共查询到20条相似文献,搜索用时 15 毫秒
1.
A. V. Pestov P. A. Slepukhin O. V. Koryakova V. N. Charushin 《Russian Journal of Coordination Chemistry》2014,40(4):216-223
New nickel(II) complexes based on N-(3-hydroxypropyl)-β-alanine, N-(bis(hydroxymethyl)methyl)-β-alanine, and N-(tris(hydroxymethyl)methyl)-β-alanine are synthesized, and their structures are studied by X-ray diffraction analysis. The coordination spheres of the nickel and copper metal centers in the condensed phase are compared for a series of N-substituted β-alaninate ligands with the regularly changed dentate mode. In the case of the copper(II) complexes, an increase in the size of the alkanolamine chelate ring or the number of hydroxymethyl groups provides the formation of achiral coordination structures, whereas the structures of the nickel(II) complexes are independent of the size of the alkanolamine chelate ring or the number of hydroxymethyl groups, thus providing the formation of the complexes as racemic modifications. 相似文献
2.
《Polyhedron》2003,22(25-26):3379-3381
We report the synthesis, characterization and cytotoxic assays of new trans-platinum compounds, trans-[PtCl2NH3(3-(hydroxymethyl)-pyridine)] and trans-[PtCl2NH3(4-(hydroxymethyl)-pyridine)]. In the present work, we found that the replacement of the ammine ligand in “classical” transplatinum with the two new ligands does not increase the cytotoxic activity, maybe because these complexes do not produce a stability of the intrastrand cross-links in DNA. 相似文献
3.
The complexation equilibria of Fe(III) with two buffer families, which are ubiquitous in biological system studies, were studied by potentiometric measurements at a constant ionic strength of I = 0.1 mol·dm?3 NaNO3 in aqueous solutions at 298.15 K. The members of TRIS family are tris(hydroxymethyl)aminomethane (TRIS), N-[tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid (TES), N-[tris(hydroxymethyl)methyl]-3-aminopropanesulfonic acid (TAPS), N-[tris(hydroxymethyl)methyl]-3-amino-2-hydroxypropanesulfonic acid (TAPSO), and N-tris(hydroxymethyl)methyl-4-aminobutanesulfonic acid (TABS) buffers. The members of morpholine family are 4-morpholineethanesulfonic acid (MES), 4-morpholinepropanesulfonic acid (MOPS), 3-morpholino-2-hydroxypropanesulfonic acid (MOPSO), and 4-(N-morpholino) butanesulfonic acid (MOBS) buffers. The overall stability constants were determined from pH-metric data using the least-squares curve-fitting program HYPERQUAD 2008. Based on the best-fit results, the species formed at equilibrium are ML, ML2, ML2H?1, and ML3 in the systems with TRIS family buffers. The complex species ML, ML2, ML2H?1, and MLH?1 are formed in the MOPSO-containing system, while ML, ML2, and ML2H?1 are formed in the systems with MES, MOPS, and MOBS. The stabilities of the complexes fall in the order TABS > TRIS > TAPS > TAPSO > TES and MOBS > MOPS > MOPSO > MES for the TRIS family and morpholine families, respectively. 相似文献
4.
Nicolas Rabasso 《Tetrahedron letters》2010,51(1):60-8006
Synthesis of α- and β-(aminomethyl)vinylphosphonates was achieved from vinyl bromide via a cross-coupling reaction with triethyl phosphite and by cross-metathesis of allyl bromide and vinylphosphonate, respectively. The 1,3-dipolar cycloaddition of these vinylphosphonates with a dipole in the presence of trifluoroacetic acid afforded selectively the β-aminopyrrolidinephosphonates. Syntheses of cis- and trans-γ-aminopyrrolidinephosphonates are also described. 相似文献
5.
T. I. Fesenko I. D. Strelnik E. I. Musina A. A. Karasik O. G. Sinyashin 《Russian Chemical Bulletin》2012,61(9):1792-1797
Reactions of 1,2-bis[(hydroxymethyl)(phenyl)phosphino]ethane with primary pyridylalkylamines gave earlier unknown 1-aza-3,6-diphosphacycloheptanes containing the pyridyl group in the exocyclic substituent. The reactions were found to be stereoselective, preferentially yielding the racemate with the RR/SS-configuration of the P atoms. A mixture of diastereomers of 3,6-diphenyl-1-[2-(2-pyridyl)ethyl]-1-aza-3,6-diphosphacycloheptane reacted with dichloro(cycloocta-1,5-diene)platinum(II) to give cis-P,P-chelate complexes from the meso-isomer and bridged oligomeric complexes from the racemate. 相似文献
6.
Yongwei Song Xinting HanXiaoli Guo Qing ZengFubin Jiang 《Colloids and surfaces. A, Physicochemical and engineering aspects》2011,392(1):110-115
The hydrolysis of p-nitrophenyl picolinate (PNPP) catalyzed by the Zn(II) complexes of 6-(n-butyloxymethyl)-2-(hydroxymethyl)pyridine and 6-(n-dodecyloxymethyl)-2-(hydroxymethyl)pyridine was kinetically investigated by observation of the rates of release of p-nitrophenol in a vesicular solution at different pH values and temperatures. A 1:1 ligand:Zn2+ stoichiometry was found to produce the most active species based on a kinetic version of the Job plot analysis. Experimental results also showed that the complex formed from ligand 2 and Zn2+ exhibited a more remarkable rate acceleration effect on the hydrolysis of PNPP in vesicular solution than that formed from ligand 1 and Zn2+. 相似文献
7.
N. G. Khusainova E. A. Berdnikov O. A. Mostovaya S. M. Rybakov R. A. Cherkasov 《Russian Journal of Organic Chemistry》2007,43(11):1703-1705
Dialkyl 3-methylbuta-1,2-dienyl- and vinylphosphonates take up imidazole at the β-carbon atom in the unsaturated fragment to give the corresponding β-(1H-imidazol-1-yl)alkenyl-and alkylphosphonates. 相似文献
8.
Konoplev V. E. Dolgushin F. M. Pisareva I. V. Vorontsov E. V. Lemenovskii D. A. Chizhevsky I. T. 《Russian Chemical Bulletin》2003,52(12):2732-2739
Heating of 1,1,3-(PPh3)3-1-H-1,2,4-RuC2B8H9 with 2-(hydroxymethyl)bicyclo[2.2.1]hepta-2,5-diene in arene solvents (benzene, toluene, or mesitylene) unexpectedly afforded the ruthenium arene complexes 1-(η6-arene)-3-(C7H9CH2O)-isonido-1,2,4-RuC2B8H9 containing the nortricyclene fragment in the carborane ligand. 相似文献
9.
F. Valiyev V. Abbasov H. J. Liu F. Y. Tsai 《Journal of the Iranian Chemical Society》2010,7(3):597-602
Syntheses of dinucleotide analogs, (S,R) cis-(4-((4-amino-2-oxopyrimidin-1(2H)-yl)methyl)-1,3-dioxolan-2-yl)methyl (2R,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl hydrogen phosphate (5a) and (S,R) cis-(5-((4-amino-2-oxopyrimidin-1(2H)-yl)methyl)-1,3-oxathiolan-2-yl)methyl (2R,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl hydrogen phosphate (5b), were accomplished by the use of a new strategy. The use of phenyldichlorophosphate (Method A) as the coupling reagent was shown to possess superiority relative to the reported use of di(1H-benzo[d][1,2,3]triazol-1-yl)phenyl phosphonate (Method B). 相似文献
10.
《Tetrahedron: Asymmetry》2014,25(6-7):578-582
Lipase Pseudomonas cepacia catalyzed acylation of (±)-2-(hydroxymethyl)-7,8-dihydro-1H-indeno[5,4-b] furan-6(2H)-one using vinyl acetate as the acyl donor in acetone gave (−)-(R)-2-acetoxy-2-(methyl)-7,8-dihydro-1H-indeno[5,4-b] furan-6(2H)-one and (+)-(S)-2-(hydroxymethyl)-7,8-dihydro-1H-indeno[5,4-b] furan-6(2H)-one with high enantiomeric excess. Enantiomerically pure 2-(hydroxymethyl)-7,8-dihydro-1H-indeno[5,4-b] furan-6(2H)-one are useful intermediates for the preparation of Ramelteon, an FDA approved drug for the treatment of insomnia. 相似文献
11.
B. A. Shainyan V. I. Meshcheryakov I. V. Sterkhova 《Russian Journal of Organic Chemistry》2016,52(7):1032-1035
Three-component heterocyclizations of trifluoro-N-(prop-2-yn-1-yl)methanesulfonamide, trifluoro-N-pheny-N-(prop-2-yn-1-yl)methanesulfonamide, and trifluoro-N,N-di(prop-2-yn-1-yl)methanesulfonamide with formaldehyde and sodium azide afforded N-{[2-(hydroxymethyl)-2H-1,2,3-triazol-4-yl]methyl}-, N-{[2-(hydroxymethyl)-2H-1,2,3-triazol-4-yl]methyl}-N-phenyl-, and N,N-bis{[2-(hydroxymethyl)-2H-1,2,3-triazol-4-yl]methyl}trifluoromethanesulfonamides as the major products together with minor 1-(hydroxymethyl)-1H-1,2,3-triazole isomers. 相似文献
12.
《Tetrahedron》2003,59(39):7751-7760
Macrocyclic bis(α-amino acids) cis- and trans-2a-b were prepared from the selectively protected tris(hydroxymethyl)aminomethane 3. The X-ray structures of the free bis(amino acids) and/or of the corresponding Cu(II) complexes have been determined allowing an unambiguous configurational assessment. At the same time, conformational in-out dichotomy of the functional groups has been demonstrated in the bis(amino acids) as well as in their Cu(II) complexes. 相似文献
13.
Kyu Myung Lee Jong Chan Kim Philjun Kang Won Koo Lee Heesung Eum Hyun-Joon Ha 《Tetrahedron》2012,68(3):883-893
Preparation of functionalized 3,4-dihydroisoquinolines 17a–j from (S)-N-methoxy-N-methyl-1-[(R)-1-phenylethyl]aziridine-2-carboxamide 4 is an effective route for the synthesis of 3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinolin-4-ols. Stereoselective reduction of the cyclic imines 17a–j resulted in (1S,3S,4R)-4-(tert-butyldimethylsilyl-oxy)-3-[(tert-butyldimethylsilyloxy)methyl]-6,7-dimethoxy-1,2-disubstituted-1,2,3,4-tetrahydroisoquinolines and the desilylation of the TBS groups afforded (1S,3S,4R)-3-(hydroxymethyl)-6,7-dimethoxy-1,2-disubstituted-1,2,3,4-tetrahydroisoquinolin-4-ols 19a–i in good yields. Also, an asymmetric synthesis of novel tetracyclic 3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinolin-4-ols 23 and 25 was successfully achieved via Pd-catalyzed N-arylation and C–C coupling reaction. 相似文献
14.
Pravin L. Kotian 《Tetrahedron letters》2011,52(3):365-368
Imino sugar compound 3 was prepared by two alternative routes starting from ribose and d-serine. From d-serine (3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methylpyrrolidin-2-one was prepared in five steps in 50% overall yield, which was further converted into (2R,3R,4S)-2-(hydroxymethyl)-4-methylpyrrolidine-3,4-diol in three steps in 23% overall yield. 相似文献
15.
Han-Bai Quan Liang-Bing Sheng Hua-Hong Zou Zi-Yuan Liu Dong-Cheng Liu Bo Li Man-Sheng Chen Fu-Pei Liang 《Journal of Cluster Science》2018,29(1):75-81
A series of twist linear tetranuclear 3d–4f Co 2 III Ln 2 III [Ln = Gd (1), Tb (2), Dy (3), Ho (4), Er (5)] complexes have been prepared under solvothermal conditions and structurally characterized with Schiff-base ligand 2-(((2-hydroxy-3-methoxyphenyl)methylene)amino)-2-(hydroxymethyl)-1,3-propanediol (H4L). The two central Co ions are linked by two alkoxyl oxygen atoms, and one Ln ion lying above and the other below the Co–Co dimer, form a twist linear array. The magnetic susceptibility studies reveal antiferromagnetic or ferromagnetic behaviour, whilst dynamic magnetic studies indicate no slow magnetic relaxation for these complexes. 相似文献
16.
The synthesis of (1R,2S)- and (1S,2R)-1-amino-2-(hydroxymethyl)cyclopropanephosphonic acids was accomplished using different strategies. The (1R,2S)-stereoisomer could be efficiently obtained by the cyclopropanation of ethyl diethoxyphosphorylacetate with the cyclic sulfate derived from (S)-3-benzyloxy-1,2-propandiol as a key step. The (1S,2R)-stereoisomer was synthesized from a readily available (1S,5R)-3-oxabicyclo[3.1.0]hexan-2-on-1-phosphonate. 相似文献
17.
(+)-MK7607 is a patented naturally occurring unsaturated pseudo-carbasugar possessing herbicidal activity. We present herein the first synthesis of the 5-fluorinated analogue (1S, 2S, 3R, 4R)-5-fluoro-6-(hydroxymethyl)cyclohex-5-ene-1,2,3,4-tetrol as well as that of two related compounds, namely its 1-epimer and its 6-deoxy derivative. 相似文献
18.
Amalia M. Estévez Raquel G. Soengas José M. Otero Juan C. Estévez Robert J. Nash Ramón J. Estévez 《Tetrahedron: Asymmetry》2010,21(1):21-26
A divergent synthesis of the two novel polyhydroxylated azepanes (2R,3R,4R,5R,6R)-2-(hydroxymethyl)azepane-3,4,5,6-tetraol and (2R,3R,4R,5R,6S)-2-(hydroxymethyl)azepane-3,4,5,6-tetraol from d-mannose is described. The method involves a Henry reaction between dimethyl-tert-butylsilyl 2,3-O-isopropylidene-α-d-lyxo-pentodialdo-1,4-furanoside and 2-nitroethanol followed by a reductive ring closure of the resulting epimeric nitro aldols. Glycosidase inhibition tests showed that (2R,3R,4R,5R,6S)-2-(hydroxymethyl)azepane-3,4,5,6-tetraol exhibits a weak but selective inhibition against α-l-fucosides. 相似文献
19.
Toru Minami Ryoji Kouno Tatsuo Okauchi Mitsuharu Nakamura Junji Ichikawa 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1):689-692
The α-phosphonovinyl anions, generated in situ from treatment of β-hetero-substituted vinyl-phosphonates 1a-c with LDA (or LTMP), were trapped with various electrophiles such as chlorotriorganosilanes, chlorotrimethylgermane, chlorotriorganotins, dimethyl disulfide, and halogen to afford the corresponding β-hetero-substituted α-functionalized vinylphosphonates 2–14 in good to excellent yields. The Friedel-Crafts reaction of α-(silyl) or α-(germyl)phosphonoketene dithioacetals 2, 9 or 4 with acid chlorides gave α-acylated phosphonoketene dithioacetals 15–19 in 53–91 % yields. The palladium-catalyzed cross-coupling reaction of β-ethoxy-α-(tributylstannyl)vinylphosphonate 13 with a variety of organic halides (R = acyl, allyl, aryl etc.) provided β-ethoxy-α-substituted vinylphosphonates 20–25 in good to moderate yields. The palladium-mediated cross-coupling reaction of α-(iodo)-vinyl-phosphonates 7, 14 with terminal acetylenes afforded α-alkynylated vinylphosphonates 26–29 in 69–83 % yields. 相似文献
20.
A. S. Burlov V. G. Vlasenko Yu. V. Koshchienko S. I. Levchenkov I. V. Pankov Ya. V. Zubavichus A. L. Trigub G. S. Borodkin T. A. Mazepina D. A. Garnovskii A. I. Uraev 《Russian Journal of Coordination Chemistry》2016,42(4):267-273
Binuclear complexes of Co(II), Сu(II), and Pd(II) with 2-(N-tosylamino)benzal-2’-(hydroxymethyl)aniline are synthesized. The compositions and structures of the ligand and complexes are determined from the data of elemental analysis, IR spectroscopy, 1Н, 13С, and 15N NMR spectroscopy, X-ray absorption spectroscopy, and magnetochemical measurements in a temperature range of 294–77.4 K. All complexes are dimeric. The Cu…Cu and Cо…Cо distances equal to 3.03 and 2.99 Å, respectively, are obtained for the Cu(II) and Co(II) complexes. These complexes are characterized by the antiferromagnetic exchange interaction with 2J = –630 and –42 cm–1, respectively. 相似文献