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1.
1-Chlorobenzyl isocyanates react with 4-hydroxy-6-methylpyran-2-one and 4-hydroxycoumarin forming 4-aryl-3,4-dihydro-2H,5H-pyrano(chromeno)[3,4-e][1,3]oxazine-2,5-diones. The reaction of 1-aryl-2,2,2-trifluoro-1-chloroethyl isocyanates with the above substrates gives rise to structurally isomeric 2-aryl-2-trifluoromethyl-2,3-dihydro-2H,5H-pyrano(chromeno)[3,4-e][1,3]-oxazine-4,5-diones. 相似文献
2.
Vovk M. V. Lebed' P. S. Chernega A. N. Pirozhenko V. V. 《Russian Journal of Organic Chemistry》2004,40(2):195-198
1-Aryl-1-chloro-2,2,2-trifluoroethyl)-N'-(p-tolyl)carbodiimides treated with triethylamine undergo intramolecular cyclization into 4-aryl-6-methyl-2-triethylammonio-4-trifluoromethyl-4-dihydroquinazolidines. 相似文献
3.
M. V. Vovk V. A. Sukach A. M. Pinchuk A. N. Chernega V. V. Pirozhenko J. A. K. Howard 《Russian Journal of Organic Chemistry》2004,40(11):1638-1643
1-Chloroalkyl isocyanates react with imidazole, 4(5)-phenylimidazole, and 4,5-dimethyl(phenyl)-imidazoles to give 5-aryl-5-trifluoromethyl-5,6-dihydro-7H-imidazo[1,5-a]imidazole-7-ones, and with benzimidazole affording 1-aryl-1-trifluoromethyl-1,2-dihydro-3H-imidazo-[1,5-a]benzimidazole-3-ones.Translated from Zhurnal Organicheskoi Khimii, Vol. 40, No. 11, 2004, pp. 1686–1691.Original Russian Text Copyright © 2004 by Vovk, Sukach, Pinchuk, Chernega, Pirozhenko, Howard.For communication IV see [1]. 相似文献
4.
Alkyl 3-oxo-1,2,3,4-tetrahydroquinoxalin-2-ylideneacetates reacted with α-chlorobenzyl isocyanates to give alkyl 3-aryl-1,5-dioxo-2,3,5,6-tetrahydro-1H-pyrimido[1,6-a]quinoxaline-4-carboxylates. 相似文献
5.
Treatment of 6-amino-5-arylazo-1,3-dimethyluracils with urea or N,N′-carbonyldiimidazole gave the respective 6-aryl-1,3-dimethyl-6,7-dihydro-6-azalumazin-7-(6H)ones, which were hydrolyzed with alkali to afford 2-aryl-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carboxylic acids (1-aryl-6-azauracil-5-carboxylic acids). Thermal decomposition of these carboxylic acids gave the corresponding 2-aryl-1,2,4-triazine-3,5-(2H,4H)diones (1-aryl-6-azauracils). Methylation of the latter with methyl iodide gave the corresponding 2-aryl-4-methyl-1,2,4-triazine-3,5-(2H,4H)diones (1-aryl-3-methyl-6-azauracils). 相似文献
6.
O. V. Kushnir N. V. Mel’nichenko M. V. Vovk 《Russian Journal of Organic Chemistry》2011,47(11):1727-1732
Dialkyl 2-oxo-3-allyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates obtained by condensation of 1-chlorobenzyl isocyanates
with N-allylfumarates reacted regioselectively with arylhydroxymoyl chlorides with the formation of dialkyl 6-aryl-3-[(3-aryl-4,5-dihydro-5-isoxazolyl)methyl]-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates. 相似文献
7.
Susan Shilcrat Ivan Lantos Michael Mcguire Lendon Pridgen Louisa Davis Drake Eggleston David Staiger Lee Webb 《Journal of heterocyclic chemistry》1993,30(6):1663-1671
The ethyl chloroformate salts of a variety of benzo-fused six membered π-deficient heteroaromatics, including quinoline, isoquinoline, 4-chloroquinoline, 3-bromoquinoline, phthalazine, and quinazoline, reacted with 6-aryl-2,3-dihydroimidazo[2,1-b]thiazole at the 5-position. The dihydroheteroaromatic adducts were oxidized by o-chloranil, sulfur, or electrochemical methodology to form the 5-heteroaromatic-6-aryl-2,3-dihydroimidazo[2,1-b]thiazoles, 10-15 . In each example, the regiochemistry of addition to the heteroaromatic ring was established. 相似文献
8.
Lichitsky B. V. Kozhinov D. V. Vorontsova L. G. Starikova Z. A. Dudinov A. A. Krayushkin M. M. 《Russian Chemical Bulletin》2002,51(10):1869-1874
A general and convenient method for the synthesis of 12-aryl-1-oxo-1,2,3,4,5,12-hexahydroindolo[2,1-b]quinazoline-6-carbonitriles was proposed. The method is based on the recyclization of 11-aryl-1-oxo-2,3,4,5,10b,11-hexahydro-1H-indolo[2,3-b]quinoline-10b-carbonitriles. The structure of 12-(3-methoxyphenyl)-8-methyl-1-oxo-1,2,3,4,5,12-hexahydroindolo[2,1-b]quinazoline-6-carbonitrile was studied by X-ray diffraction analysis. 相似文献
9.
Giulia Menozzi Pietro Schenone Luisa Mosti Franceses Mattioli 《Journal of heterocyclic chemistry》1993,30(4):997-1002
Lithium aluminum hydride reduction of 5-substituted or unsubstituted ethyl or methyl 1-aryl-1H-pyrazole-4-carboxylates gave, generally in excellent yields, 5-substituted or unsubstituted 1-aryl-1H-pyrazole-4-methanols which afforded the corresponding 1-aryl-4-(bromomethyl)-1H-pyrazoles with hydrobromic acid in acetic acid solution. These crude intermediates gave by reaction with potassium cyanide in dimethylsulfoxide solution 1-aryl-1H-pyrazole-4-acetonitriles only in the case of 5-unsubstituted compounds, otherwise mixtures of 5-substituted 1-aryl-1H-pyrazole-4-acetonitriles and 4-methyl-1-phenyl-1H-pyrazole-3-carbonitriles were generally obtained. Acetonitriles IIIa,b,i,l gave in excellent yields the corresponding 1-aryl-1H-pyrazole-4-acetic acids Va,b,i,l by alkaline hydrolysis. Compounds Vb,i,l showed in the writhing test appreciable analgesic properties, associated with low acute toxicity; moreover, compound VI exhibited a statistically significant antiinflammatory activity in the carrageenan-induced edema assay. 相似文献
10.
M. V. Vovk P. S. Lebed A. N. Chernega V. V. Pirozhenko V. I. Boiko I. F. Tsymbal 《Chemistry of Heterocyclic Compounds》2004,40(1):47-57
The interaction of 1-chloroalkyl isocyanates, 1-chloroalkylcarbodiimides, 1,1-dichloroalkyl isocyanates, and N-(1-chloroethylidene)-O-methylurethanes with 2-cyanomethylpyridine has been investigated. An effect of organic base has been detected on the regioselectivity of the cyclocondensation of 1-chloroalkyl isocyanates, which leads to 2,3-dihydro-1H-pyrido[1,2-c]pyrimidin-1-one or the isomeric 2,3-dihydro-1H-pyrido[1,2-c]pyrimidin-3-one. Irrespective of the cyclization conditions 1-chloroalkylcarbodiimides react with the formation of 1-imino-2,3-dihydro-1H-pyrido[1,2-c]pyrimidines. One type of product, a 1H-pyrido[1,2-c]pyrimidin-1-one, was also isolated from 1,1-dichloroalkyl isocyanates and N-(1-chloroalkylidene)urethanes. 相似文献
11.
Vovk M. V. Bol'but A. V. Volochnyuk D. M. Pinchuk A. M. 《Russian Journal of Organic Chemistry》2004,40(1):63-66
5-Amino-1-aryl-4-methylpyrazoles readily add to methyl 1-aryl-2,2,2-trifluoroethylidenecarbamates to give the corresponding methyl 1-aryl-2,2,2-trifluoro-1-(5-pyrazolylamino)ethylcarbamates which undergo fragmentation at elevated temperature in the presence of an organic base to afford N-(5-pyrazolyl)-1-aryl-2,2,2-trifluoroethanimines. 相似文献
12.
E. S. Denislamova N. V. Bubnov A. N. Maslivets 《Russian Journal of Organic Chemistry》2011,47(6):933-936
Methyl 1-aryl-3-benzoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates reacted with 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione to give methyl 11-aryl-12-benzoyl-9-hydroxy-4,6-dimethyl-3,5,10-trioxo-4,6,8,11-tetraazatricyclo[7.2.1.02,7]dodec-2(7)-ene-1-carboxylates which underwent thermal recyclization to 1-aryl-3-benzoyl-4-hydroxy-1′,3′-dimethylspiro[pyrrole-2,5′-pyrrolo[2,3-d]pyrimidine]-2′,4′,5,6′(1H,1′H,3′H,7′H)-tetraones. 相似文献
13.
1-Aryl-2(1H)pyrimidinones I reacted with α-haloesters in the presence of zinc to give mainly 3,4-dihydro-4-alkoxycarbonylmethyl-1-aryl-2(1H)pyrimidinones IV in addition to the minor products of 3,6-dihydro-6-alkoxycarbonylmethyl-1-aryl-2(1H)pyrimidinones V. Further, 3,4-dihydro derivatives IVa-c were successfully converted into the corresponding exomethylene compounds Vla-c in high yields. 相似文献
14.
5-Amino-1-aryl-1H-imidazole-4-carbonitriles were converted into 9-aryl-6-aminopurines viaimidates formation at treating with CH(OEt)3, Ac2O followed by reaction with ammonia. 相似文献
15.
Kosterina M. F. Morzherin Yu. Yu. Tkachev A. V. Rybalova T. V. Gatilov Yu. V. Bakulev V. A. 《Russian Chemical Bulletin》2002,51(4):653-658
2-(Alkoxycarbonylmethylidene)-4-aryl-5-(dialkylamino)thiophen-3(2H)-ones were synthesized by condensation of N,N-(dialkyl)arylthioacetamides with dialkyl acetylenedicarboxylates. Intermediate substituted vinylic sulfides were isolated. When heated or in the presence of an acid or a base, they undergo cyclization into thiophenes. 相似文献
16.
Braulio Insuasty O Henry Insuasty I Jairo Quiroga P Claudio Saitz Carolina Jullian 《Journal of heterocyclic chemistry》1999,36(3):635-638
New 4-Aryl-6-methyl-8-phenyl-2,3-dihydropyrazolo[3,4-b]diazepines and 4-aryl-8-methyl-6-phenyl-2,3-dihydropyrazolo[4,3-b]diazepines were obtained from the reaction of 4,5-diamino-3-methyl-1-phenylpyrazole 1 with one equivalent of the 3-dimethylaminopropiophenones 2 in absolute ethanol. The structures of 4-aryl-6-methyl-8-phenyl-2,3-dihydropyrazolo[3,4-b]diazepines 3 and 4-aryl-8-methyl-6-phenyl-2,3-dihydropyrazolo[4,3-b]diazepines 4 were determined by detailed nmr measurements. 相似文献
17.
Zhchepin V. V. Kalyuzhnyi M. M. Zhchepin R. V. Vakhrin M. I. 《Russian Journal of Organic Chemistry》2003,39(6):843-845
Zinc enolates formed from 1-aryl-2,2-dibromobutan-1-ones and zinc react with alkyl 6-bromo-2-oxo-2-H-chromen-3-carboxylates affording alkyl 1-aroyl-6-bromo-2-oxo-1-ethyl-1,7b-dihydrocyclopropa[c]-chromen-1a(2H)-carboxylates as a single isomer. 相似文献
18.
In the present study, the density functional theory (DFT) and Gibbs free energy calculations were performed to investigate
the stability and tautomerism of C4-substituted-3,4-dihydropyrimidin-2(1H)-ones. Three different forms are possible for the ethyl 3,4-dihydropyrimidinones (ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylates, ethyl 4-aryl-2-hydroxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates and ethyl 4-aryl-2-hydroxy-6-methyl-3,4-dihydropyrimidine-5-carboxylates)
forms that the most stable form is ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2 (1H)-one-5-carboxylates (keto-form). The obtained data showed that the substitution on the C4-substitut position can be effective
on the equilibrium constant (K
eq). 相似文献
19.
E. S. Vostrov E. V. Leont'eva O. P. Tarasova A. N. Maslivets 《Russian Journal of Organic Chemistry》2004,40(7):1058-1061
Thermal decarbonylation of 5-aryl-4-phenyl-2,3-dihydrofuran-2,3-diones gives rise to intermediate aroyl(phenyl)ketenes which react with nonactivated Schiff bases, N,N'-dicyclohexylcarbodiimide, and p-di-methylaminobenzonitrile according to the [4 + 2]-cycloaddition pattern with formation of 6-aryl-5-phenyl-4H-1,3-oxazin-4-ones. Reactions of 5-aryl-4-phenyl-2,3-dihydrofuran-2,3-diones with activated Schiff bases at a temperature below the thermolysis temperature lead to 4-aroyl-4-phenyltetrahydropyrrole-2,3-diones. 相似文献
20.
Yoshihisa Kurasawa Muneto Muramatsu Kaoru Yamazaki Setsuko Tajima Yoshihisa Okamoto Atsushi Takada 《Journal of heterocyclic chemistry》1986,23(5):1379-1382
Novel 1-aryl-1H- and 1-aryl-3-heteroaryl-1H-pyrazolo[3,4-b]quinoxalines (flavazoles) 9a-c, 12, 13 were synthesized from 3-methyl-2-oxo-1,2-dihydroquinoxaline 5 and the 3-triazolylmethylene-2-oxo-1,2,3,4-tetrahydroquinoxaline 6, respectively, via a facile hydrazone synthesis using aryl diazonium salts. Some of the above flavazoles and their related compounds exhibited the antifungal activity in some extent. The above results are described. 相似文献