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1.
The 2f1-f2 distortion product otoacoustic emission (DPOAE) is considered to consist of two components in normally hearing ears, one having constant phase with changing DP frequency (wave fixed) and one having an increasing phase lag with increasing frequency (place fixed). The aim was to identify the wave-fixed and place-fixed components of both 2f1-f2 and 2f2-f1 DPs, and, in particular, to show whether a wave-fixed 2f2-f1 DP exists in normally hearing adults. DPOAE recordings were made in 20 ears of normally hearing young adults. Four frequency ratios were used and recording entailed fixed frequency-ratio sweeps. A separation into wave-fixed and place-fixed components was carried out using a time-window separation method. A method for estimating the noise floor after data processing was developed. Results confirmed the presence of wave-fixed and place-fixed components for 2f1-f2, consistent with previous studies. Both components were also present for 2f2-f1 in virtually all subjects. This latter finding conflicts with current models of DPOAE generation, and so a modified model is proposed. Unlike the 2f1-f2 emission, which has a wave-fixed component that is strongly dependent on the frequency ratio, neither component of the 2f2-f1 emission showed such a dependence. The proposed model explains these findings in terms of the overlap of the primary frequency traveling waves. 相似文献
2.
L E Humes 《The Journal of the Acoustical Society of America》1985,78(4):1245-1251
The cancellation level and phase were measured for the (f2-f1) distortion product in six normal-hearing ears as a function of input level (L1,L2) and the frequency separation of the two input signals (f1,f2, where f2 greater than f1). The effects of input level were examined for L1 and L2, varied together (L1 = L2) and separately. Typically, f1 was 1500 Hz while f2/f1 was either 1.16, 1.32, 1.44, or 1.68. For L1 = L2, the median data indicate that the (f2-f1) level grows at a rate of approximately 1.1 dB/dB when averaged across all stimulus conditions. This slope tended to be higher (approximately 1.6 dB/dB) for L1 = L2 greater than 80 dB. Slopes for some subjects also increase as f2/f1 increases. The cancellation phase increases slightly (50 degrees - 100 degrees) with an increase in L1 = L2. With L1 at 75 to 80 dB, L2 ranging from 65 to 95 dB, and f2/f1 = 1.16, (f2-f1) increases monotonically with L2 up to L1 = L2. As L2 increases further (L2 greater than L1), the slopes for the growth of (f2-f1) decrease. For f2/f1 = 1.44, on the other hand, (f2-f1) appears to grow monotonically at a rate of approximately 0.5 dB/dB throughout the range of L2 values. The cancellation phase increases with L2 (approximately 100 degrees) only for the wider frequency separation of the two input signals (f2/f1 = 1.44). There are, however, sizable individual differences in the behavior of the (f2 - f1) distortion product. 相似文献
3.
M Furst W M Rabinowitz P M Zurek 《The Journal of the Acoustical Society of America》1988,84(1):215-221
Two aspects of the intermodulation distortion product at 2f1-f2 generated by normal human ears and measured acoustically in the ear canal were studied: (1) its relation to tone-evoked and spontaneous otoacoustic emissions, and (2) its relation to the perceived combination tone at the same frequency. With regard to (1), substantial differences among ears in the detectability of emissions were observed; ears tended to exhibit all or none of the emission types that were sought. Within ears possessing emissions, the magnitudes of tone-evoked emissions and acoustic distortion showed a similar dependence on frequency. With regard to (2), a three-primary-tone stimulus was employed to ask whether the ear canal acoustic distortion tone is canceled under the same stimulus conditions that produce perceptual cancellation. Simultaneous cancellation of perceptual and acoustic distortion was produced rarely. Results are interpreted qualitatively with a model in which primary tones produce distortion at their interaction region within the cochlea; this distortion propagates to the distortion-frequency place where it mediates perception. This same distortion wave produces emission components at additional locations, including the primary-tone interaction region, which sum vectorially to mediate the emitted acoustic distortion product. 相似文献
4.
The behavior of the acoustic distortion product, 2f1-f2, from the human ear and its relation to auditory sensitivity 总被引:1,自引:0,他引:1
The acoustic intermodulation distortion product 2f1-f2 (ADP) was measured in human subjects to investigate (1) the dependence of ADP level on stimulus parameters and (2) the relationship between ADP level and auditory sensitivity. The frequency ratio (f2/f1), at which ADP level is maximal, varies only slightly across frequency and subjects. The average optimal ratio is 1.225. Beyond the maximum, the ADP level declines with increasing f2/f1 ratio, at rates of up to 250 dB/oct. As the level of one stimulus is increased relative to the other, the ADP grows, saturates, and in most cases shows a bendover. Maximum distortion is generated when L 1 exceeds L 2. Growth rate and saturation point are dependent on which stimulus is incremented and on the level of the stationary stimulus. With optimal stimulus parameters (levels below 60 dB SPL; L 1 greater than L 2 by 15 dB; f2/f1 = 1.225), ADP levels are commonly 30 dB below L 2. Patterns of ADP level across frequency vary between subjects, but are repeatable within each subject. As the frequency of one or both of the stimuli is varied, changes in ADP level exhibit a broadly featured pattern with a fine structure superimposed upon it. This fine structure was compared with the features in the stimulus frequency emission spectrum in one subject. With appropriate stimulus parameters, half of our subjects show a statistically significant correlation across frequency, between ADP level and auditory sensitivity at the corresponding f1 frequency. Our results suggest that, with low levels of stimulation, ADP measurements could form the basis of an objective measure of cochlear function in human subjects. 相似文献
5.
The 2f1-f2 acoustic emission (AE) was recorded in the ear canals of cats following exposure to tone bursts of 200-ms duration. Exposures known to result in short-term adaptation (i.e., adaptation lasting under 1 s) at the level of the auditory nerve failed to produce significant post-exposure changes in AE amplitude. Given the apparent cochlear origin of the 2f1-f2 AE, this result is consistent with the view that short-term adaptation in the auditory periphery does not involve substantial changes in cochlear mechanics. 相似文献
6.
Recordings of dc and ac receptor potentials from pigmented guinea pig inner hair cells indicate strong responses to the 2f1-f2 intermodulation tone when f1 and f2 are greater than the hair cell characteristic frequency and do not cause a response when given individually. The effective magnitude of this cubic distortion product (CDP) was about 25-30 dB below equal sound level primaries over a 20-30-dB range of their sound levels. The relative strength of the CDP declined at a rate greater than 180-dB/oct separation of the primaries. When magnitude of f1 or f2 was held constant, the growth of CDP was nonmonotonic, exhibiting a distinct maximum. With a constant level of f1 or f2, optimal CDP was produced when the level of f2 was 10-15 dB greater than f1. Strong two-tone suppression from the primaries has a role in shaping the CDP growth. The ac receptor potentials of the CDP show a 150 degrees-200 degrees phase shift when the primaries are increased over a 50-dB range. These results support the hypothesis of a propagated CDP in the cochlea and are consistent with the major features of related studies of human psychoacoustic experiments, afferent nerve neural rate functions, and ear canal distortion products. 相似文献
7.
Distortion product otoacoustic emission (DPOAE) ipsilateral suppression has been applied to study cochlear function and maturation in laboratory animals and humans. Although DPOAE suppression appears to be sensitive to regions of specialized cochlear function and to cochlear immaturity, it is not known whether it reflects permanent cochlear damage, i.e., sensorineural hearing loss (SNHL), in a reliable and systematic manner in humans. Eight school-aged children with mild-moderate SNHL and 20 normal-hearing children served as subjects in this study. DPOAE (2f1-f2) suppression data were collected at four f2 frequencies (1500, 3000, 4000, and 6000 Hz) using moderate-level primary tones. Features of the DPOAE iso-suppression tuning curves and suppression growth were analyzed for both subject groups. Results show that DPOAE suppression tuning curves from hearing-impaired subjects can be reliably recorded. DPOAE suppression tuning curves were generally normal in appearance and shape for six out of eight hearing-impaired subjects but showed subtle abnormalities in at least one feature. There was not one single trend or pattern of abnormality that characterized all hearing-impaired subjects. The most prominent patterns of abnormality included: broadened tuning, elevated tip, and downward shift of tip frequency. The unique patterns of atypical DPOAE suppression in subjects with similar audiograms may suggest different patterns of underlying sensory cell damage. This speculation warrants further investigation. 相似文献
8.
Modifications of a single saturating non-linearity account for post-onset changes in 2f1-f2 distortion product otoacoustic emission 总被引:2,自引:0,他引:2
2f1-f2 distortion product otoacoustic emissions (DPOAEs) were recorded from guinea pigs. DPOAEs showed complex time dependence at the onset of stimulation. The DPOAE, measured during the first 500 ms, can either decrease or increase at the onset depending on both the frequencies and levels of the primary tones. These changes are closely associated with amplitude minima (notches) of the DPOAE I/O functions. These notches are characteristic of DPOAE growth functions measured from guinea pigs for primary tones of 50-60-dB sound-pressure level (SPL). Apparent changes in the DPOAE amplitude occur because the notch shifts to higher levels of the primaries during the onset of stimulation. This shift of the notch to higher levels increases for lower f2/f1 ratios but does not exceed about 2 dB. DPOAE amplitude increases for a constant level of the primaries if the onset emission is situated at the low-level, falling slope of the notch. If the onset DPOAE is located on the high-level, rising slope of the notch, then the upward shift of the notch causes the emission either to decrease monotonically, or to decrease initially and then increase. By establishing that the 2f1-f2 onset changes reflect a shift in the growth-function notch, it is possible to predict the temporal behavior of DPOAEs in the two-dimensional space of the amplitude of the primaries and for their different frequency ratios. 相似文献
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10.
Synchronization of spontaneous otoacoustic emissions to a cubic distortion frequency fs = 2f1-f2 has been studied. Stimulus, consisting of two primary tones at frequency f1 and f2, could easily be filtered out of the microphone signal. This enabled us to monitor emission phase with respect to synchronization frequency fs, by recording zero-crossing moments of the microphone signal. When primaries were sufficiently loud (typically 30 dB SPL), phase fluctuated around a constant value: The emission was constantly synchronized to fs. Lowering primary levels (to typically 20 dB SPL) resulted in 2 pi-phase jumps at random moments: The emission occasionally slipped out of synchronization, trying to maintain its own natural frequency f0. This behavior can be described as synchronization of an oscillator (frequency f0) to a sinusoidal force (frequency fs) in the presence of noise. 相似文献
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Distortion product otoacoustic emission (2f1-f2) amplitude growth in human adults and neonates 总被引:1,自引:0,他引:1
Abdala C 《The Journal of the Acoustical Society of America》2000,107(1):446-456
Distortion product otoacoustic emissions (DPOAEs) are thought to be by-products of an active amplification process in the cochlea and thus serve as a metric for evaluating the integrity of this process. Because the cochlear amplifier functions in a level-dependent fashion, DPOAEs recorded as a function of stimulus level (i.e., a DPOAE growth function) may provide important information about the range and operational characteristics of the cochlear amplifier. The DPOAE growth functions recorded in human adults and neonates may provide information about the maturation of these active cochlear processes. Two experiments were conducted. Experiment I included normal-hearing adults and term-born neonates. The 2f1-f2 DPOAE growth functions were recorded for both age groups at three f2 frequencies. Experiment II was an extension of the first experiment but added a subject group of premature neonates. The results of these studies indicate that DPOAE growth functions most often show amplitude saturation and nonmonotonic growth for all age groups. However, premature neonates show monotonic growth and the absence of amplitude saturation more often than adults. Those premature neonates who do show saturation also show an elevated threshold for amplitude saturation relative to adults. In contrast, term neonates are adultlike for most measures except that they show a larger percentage of nonsaturating growth functions than adults. These results may indicate immaturity in cochlear amplifier function prior to term birth in humans. Outer hair cell function and/or efferent regulation of outer hair cell function are hypothesized sources of this immaturity, although some contribution from the immature middle ear cannot be ruled out. 相似文献
13.
Tubis A Talmadge CL Tong C Dhar S 《The Journal of the Acoustical Society of America》2000,108(4):1772-1785
For primary frequency ratios, f2/f1, in the range 1.1-1.3, the fixed-f1 ("f2-sweep") phase derivative of the 2f1-f2 distortion product otoacoustic emission (DPOAE) is larger than the fixed-f2("f1-sweep") one. It has been proposed by some researchers that part or all of the difference between these delays may be attributed to the so-called cochlear filter "build-up" or response time in the DPOAE generation region around the f2 tonotopic site. The analysis of an approximate theoretical expression for the DPOAE signal [Talmadge et al., J. Acoust. Soc. Am. 104, 1517-1543 (1998)] shows that the contributions to the phase derivatives associated with the cochlear filter response is small. It is also shown that the difference between the phase derivatives can be qualitatively accounted for by assuming the approximate scale invariance of cochlear mechanics. The effects of DPOAE fine structure on the phase derivative are also explored, and it is found that the interpretation of the phase derivative in terms of the phase variation of a single DPOAE component can be quite problematic. 相似文献
14.
Distortion product otoacoustic emission test performance when both 2f1-f2 and 2f2-f1 are used to predict auditory status 总被引:2,自引:0,他引:2
Gorga MP Nelson K Davis T Dorn PA Neely ST 《The Journal of the Acoustical Society of America》2000,107(4):2128-2135
The objective of this study was to determine whether distortion product otoacoustic emission (DPOAE) test performance, defined as its ability to distinguish normal-hearing ears from those with hearing loss, can be improved by examining response and noise amplitudes at 2 f1-f2 and 2f2-f1 simultaneously. In addition, there was interest in knowing whether measurements at both DPs and for several primary frequency pairs can be used in a multivariate analysis to further optimize test performance. DPOAE and noise amplitudes were measured at 2f1-f2 and 2 f2-f1 for 12 primary levels (L2 from 10 to 65 dB SPL in 5-dB steps) and 9 pairs of primary frequencies (0.5 to 8 kHz in 1/2-octave steps). All data were collected in a sound-treated room from 70 subjects with normal hearing and 80 subjects with hearing loss. Subjects had normal middle-ear function at the time of the DPOAE test, based on standard tympanometric measurements. Measurement-based stopping rules were used such that the test terminated when the noise floor around the 2 f1-f2 DP was < or = -30 dB SPL or after 32 s of artifact-free averaging, whichever occurred first. Data were analyzed using clinical decision theory in which relative operating characteristics (ROC) curves were constructed and areas under the ROC curves were estimated. In addition, test performance was assessed by selecting the criterion value that resulted in a sensitivity of 90% and determining the specificity at that criterion value. Data were analyzed using traditional univariate comparisons, in which predictions about auditory status were based only on data obtained when f2 = audiometric frequency. In addition, multivariate analysis techniques were used to determine whether test performance can be optimized by using many variables to predict auditory status. As expected, DPOAEs were larger for 2f1-f2 compared to 2 f2-f1 in subjects with normal hearing. However, noise amplitudes were smaller for 2f2-f1, but this effect was restricted to the lowest f2 frequencies. A comparison of signal-to-noise ratios (SNR) within normal-hearing ears showed that the 2f1-f2 DP was more frequently characterized by larger SNRs compared to 2f2-f1. However, there were several subjects in whom 2f2-f1 produced a larger SNR. ROC curve areas and specificities for a fixed sensitivity increased only slightly when data from both DPs were used to predict auditory status. Multivariate analyses, in which the inputs included both DPs for several primary frequency pairs surrounding each audiometric frequency, produced the highest areas and specificities. Thus, DPOAE test performance was improved slightly by examining data at two DP frequencies simultaneously. This improvement was achieved at no additional cost in terms of test time. When measurements at both DPs were combined with data obtained for several primary frequency pairs and then analyzed in a multivariate context, the best test performance was achieved. Excellent test performance (ROC) curve areas >0.95% and specificities >92% at all frequencies, including 500 Hz, were achieved for these conditions. Although the results described should be validated on an independent set of data, they suggest that the accuracy with which DPOAE measurements identify auditory status can be improved with multivariate analyses and measurements at multiple DPs. 相似文献
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Young JA Elliott SJ Lineton B 《The Journal of the Acoustical Society of America》2012,131(6):4699-4709
The 2f(1)-f(2) distortion product otoacoustic emission (DPOAE) arises within the cochlea due to the nonlinear interaction of two stimulus tones (f(1) and f(2)). It is thought to comprise contributions from a wave-fixed source and a place-fixed source. The generation and transmission of the 2f(1)-f(2) DPOAE is investigated here using quasilinear solutions to an elemental model of the human cochlea with nonlinear micromechanics. The micromechanical parameters and nonlinearity are formulated to match the measured response of the cochlea to single- and two-tone stimulation. The controlled introduction of roughness into the active micromechanics of the model allows the wave- and place-fixed contributions to the DPOAE to be studied separately. It is also possible to manipulate the types of nonlinear suppression that occur within the quasilinear model to investigate the influence of stimulus parameters on DPOAE generation. The model predicts and explains a variety of 2f(1)-f(2) DPOAE phenomena: The dependence of emission amplitude on stimulus parameters, the weakness of experiments designed to quantify cochlear amplifier gain, and the predominant mechanism which gives rise to DPOAE fine structure. In addition, the model is used to investigate the properties of the wave-fixed source and how these properties are influenced by the stimulus parameters. 相似文献
17.
Distortion product otoacoustic emission (DPOAE) measures of cochlear function, including DPOAE suppression tuning curves and input/output (I/O) functions, are not adultlike in human infants. These findings suggest the cochlear amplifier might be functionally immature in newborns. However, many noncochlear factors influence DPOAEs and must be considered. This study examines whether age differences in DPOAE I/O functions recorded from infant and adult ears reflect maturation of ear-canal/middle-ear function or cochlear mechanics. A model based on linear middle-ear transmission and nonlinear cochlear generation was developed to fit the adult DPOAE I/O data. By varying only those model parameters related to middle-ear transmission (and holding cochlear parameters at adult values), the model successfully fitted I/O data from infants at birth through age 6 months. This suggests that cochlear mechanics are mature at birth. The model predicted an attenuation of stimulus energy through the immature ear canal and middle ear, and evaluated whether immaturities in forward transmission could explain the differences consistently observed between infant and adult DPOAE suppression. Results show that once the immaturity was compensated for by providing infants with a relative increase in primary tone level, DPOAE suppression tuning at f2= 6000 Hz was similar in adults and infants. 相似文献
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Adaptation of 2f1-2f2 distortion product otoacoustic emission in young-adult and old CBA and C57 mice. 总被引:1,自引:0,他引:1
The phenomenon of efferent-mediated adaptation of 2f1-f2 distortion product otoacoustic emission (DPOAE) was investigated in two strains (CBA/JNia and C57BL/6JNia) of mice of various ages using stimuli presented monaurally or binaurally. The present study demonstrated the existence of the DPOAE adaptation phenomenon in mice analogous to that previously reported in cats. The present data were fitted with one- or two-exponential functions. With a one-exponential fit in 2-month old mice, the adaptation magnitude ranged from 0 to 4 dB with the average value of 0.5 to 1.6 dB and the average time constant was 0.5 to 2.3 s. With a two-exponential fit, the shorter time constant was 0.3 to 1.7 s. The adaptation magnitude and time constant were similar between the monaural and binaural stimulations. We observed that there was a statistically significant decrease of adaptation magnitude in older CBA mice with age-related hearing loss when compared with young adult mice. The results from the young adult mice should be useful in future studies, e.g., a study of developmental changes in post-natal mice, or changes accompanying an alteration in the central auditory system arising from any etiology. We suggest that this phenomenon can be used as a tool for advancing basic knowledge of the auditory system and for assessing an impairment of the olivocochlear system, e.g., in aging. 相似文献
20.
Pure-tone threshold estimation from extrapolated distortion product otoacoustic emission I/O-functions in normal and cochlear hearing loss ears 总被引:2,自引:0,他引:2
A new method for direct pure-tone threshold estimation from input/output functions of distortion product otoacoustic emissions (DPOAEs) in humans is presented. Previous methods use statistical models relating DPOAE level to hearing threshold including additional parameters e.g., age or slope of DPOAE I/O-function. Here we derive a DPOAE threshold from extrapolated DPOAE I/O-functions directly. Cubic 2 f1-f2 distortion products and pure-tone threshold at f2 were measured at 51 frequencies between f2=500 Hz and 8 kHz at up to ten primary tone levels between L2=65 and 20 dB SPL in 30 normally hearing and 119 sensorineural hearing loss ears. Using an optimized primary tone level setting (L1 = 0.4L2 + 39 dB) that accounts for the nonlinear interaction of the two primaries at the DPOAE generation site at f2, the pressure of the 2 f1-f2 distortion product pDP is a linear function of the primary tone level L2. Linear regression yields correlation coefficients higher than 0.8 in the majority of the DPOAE I/O-functions. The linear behavior is sufficiently fulfilled for all frequencies in normal and impaired hearing. This suggests that the observed linear functional dependency is quite general. Extrapolating towards pDP=0 yields the DPOAE threshold for L2. There is a significant correlation between DPOAE threshold and pure-tone threshold (r=0.65, p<0.001). Thus, the DPOAEs that reflect the functioning of an essential element of peripheral sound processing enable a reliable estimation of cochlear hearing threshold up to hearing losses of 50 dBHL without any statistical data. 相似文献