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Diphenylcyclopropenone(1) reacts with a variety of thiopseudoureas to eventually afford dihydrouracils 相似文献
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Ernst Peter Müller 《Helvetica chimica acta》1982,65(5):1617-1626
Synthesis of 5,6-Ephnino-5,6-dihydro-β-ionone In order to synthesize the title compound 5 the 2-azidoalcohols 3 and 4 were treated with various nucleophilic phosphorus compounds. It was found that the course of the reaction depends strongly upon the kind of nucleophilic phosphorus derivative used. 相似文献
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Anna Edelsbacher Ernst Urban Waltraud Weidenauer 《Monatshefte für Chemie / Chemical Monthly》1992,123(8-9):741-747
Summary Optically pure available lactones1 and5 were diastereoselectively oxidised tocis-diols2 and6 by KMnO4 and to epoxides3 and7 by 3-chloroperoxybenzoic acid. Epoxide3 was cleaved totrans-diol4, whereas hydrolysis of7 afforded tricyclic carboxylic acid8. Optic ally puredihydroxylactones2,4, and6 are valuable models for structure determination of the antimicrobial garlic component garlicin.
Synthese enantiomerenreiner 5,6-Dihydroxy-isobenzofuranone und 5,6-Dihydroxy-4,7-methano-isobenzofuranone
Zusammenfassung Die in enatiomerenreiner Form verfügbaren Lactone1 und5 wurden durch diastereoselektive Oxidation mit KMnO4 zu dencis-Diolen2 und6 bzw. mit 3-Chlorperoxybenzoesäure zu den Epoxiden3 und7 umgesetzt. Das Epoxid3 liefert bei der Hydrolyse dastrans-Diol4, während aus7 die tricyclische Carbonsäure8 entsteht. Die optisch reinen Dihydroxylactone2,4 und6 können als Vergleichssubstanzen zur Strukturaufklärung des antimikrobiellen Knoblauchinhaltsstoffes Garlicin dienen.相似文献
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Treatment of 5-bromo-10-methylbenzocyclooctene (11) with potassium tert-butoxide gave 5-methyl-9-tert-butoxybenzocyclooctene (14), presumably via 5,6-didehydro-10-methylbenzocyclooctene (13). The cyclic acetylene (13) could be trapped by reaction with 1,3-diphenylisobenzofuran to give the adduct (15). 相似文献
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Andr Chollet Cyril Mahaim Christophe Foetisch Michle Hardy Pierre Vogel 《Helvetica chimica acta》1977,60(1):59-67
Preparation of the title compounds 11 , 12 and 13 is described. Preliminary kinetic results indicate that the hydroxyl substituents in 11 and 12 have a very small retardation effect on the Diels-Alder reactivity of 2,3-dimethylidene-norbornane. The keto group in 13 exerts a larger retardation effect, although it is much smaller than the retardation effect introduced by an exo-5,6-epoxide ring in 2,3-dimethylidene-norbornane. 相似文献
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Wilson B. Lutz Craig R. Mcnamara Max R. Olinger David F. Schmidt Douglas E. Doster Mark D. Fiedler 《Journal of heterocyclic chemistry》1984,21(4):1183-1188
5,6-Carbonyldioxyindole ( 4 ), a melanogenic derivative of 5,6-dihydroxyindole ( 1 ), was synthesized by a procedure starting with 3,4-methylenedioxycinnamic acid ( 5 ). Compound 4 is a stable crystalline solid which is readily hydrolyzed to 1 , a key intermediate on the biosynthetic pathway from tyrosine to melanin. 相似文献
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Thomas C. Butler Dorothy Johnson Kenneth H. Dudley 《Journal of heterocyclic chemistry》1982,19(3):657-658
The spectrophotometric determination of the apparent ionization exponents of 5,6-dihydrouracil (DHU) and 5,6-dihydrothymine (DHT) is described. The values of pK′α at 37°C and ionic strength of 0.16 are 11.42 for DHU and 11.57 for DHT. 相似文献
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The first synthesis of a benz[c]acridine 5,6-oxide is described. Treatment of 5,6-benz[c]-acridinequinone with phenylmagnesium bromide results in the formation of a trans-diol, which gives the title compound upon dehydration with dimethylformamide dimethylacetal. In sulfuric acid, the epoxide rearranges mainly into 6,6-diphenyl-5-benz[c]acridone. 相似文献
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Ernst Peter Müller 《Helvetica chimica acta》1985,68(5):1107-1113
Thermolysis of 5,6-epimino-5,6-dihydro-β-ionone ( 1 ) and its N-methyl derivative ( 2 ) leads to their monocyclic isomers 6 and 10 , respectively, presumably due to a direct [1,5]-H shift; on prolonged heating, these isomers are converted easily into pyrrole derivatives. In contrast, the thermoisomer 12 resulting from 5,6-(N-methoxycarbonyl)epimino-5,6-dihydro-β-ionone ( 3 ) by the same mechanism, does not undergo further ring transformation, but equilibrates with its more stable tautomer 13 . 相似文献