Synthesis, ab initio calculations, thermal, thermodynamic and antioxidant properties of some oxovanadium(IV) complexes containing N2O2 set of donor atoms

The formation constants of some oxovanadium(IV) binary complexes containing Schiff bases resulting from condensation of salicylaldehyde with aniline and with its derivatives were determined spectophotometrically. The synthesized compounds were characterized by analytical and different physico-chemical techniques like ¹H NMR, IR, elemental analysis, mass and UV-Vis spectral studies. The IR spectra affirm that coordination takes place through azomethine nitrogen and phenolate oxygen. Three of the VO(IV) Schiff base complexes i.e. bis(salicylideneaniline)oxovanadium(IV), [VO(L¹)₂], bis(salicylidene-4-methoxyaniline) oxovanadium (IV), [VO(L²)₂] and bis(salicylidene-4-cyanoaniline)oxovanadium(IV), [VO(L¹⁰)₂], were studied by thermogravimetry in order to evaluate their thermal stability and thermal decomposition pathways. The number of steps and, in particular, the starting temperature of decomposition of these complexes depends on the equatorial ligand. The complexes screened for antioxidant activity and the ab initio calculations were carried out to determine the structural and the geometrical properties of a typical vanadyl salicylideneaniline complex, [VO(L¹)₂].     

Synthesis,characterization, antibacterial,and thermal studies of unsymmetrical Schiff-base complexes of cobalt(II)

Cobalt(II) complexes of a new series of unsymmetrical Schiff bases have been synthesized and characterized by their elemental analyses, melting points, magnetic susceptibility, thermogravimetric analysis, differential scanning calorimetry, infrared (IR), and electronic spectral measurements. The purity of the ligands and the metal complexes are confirmed by microanalysis, while the unsymmetrical nature of the ligands was further corroborated by ¹H-NMR. Comparison of the IR spectra of the Schiff bases and their metal complexes confirm that the Schiff bases are tetradentate and coordinated via N₂O₂ chromophore. The magnetic moments and electronic spectral data support square-planar geometry for the cobalt(II) complexes. The complexes were thermally stable to 372.3°C and their thermal decomposition was generally via the partial loss of the organic moiety. The Schiff bases and their complexes were screened for in vitro antibacterial activities against 10 human pathogenic bacteria and their minimum inhibitory concentrations were determined. Both the free ligands and cobalt(II) complexes exhibit antibacterial activities against some strains of the microorganisms, which in a number of cases were comparable with, or higher than, that of chloramphenicol.     

Schiff base supported mononuclear organotin(IV) complexes: Syntheses,structures and fluorescence cell imaging

Three mononuclear organotin(IV) complexes supported by Schiff bases have been synthesized. The complexes [(C₆H₅)₂Sn(L)] ( 1 ), [(t‐Bu)₂Sn(L)] ( 2 ) and [(t‐Bu)₂Sn(L')] ( 3 ) (L, L' = deprotonated Schiff bases) were obtained in good yield by the reaction of Schiff bases H ₂ L or H ₂ L′ with corresponding diorganotin dichlorides respectively. All newly synthesized complexes were characterized by means of FT‐IR spectroscopy, elemental analysis and multinuclear (¹H, ¹³C and ¹¹⁹Sn) NMR spectroscopy. In addition, single crystal X‐ray diffraction analyses were employed to establish the solid state molecular structures of these complexes. The structures of 1 – 3 reveal that all complexes are mononuclear with a five‐coordinated tin(IV) centre in it. The absorption and emission properties of all complexes have been investigated. Moreover, cytotoxicity and fluorescence cell imaging studies of theses complexes have been performed.     

Synthesis, spectroscopy, electrochemistry and thermal study of vanadyl tridentate Schiff base complexes

The VO(IV) complexes of tridentate ONO Schiff ligands were synthesised and characterized by IR, UV–vis and elemental analysis. The electrochemical properties of the vanadyl complexes were investigated by cyclic voltammetry. A good correlation was observed between the oxidation potentials and the electron withdrawing character of the substituents on the Schiff base ligands, showing the following trend: MeO < H < Br < NO₂ and H < Cl. The thermogravimetry (TG) and differential thermoanalysis (DTA) of the VO(IV) complexes were carried out in the range of 20–700 °C. The VOL¹(OH₂) decomposed in two steps whereas the remaining six complexes decomposed in three steps. The thermal decomposition of these complexes is closely related to the nature of the Schiff base ligands and proceeds via first order kinetics.     

Preparation and 1H NMR study of complexes of trimethylplatinum(IV) with some tridentate schiff base ligands containing,N, O,and S donor atoms

The Schiff base ligands I–V, made by condensing either 2-acetylpyridine (I), 8-quinolinecarboxaldehyde (II and III), or o-methylthiobenzaldehyde (IV and V) with either N,N′-dimethyl-1,3-diaminopropane (I, II, and IV), 2-aminomethylpyridine (III), or 2-(2-aminoethyl)-pyridine (V), give ionic Pt^IVMe₃ complexes containing tridentate NNN- or SNN-bonded ligands. With PtMe₃Br ligand V gives a neutral complex XI in which it is coordinated only via the two N atoms. A monomeric Pt^IVMe₃ salicyladiminate complex results on treating the dimeric trimethylplatinum(IV) salicylaldehyde complex with the bidentate amine H₂N (CH₂)₃NMe₂. The complexes have been fully characterised by ¹H NMR spectroscopy.     

Synthesis, structural and spectral studies of Cu(II) and V(IV) complexes of a novel Schiff base derived from pyridoxal. Antimicrobial activity

A novel Schiff base, N-(4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one)pyridoxaldimine (HL·HCl), was prepared and structurally characterized on the basis of elemental analyses, ¹H and ¹³C NMR, and IR spectral data. The synthesis and characterization of several Cu(II) (1-6) and V(IV) (7) complexes with N-(4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one)pyridoxaldimine are reported. The composition and structures of the copper(II) and vanadium(IV) complexes were proposed based on elemental analyses, molar conductance, magnetic susceptibility measurements, IR, electronic and EPR spectroscopy. In addition, the structures of the ligand and the complex [CuL(H₂O)₂]NO₃·2.25H₂O (1) have been determined by single-crystal X-ray diffraction, showing that the Cu(II) center has a distorted square-pyramidal geometry. The ligand and the complexes were also tested for their in vitro antibacterial activity.     

Studies on Co(II) and Cu(II) complexes of a ligand derived from 1,3-phenylenediamine and 5-bromosalicylaldehyde synthesis, characterisation, thermal properties and use as new precursors for preparation cobalt and copper oxide nano-particles

A symmetric tetradentate Schiff base ligand, N,N′-bis(5-bromosalicylaldehyde)-1,3-phenylenediamine [(Brsal)₂-1,3-phen) and its Cu(II) and Co(II) complexes with general formula M₂((Brsal)₂-1,3-phen)₂, where M=Co (1) and Cu (2)], have been synthesized and characterized by elemental analyses and FTIR spectroscopy. In addition, Schiff base ligand has been characterized by ¹HNMR spectroscopy. Thermogravimetric analysis of the ligand and its metal complexes reveals their thermal stability and decomposition pattern.     

Syntheses,Spectral, and Biological Studies of New Imines Derived From 5-Bromothiophene-2-Carboxaldehyde and Their Si(IV), Sn(IV) Complexes

The Schiff bases (imines) HL¹ and HL² have been synthesized by the reaction of 5-bromothiophene-2-carboxaldehyde with 4-amino-5-mercapto-1,2,4-triazole and 4-amino-3-ethyl-5-mercapto-1,2,4-triazole, respectively. Organosilicon(IV) and organotin(IV) complexes having the general formulae R₂MCl(L¹), R₂MCl(L²), R₂M(L¹)₂, R₂M(L²)₂, (M = Si, Sn; R = CH₃) were synthesized by the reaction of R₂MCl₂ with these Schiff bases in 1:1 and 1:2 molar ratio. The Schiff bases and their metal complexes have been characterized with the aid of elemental analyses, molar conductance, and spectroscopic studies, including UV, IR, ¹H, ¹³C, MS, ²⁹Si, and ¹¹⁹Sn NMR spectroscopy. On the basis of these studies, the resulting complexes have been proposed to have trigonal bipyramidal and octahedral geometries. In vitro activities of the Schiff bases and their metal complexes against some Gram positive and Gram negative bacteria and fungi have been carried out and described.     

Organotellurium(IV) complexes of N-methylisatin-o-aminothiophenol Schiff base: Preparation,characterization, DFT,molecular docking studies,antimicrobial and antioxidant activity

The reactions of organotellurium(IV) chlorides (RTeCl₃ and R₂TeCl₂) with Schiff base(NMeIATP) derived by condensation of N-methylisatin with 2-aminothiophenol results in the formation of new organotellurium(IV) complexes (4a-4f) of type RTeCl₂.NMeIATP and R₂TeCl.NMeIATP (where R = 4-Methoxyaryl, 4-Hydroxyaryl and 3-Methy-4-hydroxyaryl; aryl = phenyl). These complexes were characterized by different experimental and spectroscopic techniques like elemental analyses, molar conductance, SEM analysis, FT-IR, DFT calculations, powder X-ray diffraction, mass spectrometry, ¹H NMR, ¹³C NMR, UV–Vis and Thermogravimetric analysis. These spectroscopic studies revealed that ligand acted as monobasic tridentate ligand coordinated with tellurium metal through Carbonyl oxygen, azomethine nitrogen and sulphur atom from the 2-aminothiophenol ring. The molecular geometries of NMeIATP and its organotellurium(IV) complexes(4a-4f) were optimized and quantum mechanical parameters were calculated by using DFT/B3LYP basis sets in Guassian09 program. Based on the spectral results, suitable geometries of the complexes are purposed. Molecular docking studies were carried out to determine the binding energy between NMeIATP and complexes with receptor proteins: S. aureus (3ty7), B. subtilis (5h67) and E. coli (3t88). Antioxidant activity of NMeIATP and organotellurium(IV) complexes were evaluated by DPPH assay. The radical scavenging activity(IC₅₀ value) of complex 4a (IC₅₀ = 59.08 μg/ml) was found to be greater than other compounds. NMeIATP and organotellurium(IV) complexes were tested against different bacteria and fungi. MIC values show that complexes possess better antimicrobial activity than Schiff base (NMeIATP).     

Synthesis, spectroscopy, electrochemistry and thermal study of vanadyl tridentate Schiff base complexes: theoretical study of the structures of compounds by ab initio calculations

The VO(IV) complexes of tridentate ONN Schiff ligands were synthesized and characterized by IR, UV–Vis and elemental analysis. The electrochemical properties of the vanadyl complexes were investigated by cyclic voltammetry. A good correlation was observed between the oxidation potentials and the electron-withdrawing character of the substituents on the Schiff base ligands, showing the following trend: MeO < H < Br < NO₂. The thermogravimetry (TG) and differential thermoanalysis (DTA) of the VO(IV) complexes were carried out in the range of 20–700 °C. The VOL¹(OH₂) and VOL²(OH₂) decomposed in three steps, whereas the VOL³(OH₂) and VOL⁴(OH₂) complexes decomposed in two steps. The thermal decomposition of these complexes is closely related to the nature of the Schiff base ligands and proceeds via first-order kinetics. The structures of compounds were determined by ab initio calculations. The optimized molecular geometry and atomic charges were calculated using MP2 method with 6-31G(d) basis. The results suggested that, in the complexes, V(IV) ion is in square-pyramid N₂O₃ coordination geometry. Also the bond lengths and angles were studied and compared.     

Conventional and microwave synthesis,spectral, thermal and antimicrobial studies of some transition metal complexes containing 2-amino-5-methylthiazole moiety

Schiff base metal complexes of Cr(III), Co(II), Ni(II) and Cu(II) derived from 5-chlorosalicylidene-2-amino-5-methylthiazole (HL¹) and 2-hydroxy-1-naphthylidene-2-amino-5-methylthiazole (HL²) have been synthesized by conventional as well as microwave methods. These compounds have been characterized by elemental analysis, FT-IR, FAB-mass, molar conductance, electronic spectra, ¹H-NMR, ESR, magnetic susceptibility, thermal, electrical conductivity and XRD analyses. The complexes exhibit coordination number 4 or 6. The complexes are coloured and stable in air. Analytical data reveal that all the complexes exhibit 1:2 (metal:ligand) ratio. IR data show that the ligand coordinates with the metal ions in a bidentate manner through the phenolic oxygen and azomethine nitrogen. FAB-mass and thermal data show degradation pattern of the complexes. The thermal behaviour of metal complexes shows that the hydrated complexes lose water molecules of hydration in the first step; followed by decomposition of ligand molecules in the subsequent steps. XRD patterns indicate crystalline nature for the complexes. The Schiff bases and metal complexes show good activity against the Gram-positive bacteria; Staphylococcus aureus and Gram-negative bacteria; Escherichia coli and fungi Aspergillus niger and Candida albicans. The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the Schiff bases.     

Ligational behavior of thiosemicarbazone,semicarbazone and thiocarbohydrazone ligands towards VO(IV), Ce(III), Th(IV) and UO2(VI) ions: Synthesis,structural characterization and biological studies

Mono- and binuclear VO(IV), Ce(III), Th(IV) and UO₂(VI) complexes of thiosemicarbazone, semicarbazone and thiocarbohydrazone ligands derived from 4,6-diacetylresorcinol were synthesized. The structures of these complexes were elucidated by elemental analyses, IR, UV–vis, ESR, ¹H NMR and mass spectra as well as conductivity and magnetic susceptibility measurements and thermal analyses. The thiosemicarbazone (H₄L¹) and the semicarbazone (H₄L²) ligands behave as dibasic pentadentate ligands in case of VO(IV) and UO₂(VI) complexes, tribasic pentadentate in case of Ce(III) complexes and monobasic pentadentate in case of Th(IV) complexes. However, the thiocarbohydrazone ligand (H₃L³) acts as a monobasic tridentate ligand in all complexes except the VO(IV) complex in which it acts as a dibasic tridentate ligand. The antibacterial and antifungal activities were also tested against Rhizobium bacteria and Fusarium-Oxysporium fungus. The metal complexes of H₄L¹ ligand showed a higher antibacterial effect than the free ligand while the other ligands (H₄L² and H₃L³) showed a higher effect than their metal complexes. The antifungal effect of all metal complexes is lower than the free ligands.     

Synthetic,spectroscopic and thermal studies of some complexes of unsymmetrical Schiff base ligand

New unsymmetrical Schiff base ligand (H₂L) is prepared via condensation of 2-hydroxy-5-methyl acetophenone, 2-hydroxy-5-chloro-3-nitro acetophenone and carbohydrazide in 1:1:1 ratio. Metal complexes of VO(IV), Cr(III), Mn(III), Fe(III), Zr(IV), MoO₂(VI), WO₂(VI) and UO₂(VI) have been prepared. These complexes were characterized by elemental analysis, UV–Vis and IR spectroscopy and magnetic moment and thermogravimetric analysis. The purity of the ligand and the metal complexes is confirmed by microanalyses, while unsymmetrical nature of ligand was further corroborated by ¹H NMR. All the complexes are air stable and insoluble in water and common organic solvents but fairly soluble in DMSO. The elemental analysis shows 1:1 metal to ligand stoichiometry for all the complexes. Thermal behaviour of the complexes was studied, the complexes were found to be quite stable and their thermal decomposition was generally via partially loss of the organic moiety and ended with respective metal oxide as a final product. Comparison of the IR spectrum of ligand and its metal complexes confirm that Schiff base behave as a dibasic tetradentate ligand towards the central metal ion with an ONNO donor sequence. The dc electrical conductivity is studied and data obtained obeyed the relation σ = σ ₀ exp(−E _a/kT) over the temperature range 40–130 °C. X-ray diffraction study of VO(IV) complex shows its crystalline nature with triclinic crystal system.     

Spectroscopic,thermal, biological activity,molecular docking and density functional theoretical investigation of novel bis Schiff base complexes

New Schiff base ligand (H₂L, 1,2‐bis[(2‐(2‐hydroxyphenylimino)‐methyl)phenoxy]ethane) came from condensation reaction of bisaldehyde and 2‐aminophenol was synthesized in a molar ratio 1:2. Metal complexes and the ligand were completely discussed with spectroscopic and theoretical mechanism. The complexes with Fe(III), Cr(III), Mn(II), Co(II), Cu(II), Ni(II), Th(IV) and Zn(II) have been discussed and characterized by elemental analyses, molar conductance, IR, mass spectroscopy, thermal, magnetic measurements, and ¹H NMR. The results proved that the Schiff base was a divalent anion with hexadentate O₄N₂ donors came from the etheric oxygens (O1, O2), azomethine nitrogens (N1, N2) and deprotonated phenolic oxygens (O3, O4). Density Functional Theory using (B3LYP/6‐31G*) level of theory were implemented to predict molecular geometry, Mulliken atomic energetic and charges of the ligand and complexes. The calculation display that complexes had weak field ligand. The binding energy ranged from 650.5 to 1499.0 kcal/mol for Mn(II) and Th(IV) complexes, respectively. The biological behavior of the Schiff base ligand and its metal complexes were displayed against bacteria and fungi organisms. Fe(III) complex gave remarkable biological activity in comparison with the parent bis Schiff base.     

Synthesis,characterization and biological studies of oxovanadium(IV) complexes with triazole‐derived Schiff bases

A series of triazole‐derived Schiff bases (L¹–L⁵) and their oxovanadium(IV) complexes have been synthesized. The chemical structures of Schiff bases were characterized by their analytical (CHN analysis) and spectral (IR, ¹H and ¹³C NMR and mass spectrometry) data, and oxovanadium(IV) complexes were elucidated by their physical (magnetic susceptibility and conductivity), analytical (CHN analysis), conductance measurements and electronic spectral data. The molar conductivity data indicate the oxovanadium(IV) complexes to be non‐electrolyte. The Schiff bases act as bidentate and coordinate with the oxovanadium(IV)‐forming stoichiometry of a complex as [M (L‐H)₂] where M = VO and L = L¹–L⁵ in a square‐pyramidal geometry. The agar well diffusion method was used for in vitro antibacterial screening against E. coli, S. flexenari, P. aeruginosa, S. typhi, S. aureus and B. subtilis and for antifungal activity against T. longifucus, C. albican, A. flavus, M. canis, F. solani and C. glaberata. The biological activity data show the oxovanadium(IV) complexes to be more antibacterial and antifungal than the parent Schiff bases against one or more bacterial and fungal strains. Copyright © 2009 John Wiley & Sons, Ltd.     

Preparation,characterization and biological activity of novel metal-NNNN donor Schiff base complexes

Novel Schiff base (H₂L) ligand is prepared via condensation of benzil and triethylenetetraamine. The ligand is characterized based on elemental analysis, mass, IR and ¹H NMR spectra. Metal complexes are reported and characterized based on elemental analyses, IR, ¹H NMR, solid reflectance, magnetic moment, molar conductance, and thermal analyses (TG, DTG and DTA). 1:1 [M]:[H₂L] complexes are found from the elemental analyses data having the formulae [M(H₂L)Cl₂]·yH₂O (M = Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II)), [Fe(H₂L)Cl₂]Cl·H₂O, [Th(H₂L)Cl₂]Cl₂·3H₂O and [UO₂(H₂L)](CH₃COO)₂·2H₂O. The metal chelates are found to be non-electrolytes except Fe(III), Th(IV) and UO₂(II) complexes are electrolytes. IR spectra show that H₂L is coordinated to the metal ions in a neutral tetradentate manner with 4Ns donor sites of the two azomethine N and two NH groups. The geometrical structures of these complexes are found to be octahedral. The thermal behaviour of these chelates is studied where the hydrated complexes lose water molecules of hydration in the first step followed immediately by decomposition of the anions and ligand molecules in the subsequent steps. The activation thermodynamic parameters are calculated using Coats–Redfern method. The ligand (H₂L), in comparison to its metal complexes, is screened for its antibacterial activity. The activity data show that the metal complexes have antibacterial activity more than the parent Schiff base ligand and cefepime standard against one or more bacterial species.     

Synthesis and characterization of four new manganese(III) complexes and amino acid (L-aspartic acid, L-asparagine, L-glutamic acid, L-glutamine) Schiff bases

New series of manganese(III) complexes and amino acid Schiff bases have been prepared from 2-hydroxy-1-naphthaldehyde and α-amino acids [L-aspartic acid (Asp), L-asparagine (Asn), L-glutamic acid (Glu) and L-glutamine (Gln)]. The structures of the ligands and manganese complexes were identified using elemental analyses, i.r, electronic spectra, ¹H-n.m.r spectra, magnetic moment measurements and thermogravimetric analyses (t.g.a). The results suggest that H₂L¹: [N-(2-hydroxy-1-naphthylidene) aspartic acid] and H₂L³: [N-(2-hydroxy-1-naphthylidene)glutamic acid] Schiff bases behave as trianionic tetradentate species and coordinate to Mn(III) ion according to the general formula [MnL] · xH₂O complexes. But, H₂L²: [N-(2-hydroxy-1-naphthylidene) asparagine] and H₂L⁴: [N-(2-hydroxy-1-naphthylidene)glutamine] Schiff bases behave as dianionic tridentate and coordinate to Mn(III) ion in the general formula for [MnL(OOCH₃)] · xH₂O complexes.     

Synthesis, spectral characterization and in vitro microbiological evaluation of novel glyoxal, biacetyl and benzil bis-hydrazone macrocyclic Schiff bases and their Co(II), Ni(II) and Cu(II) complexes

A series of binuclear Co(II), Ni(II) and Cu(II) complexes were synthesized by the template condensation of glyoxal, biacetyl or benzil bis-hydrazide, 2,6-diformyl-4-methylphenol and Co(II), Ni(II) or Cu(II) chloride in a 2:2:2 M ratio in ethanol. These 22-membered macrocyclic complexes were characterized by elemental analyses, magnetic, molar conductance, spectral, thermal and fluorescence studies. Elemental analyses suggest the complexes have a 2:1 stoichiometry of the type [M₂LX₂]·nH₂O and [Ni₂LX₂2H₂O]·nH₂O (where M = Co(II) and Cu(II); L = H₂L¹, H₂L² and H₂L³; X = Cl; n = 2). From the spectroscopic and magnetic studies, it has been concluded that the Co(II) and Cu(II) complexes display a five coordinated square pyramidal geometry and the Ni(II) complexes have a six coordinated octahedral geometry. The Schiff bases and their metal complexes have also been screened for their antibacterial and antifungal activities by the MIC method.     

Synthesis and characterization of diorganotin(IV) complexes of tetradentate Schiff bases: crystal structure of n-Bu2Sn(Vanophen)

Diorganotin(IV) complexes of the general formula R₂SnL (R=Ph, n-Bu and Me) have been prepared from diorganotin(IV) dichlorides (R₂SnCl₂) and tetradentate Schiff bases (H₂L) containing N₂O₂ donor atoms in the presence of triethylamine in benzene. The Schiff bases, H₂L, were derived from salicylaldehyde, 3-methoxysalicylaldehyde (o-vanillin), 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone and diamines such as o-phenylenediamine and 1,3-propylenediamine. The complexes were characterized by IR, NMR (¹H, ¹³C, ¹¹⁹Sn) and elemental analysis. The structure of the complex, n-Bu₂Sn(Vanophen), was determined using single crystal X-ray diffraction. The tin atom has a distorted octahedral coordination, with the Vanophen ligand occupying the four equatorial positions and the n-butyl groups in the trans axial positions. Six-coordinated distorted octahedral structures have been proposed for all diorganotin(IV) complexes studied here, as they possess similar spectroscopic data.     

Synthesis,characterization, anticancer activity,thermal and electrochemical studies of some novel uranyl Schiff base complexes

Some tetradentate N₂O₂ Schiff base ligands, such as N,N′-bis(naphtalidene)-1,2-phenylenediamine, N,N′-bis(naphtalidene)-4-methyl-1,2-phenylenediamine, N,N′-bis(naphtalidene)-4-chloro-1,2-phenylenediamine, N,N′-bis(naphtalidene)-4-nitro-1,2-phenylenediamine, N,N′-bis(naphtalidene)-4-carboxyl-1,2-phenylenediamine, and their uranyl complexes were synthesized and characterized by ¹H NMR, IR, UV–Vis spectroscopy, TG (thermogravimetry), and elemental analysis (C.H.N.). Thermogravimetric analysis shows that uranyl complexes have very different thermal stabilities. This method is used also to establish that only one solvent molecule is coordinated to the central uranium ion and this solvent molecule does not coordinate strongly and is removed easier than the tetradentate ligand and also trans oxides. The electrochemical properties of the uranyl complexes were investigated by cyclic voltammetry. Electrochemistry of these complexes showed a quasireversible redox reaction without any successive reactions. Also, the kinetic parameters of thermal decomposition were calculated using Coats–Redfern equation. According to Coats–Redfern plots the kinetics of thermal decomposition of the studied complexes is first-order in all stages. Anticancer activity of the uranyl Schiff base complexes against cancer cell lines (Jurkat) was studied and determined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazoliumbromide) assay.