（u）～|u|^p并且p>（3+(17)^1/2)/4.利用经典的迭代方法证明了:如果初始值很小并且紧支的,径向对称方程有一个经典整体解.     

Eigenvalues for Radially Symmetric Fully Nonlinear Operators

In this paper we present an elementary theory about the existence of eigenvalues for fully nonlinear radially symmetric 1-homogeneous operators. A general theory for first eigenvalues and eigenfunctions of 1-homogeneous fully nonlinear operators exists in the framework of viscosity solutions. Here we want to show that for the radially symmetric operators or in the one dimensional case a much simpler theory, based on ode and degree theory arguments, can be established. We obtain the complete set of eigenvalues and eigenfunctions characterized by the number of zeroes.     

Nonradial positive solutions of the ‐Laplace Emden–Fowler equation with sign‐changing weight

In this paper we study the p‐Laplace Emden–Fowler equation with a radial and sign‐changing weight in the unit ball under the Dirichlet boundary condition. We show that if the weight function is negative in the unit ball except for a small neighborhood of the boundary and positive at somewhere in this neighborhood, then no least energy solution is radially symmetric. Therefore the equation has both a positive radial solution and a positive nonradial solution. Moreover, we prove in the one dimensional case that if the neighborhood is large, then a positive solution is unique.     

Partial symmetry of least energy nodal solutions to some variational problems

We investigate the symmetry properties of several radially symmetric minimization problems. The minimizers which we obtain are nodal solutions of superlinear elliptic problems, or eigenfunctions of weighted asymmetric eigenvalue problems, or they lie on the first curve in the Fucik spectrum. In all instances, we prove that the minimizers are foliated Schwarz symmetric. We give examples showing that the minimizers are in general not radially symmetric. The basic tool which we use is polarization, a concept going back to Ahlfors. We develop this method of symmetrization for sign changing functions. Supported by NATO grant PST.CLG.978736. Supported by DFG grant WE 2821/2-1. Supported by NATO grant SPT.CLG.978736.     

Existence of non-radially symmetric viscosity solutions to semilinear degenerate elliptic equations with radially symmetric coefficients in the plane, Part I

We prove the existence of non-radially symmetric solutions for semilinear degenerate elliptic equations with radially symmetric coefficients in the plane. We adapt the viscosity solution for the weak solution. The key arguments consist of the analysis of the structure of 2π-periodic solutions for the associated Laplace-Beltrami operator and construction of super- and sub-solutions which have the prescribed asymptotic structures.     

A regularization method for solving the radially symmetric backward heat conduction problem

This work is devoted to solving the radially symmetric backward heat conduction problem, starting from the final temperature distribution. The problem is ill-posed: the solution (if it exists) does not depend continuously on the given data. A modified Tikhonov regularization method is proposed for solving this inverse problem. A quite sharp estimate of the error between the approximate solution and the exact solution is obtained with a suitable choice of regularization parameter. A numerical example is presented to verify the efficiency and accuracy of the method.     

The rate of concentration for the radially symmetric solution to a degenerate drift-diffusion equation with the mass critical exponent

We consider the concentration rate of the total mass for radially symmetric blow-up solutions to the Cauchy problem of a degenerate drift-diffusion system with the mass critical exponent. We proved that the radially symmetric solution blows up in finite time when the initial data has negative free energy. We show that the mass concentration phenomenon occurs with the sharp lower constant related to the best constant of the Hardy–Littlewood–Sobolev inequality and the concentration rate of the total mass.