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正如前文报道,l,3,4—噻二唑类杂环之所以有除草,植物生长调节,驱虫以及消炎等多种生物活性,无疑起因于噻唑母核。尽管母核上取代基不起主导作用,但它作为辅助基,在改善分子溶解性以及药效方面所产生的影响是不能忽略的。因而深入研究各种生物活性基团导入噻二唑环母核以制得多结构单元聚集于同一分子中的噻二唑新衍生物,对于开发多功能新药具有一定的理论意义和实际价值。 相似文献
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2-芳氧基-5-苯基-1,3,4-噁二唑类化合物的合成 总被引:1,自引:0,他引:1
本文通过芳氧基负离子在2—甲磺酰基—苯基—1,3,4—噁二唑环2—位上的亲核取代反应制得9个新的2—芳氧基—5—苯基—l,3,4—噁二唑衍生物。所有化合物的结构经元素分析,IR,~1H NMR和MS确认。初步抗菌实验表明这些化合物具有一定的抑制枯草芽孢杆菌繁殖的活性。 2,5—二取代l,3,4—噁二唑衍生物具有广泛的生物活性,如抗菌,抗黄球菌,除草杀棉花牙虫等。Madhavan等曾通过芳胺在2— 甲磺酰基—5—芳基1,3,4—噁二唑环上的亲核取代反应,制得了2—芳氨基—5—芳基—l,3,4—噁二唑衍生物,我们也曾通过酰肼等亲核试剂在2—甲磺酰基—5—(3,4,5—三甲氧基苯基)—1,3,4—噁二唑环上的亲核取代反应,得到了2—取代酰肼基—5—(3,4,5—三甲氧基苯基)—l,3,4—噁二唑衍生物。在此基础上,我们拟通过Aro在2—甲磺酰基 相似文献
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1INTRODUCTIONInorganicsolidsupportsascatalystshavebeenwellstudied,becauseoftheirap-plicationsinorganicsynthese('~".Recently,wehavereportedtheKnoevenagelcon-densationcatalysedbyKF-Al,O,['i.Inthispaper,wediscussedthecrystalstruc-tureofthetitlecomPoundsynthesizedbythereactionof2-chlorobenzaldehydey5,5-dimethyl-1,3-cyclohexanedioneandisopropylidenemalonateinmethanolcatalyzedbyKF-Alzo,'Inordertoconfirmthestructureofthetitlecompound,theX-raycrys-tallOgraphicstudywascarriedout.2EXPER1MEN… 相似文献
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Inasearchfornewsensitiveandselectiveorganicreagents,athoroughstudyofsomeofthequinolylazo,pyridylazocompoundshasbeenreported'-'.Buttriazolylazocompoundshavenotbeenstudied.Inthispapef,2-(l,3,4-triazolylazo)-5-diethyIaminophenol(TZAPN)and2-(5-carboxy-l,3,4-triazoiylazo)-diethyIaminophenoI(CTZAPN)wereprepared,theconditionsofthisreactionwithcobaltwerestudied.Itwasfoundthatthereagentshadhighsensitivityandselectivityinthedeterminationofmicrogramamountsofcobaltundertheconditionsestablished.Thest… 相似文献
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对标题化合物进行了X-射线分析。C_(16)H_(16)O_2属三斜晶系,P1空间群,a=12.720(3),b=12.117(3),c=9.625(3),a=80.60(2)°,β=89.16(2)°,Υ=75.30(2)°,Z=4。共对2530个I≥2σ(I)、的反射数据进行了计算。由于该化合物烯基平面与反式乙酰基平面的二面角小于与顺式乙酰基平面的二面角,因此前者比后者能更有效地参予分子骨架的共轭,从而解释了在此类三岔共轭体系的电子吸收光谱中,一岔起代基的作用,一岔起端基作用的现象。 相似文献
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DongMeiCAI MinJieLI DaLiangLI TianPaYOU 《中国化学快报》2004,15(2):163-166
Novel C-nucleosides of tiazofurin analogue (2-[2-(hydroxymethyl)-1,3-dioxolan-5-yl] 1,3-thiazole-4-carboxamide) and its thiol-substituted derivative (2-[2-(mercaptomethyl)-1,3-dioxolan-5-yl] 1, 3-thiazole-4-carboxamide) were synthesized from methyl acrylate through a multistep procedure. Their structures were confirmed by IR, ^1HNMR, ^13CNMR and elemental analysis. 相似文献
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Dihydropyrimidinone derivatives were prepared by tri-component reaction of ethyl aceto acetate, aldehydes and thiourea in the presence of modified montmorillonite nanostructure as a catalyst and used as key intermediates for the synthesis of ethyl-5-(aryl)-2-(2-alkokxy-2-oxoethylidene)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyri midine-6-carboxylate derivatives with use of diethyl and dimethyl acetylene dicarboxylate by two methods: (a) in methanol as a solvent under ultrasonic irradiation at ambient temperature (b) in methanol as a solvent at ambient temperature (conventional magnetic stirring). Ultrasound-assisted synthesis provides excellent yields in short reaction times (15–25 min) at room temperature. 相似文献
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Synthetic methods for preparing of 2-, 3-, 4-halomethyl-5-tert-butylfurans are developed. Itwas established that the bromination of 3- and 4-methyl-2-tert-butylfurans with N-bromosuccinimide proceedsmainly at the free -position of the furan ring, and not at the methyl group. Therefore, the target halomethyl- furans were prepared through the corresponding 3- and 4-methoxymethyl derivatives. The obtained five products were phosphorylated with sodium diethyl phosphite under the conditions of the Michaelis-Becker reaction to give the corresponding phosphonates. 相似文献
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O. V. Shablykina O. V. Khilya V. V. Ishchenko V. P. Khilya 《Chemistry of Natural Compounds》2005,41(5):529-532
3-(2-Quinolyl)- and 3-(5-carbethoxyfuryl-2)coumarins were prepared by reaction of substituted salicylaldehydes and hetarylacetonitriles.
Alkylation and acylation of 3-hetaryl-7-hydroxycoumarins were studied.
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Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 432–434, September–October, 2005. 相似文献